JPH0430927B2 - - Google Patents
Info
- Publication number
- JPH0430927B2 JPH0430927B2 JP59242472A JP24247284A JPH0430927B2 JP H0430927 B2 JPH0430927 B2 JP H0430927B2 JP 59242472 A JP59242472 A JP 59242472A JP 24247284 A JP24247284 A JP 24247284A JP H0430927 B2 JPH0430927 B2 JP H0430927B2
- Authority
- JP
- Japan
- Prior art keywords
- collagen
- protamine
- hemostatic agent
- atelocollagen
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 108010035532 Collagen Proteins 0.000 claims description 51
- 102000008186 Collagen Human genes 0.000 claims description 51
- 229920001436 collagen Polymers 0.000 claims description 51
- 108010007568 Protamines Proteins 0.000 claims description 40
- 102000007327 Protamines Human genes 0.000 claims description 40
- 229940048914 protamine Drugs 0.000 claims description 33
- 229940030225 antihemorrhagics Drugs 0.000 claims description 24
- 239000002874 hemostatic agent Substances 0.000 claims description 24
- 108010010803 Gelatin Proteins 0.000 claims description 11
- 229920000159 gelatin Polymers 0.000 claims description 11
- 239000008273 gelatin Substances 0.000 claims description 11
- 235000019322 gelatine Nutrition 0.000 claims description 11
- 235000011852 gelatine desserts Nutrition 0.000 claims description 11
- 239000003431 cross linking reagent Substances 0.000 claims description 5
- 230000001588 bifunctional effect Effects 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 108010045569 atelocollagen Proteins 0.000 description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 13
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 12
- 230000023597 hemostasis Effects 0.000 description 11
- 239000000243 solution Substances 0.000 description 11
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 9
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 8
- 239000000835 fiber Substances 0.000 description 7
- 239000007864 aqueous solution Substances 0.000 description 6
- 230000000740 bleeding effect Effects 0.000 description 6
- 239000000843 powder Substances 0.000 description 6
- 229950008679 protamine sulfate Drugs 0.000 description 6
- 102000057297 Pepsin A Human genes 0.000 description 4
- 108090000284 Pepsin A Proteins 0.000 description 4
- 229940111202 pepsin Drugs 0.000 description 4
- 210000002435 tendon Anatomy 0.000 description 4
- 239000003929 acidic solution Substances 0.000 description 3
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 description 3
- 239000006185 dispersion Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 description 3
- 230000002439 hemostatic effect Effects 0.000 description 3
- 230000007935 neutral effect Effects 0.000 description 3
- 239000002244 precipitate Substances 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 241000283690 Bos taurus Species 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 208000007536 Thrombosis Diseases 0.000 description 2
- 238000004220 aggregation Methods 0.000 description 2
- 230000002776 aggregation Effects 0.000 description 2
- 230000023555 blood coagulation Effects 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 244000309466 calf Species 0.000 description 2
- 210000004207 dermis Anatomy 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- -1 hexamethylene diisocyanate-methanol Chemical compound 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000010118 platelet activation Effects 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- 102000029816 Collagenase Human genes 0.000 description 1
