JPH0461868B2 - - Google Patents
Info
- Publication number
- JPH0461868B2 JPH0461868B2 JP59155045A JP15504584A JPH0461868B2 JP H0461868 B2 JPH0461868 B2 JP H0461868B2 JP 59155045 A JP59155045 A JP 59155045A JP 15504584 A JP15504584 A JP 15504584A JP H0461868 B2 JPH0461868 B2 JP H0461868B2
- Authority
- JP
- Japan
- Prior art keywords
- compound
- acid
- present
- carbon atoms
- amidino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C277/08—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups of substituted guanidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
- C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/88—Nitrogen atoms, e.g. allantoin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (21)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15504584A JPS6133173A (ja) | 1984-07-25 | 1984-07-25 | アミジン化合物 |
| CA000486773A CA1254205A (en) | 1984-07-25 | 1985-07-12 | 6-amidino-2-naphthyl benzoate compounds |
| HU853727A HU195769B (en) | 1984-07-25 | 1985-07-12 | Process for the production of new amidin compounds and medecal preparatives containing thereof as active substance |
| KR1019860700140A KR870001087B1 (ko) | 1984-07-25 | 1985-07-12 | 아미딘 화합물의 제조방법 |
| EP85903394A EP0190356B1 (en) | 1984-07-25 | 1985-07-12 | Novel amidine compounds |
| AU45492/85A AU567039B2 (en) | 1984-07-25 | 1985-07-12 | Novel amidine compounds |
| PCT/JP1985/000392 WO1986000893A1 (en) | 1984-07-25 | 1985-07-12 | Novel amidine compounds |
| DE8585903394T DE3582057D1 (en) | 1984-07-25 | 1985-07-12 | Amidinverbindungen. |
| US06/835,853 US4777182A (en) | 1984-07-25 | 1985-07-12 | 6-Amidino-2-naphthyl 4-guanidinobenzoate derivatives and pharmaceutical composition containing them |
| ZA855552A ZA855552B (en) | 1984-07-25 | 1985-07-23 | Amidine compounds |
| PH32559A PH20585A (en) | 1984-07-25 | 1985-07-23 | Novel amidine compound |
| DD85278877A DD235637A5 (de) | 1984-07-25 | 1985-07-23 | Verfahren zur herstellung von amidinverbindungen |
| ES545482A ES8607218A1 (es) | 1984-07-25 | 1985-07-23 | Un procedimiento para preparar compuestos de amidina |
| MX206081A MX160912A (es) | 1984-07-25 | 1985-07-24 | Procedimiento para la preparacion de derivados de benzoato de 6-amidino-2-naftilo |
| CS855463A CS255891B2 (en) | 1984-07-25 | 1985-07-24 | Process for preparing new derivatives of amidine |
| DK096286A DK169069B1 (da) | 1984-07-25 | 1986-03-03 | 6-Amidino-2-naphthyl-4-amino-benzoat-derivater og farmaceutisk acceptable syreadditionssalte deraf |
| FI860904A FI78461C (fi) | 1984-07-25 | 1986-03-04 | Foerfarande foer framstaellning av nya terapeutiskt anvaendbara amidinfoereningar. |
| NO86860865A NO163954C (no) | 1984-07-25 | 1986-03-07 | Analogifremgangsmaate for fremstilling av et terapeutisk aktivt amidinderivat. |
| KR1019860700140A KR860700250A (ko) | 1984-07-25 | 1986-03-10 | 신규 아미딘 화합물 |
| SU864027333A SU1456008A3 (ru) | 1984-07-25 | 1986-03-24 | Способ получени кислотно-аддитивных солей амидиновых соединений |
| US07/217,405 US4820730A (en) | 1984-07-25 | 1988-07-11 | 6-amino-2-naphthyl 4-gusnichinobenzoate derivatives and pharmaceutical composition containing them |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15504584A JPS6133173A (ja) | 1984-07-25 | 1984-07-25 | アミジン化合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6133173A JPS6133173A (ja) | 1986-02-17 |
| JPH0461868B2 true JPH0461868B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1992-10-02 |
Family
ID=15597463
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP15504584A Granted JPS6133173A (ja) | 1984-07-25 | 1984-07-25 | アミジン化合物 |
Country Status (19)
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3824236C1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1988-07-16 | 1989-12-28 | Heidelberger Druckmaschinen Ag, 6900 Heidelberg, De | |
| CA2032420A1 (en) * | 1989-12-22 | 1991-06-23 | Akira Okuyama | Guanidinobenzene derivatives |
| US5238964A (en) * | 1990-04-05 | 1993-08-24 | Torii & Co., Ltd. | Agent for treatment of cerebrovascular contraction |
| US5652237A (en) * | 1994-09-09 | 1997-07-29 | Warner-Lambert Company | 2-substituted-4H-3, 1-benzoxazin-4-ones and benzthiazin-4-ones as inhibitors of complement C1r protease for the treatment of inflammatory processes |
| KR100258496B1 (ko) * | 1995-01-05 | 2000-06-15 | 쓰까다 후미끼 | 치환아미디노나프틸에스테르유도체 |
