WO1988002374A3 - Peptides inhibiteurs de la rennine presentant des parties nouvelles a terminaison en c - Google Patents
Peptides inhibiteurs de la rennine presentant des parties nouvelles a terminaison en c Download PDFInfo
- Publication number
- WO1988002374A3 WO1988002374A3 PCT/US1987/002264 US8702264W WO8802374A3 WO 1988002374 A3 WO1988002374 A3 WO 1988002374A3 US 8702264 W US8702264 W US 8702264W WO 8802374 A3 WO8802374 A3 WO 8802374A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- novel
- renin
- inhibitory peptides
- terminal moieties
- renin inhibitory
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Nouveaux peptides inhibiteurs de la rennine, de formule (I): X-A6-B7-C8-D9-E10-F11-V, et plus particulièrement peptides présentant la formule (I) dans laquelle A6, B7, C8 et D9 peuvent représenter un reste d'acide aminé, E10 et F11 peuvent représenter le diamino-1,4 3-hydroxybutane disubstitué ou une autre partie stable de transition; X est un groupe terminal et V est un groupe terminal nouveau. De tels inhibiteurs sont utiles pour le diagnostic et le traitement de l'hypertension liée à la rennine.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP87505681A JPH02500025A (ja) | 1986-09-30 | 1987-09-10 | 新規なc末端基を有するレニン抑制ペプチド |
DK290588A DK290588D0 (da) | 1986-09-30 | 1988-05-27 | Renin-inhiberebde peptid |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US91349086A | 1986-09-30 | 1986-09-30 | |
US913,490 | 1986-09-30 | ||
US92583086A | 1986-10-30 | 1986-10-30 | |
US925,830 | 1986-10-30 | ||
US707987A | 1987-01-27 | 1987-01-27 | |
US007,079 | 1987-01-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1988002374A2 WO1988002374A2 (fr) | 1988-04-07 |
WO1988002374A3 true WO1988002374A3 (fr) | 1988-08-11 |
Family
ID=27358265
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1987/002264 WO1988002374A2 (fr) | 1986-09-30 | 1987-09-10 | Peptides inhibiteurs de la rennine presentant des parties nouvelles a terminaison en c |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0321497A1 (fr) |
JP (1) | JPH02500025A (fr) |
AU (1) | AU7968687A (fr) |
DK (1) | DK290588D0 (fr) |
WO (1) | WO1988002374A2 (fr) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU619222B2 (en) * | 1987-10-21 | 1992-01-23 | Upjohn Company, The | Renin inhibitors containing a (1-amino-2-hydroxy-2- heterocyclic)ethyl moiety |
DE3814325A1 (de) * | 1988-04-28 | 1989-11-09 | Merck Patent Gmbh | Aminosaeurederivate |
SE8802428D0 (sv) * | 1988-06-28 | 1988-06-28 | Haessle Ab | New compounds |
JPH04500202A (ja) * | 1988-08-19 | 1992-01-16 | ジ・アップジョン・カンパニー | スレプタン酸またはその誘導体類を含有するレニン抑制ペプチド類 |
US5164388A (en) * | 1988-10-19 | 1992-11-17 | Abbott Laboratories | Heterocyclic peptide renin inhibitors |
US5354866A (en) * | 1989-05-23 | 1994-10-11 | Abbott Laboratories | Retroviral protease inhibiting compounds |
US5554783A (en) * | 1989-05-23 | 1996-09-10 | Abbott Laboratories | Retroviral protease inhibiting compounds |
US5539122A (en) * | 1989-05-23 | 1996-07-23 | Abbott Laboratories | Retroviral protease inhibiting compounds |
US5643878A (en) * | 1991-09-12 | 1997-07-01 | Ciba-Geigy Corporation | 5-amino-4-hydroxyhexanoic acid derivatives |
TW217410B (fr) * | 1992-04-01 | 1993-12-11 | Ciba Geigy | |
DE69334250D1 (de) * | 1992-12-29 | 2009-01-29 | Abbott Lab | Verfahren und Intermediate zur Herstellung von retroviralen Proteasehemmern |
US5786500A (en) * | 1993-10-22 | 1998-07-28 | Abbott Laboratories | Process for the preparation of a substituted 2.5-diamino-3-hydroxyhexane |
US5491253A (en) * | 1993-10-22 | 1996-02-13 | Abbott Laboratories | Process for the preparation of a substituted 2,5-diamino-3-hydroxyhexane |
ATE220661T1 (de) * | 1994-10-19 | 2002-08-15 | Novartis Erfind Verwalt Gmbh | Antivirale ether von aspartat-protease-substrat- isosteren |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0111266A2 (fr) * | 1982-12-03 | 1984-06-20 | Ciba-Geigy Ag | Tétrapeptides substitués |
EP0163237A2 (fr) * | 1984-05-29 | 1985-12-04 | Merck & Co. Inc. | Inhibiteurs di- et tri-peptidiques de la rénine |
EP0173481A2 (fr) * | 1984-08-06 | 1986-03-05 | The Upjohn Company | Peptides |
-
1987
- 1987-09-10 JP JP87505681A patent/JPH02500025A/ja active Pending
- 1987-09-10 EP EP87906262A patent/EP0321497A1/fr not_active Withdrawn
- 1987-09-10 WO PCT/US1987/002264 patent/WO1988002374A2/fr not_active Application Discontinuation
- 1987-09-10 AU AU79686/87A patent/AU7968687A/en not_active Abandoned
-
1988
- 1988-05-27 DK DK290588A patent/DK290588D0/da not_active Application Discontinuation
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0111266A2 (fr) * | 1982-12-03 | 1984-06-20 | Ciba-Geigy Ag | Tétrapeptides substitués |
EP0163237A2 (fr) * | 1984-05-29 | 1985-12-04 | Merck & Co. Inc. | Inhibiteurs di- et tri-peptidiques de la rénine |
EP0173481A2 (fr) * | 1984-08-06 | 1986-03-05 | The Upjohn Company | Peptides |
Non-Patent Citations (2)
Title |
---|
Chemical Abstracts, volume 105, no. 3, 21 July 1986, (Columbus, Ohio, US), J.A. Fehrentz et al.: "Synthesis of aldehydic peptides inhibiting renin", see page 676, abstract 24605p & Int. J. Pept. Protein Res. 1985, 26(3), 236-41 * |
Journal of Medicinal Chemistry, volume 30, August 1987, American Chemical Society, (Washington, DC, US), S.H. Rosenberg et al.: "Novel renin inhibitors containing analogues of statine retro-inverted at the C-termini: specificity at the P2 histidine site 1,2", pages 1224-1228 * |
Also Published As
Publication number | Publication date |
---|---|
DK290588A (da) | 1988-05-27 |
WO1988002374A2 (fr) | 1988-04-07 |
JPH02500025A (ja) | 1990-01-11 |
DK290588D0 (da) | 1988-05-27 |
EP0321497A1 (fr) | 1989-06-28 |
AU7968687A (en) | 1988-04-21 |
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