- 108060005980 Collagenase Proteins 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 239000005057 Hexamethylene diisocyanate Substances 0.000 description 1
- 108090000604 Hydrolases Proteins 0.000 description 1
- 102000004157 Hydrolases Human genes 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 229910002651 NO3 Inorganic materials 0.000 description 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 108010019160 Pancreatin Proteins 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 101710093543 Probable non-specific lipid-transfer protein Proteins 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 235000015278 beef Nutrition 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 239000000515 collagen sponge Substances 0.000 description 1
- 229960002424 collagenase Drugs 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- OKISBDHRUPZLOC-UHFFFAOYSA-N gallin Chemical compound OC(=O)C1=CC=CC=C1C1C2=CC=C(O)C(O)=C2OC2=C(O)C(O)=CC=C21 OKISBDHRUPZLOC-UHFFFAOYSA-N 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- RRAMGCGOFNQTLD-UHFFFAOYSA-N hexamethylene diisocyanate Chemical compound O=C=NCCCCCCN=C=O RRAMGCGOFNQTLD-UHFFFAOYSA-N 0.000 description 1
- 125000004836 hexamethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[*:1] 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 229940055695 pancreatin Drugs 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 229940070353 protamines Drugs 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000002683 reaction inhibitor Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000009987 spinning Methods 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 229930193551 sterin Natural products 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/07—Stiffening bandages
- A61L15/12—Stiffening bandages containing macromolecular materials
- A61L15/125—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0052—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S128/00—Surgery
- Y10S128/08—Collagen
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Materials Engineering (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Materials For Medical Uses (AREA)
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59242472A JPS61122222A (ja) | 1984-11-19 | 1984-11-19 | コラ−ゲン又はゼラチンとプロタミンとよりなる止血剤 |
| DE8585114439T DE3573214D1 (en) | 1984-11-19 | 1985-11-13 | A hemostatic agent composed of collagen/gelatin and protamine |
| EP85114439A EP0183136B1 (en) | 1984-11-19 | 1985-11-13 | A hemostatic agent composed of collagen/gelatin and protamine |
| US07/087,966 US4749689A (en) | 1984-11-19 | 1987-08-17 | Hemostatic agent composed of collagen/gelatin and protamine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59242472A JPS61122222A (ja) | 1984-11-19 | 1984-11-19 | コラ−ゲン又はゼラチンとプロタミンとよりなる止血剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS61122222A JPS61122222A (ja) | 1986-06-10 |
| JPH0430927B2 true JPH0430927B2 (enExample) | 1992-05-25 |
Family
ID=17089590
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP59242472A Granted JPS61122222A (ja) | 1984-11-19 | 1984-11-19 | コラ−ゲン又はゼラチンとプロタミンとよりなる止血剤 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US4749689A (enExample) |
| EP (1) | EP0183136B1 (enExample) |
| JP (1) | JPS61122222A (enExample) |
| DE (1) | DE3573214D1 (enExample) |
Families Citing this family (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4883864A (en) * | 1985-09-06 | 1989-11-28 | Minnesota Mining And Manufacturing Company | Modified collagen compound and method of preparation |
