JPH04505101A - ヒトラクトフェリンcDNA配列 - Google Patents
ヒトラクトフェリンcDNA配列Info
- Publication number
- JPH04505101A JPH04505101A JP2507801A JP50780190A JPH04505101A JP H04505101 A JPH04505101 A JP H04505101A JP 2507801 A JP2507801 A JP 2507801A JP 50780190 A JP50780190 A JP 50780190A JP H04505101 A JPH04505101 A JP H04505101A
- Authority
- JP
- Japan
- Prior art keywords
- cdna
- lactoferrin
- human lactoferrin
- protein
- cdna sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
Description
Claims (13)
- 1.第2図に示すDNA配列からなる、ヒトラクトフェリン蛋白をコードしてい るcDNA配列。
- 2.第2図に示すcDNA配列と類似する配列からなる、ヒトラクトフェリンの 機能的等価物をコードしているcDNA配列。
- 3.第2図に示すcDNA配列から生産される産物からなる合成ヒトラクトフェ リン。
- 4.第2図に示すcDNA配列と類似する配列から生産される産物からなる、合 成ヒトラクトフェリン機能的等価物。
- 5.第2図のcDNA配列を使用することからなる、合成ヒトラクトフェリン産 物を生産する方法。
- 6.第2図に示すcDNA配列と類似する配列を使用することからなる、合成ヒ トラクトフェリン機能的等価物を生産する方法。
- 7.真核性発現系を用いる、請求項5または6に記載の合成ヒトラクトフェリン およびその機能的等価物の生産方法。
- 8.Fe結合部位を有する鉄結合ドメインの少なくとも1つを含んでいるヒトラ クトフェリン蛋白をコードしている第2図のcDNAの一部を含んでいるcDN A配列。
- 9.該cDNA配列の1部の類似物が、Fe結合部位を有する少なくとも1つの 鉄結合ドメインと機能的等価物をコードしている請求項8に記載のcDNA配列 。
- 10.請求項8に記載の合成ヒトラクトフェリンの1部を生産することからなる 方法。
- 11.請求項9に記載の合成ヒトラクトフェリン機能的等価物の1部を生産する ことからなる方法。
- 12.Fe結合部位を有する鉄結合領域の少なくとも1つを含んでいる第2図に 記載のcDNA配列から生産される合成ヒトラクトフェリン産物の1部からなる 、合成ヒトラクトフェリン産物。
- 13.Fe結合部位を有する鉄結合領域の少なくとも1つの機能的等価物を含ん でいる第2図のcDNA配列の等価物によって生産されるヒトラクトフェリン蛋 白の1部の合成機能的等価物からなる合成ヒトラクトフェリン産物。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US34827089A | 1989-05-05 | 1989-05-05 | |
US348,270 | 1989-05-05 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH04505101A true JPH04505101A (ja) | 1992-09-10 |
JP2701976B2 JP2701976B2 (ja) | 1998-01-21 |
Family
ID=23367308
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2507801A Expired - Lifetime JP2701976B2 (ja) | 1989-05-05 | 1990-04-27 | ヒトラクトフェリンcDNA配列 |
Country Status (13)
Country | Link |
---|---|
US (3) | US6228614B1 (ja) |
EP (1) | EP0471011B2 (ja) |
JP (1) | JP2701976B2 (ja) |
AT (1) | ATE112801T1 (ja) |
AU (1) | AU5661890A (ja) |
CA (1) | CA2015994C (ja) |
DE (1) | DE69013342T3 (ja) |
DK (1) | DK0471011T4 (ja) |
ES (1) | ES2061038T5 (ja) |
IE (1) | IE66820B1 (ja) |
IL (1) | IL94183A (ja) |
NZ (1) | NZ233450A (ja) |
WO (1) | WO1990013642A1 (ja) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH07274970A (ja) * | 1994-04-01 | 1995-10-24 | Morinaga Milk Ind Co Ltd | 組換えベクターと、この組換えベクターを保持する形 質転換体、およびこの形質転換体による抗菌性ペプチ ドの製造方法 |
JPH11505268A (ja) * | 1995-10-19 | 1999-05-18 | イエナファーム・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング ウント コンパニー コマンディートゲゼルシャフト | 1,3,5(10)−エストラトリエン誘導体のスルファメート誘導体、それらの製造法およびそれらを含有する医薬化合物 |
KR20180083909A (ko) * | 2015-11-20 | 2018-07-23 | 게로아 디아그노스틱스, 에스.엘. | 알츠하이머병의 진단 또는 예측, 또는 파킨슨병의 진단을 위한 락토페린 |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL94183A (en) * | 1989-05-05 | 2003-09-17 | Baylor College Medicine | cDNA SEQUENCE CODING FOR HUMAN LACTOFERRIN PROTEIN OR PORTION THEREOF AND LACTOFERRIN PROTEIN PRODUCED FROM SAID SEQUENCE |
