WO1988002374A3 - Peptides inhibiteurs de la rennine presentant des parties nouvelles a terminaison en c - Google Patents

Peptides inhibiteurs de la rennine presentant des parties nouvelles a terminaison en c Download PDF

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Publication number
WO1988002374A3
WO1988002374A3 PCT/US1987/002264 US8702264W WO8802374A3 WO 1988002374 A3 WO1988002374 A3 WO 1988002374A3 US 8702264 W US8702264 W US 8702264W WO 8802374 A3 WO8802374 A3 WO 8802374A3
Authority
WO
WIPO (PCT)
Prior art keywords
novel
renin
inhibitory peptides
terminal moieties
renin inhibitory
Prior art date
Application number
PCT/US1987/002264
Other languages
English (en)
Other versions
WO1988002374A2 (fr
Inventor
Heinrich J Schostarez
Jackson B Hester Jr
Tomi K Sawyer
Original Assignee
Upjohn Co
Heinrich J Schostarez
Jackson B Hester Jr
Tomi K Sawyer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co, Heinrich J Schostarez, Jackson B Hester Jr, Tomi K Sawyer filed Critical Upjohn Co
Priority to JP87505681A priority Critical patent/JPH02500025A/ja
Publication of WO1988002374A2 publication Critical patent/WO1988002374A2/fr
Priority to DK290588A priority patent/DK290588D0/da
Publication of WO1988002374A3 publication Critical patent/WO1988002374A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Nouveaux peptides inhibiteurs de la rennine, de formule (I): X-A6-B7-C8-D9-E10-F11-V, et plus particulièrement peptides présentant la formule (I) dans laquelle A6, B7, C8 et D9 peuvent représenter un reste d'acide aminé, E10 et F11 peuvent représenter le diamino-1,4 3-hydroxybutane disubstitué ou une autre partie stable de transition; X est un groupe terminal et V est un groupe terminal nouveau. De tels inhibiteurs sont utiles pour le diagnostic et le traitement de l'hypertension liée à la rennine.
PCT/US1987/002264 1986-09-30 1987-09-10 Peptides inhibiteurs de la rennine presentant des parties nouvelles a terminaison en c WO1988002374A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP87505681A JPH02500025A (ja) 1986-09-30 1987-09-10 新規なｃ末端基を有するレニン抑制ペプチド
DK290588A DK290588D0 (da) 1986-09-30 1988-05-27 Renin-inhiberebde peptid

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US91349086A 1986-09-30 1986-09-30
US913,490 1986-09-30
US92583086A 1986-10-30 1986-10-30
US925,830 1986-10-30
US707987A 1987-01-27 1987-01-27
US007,079 1987-01-27

Publications (2)

Publication Number Publication Date
WO1988002374A2 WO1988002374A2 (fr) 1988-04-07
WO1988002374A3 true WO1988002374A3 (fr) 1988-08-11

Family

ID=27358265

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1987/002264 WO1988002374A2 (fr) 1986-09-30 1987-09-10 Peptides inhibiteurs de la rennine presentant des parties nouvelles a terminaison en c

Country Status (5)

Country Link
EP (1) EP0321497A1 (fr)
JP (1) JPH02500025A (fr)
AU (1) AU7968687A (fr)
DK (1) DK290588D0 (fr)
WO (1) WO1988002374A2 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU619222B2 (en) * 1987-10-21 1992-01-23 Upjohn Company, The Renin inhibitors containing a (1-amino-2-hydroxy-2- heterocyclic)ethyl moiety
DE3814325A1 (de) * 1988-04-28 1989-11-09 Merck Patent Gmbh Aminosaeurederivate
SE8802428D0 (sv) * 1988-06-28 1988-06-28 Haessle Ab New compounds
JPH04500202A (ja) * 1988-08-19 1992-01-16 ジ・アップジョン・カンパニー スレプタン酸またはその誘導体類を含有するレニン抑制ペプチド類
US5164388A (en) * 1988-10-19 1992-11-17 Abbott Laboratories Heterocyclic peptide renin inhibitors
US5552558A (en) * 1989-05-23 1996-09-03 Abbott Laboratories Retroviral protease inhibiting compounds
US5554783A (en) * 1989-05-23 1996-09-10 Abbott Laboratories Retroviral protease inhibiting compounds
US5354866A (en) * 1989-05-23 1994-10-11 Abbott Laboratories Retroviral protease inhibiting compounds
US5643878A (en) * 1991-09-12 1997-07-01 Ciba-Geigy Corporation 5-amino-4-hydroxyhexanoic acid derivatives
TW217410B (fr) * 1992-04-01 1993-12-11 Ciba Geigy
DK1302468T3 (da) * 1992-12-29 2009-03-02 Abbott Lab Fremgangsmåder og mellemprodukter til fremstilling af forbindelser, der inhiberer retroviral protease
US5491253A (en) * 1993-10-22 1996-02-13 Abbott Laboratories Process for the preparation of a substituted 2,5-diamino-3-hydroxyhexane
US5786500A (en) * 1993-10-22 1998-07-28 Abbott Laboratories Process for the preparation of a substituted 2.5-diamino-3-hydroxyhexane
DK0708085T3 (da) * 1994-10-19 2002-11-11 Novartis Ag Antivirale ethere af aspartatproteasesubstrat-isostere

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0111266A2 (fr) * 1982-12-03 1984-06-20 Ciba-Geigy Ag Tétrapeptides substitués
EP0163237A2 (fr) * 1984-05-29 1985-12-04 Merck & Co. Inc. Inhibiteurs di- et tri-peptidiques de la rénine
EP0173481A2 (fr) * 1984-08-06 1986-03-05 The Upjohn Company Peptides

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0111266A2 (fr) * 1982-12-03 1984-06-20 Ciba-Geigy Ag Tétrapeptides substitués
EP0163237A2 (fr) * 1984-05-29 1985-12-04 Merck & Co. Inc. Inhibiteurs di- et tri-peptidiques de la rénine
EP0173481A2 (fr) * 1984-08-06 1986-03-05 The Upjohn Company Peptides

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Chemical Abstracts, volume 105, no. 3, 21 July 1986, (Columbus, Ohio, US), J.A. Fehrentz et al.: "Synthesis of aldehydic peptides inhibiting renin", see page 676, abstract 24605p & Int. J. Pept. Protein Res. 1985, 26(3), 236-41 *
Journal of Medicinal Chemistry, volume 30, August 1987, American Chemical Society, (Washington, DC, US), S.H. Rosenberg et al.: "Novel renin inhibitors containing analogues of statine retro-inverted at the C-termini: specificity at the P2 histidine site 1,2", pages 1224-1228 *

Also Published As

Publication number Publication date
AU7968687A (en) 1988-04-21
DK290588A (da) 1988-05-27
EP0321497A1 (fr) 1989-06-28
WO1988002374A2 (fr) 1988-04-07
JPH02500025A (ja) 1990-01-11
DK290588D0 (da) 1988-05-27

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