IT1130997B - Esteri e derivati chinucleidinici di acidi fenossicarbossilici,procedimento per la loro preparazione e relative composizioni farmaceutiche - Google Patents

Esteri e derivati chinucleidinici di acidi fenossicarbossilici,procedimento per la loro preparazione e relative composizioni farmaceutiche

Info

Publication number
IT1130997B
IT1130997B IT20764/80A IT2076480A IT1130997B IT 1130997 B IT1130997 B IT 1130997B IT 20764/80 A IT20764/80 A IT 20764/80A IT 2076480 A IT2076480 A IT 2076480A IT 1130997 B IT1130997 B IT 1130997B
Authority
IT
Italy
Prior art keywords
sub
pharmaceutical compositions
phinoxycarboxylic
kinucleidin
derivatives
Prior art date
Application number
IT20764/80A
Other languages
English (en)
Other versions
IT8020764A0 (it
Inventor
Alberto Reiner
Original Assignee
D & D Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by D & D Srl filed Critical D & D Srl
Publication of IT8020764A0 publication Critical patent/IT8020764A0/it
Priority to IT20764/80A priority Critical patent/IT1130997B/it
Priority to BE0/204136A priority patent/BE887965A/fr
Priority to IL62386A priority patent/IL62386A0/xx
Priority to CA000373231A priority patent/CA1160633A/en
Priority to ES500450A priority patent/ES500450A0/es
Priority to AT81102030T priority patent/ATE14583T1/de
Priority to EP81102030A priority patent/EP0036218B1/en
Priority to DE8181102030T priority patent/DE3171537D1/de
Priority to ZA00811791A priority patent/ZA811791B/xx
Priority to JP3879981A priority patent/JPS56140991A/ja
Priority to US06/245,273 priority patent/US4355166A/en
Priority to FR8105502A priority patent/FR2478638A1/fr
Application granted granted Critical
Publication of IT1130997B publication Critical patent/IT1130997B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/124—Acids containing four carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/03—Monocarboxylic acids
    • C07C57/12—Straight chain carboxylic acids containing eighteen carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
IT20764/80A 1980-03-19 1980-03-19 Esteri e derivati chinucleidinici di acidi fenossicarbossilici,procedimento per la loro preparazione e relative composizioni farmaceutiche IT1130997B (it)

Priority Applications (12)

Application Number Priority Date Filing Date Title
IT20764/80A IT1130997B (it) 1980-03-19 1980-03-19 Esteri e derivati chinucleidinici di acidi fenossicarbossilici,procedimento per la loro preparazione e relative composizioni farmaceutiche
BE0/204136A BE887965A (fr) 1980-03-19 1981-03-16 Ester d'acide p-(4-chlorobenzoyl)-phenoxyisobutyrique de la 3-hydroxyquinuclidine et ses derives, procede pour leur preparation ry medicaments les contenant, utiles notamment comme hypocholesterolemiants et hypotriglyceridemiants
IL62386A IL62386A0 (en) 1980-03-19 1981-03-16 Quinuclidinic esters of phenoxycarboxylic acids and derivatives thereof,their preparation and pharmaceutical compositions containing them
CA000373231A CA1160633A (en) 1980-03-19 1981-03-17 Quinuclidinic esters and derivatives of phenoxycarboxylic acids, a process for the preparation thereof, and related pharmaceutical compositions
ES500450A ES500450A0 (es) 1980-03-19 1981-03-17 Procedimiento de preparar esteres de 3-hidroxiquinuclidina con acidos fenoxicarboxilicos y sus sales
EP81102030A EP0036218B1 (en) 1980-03-19 1981-03-18 Salts of the 3-hydroxy quinuclidine esters of a phenoxycarboxylic acid, a process for the preparation thereof, and related pharmaceutical compositions
AT81102030T ATE14583T1 (de) 1980-03-19 1981-03-18 Salze von 3-hydroxy-chinuclidin-estern einer phenoxycarboxylsaeure, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
DE8181102030T DE3171537D1 (en) 1980-03-19 1981-03-18 Salts of the 3-hydroxy quinuclidine esters of a phenoxycarboxylic acid, a process for the preparation thereof, and related pharmaceutical compositions
ZA00811791A ZA811791B (en) 1980-03-19 1981-03-18 Quinuclindinic esters and derivatives of phenoxycarboxylic acids,a process for the preparation thereof,and related pharmaceutical compositions
JP3879981A JPS56140991A (en) 1980-03-19 1981-03-19 Quinuclidine ester and derivative of phenoxycarboxylic acid, manufacture and related pharmaceutical compositions
US06/245,273 US4355166A (en) 1980-03-19 1981-03-19 Quinuclidinic ester and derivatives of phenoxycarboxylic acids
FR8105502A FR2478638A1 (fr) 1980-03-19 1981-03-19 Ester d'acide p-(4-chlorobenzoyl)-phenoxyisobutyrique de la 3-hydroxy-quinuclidine et ses derives, procede pour leur preparation et medicaments les contenant, utiles notamment comme hypocholesterolemiants et hypotriglyceridemiants

