JPH04500377A - グリコサミノグリカン塩、その製造方法およびそれを含有する医薬組成物 - Google Patents

グリコサミノグリカン塩、その製造方法およびそれを含有する医薬組成物

Info

Publication number
JPH04500377A
JPH04500377A JP1506141A JP50614189A JPH04500377A JP H04500377 A JPH04500377 A JP H04500377A JP 1506141 A JP1506141 A JP 1506141A JP 50614189 A JP50614189 A JP 50614189A JP H04500377 A JPH04500377 A JP H04500377A
Authority
JP
Japan
Prior art keywords
group
heparin
formula
tables
carbonate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP1506141A
Other languages
English (en)
Japanese (ja)
Inventor
ダル　ポッツォ　アルマ
アクアサリエンテ　マウリツィオ
スポルトレッティ　ジアンカルロ
サッレトゥ　モニクェ
フェッルティ　パオロ
デ　サンティス　フランチェスコ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Italfarmaco SpA
Original Assignee
Italfarmaco SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT20854/88A external-priority patent/IT1219704B/it
Priority claimed from IT8947985A external-priority patent/IT1231915B/it
Application filed by Italfarmaco SpA filed Critical Italfarmaco SpA
Publication of JPH04500377A publication Critical patent/JPH04500377A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0069—Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP1506141A 1988-06-03 1989-05-30 グリコサミノグリカン塩、その製造方法およびそれを含有する医薬組成物 Pending JPH04500377A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IT20854/88A IT1219704B (it) 1988-06-03 1988-06-03 Sali di glicosaminoglicani,procedimento per la loro preparazione e relative composizioni farmaceutiche
IT20854A/88 1988-06-03
IT8947985A IT1231915B (it) 1989-05-24 1989-05-24 Sali di glicosaminoglicani, procedimento per la loro preparazione e relative composizioni farmaceutiche
IT47985A/89 1989-05-24

Publications (1)

Publication Number Publication Date
JPH04500377A true JPH04500377A (ja) 1992-01-23

Family

ID=26327686

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1506141A Pending JPH04500377A (ja) 1988-06-03 1989-05-30 グリコサミノグリカン塩、その製造方法およびそれを含有する医薬組成物

Country Status (13)

Country Link
US (1) US5264425A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0423151B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPH04500377A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR920700232A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU630359B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1335375C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE68909412T2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK286190D0 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (1) HU208029B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IN (1) IN169470B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
MC (1) MC2098A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ229403A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
WO (1) WO1989012070A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1327354C (en) * 1987-03-19 1994-03-01 David Cullis-Hill Anti-inflamatory compounds and compositions
US5668116A (en) * 1987-03-19 1997-09-16 Anthropharm Pty. Limited Anti-inflammatory compounds and compositions
IT1237518B (it) * 1989-11-24 1993-06-08 Renato Conti Eparine supersolfatate
IT1242604B (it) * 1990-11-13 1994-05-16 Alfa Wassermann Spa Sali di glicosaminoglicani con esteri di aminoacidi, loro preparazione e formulazioni farmaceutiche che li contengono.
IT1274021B (it) * 1994-02-28 1997-07-14 Italfarmaco Spa Diesteri dell'acido carbonico ad attivita' antivirale ed antinfiammatoria
AU4137996A (en) * 1994-10-28 1996-05-23 Trustees Of The University Of Pennsylvania, The Heparin, compositions and methods of use therefore
ZA978537B (en) 1996-09-23 1998-05-12 Focal Inc Polymerizable biodegradable polymers including carbonate or dioxanone linkages.
WO2001002855A1 (en) 1999-07-01 2001-01-11 Scios Inc. Prevention and treatment of amyloid-associated disorders
AU2003225724A1 (en) 2002-03-11 2003-09-29 Momenta Pharmaceuticals, Inc. Analysis of sulfated polysaccharides
WO2003090696A2 (en) * 2002-04-25 2003-11-06 Momenta Pharmaceuticals, Inc. Methods and products for mucosal delivery
US8719242B2 (en) * 2003-08-29 2014-05-06 Sap Ag System and method for a database access statement interceptor
US9139876B1 (en) 2007-05-03 2015-09-22 Momenta Pharmacueticals, Inc. Method of analyzing a preparation of a low molecular weight heparin
ES2567079T3 (es) * 2007-11-02 2016-04-19 Momenta Pharmaceuticals, Inc. Composiciones de polisacáridos que no son anticoagulantes
US8569262B2 (en) * 2007-11-02 2013-10-29 Momenta Pharmaceuticals, Inc. Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization
US8592393B2 (en) 2007-11-02 2013-11-26 Momenta Pharmaceuticals, Inc. Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization
EP2526122B1 (en) * 2010-01-19 2020-06-10 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
EP2558506B1 (en) 2010-04-16 2019-06-26 Momenta Pharmaceuticals, Inc. Tissue targeting
US10017585B2 (en) 2010-06-17 2018-07-10 Momenta Pharmaceuticals, Inc. Methods and compositions for promoting hair growth
US9068957B2 (en) 2011-02-21 2015-06-30 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
US10016449B2 (en) 2013-05-28 2018-07-10 Momenta Pharmaceuticals, Inc. Pharmaceutical compositions
KR20230138496A (ko) * 2021-02-02 2023-10-05 라모트 앳 텔-아비브 유니버시티 리미티드 핵산 전달에 적합한 지질