| US4851513A (en) * | 1985-09-06 | 1989-07-25 | Minnesota Mining And Manufacturing Company | Viscoelastic collagen solution for opthalmic use and method of preparation |
| US4713446A (en) * | 1985-09-06 | 1987-12-15 | Minnesota Mining And Manufacturing Company | Viscoelastic collagen solution for ophthalmic use and method of preparation |
| DE3687255T2 (de) * | 1985-09-10 | 1993-05-06 | Eisai Co Ltd | Einen gewebe-plasminogen-aktivator enthaltende zusammensetzung. |
| DE3608158A1 (de) * | 1986-03-12 | 1987-09-17 | Braun Melsungen Ag | Mit vernetzter gelatine impraegnierte gefaessprothese und verfahren zu ihrer herstellung |
| US4954358A (en) * | 1986-12-04 | 1990-09-04 | Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo | Multiplication inhibitor for Bacillus cereus |
| USRE34866E (en) * | 1987-02-17 | 1995-02-21 | Kensey Nash Corporation | Device for sealing percutaneous puncture in a vessel |
| US4890612A (en) * | 1987-02-17 | 1990-01-02 | Kensey Nash Corporation | Device for sealing percutaneous puncture in a vessel |
| DE68915540T2 (de) * | 1988-03-09 | 1994-10-13 | Terumo Corp | Für zellen eindringbares medizinisches material und kunsthaut. |
| US5447966A (en) * | 1988-07-19 | 1995-09-05 | United States Surgical Corporation | Treating bioabsorbable surgical articles by coating with glycerine, polalkyleneoxide block copolymer and gelatin |
| US6764500B1 (en) * | 1989-05-29 | 2004-07-20 | Kensey Nash Corporation | Sealing device |
| US5620461A (en) * | 1989-05-29 | 1997-04-15 | Muijs Van De Moer; Wouter M. | Sealing device |
| US7008439B1 (en) * | 1990-09-21 | 2006-03-07 | Datascope Investments Corp. | Device and method for sealing puncture wounds |
| US20080077178A1 (en) * | 1990-09-21 | 2008-03-27 | Datascope Investment Corp. | Device and method for sealing puncture wounds |
| US5391183A (en) * | 1990-09-21 | 1995-02-21 | Datascope Investment Corp | Device and method sealing puncture wounds |
| US5108421A (en) * | 1990-10-01 | 1992-04-28 | Quinton Instrument Company | Insertion assembly and method of inserting a vessel plug into the body of a patient |
| US6325789B1 (en) | 1990-12-27 | 2001-12-04 | Datascope Investment Corporation | Device and method for sealing puncture wounds |
| US5310407A (en) * | 1991-06-17 | 1994-05-10 | Datascope Investment Corp. | Laparoscopic hemostat delivery system and method for using said system |
| US20070135842A1 (en) * | 1991-10-22 | 2007-06-14 | Kensey Nash Corporation | Sealing device |
| US5282827A (en) * | 1991-11-08 | 1994-02-01 | Kensey Nash Corporation | Hemostatic puncture closure system and method of use |
| US5676689A (en) * | 1991-11-08 | 1997-10-14 | Kensey Nash Corporation | Hemostatic puncture closure system including vessel location device and method of use |
| US5403278A (en) * | 1992-04-15 | 1995-04-04 | Datascope Investment Corp. | Device and method for treating hematomas and false aneurysms |
| US5413571A (en) * | 1992-07-16 | 1995-05-09 | Sherwood Medical Company | Device for sealing hemostatic incisions |
| WO1994006460A1 (en) * | 1992-09-21 | 1994-03-31 | Vitaphore Corporation | Embolization plugs for blood vessels |
| US5487392A (en) * | 1993-11-15 | 1996-01-30 | Haaga; John R. | Biopxy system with hemostatic insert |
| FR2726571B1 (fr) * | 1994-11-03 | 1997-08-08 | Izoret Georges | Colle biologique, procede de preparation et dispositif d'application pour colle biologique, et durcisseurs pour colle biologique |