US5571697A (en) * | 1989-05-05 | 1996-11-05 | Baylor College Of Medicine Texas Medical Center | Expression of processed recombinant lactoferrin and lactoferrin polypeptide fragments from a fusion product in Aspergillus |
US6066469A (en) | 1990-03-08 | 2000-05-23 | Ferro Dynamics, Inc. | Cloning, expression, and uses of human lactoferrin |
DE69223844T2 (de) * | 1991-04-24 | 1998-04-16 | Morinaga Milk Industry Co Ltd | Antimikrobielles Peptid und antimikrobieller Wirkstoff |
AU2029192A (en) * | 1991-05-31 | 1993-01-08 | United States Of America, Represented By The Secretary, Department Of Health And Human Services, The | Human lactoferrin |
ZA932568B (en) * | 1992-04-24 | 1993-11-12 | Baylor College Midecine A Non | Production of recombinant human lactoferrin |
WO1995030339A1 (en) * | 1994-05-05 | 1995-11-16 | Ferrodynamics, Inc. | Cloning, expression, and uses of human lactoferrin |
FR2735983B1 (fr) | 1995-06-29 | 1997-12-05 | Centre Nat Rech Scient | Peptide permettant de modifier l'activite du systeme immunitaire humain ou animal |
ES2212357T3 (es) * | 1997-09-16 | 2004-07-16 | Wolf-Georg Forssmann | Peptidos bifidogenos y su uso. |
US6399570B1 (en) * | 1999-02-05 | 2002-06-04 | Agennix, Inc. | Antimicrobial/endotoxin neutralizing polypeptide |
WO2001047545A1 (fr) * | 1999-12-28 | 2001-07-05 | Sumitomo Pharmaceuticals Company, Limited | Produits therapeutiques et prophylactiques pour l'hepatique chronique |
EP1478379A4 (en) * | 2001-12-28 | 2005-12-21 | Campina Bv | HUMANIZED LACTOFERRIN AND ITS APPLICATIONS |
ATE519499T1 (de) * | 2002-05-10 | 2011-08-15 | Agennix Inc | Lactoferrin bei der behandlung maligner neoplasien und anderer hyperproliferativer erkrankungen |
WO2003099207A2 (en) * | 2002-05-24 | 2003-12-04 | Agennix Incorporated | Oral lactoferrin in the treatment of respiratory disorders |
CA2499014A1 (en) | 2002-09-16 | 2004-03-25 | Agennix Incorporated | Lactoferrin compositions and methods of wound treatment |
EP1581243A4 (en) * | 2002-12-06 | 2008-01-02 | Agennix Inc | ORAL LACTOFERRINE FOR THE TREATMENT OF SEPSIES |
US7592306B2 (en) | 2002-12-10 | 2009-09-22 | Agennix, Inc. | Lactoferrin as an agent in the prevention of organ transplant rejection and graft-versus-host-disease |
WO2004054608A2 (en) * | 2002-12-12 | 2004-07-01 | Agennix Incorporated | Lactoferrin in the reduction of pain |
WO2004103285A2 (en) * | 2003-05-14 | 2004-12-02 | Agennix Incorporated | Lactoferrin in the treatment of diabetes mellitus |
EP1635766A4 (en) * | 2003-06-06 | 2009-09-30 | Agennix Inc | LACTOFERRIN AS ADJUVANS IN CANCER VACCINES |