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT20764/80A IT1130997B (it) 1980-03-19 1980-03-19 Esteri e derivati chinucleidinici di acidi fenossicarbossilici,procedimento per la loro preparazione e relative composizioni farmaceutiche

Publications (2)

Publication Number Publication Date
IT8020764A0 IT8020764A0 (it) 1980-03-19
IT1130997B true IT1130997B (it) 1986-06-18

Family

ID=11171711

Family Applications (1)

Application Number Title Priority Date Filing Date
IT20764/80A IT1130997B (it) 1980-03-19 1980-03-19 Esteri e derivati chinucleidinici di acidi fenossicarbossilici,procedimento per la loro preparazione e relative composizioni farmaceutiche

Country Status (12)

Country Link
US (1) US4355166A (it)
EP (1) EP0036218B1 (it)
JP (1) JPS56140991A (it)
AT (1) ATE14583T1 (it)
BE (1) BE887965A (it)
CA (1) CA1160633A (it)
DE (1) DE3171537D1 (it)
ES (1) ES500450A0 (it)
FR (1) FR2478638A1 (it)
IL (1) IL62386A0 (it)
IT (1) IT1130997B (it)
ZA (1) ZA811791B (it)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5385912A (en) * 1991-03-08 1995-01-31 Rhone-Poulenc Rorer Pharmaceuticals Inc. Multicyclic tertiary amine polyaromatic squalene synthase inhibitors
WO1995031458A1 (en) * 1992-10-13 1995-11-23 Rhone-Poulenc Rorer Pharmaceuticals Inc. 3-hydroxyquinuclidin-3-ylphenylquinolines as squalene synthase inhibitors
US20090054450A1 (en) * 2007-06-19 2009-02-26 Ironwood Pharmaceuticals, Inc. Compositions and methods of use for treating or preventing lipid related disorders

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1219606A (en) * 1968-07-15 1971-01-20 Rech S Et D Applic Scient Soge Quinuclidinol derivatives and preparation thereof
GB1539897A (en) * 1975-02-12 1979-02-07 Orchimed Sa Phenoxypropionic acid derivatives
FR2322867A1 (fr) * 1975-09-08 1977-04-01 Merck Sharp Dohme Cie Chimique Procede de preparation d'esters de 3-quinuclidinol et d'halogenohydrates de ces esters
NL7903434A (nl) * 1978-05-09 1979-11-13 Alfa Farmaceutici Spa Derivaten van benzoylfenoxyalkaancarbonzuren met anti- lipemische en anticholesterolemische werking, alsmede farmaceutische preparaten die zo'n verbinding bevatten.

Also Published As

Publication number Publication date
EP0036218A3 (en) 1981-12-30
IT8020764A0 (it) 1980-03-19
IL62386A0 (en) 1981-05-20
JPS56140991A (en) 1981-11-04
FR2478638A1 (fr) 1981-09-25
ZA811791B (en) 1982-06-30
FR2478638B1 (it) 1984-01-06
ATE14583T1 (de) 1985-08-15
CA1160633A (en) 1984-01-17
BE887965A (fr) 1981-07-16
EP0036218A2 (en) 1981-09-23
ES8202002A1 (es) 1982-02-01
ES500450A0 (es) 1982-02-01
EP0036218B1 (en) 1985-07-31
DE3171537D1 (en) 1985-09-05
US4355166A (en) 1982-10-19

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