JPS6133173A - アミジン化合物 - Google Patents

アミジン化合物

Info

Publication number
JPS6133173A
JPS6133173A JP15504584A JP15504584A JPS6133173A JP S6133173 A JPS6133173 A JP S6133173A JP 15504584 A JP15504584 A JP 15504584A JP 15504584 A JP15504584 A JP 15504584A JP S6133173 A JPS6133173 A JP S6133173A
Authority
JP
Japan
Prior art keywords
compound
complement
acid
present
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP15504584A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0461868B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html
Inventor
Setsuo Fujii
藤井　節郎
Toshiyuki Okutome
奥留　敏之
Toyoo Nakayama
中山　豊男
Shigeki Nunomura
茂樹 布村
Kimio Sudo
須藤　公夫
Shinichi Watabe
伸一 渡部
Masateru Kurumi
来海　正輝
Takuo Aoyama
青山　卓夫
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Torii Pharmaceutical Co Ltd
Original Assignee
Torii Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Torii Pharmaceutical Co Ltd filed Critical Torii Pharmaceutical Co Ltd
Priority to JP15504584A priority Critical patent/JPS6133173A/ja
Priority to HU853727A priority patent/HU195769B/hu
Priority to PCT/JP1985/000392 priority patent/WO1986000893A1/ja
Priority to US06/835,853 priority patent/US4777182A/en
Priority to CA000486773A priority patent/CA1254205A/en
Priority to DE8585903394T priority patent/DE3582057D1/de
Priority to EP85903394A priority patent/EP0190356B1/en
Priority to AU45492/85A priority patent/AU567039B2/en
Priority to KR1019860700140A priority patent/KR870001087B1/ko
Priority to ES545482A priority patent/ES8607218A1/es
Priority to DD85278877A priority patent/DD235637A5/de
Priority to PH32559A priority patent/PH20585A/en
Priority to ZA855552A priority patent/ZA855552B/xx
Priority to CS855463A priority patent/CS255891B2/cs
Priority to MX206081A priority patent/MX160912A/es
Publication of JPS6133173A publication Critical patent/JPS6133173A/ja
Priority to DK096286A priority patent/DK169069B1/da
Priority to FI860904A priority patent/FI78461C/fi
Priority to NO86860865A priority patent/NO163954C/no
Priority to KR1019860700140A priority patent/KR860700250A/ko
Priority to SU864027333A priority patent/SU1456008A3/ru
Priority to US07/217,405 priority patent/US4820730A/en
Publication of JPH0461868B2 publication Critical patent/JPH0461868B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C277/08—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups of substituted guanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP15504584A 1984-07-25 1984-07-25 アミジン化合物 Granted JPS6133173A (ja)

Priority Applications (21)