| US5649959A (en) * | 1995-02-10 | 1997-07-22 | Sherwood Medical Company | Assembly for sealing a puncture in a vessel |
| JP3799626B2 (ja) * | 1995-04-25 | 2006-07-19 | 有限会社ナイセム | 心臓血管修復材及びその製造方法 |
| AU5638096A (en) * | 1995-06-07 | 1996-12-30 | Clarion Pharmaceuticals, Inc. | Non-biological patch for hemostasis |
| EP0863725B1 (en) | 1996-08-06 | 2007-10-17 | St. Jude Medical Puerto Rico B.V. | Insertion assembly for a hemostatic closure device into an incision |
| US7871637B2 (en) | 1996-08-27 | 2011-01-18 | Baxter International Inc. | Dry hemostatic compositions and methods for their preparation |
| US6066325A (en) | 1996-08-27 | 2000-05-23 | Fusion Medical Technologies, Inc. | Fragmented polymeric compositions and methods for their use |
| US8303981B2 (en) | 1996-08-27 | 2012-11-06 | Baxter International Inc. | Fragmented polymeric compositions and methods for their use |
| US6063061A (en) * | 1996-08-27 | 2000-05-16 | Fusion Medical Technologies, Inc. | Fragmented polymeric compositions and methods for their use |
| US8603511B2 (en) | 1996-08-27 | 2013-12-10 | Baxter International, Inc. | Fragmented polymeric compositions and methods for their use |
| US7435425B2 (en) * | 2001-07-17 | 2008-10-14 | Baxter International, Inc. | Dry hemostatic compositions and methods for their preparation |
| US6117444A (en) * | 1997-04-10 | 2000-09-12 | Brigham & Women's Hospital | Polyethylene glycol/microfibrillar collagen composite serves as a resorbable hemostatic agent |
| US7914814B2 (en) * | 1997-09-17 | 2011-03-29 | Strategic Science & Technologies, Llc | Topical delivery of arginine of cause beneficial effects |
| CA2350628A1 (en) * | 1998-11-12 | 2000-05-18 | Polymer Biosciences, Inc. | Hemostatic polymer useful for rapid blood coagulation and hemostasis |
| US6309454B1 (en) | 2000-05-12 | 2001-10-30 | Johnson & Johnson Medical Limited | Freeze-dried composite materials and processes for the production thereof |
| US7923431B2 (en) | 2001-12-21 | 2011-04-12 | Ferrosan Medical Devices A/S | Haemostatic kit, a method of preparing a haemostatic agent and a method of promoting haemostatis |
| US7101862B2 (en) * | 2001-12-31 | 2006-09-05 | Area Laboratories, Llc | Hemostatic compositions and methods for controlling bleeding |
| CA2509914A1 (en) * | 2002-12-11 | 2004-06-24 | Ferrosan A/S | Gelatine-based materials as swabs |
| US20040122349A1 (en) * | 2002-12-20 | 2004-06-24 | Lafontaine Daniel M. | Closure device with textured surface |
| US8709038B2 (en) * | 2002-12-20 | 2014-04-29 | Boston Scientific Scimed, Inc. | Puncture hole sealing device |
| US8834864B2 (en) * | 2003-06-05 | 2014-09-16 | Baxter International Inc. | Methods for repairing and regenerating human dura mater |
| US7942897B2 (en) * | 2003-07-10 | 2011-05-17 | Boston Scientific Scimed, Inc. | System for closing an opening in a body cavity |
| US20050033157A1 (en) * | 2003-07-25 | 2005-02-10 | Klein Dean A. | Multi-modality marking material and method |
| US7927626B2 (en) * | 2003-08-07 | 2011-04-19 | Ethicon, Inc. | Process of making flowable hemostatic compositions and devices containing such compositions |
| EP1713521B1 (en) * | 2004-01-30 | 2010-07-28 | Ferrosan A/S | Haemostatic sprays and compositions |
| AU2005262070B2 (en) * | 2004-07-09 | 2011-01-27 | Ferrosan Medical Devices A/S | Haemostatic composition comprising hyaluronic acid |
| US20070248653A1 (en) * | 2006-04-20 | 2007-10-25 | Cochrum Kent C | Hemostatic compositions and methods for controlling bleeding |
