AR010237A1 - Compuestos acidos carboxilicos azaheterociclicos n-sustituidos, un metodo para su preparacion, composicion farmaceutica y uso de los mismos para lapreparacion de composiciones farmaceuticas - Google Patents
Compuestos acidos carboxilicos azaheterociclicos n-sustituidos, un metodo para su preparacion, composicion farmaceutica y uso de los mismos para lapreparacion de composiciones farmaceuticasInfo
- Publication number
- AR010237A1 AR010237A1 ARP970104588A ARP970104588A AR010237A1 AR 010237 A1 AR010237 A1 AR 010237A1 AR P970104588 A ARP970104588 A AR P970104588A AR P970104588 A ARP970104588 A AR P970104588A AR 010237 A1 AR010237 A1 AR 010237A1
- Authority
- AR
- Argentina
- Prior art keywords
- preparation
- pharmaceutical compositions
- acid compounds
- carbon acid
- pharmaceutical composition
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Endocrinology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Se describen nuevos ácidos carboxílicos azaheterocíclicos N-sustituidos de la formula (I) en donde R1 y R2 independientemente son hidrogeno, halogeno, oC1-6-alquilo; e Y es > que (N)-CH2- o > que (C)=CH- en donde solo el átomo entre paréntesis participa en el sistema de anillo;y X es -S-, -CH2-CH2-,O-CH2-,-CH2-O-, -S-CH2-, -CH2-S-; y r es 1 o 2; Z es de formulas II en donde R3 es (CH2)pCOOH en donde p es 0 o 1; o una sal farmacéuticamente aceptable delmismos, con métodos para su preparacion, con composiciones farmacéuticas que los contienen, y con su uso para la preparacion de composiciones farmacéuticaspara el tratamiento clínico de condiciones dolorosas, hiperalgésicas, y/o inflamatorias, en las cuales las fibras C juegan un papel patofisiologicoproduciendo dolor neurogénico o inflamacion, así como para el tratamiento de indicaciones causadas o relacionadas con la secrecion y circulacion de péptidosantagonizantes de la insulina.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK108896 | 1996-10-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR010237A1 true AR010237A1 (es) | 2000-06-07 |
Family
ID=8100865
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP970104588A AR010237A1 (es) | 1996-10-04 | 1997-10-03 | Compuestos acidos carboxilicos azaheterociclicos n-sustituidos, un metodo para su preparacion, composicion farmaceutica y uso de los mismos para lapreparacion de composiciones farmaceuticas |
Country Status (21)
Country | Link |
---|---|
US (1) | US6004983A (es) |
EP (1) | EP0934313B1 (es) |
JP (1) | JP2001501937A (es) |
KR (1) | KR20000048901A (es) |
CN (3) | CN1084744C (es) |
AR (1) | AR010237A1 (es) |
AT (1) | ATE240320T1 (es) |
AU (1) | AU740958B2 (es) |
BR (1) | BR9712204A (es) |
CA (1) | CA2267691A1 (es) |
CZ (1) | CZ114299A3 (es) |
DE (1) | DE69722022D1 (es) |
HU (1) | HUP9904705A3 (es) |
IL (1) | IL129121A (es) |
MX (1) | MXPA99003106A (es) |
NO (1) | NO991564L (es) |
PL (1) | PL332592A1 (es) |
RU (1) | RU2186769C2 (es) |
TW (1) | TW420675B (es) |
WO (1) | WO1998015549A1 (es) |
ZA (1) | ZA978792B (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6613905B1 (en) * | 1998-01-21 | 2003-09-02 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
US7355042B2 (en) | 2001-10-16 | 2008-04-08 | Hypnion, Inc. | Treatment of CNS disorders using CNS target modulators |
US7541365B2 (en) | 2001-11-21 | 2009-06-02 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
TWI291467B (en) | 2002-11-13 | 2007-12-21 | Millennium Pharm Inc | CCR1 antagonists and methods of use therefor |
AU2004253898A1 (en) * | 2003-06-27 | 2005-01-13 | Janssen Pharmaceutica N.V. | Tricyclic delta opioid modulators |
AU2005335481A1 (en) * | 2004-08-05 | 2007-04-19 | Janssen Pharmaceutica N.V. | Tricyclic delta- opioid modulators |
MX2007007626A (es) * | 2004-12-22 | 2008-01-28 | Johnson & Johnson | Moduladores delta-opioides triciclicos. |
US7589104B2 (en) * | 2004-12-22 | 2009-09-15 | Janssen Pharmaceutica Nv | Tricyclic-bridged piperidinyline derivatives as §-opioid modulators |
