AU7968687A - Renin inhibitory peptides having novel c-terminal moieties - Google Patents

Renin inhibitory peptides having novel c-terminal moieties

Info

Publication number
AU7968687A
AU7968687A AU79686/87A AU7968687A AU7968687A AU 7968687 A AU7968687 A AU 7968687A AU 79686/87 A AU79686/87 A AU 79686/87A AU 7968687 A AU7968687 A AU 7968687A AU 7968687 A AU7968687 A AU 7968687A
Authority
AU
Australia
Prior art keywords
novel
inhibitory peptides
terminal moieties
renin inhibitory
renin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU79686/87A
Other languages
English (en)
Inventor
Jackson B. Hester Jr.
Tomi K. Sawyer
Heinrich J. Schostarez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of AU7968687A publication Critical patent/AU7968687A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AU79686/87A 1986-09-30 1987-09-10 Renin inhibitory peptides having novel c-terminal moieties Abandoned AU7968687A (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US91349086A 1986-09-30 1986-09-30
US913490 1986-09-30
US92583086A 1986-10-30 1986-10-30
US925830 1986-10-30
US707987A 1987-01-27 1987-01-27
US007079 1993-01-21

Publications (1)

Publication Number Publication Date
AU7968687A true AU7968687A (en) 1988-04-21

Family

ID=27358265

Family Applications (1)

Application Number Title Priority Date Filing Date
AU79686/87A Abandoned AU7968687A (en) 1986-09-30 1987-09-10 Renin inhibitory peptides having novel c-terminal moieties

Country Status (5)

Country Link
EP (1) EP0321497A1 (fr)
JP (1) JPH02500025A (fr)
AU (1) AU7968687A (fr)
DK (1) DK290588D0 (fr)
WO (1) WO1988002374A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU619222B2 (en) * 1987-10-21 1992-01-23 Upjohn Company, The Renin inhibitors containing a (1-amino-2-hydroxy-2- heterocyclic)ethyl moiety

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3814325A1 (de) * 1988-04-28 1989-11-09 Merck Patent Gmbh Aminosaeurederivate
SE8802428D0 (sv) * 1988-06-28 1988-06-28 Haessle Ab New compounds
JPH04500202A (ja) * 1988-08-19 1992-01-16 ジ・アップジョン・カンパニー スレプタン酸またはその誘導体類を含有するレニン抑制ペプチド類
US5164388A (en) * 1988-10-19 1992-11-17 Abbott Laboratories Heterocyclic peptide renin inhibitors
US5552558A (en) * 1989-05-23 1996-09-03 Abbott Laboratories Retroviral protease inhibiting compounds
US5554783A (en) * 1989-05-23 1996-09-10 Abbott Laboratories Retroviral protease inhibiting compounds
US5354866A (en) * 1989-05-23 1994-10-11 Abbott Laboratories Retroviral protease inhibiting compounds
US5643878A (en) * 1991-09-12 1997-07-01 Ciba-Geigy Corporation 5-amino-4-hydroxyhexanoic acid derivatives
TW217410B (fr) * 1992-04-01 1993-12-11 Ciba Geigy
DK1302468T3 (da) * 1992-12-29 2009-03-02 Abbott Lab Fremgangsmåder og mellemprodukter til fremstilling af forbindelser, der inhiberer retroviral protease
US5491253A (en) * 1993-10-22 1996-02-13 Abbott Laboratories Process for the preparation of a substituted 2,5-diamino-3-hydroxyhexane
US5786500A (en) * 1993-10-22 1998-07-28 Abbott Laboratories Process for the preparation of a substituted 2.5-diamino-3-hydroxyhexane
DK0708085T3 (da) * 1994-10-19 2002-11-11 Novartis Ag Antivirale ethere af aspartatproteasesubstrat-isostere

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4595677A (en) * 1982-12-03 1986-06-17 Ciba-Geigy Corporation Substituted tetrapeptides
EP0163237A3 (fr) * 1984-05-29 1988-04-27 Merck & Co. Inc. Inhibiteurs di- et tri-peptidiques de la rénine
EP0486478A3 (en) * 1984-08-06 1992-08-12 The Upjohn Company Renin-inhibiting peptides

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU619222B2 (en) * 1987-10-21 1992-01-23 Upjohn Company, The Renin inhibitors containing a (1-amino-2-hydroxy-2- heterocyclic)ethyl moiety

Also Published As

Publication number Publication date
DK290588A (da) 1988-05-27
WO1988002374A3 (fr) 1988-08-11
EP0321497A1 (fr) 1989-06-28
WO1988002374A2 (fr) 1988-04-07
JPH02500025A (ja) 1990-01-11
DK290588D0 (da) 1988-05-27

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