JPH02500025A - 新規なｃ末端基を有するレニン抑制ペプチド - Google Patents

新規なｃ末端基を有するレニン抑制ペプチド

Info

Publication number
JPH02500025A
JPH02500025A JP87505681A JP50568187A JPH02500025A JP H02500025 A JPH02500025 A JP H02500025A JP 87505681 A JP87505681 A JP 87505681A JP 50568187 A JP50568187 A JP 50568187A JP H02500025 A JPH02500025 A JP H02500025A
Authority
JP
Japan
Prior art keywords
alkyl
amino
aryl
formula
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP87505681A
Other languages
English (en)
Japanese (ja)
Inventor
ショスタレツ，ハインリッヒ・ジェイ
ヘスター，ジャクソン・ビイ・ジュニア
ソーヤ，トミ・ケイ
Original Assignee
ジ・アップジョン・カンパニー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ジ・アップジョン・カンパニー filed Critical ジ・アップジョン・カンパニー
Publication of JPH02500025A publication Critical patent/JPH02500025A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP87505681A 1986-09-30 1987-09-10 新規なｃ末端基を有するレニン抑制ペプチド Pending JPH02500025A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US91349086A 1986-09-30 1986-09-30
US913,490 1986-09-30
US92583086A 1986-10-30 1986-10-30
US925,830 1986-10-30
US707987A 1987-01-27 1987-01-27
US007,079 1987-01-27
PCT/US1987/002264 WO1988002374A2 (fr) 1986-09-30 1987-09-10 Peptides inhibiteurs de la rennine presentant des parties nouvelles a terminaison en c

Publications (1)

Publication Number Publication Date
JPH02500025A true JPH02500025A (ja) 1990-01-11

Family

ID=27358265

Family Applications (1)

Application Number Title Priority Date Filing Date
JP87505681A Pending JPH02500025A (ja) 1986-09-30 1987-09-10 新規なｃ末端基を有するレニン抑制ペプチド

Country Status (5)

Country Link
EP (1) EP0321497A1 (fr)
JP (1) JPH02500025A (fr)
AU (1) AU7968687A (fr)
DK (1) DK290588D0 (fr)
WO (1) WO1988002374A2 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU619222B2 (en) * 1987-10-21 1992-01-23 Upjohn Company, The Renin inhibitors containing a (1-amino-2-hydroxy-2- heterocyclic)ethyl moiety
DE3814325A1 (de) * 1988-04-28 1989-11-09 Merck Patent Gmbh Aminosaeurederivate
SE8802428D0 (sv) * 1988-06-28 1988-06-28 Haessle Ab New compounds
KR900701825A (ko) * 1988-08-19 1990-12-04 로버트 에이. 아미테이지 설렙탄산 또는 그의 유도체를 함유한 레닌 억제 펩티드
US5164388A (en) * 1988-10-19 1992-11-17 Abbott Laboratories Heterocyclic peptide renin inhibitors
US5696270A (en) * 1989-05-23 1997-12-09 Abbott Laboratories Intermediate for making retroviral protease inhibiting compounds
US5354866A (en) * 1989-05-23 1994-10-11 Abbott Laboratories Retroviral protease inhibiting compounds
US5554783A (en) * 1989-05-23 1996-09-10 Abbott Laboratories Retroviral protease inhibiting compounds
US5643878A (en) * 1991-09-12 1997-07-01 Ciba-Geigy Corporation 5-amino-4-hydroxyhexanoic acid derivatives
TW217410B (fr) * 1992-04-01 1993-12-11 Ciba Geigy
ATE143262T1 (de) 1992-12-29 1996-10-15 Abbott Lab Inhibitoren der retroviralen protease
US5491253A (en) * 1993-10-22 1996-02-13 Abbott Laboratories Process for the preparation of a substituted 2,5-diamino-3-hydroxyhexane
US5786500A (en) * 1993-10-22 1998-07-28 Abbott Laboratories Process for the preparation of a substituted 2.5-diamino-3-hydroxyhexane
EP0708085B1 (fr) * 1994-10-19 2002-07-17 Novartis AG Ethers antiviraux des isostères du substrat de l'aspartate-protéase

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4595677A (en) * 1982-12-03 1986-06-17 Ciba-Geigy Corporation Substituted tetrapeptides
EP0163237A3 (fr) * 1984-05-29 1988-04-27 Merck & Co. Inc. Inhibiteurs di- et tri-peptidiques de la rénine
FI88400C (fi) * 1984-08-06 1993-05-10 Upjohn Co Foerfarande foer framstaellning av renin inhiberande peptider

Also Published As

Publication number Publication date
DK290588A (da) 1988-05-27
WO1988002374A3 (fr) 1988-08-11
WO1988002374A2 (fr) 1988-04-07
EP0321497A1 (fr) 1989-06-28
DK290588D0 (da) 1988-05-27
AU7968687A (en) 1988-04-21

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