Application Number Priority Date Filing Date Title
JP15504584A JPS6133173A (ja) 1984-07-25 1984-07-25 アミジン化合物
HU853727A HU195769B (en) 1984-07-25 1985-07-12 Process for the production of new amidin compounds and medecal preparatives containing thereof as active substance
PCT/JP1985/000392 WO1986000893A1 (en) 1984-07-25 1985-07-12 Novel amidine compounds
US06/835,853 US4777182A (en) 1984-07-25 1985-07-12 6-Amidino-2-naphthyl 4-guanidinobenzoate derivatives and pharmaceutical composition containing them
CA000486773A CA1254205A (en) 1984-07-25 1985-07-12 6-amidino-2-naphthyl benzoate compounds
DE8585903394T DE3582057D1 (en) 1984-07-25 1985-07-12 Amidinverbindungen.
EP85903394A EP0190356B1 (en) 1984-07-25 1985-07-12 Novel amidine compounds
AU45492/85A AU567039B2 (en) 1984-07-25 1985-07-12 Novel amidine compounds
KR1019860700140A KR870001087B1 (ko) 1984-07-25 1985-07-12 아미딘 화합물의 제조방법
DD85278877A DD235637A5 (de) 1984-07-25 1985-07-23 Verfahren zur herstellung von amidinverbindungen
ZA855552A ZA855552B (en) 1984-07-25 1985-07-23 Amidine compounds
ES545482A ES8607218A1 (es) 1984-07-25 1985-07-23 Un procedimiento para preparar compuestos de amidina
PH32559A PH20585A (en) 1984-07-25 1985-07-23 Novel amidine compound
CS855463A CS255891B2 (en) 1984-07-25 1985-07-24 Process for preparing new derivatives of amidine
MX206081A MX160912A (es) 1984-07-25 1985-07-24 Procedimiento para la preparacion de derivados de benzoato de 6-amidino-2-naftilo
DK096286A DK169069B1 (da) 1984-07-25 1986-03-03 6-Amidino-2-naphthyl-4-amino-benzoat-derivater og farmaceutisk acceptable syreadditionssalte deraf
FI860904A FI78461C (fi) 1984-07-25 1986-03-04 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara amidinfoereningar.
NO86860865A NO163954C (no) 1984-07-25 1986-03-07 Analogifremgangsmaate for fremstilling av et terapeutisk aktivt amidinderivat.
KR1019860700140A KR860700250A (ko) 1984-07-25 1986-03-10 신규 아미딘 화합물
SU864027333A SU1456008A3 (ru) 1984-07-25 1986-03-24 Способ получени кислотно-аддитивных солей амидиновых соединений
US07/217,405 US4820730A (en) 1984-07-25 1988-07-11 6-amino-2-naphthyl 4-gusnichinobenzoate derivatives and pharmaceutical composition containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15504584A JPS6133173A (ja) 1984-07-25 1984-07-25 アミジン化合物

Publications (2)

Publication Number Publication Date
JPS6133173A true JPS6133173A (ja) 1986-02-17
JPH0461868B2 JPH0461868B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1992-10-02

Family

ID=15597463

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15504584A Granted JPS6133173A (ja) 1984-07-25 1984-07-25 アミジン化合物

Country Status (19)

Country Link
US (2) US4777182A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0190356B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS6133173A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (2) KR870001087B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU567039B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1254205A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CS (1) CS255891B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DD (1) DD235637A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3582057D1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK169069B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES8607218A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI78461C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (1) HU195769B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
MX (1) MX160912A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (1) NO163954C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PH (1) PH20585A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SU (1) SU1456008A3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
WO (1) WO1986000893A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA855552B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996020917A1 (fr) * 1995-01-05 1996-07-11 Torii Pharmaceutical Co., Ltd. Derives d'ester d'amidinonaphtyle substitues
WO1996020706A1 (fr) * 1995-01-05 1996-07-11 Torii Pharmaceutical Co., Ltd. Agent thrombolytique
WO2001094299A1 (fr) * 2000-06-08 2001-12-13 Shizuoka Coffein Co., Ltd. Derives de benzene
WO2006123674A1 (ja) * 2005-05-17 2006-11-23 Santen Pharmaceutical Co., Ltd. アミン誘導体を有効成分として含む血管新生阻害剤
EP2119440A1 (en) 2005-05-17 2009-11-18 Santen Pharmaceutical Co., Ltd. Amidino derivatives for use in the prevention or treatment of retinitis pigmentosa and Leber's disease
JPWO2014007326A1 (ja) * 2012-07-04 2016-06-02 味の素株式会社 ナファモスタットメシル酸塩の製造方法

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3824236C1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1988-07-16 1989-12-28 Heidelberger Druckmaschinen Ag, 6900 Heidelberg, De
CA2032420A1 (en) * 1989-12-22 1991-06-23 Akira Okuyama Guanidinobenzene derivatives
US5238964A (en) * 1990-04-05 1993-08-24 Torii & Co., Ltd. Agent for treatment of cerebrovascular contraction
US5652237A (en) * 1994-09-09 1997-07-29 Warner-Lambert Company 2-substituted-4H-3, 1-benzoxazin-4-ones and benzthiazin-4-ones as inhibitors of complement C1r protease for the treatment of inflammatory processes
AP1224A (en) 1998-03-19 2003-11-14 Bristol Myers Squibb Co Biphasic controlled release delivery system for high solubility pharmaceuticals and method.
WO2001077082A1 (fr) * 1999-06-02 2001-10-18 Torii Pharmaceutical Co., Ltd. Derives de naphtalene
WO2008058167A2 (en) * 2006-11-07 2008-05-15 Case Western Reserve University Method for treating disorders associated with complement activation
PL2590634T3 (pl) 2010-07-09 2016-10-31 Skojarzony system natychmiastowego / opóźnionego uwalniania leków o krótkim okresie półtrwania, w tym remogliflozyny