WO2006069275A1 (en) * | 2004-12-22 | 2006-06-29 | Janssen Pharmaceutica N.V. | Tricyclic delta-opioid modulators |
CA2594347A1 (en) * | 2005-01-06 | 2006-07-13 | Janssen Pharmaceutica N.V. | Tricyclic d-opioid modulators |
DE102005022020A1 (de) * | 2005-05-12 | 2006-11-23 | Merckle Gmbh | Dibenzocycloheptanverbindungen und pharmazeutische Mittel, welche diese Verbindungen enthalten |
ATE490251T1 (de) * | 2005-06-16 | 2010-12-15 | Janssen Pharmaceutica Nv | Tricyclische opioidmodulatoren |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MY113463A (en) * | 1994-01-04 | 2002-03-30 | Novo Nordisk As | Novel heterocyclic compounds |
US5716949A (en) * | 1995-04-07 | 1998-02-10 | Novo Nordisk A/S | Heterocyclic compounds |
UA54385C2 (uk) * | 1995-04-07 | 2003-03-17 | Ново Нордіск А/С | N-заміщені азагетероциклічні карбонові кислоти та їх ефіри, спосіб їх одержання, фармацевтична композиція та спосіб лікування |
IL124557A0 (en) * | 1995-12-15 | 1998-12-06 | Novo Nordisk As | Compositions for reducing blood glucose and/or inhibiting the activity of cgrp |
-
1997
- 1997-10-01 ZA ZA9708792A patent/ZA978792B/xx unknown
- 1997-10-02 CN CN97199197A patent/CN1084744C/zh not_active Expired - Fee Related
- 1997-10-02 CA CA002267691A patent/CA2267691A1/en not_active Abandoned
- 1997-10-02 PL PL97332592A patent/PL332592A1/xx unknown
- 1997-10-02 CN CNB011393572A patent/CN1191233C/zh not_active Expired - Fee Related
- 1997-10-02 WO PCT/DK1997/000420 patent/WO1998015549A1/en not_active Application Discontinuation
- 1997-10-02 HU HU9904705A patent/HUP9904705A3/hu unknown
- 1997-10-02 RU RU99109018/04A patent/RU2186769C2/ru not_active IP Right Cessation
- 1997-10-02 DE DE69722022T patent/DE69722022D1/de not_active Expired - Lifetime
- 1997-10-02 EP EP97941882A patent/EP0934313B1/en not_active Expired - Lifetime
- 1997-10-02 KR KR1019990702931A patent/KR20000048901A/ko not_active Application Discontinuation
- 1997-10-02 MX MXPA99003106A patent/MXPA99003106A/es unknown
- 1997-10-02 IL IL12912197A patent/IL129121A/en not_active IP Right Cessation
- 1997-10-02 AT AT97941882T patent/ATE240320T1/de not_active IP Right Cessation
- 1997-10-02 JP JP10517091A patent/JP2001501937A/ja not_active Ceased
- 1997-10-02 CZ CZ991142A patent/CZ114299A3/cs unknown
- 1997-10-02 BR BR9712204-1A patent/BR9712204A/pt not_active IP Right Cessation
- 1997-10-02 AU AU43770/97A patent/AU740958B2/en not_active Ceased
- 1997-10-03 AR ARP970104588A patent/AR010237A1/es unknown
- 1997-10-03 US US08/943,501 patent/US6004983A/en not_active Expired - Fee Related
- 1997-11-19 TW TW086117257A patent/TW420675B/zh not_active IP Right Cessation
-
1999
- 1999-03-30 NO NO991564A patent/NO991564L/no not_active Application Discontinuation
-
2001
- 2001-11-21 CN CNB011393564A patent/CN1198820C/zh not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ATE240320T1 (de) | 2003-05-15 |
WO1998015549A1 (en) | 1998-04-16 |
NO991564L (no) | 1999-06-04 |
CN1191233C (zh) | 2005-03-02 |
EP0934313A1 (en) | 1999-08-11 |
CN1084744C (zh) | 2002-05-15 |
AU740958B2 (en) | 2001-11-15 |
EP0934313B1 (en) | 2003-05-14 |
IL129121A0 (en) | 2000-02-17 |
CZ114299A3 (cs) | 1999-09-15 |
TW420675B (en) | 2001-02-01 |
BR9712204A (pt) | 1999-08-31 |
CN1403454A (zh) | 2003-03-19 |
ZA978792B (en) | 1998-04-06 |
MXPA99003106A (es) | 2004-12-02 |
CN1403445A (zh) | 2003-03-19 |
US6004983A (en) | 1999-12-21 |
IL129121A (en) | 2004-03-28 |
KR20000048901A (ko) | 2000-07-25 |
RU2186769C2 (ru) | 2002-08-10 |
PL332592A1 (en) | 1999-09-27 |
CN1198820C (zh) | 2005-04-27 |
HUP9904705A3 (en) | 2000-09-28 |
JP2001501937A (ja) | 2001-02-13 |
CA2267691A1 (en) | 1998-04-16 |
HUP9904705A2 (hu) | 2000-06-28 |
AU4377097A (en) | 1998-05-05 |
NO991564D0 (no) | 1999-03-30 |
DE69722022D1 (de) | 2003-06-18 |
CN1235603A (zh) | 1999-11-17 |
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