US20050075277A1 (en) * | 2003-07-10 | 2005-04-07 | Agennix Incorporated | Use of lactoferrin in prophylaxis against infection and/or inflammation in immunosuppressed subjects |
WO2006047744A2 (en) * | 2004-10-26 | 2006-05-04 | Agennix Incorporated | Compositions of lactoferrin related peptides and uses thereof |
WO2006074450A2 (en) * | 2005-01-07 | 2006-07-13 | President And Fellows Of Harvard College | Methods and compositions for detecting and modulating periodontal disorders and periodontal diseases |
CA2570744C (en) * | 2006-04-24 | 2014-07-15 | Bce Inc. | Method, system and apparatus for conveying an event reminder |
NZ555163A (en) | 2007-05-14 | 2010-05-28 | Fonterra Co Operative Group | Methods of immune or hematological enhancement, inhibiting tumour formation or growth, and treating or preventing cancer, cancer symptoms, or the symptoms of cancer treatments |
EP2560677A4 (en) * | 2010-04-23 | 2013-09-11 | Probiotec Ltd | COLD TREATMENT |
RU2554742C1 (ru) * | 2013-12-26 | 2015-06-27 | Российская Федерация, от имени которой выступает Министерство образования и науки РФ | Технология опытного выделения лактоферрина человека |
TWI614022B (zh) * | 2016-02-23 | 2018-02-11 | 肌活麗學創研所股份有限公司 | 降低黑色素含量的胜肽、方法及組合物 |
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US82504A (en) * | 1868-09-29 | Improvement in mitre-machines | ||
US75277A (en) * | 1868-03-10 | Improvement in deiees | ||
US105006A (en) * | 1870-07-05 | Improvement in cotton-seed planters | ||
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US5849881A (en) * | 1989-05-05 | 1998-12-15 | Baylor College Medicine | Production of recombinant lactoferrin and lactoferrin polypeptides using cDNA sequences in various organisms |
US6100054A (en) * | 1989-05-05 | 2000-08-08 | Baylor College Of Medicine | Production for recombinant lactoferrin and lactoferrin polypeptides using DNA sequences in various organisms |
IL94183A (en) | 1989-05-05 | 2003-09-17 | Baylor College Medicine | cDNA SEQUENCE CODING FOR HUMAN LACTOFERRIN PROTEIN OR PORTION THEREOF AND LACTOFERRIN PROTEIN PRODUCED FROM SAID SEQUENCE |
US5766939A (en) * | 1989-05-05 | 1998-06-16 | Baylor College Of Medicine | Production of recombinant lactoferrin and lactoferrin polypeptides using CDNA sequences in various organisms |
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ZA932568B (en) * | 1992-04-24 | 1993-11-12 | Baylor College Midecine A Non | Production of recombinant human lactoferrin |
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US6111081A (en) * | 1996-05-31 | 2000-08-29 | Baylor College Of Medicine | Lactoferrin variants and uses thereof |
US6399570B1 (en) * | 1999-02-05 | 2002-06-04 | Agennix, Inc. | Antimicrobial/endotoxin neutralizing polypeptide |
-
1990
- 1990-04-24 IL IL9418390A patent/IL94183A/xx not_active IP Right Cessation
