IT1274021B - Diesteri dell'acido carbonico ad attivita' antivirale ed antinfiammatoria - Google Patents

Diesteri dell'acido carbonico ad attivita' antivirale ed antinfiammatoria

Info

Publication number
IT1274021B
IT1274021B ITMI940349A ITMI940349A IT1274021B IT 1274021 B IT1274021 B IT 1274021B IT MI940349 A ITMI940349 A IT MI940349A IT MI940349 A ITMI940349 A IT MI940349A IT 1274021 B IT1274021 B IT 1274021B
Authority
IT
Italy
Prior art keywords
independently
optionally
formula
optionally substituted
alkyl
Prior art date
Application number
ITMI940349A
Other languages
English (en)
Inventor
Alberto Sala
Giorgio Bertolini
Gianfranco Pavich
Fabrizio Marcucci
Gianni Gromo
Giuliana Porro
Original Assignee
Italfarmaco Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Italfarmaco Spa filed Critical Italfarmaco Spa
Publication of ITMI940349A0 publication Critical patent/ITMI940349A0/it
Priority to ITMI940349A priority Critical patent/IT1274021B/it
Priority to DE69510043T priority patent/DE69510043T2/de
Priority to CA002184155A priority patent/CA2184155A1/en
Priority to CN95191817A priority patent/CN1142222A/zh
Priority to EP95910509A priority patent/EP0748310B1/en
Priority to AT95910509T priority patent/ATE180766T1/de
Priority to PCT/EP1995/000637 priority patent/WO1995023128A1/en
Priority to AU17588/95A priority patent/AU1758895A/en
Priority to HU9602345A priority patent/HUT75334A/hu
Priority to JP7522122A priority patent/JPH09511497A/ja
Priority to ES95910509T priority patent/ES2131815T3/es
Priority to IL11281395A priority patent/IL112813A0/xx
Priority to ZA951612A priority patent/ZA951612B/xx
Publication of ITMI940349A1 publication Critical patent/ITMI940349A1/it
Priority to NO963554A priority patent/NO963554L/no
Priority to FI963316A priority patent/FI963316A/fi
Priority to US08/869,043 priority patent/US5827881A/en
Application granted granted Critical
Publication of IT1274021B publication Critical patent/IT1274021B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C219/04—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C219/16—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the hydroxy groups esterified by an inorganic acid or a derivative thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C219/20—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C219/22—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/24—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups or amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/32—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings and esterified hydroxy groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Composti di formula (I): (FORMULA I) dove R e R1 sono indipendentemente metilene, etilene, (C3-10) alchilene facoltativamente ramificato, (C2-10) alchilidene facoltativamente ramificato, (C3-7) cicloalchilene facoltativamente sostituito, oppure sono indipendentemente assenti; A e A' sono indipendentemente:a) un gruppo (FORMULA)dove R2 e R3 sano indipendentemente H, (C1-8) alchile facoltativamente ramificato, (C3-7) cicloalchile, fenile o fenil-(C1-4) alchile facoltativamente sostituiti, oppure R2 e R3 presi insieme all'atomo di azoto formano un eterociclo di da 5 a 7 atomi di carbonio contenente facoltativamente un altro eteroatomo scelto tra O, N o S, facoltativamente sostituito da uno o più gruppi (C1-6) alchile; b) un radicale eterociclo basico aromatico legato tramite un atomo di carbonio; c) un radicale eterociclo basico parzialmente o totalmente idrogenato, legato tramite un atomo di carbonio, facoltativamente sostituito da uno o più gruppi (C1-6) alchile; e i loro sali con acidi farmaceuticamente accettabili, sono sostanze antivirali ed antinfiammatorie.
ITMI940349A 1994-02-28 1994-02-28 Diesteri dell'acido carbonico ad attivita' antivirale ed antinfiammatoria IT1274021B (it)

Priority Applications (16)

Application Number Priority Date Filing Date Title
ITMI940349A IT1274021B (it) 1994-02-28 1994-02-28 Diesteri dell'acido carbonico ad attivita' antivirale ed antinfiammatoria
HU9602345A HUT75334A (en) 1994-02-28 1995-02-22 Diesters of carbonic acid endowed with antiviral and anti-inflammatory activity, their use and pharmaceutical compns. contg. the said cmpds.
ES95910509T ES2131815T3 (es) 1994-02-28 1995-02-22 Diesteres de acido carbonico dotados de actividad antiviral y antiinflamatoria.
CN95191817A CN1142222A (zh) 1994-02-28 1995-02-22 具有抗病毒和抗炎活性的碳酸二酯
EP95910509A EP0748310B1 (en) 1994-02-28 1995-02-22 Diesters of carbonic acid endowed with antiviral and anti-inflammatory activity
AT95910509T ATE180766T1 (de) 1994-02-28 1995-02-22 Diester von carbonsäure mit antiviraler und anti- entzündungsaktivität
PCT/EP1995/000637 WO1995023128A1 (en) 1994-02-28 1995-02-22 Diesters of carbonic acid endowed with antiviral and anti-inflammatory activity
AU17588/95A AU1758895A (en) 1994-02-28 1995-02-22 Diesters of carbonic acid endowed with antiviral and anti-inflammatory activity
DE69510043T DE69510043T2 (de) 1994-02-28 1995-02-22 Diester von carbonsäure mit antiviraler und anti-entzündungsaktivität
JP7522122A JPH09511497A (ja) 1994-02-28 1995-02-22 抗ウイルス活性及び抗炎症活性を賦与された炭酸のジエステル
CA002184155A CA2184155A1 (en) 1994-02-28 1995-02-22 Diesters of carbonic acid endowed with antiviral and anti-inflammatory activity
IL11281395A IL112813A0 (en) 1994-02-28 1995-02-27 Diesters of carbonic acid endowed with antiviral and anti-inflammatory activity
ZA951612A ZA951612B (en) 1994-02-28 1995-02-27 Diesters of carbonic acid endowed with antiviral and anti-inflammatory activity
NO963554A NO963554L (no) 1994-02-28 1996-08-26 Diestere av kullsyre utstyrt med antiviral og antiinflammatorisk virkning
FI963316A FI963316A (fi) 1994-02-28 1996-08-26 Hiilihapon diesterit, joilla on viruksia torjuvaa ja tulehdusta torjuvaa aktiivisuutta
US08/869,043 US5827881A (en) 1994-02-28 1997-06-04 Diesters of carbonic acid endowed with antiviral and anti-inflammatory activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI940349A IT1274021B (it) 1994-02-28 1994-02-28 Diesteri dell'acido carbonico ad attivita' antivirale ed antinfiammatoria