| JP5231401B2 (ja) * | 2006-05-31 | 2013-07-10 | バクスター・インターナショナル・インコーポレイテッド | 脊髄の手術における導かれた細胞内殖及び制御された組織再生の方法 |
| TWI436793B (zh) * | 2006-08-02 | 2014-05-11 | Baxter Int | 快速作用之乾密封膠及其使用和製造方法 |
| CN101842122B (zh) | 2007-10-30 | 2013-12-25 | 巴克斯特国际公司 | 再生性生物功能胶原生物基质用于治疗内脏或腔壁缺损的应用 |
| US8642831B2 (en) * | 2008-02-29 | 2014-02-04 | Ferrosan Medical Devices A/S | Device for promotion of hemostasis and/or wound healing |
| US20100256671A1 (en) * | 2009-04-07 | 2010-10-07 | Biomedica Management Corporation | Tissue sealant for use in noncompressible hemorrhage |
| US9039783B2 (en) * | 2009-05-18 | 2015-05-26 | Baxter International, Inc. | Method for the improvement of mesh implant biocompatibility |
| PT2442835E (pt) * | 2009-06-16 | 2015-03-23 | Baxter Healthcare Sa | Esponja hemostática |
| CA2784432C (en) | 2009-12-16 | 2019-01-15 | Baxter Healthcare S.A. | Hemostatic sponge |
| SA111320355B1 (ar) | 2010-04-07 | 2015-01-08 | Baxter Heathcare S A | إسفنجة لايقاف النزف |
| CA2801120C (en) | 2010-06-01 | 2019-08-20 | Baxter International Inc. | Process for making dry and stable hemostatic compositions |
| CA2801116C (en) | 2010-06-01 | 2019-02-12 | Baxter International Inc. | Process for making dry and stable hemostatic compositions |
| WO2011151386A1 (en) | 2010-06-01 | 2011-12-08 | Baxter International Inc. | Process for making dry and stable hemostatic compositions |
| US20130090291A1 (en) | 2011-10-11 | 2013-04-11 | Baxter Healthcare S.A. | Hemostatic compositions |
| WO2013053759A2 (en) | 2011-10-11 | 2013-04-18 | Baxter International Inc. | Hemostatic compositions |
| TWI548417B (zh) | 2011-10-27 | 2016-09-11 | 巴克斯特國際公司 | 止血組成物 |
| RU2657955C2 (ru) | 2012-03-06 | 2018-06-18 | Ферросан Медикал Дивайсиз А/С | Контейнер под давлением, содержащий гемостатическую пасту |
| AU2013275758B2 (en) | 2012-06-12 | 2015-03-12 | Ferrosan Medical Devices A/S | Dry haemostatic composition |
| RU2700162C2 (ru) | 2013-06-21 | 2019-09-13 | Ферросан Медикал Дивайсиз А/С | Расширенная под вакуумом сухая композиция и шприц для ее сохранения |
| EP3079731B1 (en) | 2013-12-11 | 2018-08-08 | Ferrosan Medical Devices A/S | Dry composition comprising an extrusion enhancer |
| CA2960309A1 (en) | 2014-10-13 | 2016-04-21 | Ferrosan Medical Devices A/S | Dry composition for use in haemostasis and wound healing |
| AU2015371184B2 (en) | 2014-12-24 | 2020-06-25 | Ferrosan Medical Devices A/S | Syringe for retaining and mixing first and second substances |
| CN107771093B (zh) | 2015-07-03 | 2021-06-15 | 弗罗桑医疗设备公司 | 用于混合两种组分和用于在存储条件下保持真空的注射器 |
| US10137221B2 (en) | 2015-11-08 | 2018-11-27 | Omrix Biopharmaceuticals Ltd. | Hemostatic mixture of cellulose-based short and long fibers |
| KR20210008479A (ko) | 2018-05-09 | 2021-01-22 | 훼로산 메디칼 디바이스 에이/에스 | 지혈 조성물을 제조하는 방법 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2584093A (en) * | 1949-07-07 | 1952-01-29 | Sharp & Dohme Inc | Method of purifying diphtheria toxoids |
| US3717469A (en) * | 1970-01-12 | 1973-02-20 | I Elementoorganischeskikt Soed | Granular protein containing food product resembling the natural caviar of sturgeon, salmon and other fish, and a method of preparing same |
| US3742955A (en) * | 1970-09-29 | 1973-07-03 | Fmc Corp | Fibrous collagen derived product having hemostatic and wound binding properties |
| CA1073360A (en) * | 1975-10-22 | 1980-03-11 | John R. Daniels | Non-antigenic collagen and articles of manufacture |
| GB1584080A (en) * | 1977-12-05 | 1981-02-04 | Ethicon Inc | Absorbable hemostatic composition |