- 1990-04-26 IE IE148390A patent/IE66820B1/en not_active IP Right Cessation
- 1990-04-26 NZ NZ233450A patent/NZ233450A/xx unknown
- 1990-04-27 AU AU56618/90A patent/AU5661890A/en not_active Abandoned
- 1990-04-27 JP JP2507801A patent/JP2701976B2/ja not_active Expired - Lifetime
- 1990-04-27 AT AT90907718T patent/ATE112801T1/de not_active IP Right Cessation
- 1990-04-27 DE DE69013342T patent/DE69013342T3/de not_active Expired - Lifetime
- 1990-04-27 WO PCT/US1990/002356 patent/WO1990013642A1/en active IP Right Grant
- 1990-04-27 DK DK90907718T patent/DK0471011T4/da active
- 1990-04-27 EP EP90907718A patent/EP0471011B2/en not_active Expired - Lifetime
- 1990-04-27 ES ES90907718T patent/ES2061038T5/es not_active Expired - Lifetime
- 1990-05-03 CA CA002015994A patent/CA2015994C/en not_active Expired - Lifetime
-
1999
- 1999-03-09 US US09/265,577 patent/US6228614B1/en not_active Expired - Fee Related
-
2000
- 2000-08-07 US US09/633,739 patent/US6635447B1/en not_active Expired - Fee Related
-
2003
- 2003-07-15 US US10/620,256 patent/US20050064546A1/en not_active Abandoned
Non-Patent Citations (2)
Title |
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ACTA.HISTOCHEM.CYTOCHM=1984 * |
EUR.J.BIOCHM=1984 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH07274970A (ja) * | 1994-04-01 | 1995-10-24 | Morinaga Milk Ind Co Ltd | 組換えベクターと、この組換えベクターを保持する形 質転換体、およびこの形質転換体による抗菌性ペプチ ドの製造方法 |
JPH11505268A (ja) * | 1995-10-19 | 1999-05-18 | イエナファーム・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング ウント コンパニー コマンディートゲゼルシャフト | 1,3,5(10)−エストラトリエン誘導体のスルファメート誘導体、それらの製造法およびそれらを含有する医薬化合物 |
KR20180083909A (ko) * | 2015-11-20 | 2018-07-23 | 게로아 디아그노스틱스, 에스.엘. | 알츠하이머병의 진단 또는 예측, 또는 파킨슨병의 진단을 위한 락토페린 |
JP2018536410A (ja) * | 2015-11-20 | 2018-12-13 | へロア ダイアグノスティクス,エセ.エレ. | アルツハイマー病の診断もしくは予見、またはパーキンソン病の診断に用いるラクトフェリン |
Also Published As
Publication number | Publication date |
---|---|
DK0471011T4 (da) | 2004-09-13 |
CA2015994A1 (en) | 1990-11-05 |
EP0471011B2 (en) | 2004-08-18 |
ATE112801T1 (de) | 1994-10-15 |
DE69013342T2 (de) | 1995-03-23 |
IE66820B1 (en) | 1996-02-07 |
AU5661890A (en) | 1990-11-29 |
EP0471011B1 (en) | 1994-10-12 |
JP2701976B2 (ja) | 1998-01-21 |
US6635447B1 (en) | 2003-10-21 |
DE69013342D1 (de) | 1994-11-17 |
US6228614B1 (en) | 2001-05-08 |
IL94183A0 (en) | 1991-01-31 |
DE69013342T3 (de) | 2005-02-17 |
IE901483L (en) | 1990-11-05 |
ES2061038T5 (es) | 2005-03-16 |
IL94183A (en) | 2003-09-17 |
CA2015994C (en) | 2000-02-15 |
ES2061038T3 (es) | 1994-12-01 |
US20050064546A1 (en) | 2005-03-24 |
WO1990013642A1 (en) | 1990-11-15 |
NZ233450A (en) | 1992-10-28 |
EP0471011A1 (en) | 1992-02-19 |
DK0471011T3 (da) | 1994-11-14 |
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Publication | Publication Date | Title |
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