| WO1996020706A1 (fr) * | 1995-01-05 | 1996-07-11 | Torii Pharmaceutical Co., Ltd. | Agent thrombolytique |
| BR9908911A (pt) | 1998-03-19 | 2001-10-02 | Bristol Myers Squibb Co | Sistema bifásico e processo de distribuição por liberação controlada de substâncias farmacêuticas de alta solubilidade |
| WO2001077082A1 (fr) * | 1999-06-02 | 2001-10-18 | Torii Pharmaceutical Co., Ltd. | Derives de naphtalene |
| AU2000252458A1 (en) * | 2000-06-08 | 2001-12-17 | Shizuoka Coffein Co., Ltd. | Benzene derivatives |
| EP2236136A1 (en) | 2005-05-17 | 2010-10-06 | Santen Pharmaceutical Co., Ltd. | Angiogenesis inhibitor containing amine derivate as active ingredient |
| ES2354223T3 (es) * | 2005-05-17 | 2011-03-11 | Santen Pharmaceutical Co., Ltd. | Derivados de amidina para uso en la prevención o el tratamiento de glaucoma. |
| WO2008058167A2 (en) * | 2006-11-07 | 2008-05-15 | Case Western Reserve University | Method for treating disorders associated with complement activation |
| JP6042330B2 (ja) | 2010-07-09 | 2016-12-14 | ビーエイチヴィ ファーマ、インコーポレイテッド | レモグリフロジンを含めた半減期が短い医薬品のための組合せ即時／遅延放出送達システム |
| JP6252991B2 (ja) * | 2012-07-04 | 2017-12-27 | 味の素株式会社 | ナファモスタットメシル酸塩の製造方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4292429A (en) * | 1978-03-08 | 1981-09-29 | Ciba-Geigy Corporation | Imidazole urea and amido compounds |
| AU527371B2 (en) * | 1980-09-16 | 1983-03-03 | Torii & Co., Ltd. | Amidine |
| JPS57179146A (en) * | 1981-04-28 | 1982-11-04 | Torii Yakuhin Kk | Amidine compound |
| JPS60130561A (ja) * | 1983-12-16 | 1985-07-12 | Torii Yakuhin Kk | アミジン誘導体およびそれを含む強心剤 |
-
1984
- 1984-07-25 JP JP15504584A patent/JPS6133173A/ja active Granted
-
1985
- 1985-07-12 HU HU853727A patent/HU195769B/hu not_active IP Right Cessation
- 1985-07-12 WO PCT/JP1985/000392 patent/WO1986000893A1/ja active IP Right Grant
- 1985-07-12 CA CA000486773A patent/CA1254205A/en not_active Expired
- 1985-07-12 KR KR1019860700140A patent/KR870001087B1/ko not_active Expired
- 1985-07-12 US US06/835,853 patent/US4777182A/en not_active Expired - Fee Related
- 1985-07-12 EP EP85903394A patent/EP0190356B1/en not_active Expired - Lifetime
- 1985-07-12 AU AU45492/85A patent/AU567039B2/en not_active Ceased
- 1985-07-12 DE DE8585903394T patent/DE3582057D1/de not_active Expired - Fee Related
- 1985-07-23 ZA ZA855552A patent/ZA855552B/xx unknown
- 1985-07-23 PH PH32559A patent/PH20585A/en unknown
- 1985-07-23 DD DD85278877A patent/DD235637A5/de not_active IP Right Cessation
- 1985-07-23 ES ES545482A patent/ES8607218A1/es not_active Expired
- 1985-07-24 CS CS855463A patent/CS255891B2/cs not_active IP Right Cessation
- 1985-07-24 MX MX206081A patent/MX160912A/es unknown
-
1986
- 1986-03-03 DK DK096286A patent/DK169069B1/da not_active IP Right Cessation
- 1986-03-04 FI FI860904A patent/FI78461C/fi not_active IP Right Cessation
- 1986-03-07 NO NO86860865A patent/NO163954C/no not_active IP Right Cessation
- 1986-03-10 KR KR1019860700140A patent/KR860700250A/ko active Granted
- 1986-03-24 SU SU864027333A patent/SU1456008A3/ru active
-
1988
- 1988-07-11 US US07/217,405 patent/US4820730A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| FI860904A0 (fi) | 1986-03-04 |
| CA1254205A (en) | 1989-05-16 |
| KR860700250A (ko) | 1986-08-01 |
| DE3582057D1 (en) | 1991-04-11 |
| EP0190356B1 (en) | 1991-03-06 |
| ZA855552B (en) | 1986-03-26 |
| HU195769B (en) | 1988-07-28 |
| DK96286A (da) | 1986-03-03 |
| NO860865L (no) | 1986-04-10 |
| CS546385A2 (en) | 1987-07-16 |
| MX160912A (es) | 1990-06-14 |
| FI78461B (fi) | 1989-04-28 |
| DD235637A5 (de) | 1986-05-14 |
| DK96286D0 (da) | 1986-03-03 |
| KR870001087B1 (ko) | 1987-06-04 |
| US4777182A (en) | 1988-10-11 |
| HUT42433A (en) | 1987-07-28 |
| AU4549285A (en) | 1986-02-25 |
| EP0190356A4 (en) | 1987-12-09 |
| JPS6133173A (ja) | 1986-02-17 |
| WO1986000893A1 (en) | 1986-02-13 |
| AU567039B2 (en) | 1987-11-05 |
| EP0190356A1 (en) | 1986-08-13 |
| CS255891B2 (en) | 1988-03-15 |
| FI78461C (fi) | 1989-08-10 |
| US4820730A (en) | 1989-04-11 |
| ES545482A0 (es) | 1986-05-16 |
| SU1456008A3 (ru) | 1989-01-30 |
| FI860904A7 (fi) | 1986-03-04 |
| NO163954C (no) | 1990-08-15 |
| ES8607218A1 (es) | 1986-05-16 |
| PH20585A (en) | 1987-02-20 |
| DK169069B1 (da) | 1994-08-08 |
| NO163954B (no) | 1990-05-07 |