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57179146A (en) * 1981-04-28 1982-11-04 Torii Yakuhin Kk Amidine compound

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4292429A (en) * 1978-03-08 1981-09-29 Ciba-Geigy Corporation Imidazole urea and amido compounds
AU527371B2 (en) * 1980-09-16 1983-03-03 Torii & Co., Ltd. Amidine
JPS60130561A (ja) * 1983-12-16 1985-07-12 Torii Yakuhin Kk アミジン誘導体およびそれを含む強心剤

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57179146A (en) * 1981-04-28 1982-11-04 Torii Yakuhin Kk Amidine compound

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996020917A1 (fr) * 1995-01-05 1996-07-11 Torii Pharmaceutical Co., Ltd. Derives d'ester d'amidinonaphtyle substitues
WO1996020706A1 (fr) * 1995-01-05 1996-07-11 Torii Pharmaceutical Co., Ltd. Agent thrombolytique
AU686104B2 (en) * 1995-01-05 1998-02-05 Torii Pharmaceutical Co., Ltd. Substituted amidinonaphthyl ester derivatives
WO2001094299A1 (fr) * 2000-06-08 2001-12-13 Shizuoka Coffein Co., Ltd. Derives de benzene
WO2006123674A1 (ja) * 2005-05-17 2006-11-23 Santen Pharmaceutical Co., Ltd. アミン誘導体を有効成分として含む血管新生阻害剤
EP2119440A1 (en) 2005-05-17 2009-11-18 Santen Pharmaceutical Co., Ltd. Amidino derivatives for use in the prevention or treatment of retinitis pigmentosa and Leber's disease
EP2143431A1 (en) 2005-05-17 2010-01-13 Santen Pharmaceutical Co., Ltd. Protective agent for neurocyte comprising amidino derivative as active ingredient
EP2236136A1 (en) 2005-05-17 2010-10-06 Santen Pharmaceutical Co., Ltd. Angiogenesis inhibitor containing amine derivate as active ingredient
JPWO2014007326A1 (ja) * 2012-07-04 2016-06-02 味の素株式会社 ナファモスタットメシル酸塩の製造方法

Also Published As

Publication number Publication date
ZA855552B (en) 1986-03-26
FI860904A7 (fi) 1986-03-04
AU567039B2 (en) 1987-11-05
US4777182A (en) 1988-10-11
DK96286D0 (da) 1986-03-03
SU1456008A3 (ru) 1989-01-30
JPH0461868B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1992-10-02
US4820730A (en) 1989-04-11
FI78461C (fi) 1989-08-10
FI78461B (fi) 1989-04-28
EP0190356A1 (en) 1986-08-13
MX160912A (es) 1990-06-14
KR860700250A (ko) 1986-08-01
DE3582057D1 (en) 1991-04-11
EP0190356A4 (en) 1987-12-09
NO860865L (no) 1986-04-10
CS255891B2 (en) 1988-03-15
NO163954B (no) 1990-05-07
ES545482A0 (es) 1986-05-16
HUT42433A (en) 1987-07-28
NO163954C (no) 1990-08-15
WO1986000893A1 (en) 1986-02-13
CS546385A2 (en) 1987-07-16
AU4549285A (en) 1986-02-25
HU195769B (en) 1988-07-28
PH20585A (en) 1987-02-20
DD235637A5 (de) 1986-05-14
CA1254205A (en) 1989-05-16
FI860904A0 (fi) 1986-03-04
DK169069B1 (da) 1994-08-08
KR870001087B1 (ko) 1987-06-04
ES8607218A1 (es) 1986-05-16
DK96286A (da) 1986-03-03
EP0190356B1 (en) 1991-03-06

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