Publications (3)

Publication Number Publication Date
ITMI940349A0 ITMI940349A0 (it) 1994-02-28
ITMI940349A1 ITMI940349A1 (it) 1995-09-01
IT1274021B true IT1274021B (it) 1997-07-14

Family

ID=11367992

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI940349A IT1274021B (it) 1994-02-28 1994-02-28 Diesteri dell'acido carbonico ad attivita' antivirale ed antinfiammatoria

Country Status (16)

Country Link
US (1) US5827881A (it)
EP (1) EP0748310B1 (it)
JP (1) JPH09511497A (it)
CN (1) CN1142222A (it)
AT (1) ATE180766T1 (it)
AU (1) AU1758895A (it)
CA (1) CA2184155A1 (it)
DE (1) DE69510043T2 (it)
ES (1) ES2131815T3 (it)
FI (1) FI963316A (it)
HU (1) HUT75334A (it)
IL (1) IL112813A0 (it)
IT (1) IT1274021B (it)
NO (1) NO963554L (it)
WO (1) WO1995023128A1 (it)
ZA (1) ZA951612B (it)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4044740B2 (ja) * 2001-05-31 2008-02-06 信越化学工業株式会社 レジスト材料及びパターン形成方法
ES2625547T3 (es) 2012-09-27 2017-07-19 Bayer Cropscience Ag Procedimiento de preparación de fenil y piridil pirrolidinas opcionalmente sustituidas
CN112876408B (zh) * 2019-11-29 2022-05-17 四川大学华西医院 一类短效双季铵化合物及其制备方法和用途
CN113087686B (zh) * 2020-01-08 2023-06-09 四川大学华西医院 一类含氰基的双季铵类化合物及其制备方法和用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE887650C (de) * 1951-05-03 1953-08-24 Hoechst Ag Verfahren zur Herstellung basischer Carbonate
US2691017A (en) * 1952-10-25 1954-10-05 Searle & Co Bis-aminoalkyl carbonate derivatives
US3268574A (en) * 1960-12-28 1966-08-23 Union Carbide Corp Bis (aminohydrocarbyl) carbonates
US3162673A (en) * 1960-12-28 1964-12-22 Union Carbide Corp Bis (aminoaliphatic) carbonates and process for preparation
US3318942A (en) * 1963-11-14 1967-05-09 Union Carbide Corp Stabilized polymerizable carbonate diisocyanate compounds and process for effecting stabilization
US3864335A (en) * 1968-10-18 1975-02-04 Rohm & Haas Polyfunctional Ester Oxazolidines
US3622613A (en) * 1969-04-25 1971-11-23 Gen Mills Inc Carbonate esters of hydroxy substituted fatty nitriles
DE3347072A1 (de) * 1983-12-24 1985-07-04 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von n-vinylierten ungesaettigten fuenfgliedrigen n-heterocyclen
US5264425A (en) * 1988-06-03 1993-11-23 Italfarmaco S.P.A. Glycosaminoglycan salts and pharmaceutical compositions containing them
US5153348A (en) * 1990-09-14 1992-10-06 Lever Brothers Company, Division Of Conopco, Inc. Transesterification route to quaternary ammonium substituted carbonate esters
US5164497A (en) * 1990-09-20 1992-11-17 Union Carbide Chemicals & Plastics Technology Corporation Decarboxylation processes using mixed metal oxide catalysts
DE4203908A1 (de) * 1992-02-11 1993-08-12 Rwe Dea Ag Diaminocarbonat-verbindungen und deren anwendung als katalysatoren

Also Published As

Publication number Publication date
US5827881A (en) 1998-10-27
CA2184155A1 (en) 1995-08-31
ITMI940349A0 (it) 1994-02-28
EP0748310B1 (en) 1999-06-02
ZA951612B (en) 1995-12-07
NO963554L (no) 1996-08-26
HU9602345D0 (en) 1996-10-28
HUT75334A (en) 1997-05-28
FI963316A0 (fi) 1996-08-26
ATE180766T1 (de) 1999-06-15
DE69510043T2 (de) 1999-09-23
ES2131815T3 (es) 1999-08-01
EP0748310A1 (en) 1996-12-18
AU1758895A (en) 1995-09-11
CN1142222A (zh) 1997-02-05
FI963316A (fi) 1996-10-17
IL112813A0 (en) 1995-05-26
JPH09511497A (ja) 1997-11-18
ITMI940349A1 (it) 1995-09-01
DE69510043D1 (de) 1999-07-08
WO1995023128A1 (en) 1995-08-31

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