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA676310A (en) * 1963-12-17 Union Carbide Corporation Diamines and process for preparation
US2830932A (en) * 1952-12-06 1958-04-15 Abbott Lab N,n'dibenzylethylene diamine salt of heparin
GB768524A (en) * 1954-04-20 1957-02-20 Erba Carlo Spa Improvements in or relating to the production of heparin
US3162673A (en) * 1960-12-28 1964-12-22 Union Carbide Corp Bis (aminoaliphatic) carbonates and process for preparation
US3244594A (en) * 1962-01-12 1966-04-05 Egyt Gyogyszervegyeszeti Gyar 1, 6-bis-(beta-chloro-ethyl-amino)-1, 6-deoxy-d-mannitol heparinate
US3661923A (en) * 1968-10-18 1972-05-09 Rohm & Haas Polyfunctional polyol ester oxazolidines
US4352913A (en) * 1979-04-10 1982-10-05 Ciba-Geigy Corporation Dimethylamino derivatives and their use
US4324739A (en) * 1979-04-10 1982-04-13 Ciba-Geigy Corporation Dimethylamino derivatives and their use
DE3020220A1 (de) * 1980-05-28 1981-12-03 Theodor Prof. Dr. 4400 Münster Eckert Organische salze des heparin, der heparinoide, ihre herstellung und sie enthaltende arzneimittel
SE8103137L (sv) * 1981-05-19 1982-11-20 Pharmacia Ab Polymer med kvartera aminogrupper
US4510135A (en) * 1982-04-21 1985-04-09 Research Corporation Orally administered heparin
US4654327A (en) * 1982-04-21 1987-03-31 Research Corp. Quaternary ammonium complexes of heparin
US4604376A (en) * 1982-04-21 1986-08-05 Research Corporation Enteric compounds and complexes
US4581058A (en) * 1982-09-02 1986-04-08 Buckman Laboratories, Inc. Polymeric quaternary ammonium compounds and their uses
US4506081A (en) * 1982-09-02 1985-03-19 Buckman Laboratories, Inc. Polymeric quaternary ammonium compounds and their uses
FR2538404B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1982-12-28 1985-08-23 Anic Spa
US4478822A (en) * 1983-05-16 1984-10-23 Merck & Co., Inc. Drug delivery system utilizing thermosetting gels
DE3402927A1 (de) * 1984-01-28 1985-08-08 Pfeifer & Langen, 5000 Köln Zellkulturmikrotraeger, verfahren zu seiner herstellung und seine verwendung zum zuechten von verankerungsabhaengigen zellen
US4703042A (en) * 1984-05-21 1987-10-27 Bodor Nicholas S Orally active heparin salts containing multivalent cationic units
IT1208509B (it) * 1985-03-13 1989-07-10 Mediolanum Farmaceutici Srl Processo per la produzione di eparan solfato e dermatan solfato naturali sostanzialmente puri eloro impiego farmaceutico.
HU193769B (en) * 1985-06-04 1987-11-30 Richter Gedeon Vegyeszet Sodium-exchanging process for producing pharmaceutically acceptable heparinates applicable even for injections
IT1188184B (it) * 1985-08-14 1988-01-07 Texcontor Ets Sali ammonici quaternari di polisaccaridi ad attivita' ipocolesterolemizzante
US4981955A (en) * 1988-06-28 1991-01-01 Lopez Lorenzo L Depolymerization method of heparin

Also Published As

Publication number Publication date
AU3746489A (en) 1990-01-05
NZ229403A (en) 1991-02-26
HU893408D0 (en) 1991-10-28
EP0423151B1 (en) 1993-09-22
CA1335375C (en) 1995-04-25
MC2098A1 (fr) 1991-02-15
AU630359B2 (en) 1992-10-29
WO1989012070A1 (en) 1989-12-14
US5264425A (en) 1993-11-23
DK286190A (da) 1990-11-30
DE68909412D1 (de) 1993-10-28
HUT57237A (en) 1991-11-28
IN169470B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1991-10-19
HU208029B (en) 1993-07-28
KR920700232A (ko) 1992-02-19
DE68909412T2 (de) 1994-02-03
DK286190D0 (da) 1990-11-30
EP0423151A1 (en) 1991-04-24

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