| US4238480A (en) * | 1978-05-19 | 1980-12-09 | Sawyer Philip Nicholas | Method for preparing an improved hemostatic agent and method of employing the same |
| US4215200A (en) * | 1978-10-02 | 1980-07-29 | Cornell Research Foundation, Inc. | Chemically and enzymatically modified collagen hemostatic agent |
| US4223984A (en) * | 1979-04-04 | 1980-09-23 | Opticol Corporation | Collagen soft contact lens |
| US4268131A (en) * | 1979-04-11 | 1981-05-19 | Opticol Corporation | Fiber collagen contact lens |
| US4374830A (en) * | 1979-10-04 | 1983-02-22 | Research Corp. | Platelet aggregating material from equine arterial tissue |
| US4260228A (en) * | 1980-01-21 | 1981-04-07 | Opticol Corporation | Collagen gel contact lens and method of preparation |
| US4271070A (en) * | 1980-05-05 | 1981-06-02 | Cornell Research Foundation, Inc. | Chemically-modified fiber collagen hemostatic agents |
| US4424208A (en) * | 1982-01-11 | 1984-01-03 | Collagen Corporation | Collagen implant material and method for augmenting soft tissue |
| US4582640A (en) * | 1982-03-08 | 1986-04-15 | Collagen Corporation | Injectable cross-linked collagen implant material |
| JPS58180162A (ja) * | 1982-04-19 | 1983-10-21 | 株式会社高研 | 抗血栓性医用材料 |
| JPS59164723A (ja) * | 1983-03-10 | 1984-09-17 | Koken:Kk | 再生コラーゲンフイブリルを含有する基質及びその製造方法 |
| JPS6028936A (ja) * | 1983-07-27 | 1985-02-14 | Koken:Kk | アテロコラ−ゲン水溶液およびその製造方法 |
| US4557764A (en) * | 1984-09-05 | 1985-12-10 | Collagen Corporation | Process for preparing malleable collagen and the product thereof |
-
1984
- 1984-11-19 JP JP59242472A patent/JPS61122222A/ja active Granted
-
1985
- 1985-11-13 EP EP85114439A patent/EP0183136B1/en not_active Expired
- 1985-11-13 DE DE8585114439T patent/DE3573214D1/de not_active Expired
-
1987
- 1987-08-17 US US07/087,966 patent/US4749689A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0183136A1 (en) | 1986-06-04 |
| US4749689A (en) | 1988-06-07 |
| EP0183136B1 (en) | 1989-09-27 |
| DE3573214D1 (en) | 1989-11-02 |
| JPS61122222A (ja) | 1986-06-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPH0430927B2 (enExample) | ||
| JP4025897B2 (ja) | コラーゲンの調製 | |
| DE2914822C2 (enExample) | ||
| US4592864A (en) | Aqueous atelocollagen solution and method of preparing same | |
| DE2631908C2 (enExample) | ||
| US4066083A (en) | Sterile surgical collagen product | |
| US5116824A (en) | Biomaterial comprising a composite material of a chitosan derivative and collagen derivative | |
| US4818291A (en) | Silk-fibroin and human-fibrinogen adhesive composition | |
| CA2258990C (en) | Use of oxidized cellulose and complexes thereof for chronic wound healing | |
| US7781158B2 (en) | Method of separating collagen from the various animal tissues for producing collagen solution and product using the same | |
| US4271070A (en) | Chemically-modified fiber collagen hemostatic agents | |
| JP6316795B2 (ja) | 新規なコラーゲン材料およびそれを得る方法 | |
| JPH07509262A (ja) | アルデヒド−硬化されたタンパク質性接着剤 | |
| WO2003097694A1 (en) | Collagen and method for producing same | |
| JPH0811121B2 (ja) | 生物分解可能なマトリックスおよびその製造法 | |
| JPH0461862A (ja) | コラーゲン繊維止血材及びその製造方法 | |
| JPS59133276A (ja) | 結合コラ−ゲン繊維シ−トの製造方法 | |
| JPH1156897A (ja) | コラーゲン眼科手術補助剤 | |
| JP2955653B2 (ja) | 絹蛋白質／コラーゲン複合体およびその製造方法 | |
| JPH02145600A (ja) | ヒアルロン酸固定化蛋白質及びその製造方法 | |
| JPS6330023B2 (enExample) | ||
| JPS6363700A (ja) | 細胞培養用高ゲル強度酸可溶性コラーゲンの製法 | |
| JPH06296673A (ja) | 止血材用繊維 | |
| JPH05208042A (ja) | 接着剤 | |
| JPS6328891B2 (enExample) |