EP0321497A1 - Peptides inhibiteurs de la rennine presentant des parties nouvelles a terminaison en c - Google Patents

Peptides inhibiteurs de la rennine presentant des parties nouvelles a terminaison en c

Info

Publication number
EP0321497A1
EP0321497A1 EP87906262A EP87906262A EP0321497A1 EP 0321497 A1 EP0321497 A1 EP 0321497A1 EP 87906262 A EP87906262 A EP 87906262A EP 87906262 A EP87906262 A EP 87906262A EP 0321497 A1 EP0321497 A1 EP 0321497A1
Authority
EP
European Patent Office
Prior art keywords
amino
hydroxy
alkyl
aryl
het
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP87906262A
Other languages
German (de)
English (en)
Inventor
Heinrich J. Schostarez
Jackson B. Hester, Jr.
Tomi K. Sawyer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of EP0321497A1 publication Critical patent/EP0321497A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Nouveaux peptides inhibiteurs de la rennine, de formule (I): X-A6-B7-C8-D9-E10-F11-V, et plus particulièrement peptides présentant la formule (I) dans laquelle A6, B7, C8 et D9 peuvent représenter un reste d'acide aminé, E10 et F11 peuvent représenter le diamino-1,4 3-hydroxybutane disubstitué ou une autre partie stable de transition; X est un groupe terminal et V est un groupe terminal nouveau. De tels inhibiteurs sont utiles pour le diagnostic et le traitement de l'hypertension liée à la rennine.
EP87906262A 1986-09-30 1987-09-10 Peptides inhibiteurs de la rennine presentant des parties nouvelles a terminaison en c Withdrawn EP0321497A1 (fr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US91349086A 1986-09-30 1986-09-30
US913490 1986-09-30
US92583086A 1986-10-30 1986-10-30
US925830 1986-10-30
US707987A 1987-01-27 1987-01-27
US7079 1987-01-27

Publications (1)

Publication Number Publication Date
EP0321497A1 true EP0321497A1 (fr) 1989-06-28

Family

ID=27358265

Family Applications (1)

Application Number Title Priority Date Filing Date
EP87906262A Withdrawn EP0321497A1 (fr) 1986-09-30 1987-09-10 Peptides inhibiteurs de la rennine presentant des parties nouvelles a terminaison en c

Country Status (5)

Country Link
EP (1) EP0321497A1 (fr)
JP (1) JPH02500025A (fr)
AU (1) AU7968687A (fr)
DK (1) DK290588D0 (fr)
WO (1) WO1988002374A2 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU619222B2 (en) * 1987-10-21 1992-01-23 Upjohn Company, The Renin inhibitors containing a (1-amino-2-hydroxy-2- heterocyclic)ethyl moiety
DE3814325A1 (de) * 1988-04-28 1989-11-09 Merck Patent Gmbh Aminosaeurederivate
SE8802428D0 (sv) * 1988-06-28 1988-06-28 Haessle Ab New compounds
AU4035189A (en) * 1988-08-19 1990-03-23 Upjohn Company, The Renin inhibitory peptides containing suleptanic acid or derivatives thereof
US5164388A (en) * 1988-10-19 1992-11-17 Abbott Laboratories Heterocyclic peptide renin inhibitors
US5539122A (en) * 1989-05-23 1996-07-23 Abbott Laboratories Retroviral protease inhibiting compounds
US5354866A (en) * 1989-05-23 1994-10-11 Abbott Laboratories Retroviral protease inhibiting compounds
US5554783A (en) * 1989-05-23 1996-09-10 Abbott Laboratories Retroviral protease inhibiting compounds
US5643878A (en) * 1991-09-12 1997-07-01 Ciba-Geigy Corporation 5-amino-4-hydroxyhexanoic acid derivatives
TW217410B (fr) * 1992-04-01 1993-12-11 Ciba Geigy
DK0727419T3 (da) 1992-12-29 2002-06-10 Abbott Lab Mellemprodukter til fremstilling af forbindelser, som inhiberer retroviral protease
US5491253A (en) * 1993-10-22 1996-02-13 Abbott Laboratories Process for the preparation of a substituted 2,5-diamino-3-hydroxyhexane
US5786500A (en) * 1993-10-22 1998-07-28 Abbott Laboratories Process for the preparation of a substituted 2.5-diamino-3-hydroxyhexane
ATE220661T1 (de) * 1994-10-19 2002-08-15 Novartis Erfind Verwalt Gmbh Antivirale ether von aspartat-protease-substrat- isosteren

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4595677A (en) * 1982-12-03 1986-06-17 Ciba-Geigy Corporation Substituted tetrapeptides
EP0163237A3 (fr) * 1984-05-29 1988-04-27 Merck & Co. Inc. Inhibiteurs di- et tri-peptidiques de la rénine
EP0486478A3 (en) * 1984-08-06 1992-08-12 The Upjohn Company Renin-inhibiting peptides

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO8802374A2 *

Also Published As

Publication number Publication date
DK290588A (da) 1988-05-27
AU7968687A (en) 1988-04-21
WO1988002374A2 (fr) 1988-04-07
DK290588D0 (da) 1988-05-27
WO1988002374A3 (fr) 1988-08-11
JPH02500025A (ja) 1990-01-11

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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