WO1988002374A3 - Renin inhibitory peptides having novel c-terminal moieties - Google Patents

Renin inhibitory peptides having novel c-terminal moieties Download PDF

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Publication number
WO1988002374A3
WO1988002374A3 PCT/US1987/002264 US8702264W WO8802374A3 WO 1988002374 A3 WO1988002374 A3 WO 1988002374A3 US 8702264 W US8702264 W US 8702264W WO 8802374 A3 WO8802374 A3 WO 8802374A3
Authority
WO
WIPO (PCT)
Prior art keywords
novel
renin
inhibitory peptides
terminal moieties
renin inhibitory
Prior art date
Application number
PCT/US1987/002264
Other languages
French (fr)
Other versions
WO1988002374A2 (en
Inventor
Heinrich J Schostarez
Jackson B Hester Jr
Tomi K Sawyer
Original Assignee
Upjohn Co
Heinrich J Schostarez
Jackson B Hester Jr
Tomi K Sawyer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co, Heinrich J Schostarez, Jackson B Hester Jr, Tomi K Sawyer filed Critical Upjohn Co
Priority to JP87505681A priority Critical patent/JPH02500025A/en
Publication of WO1988002374A2 publication Critical patent/WO1988002374A2/en
Priority to DK290588A priority patent/DK290588A/en
Publication of WO1988002374A3 publication Critical patent/WO1988002374A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Novel renin-inhibiting peptides of formula (I): X-A6-B7-C8-D9-E10-F11-V. More particularly the present invention provides renin-inhibiting peptides of the formula (I), wherein A6, B7, C8 and D9 may represent amino acid residues; E10 and F11 may represent the 1,4-diamino-1,4-disubstituted-3-hydroxybutane or other stable transition state moieties; X is a terminal group and V is a novel terminal group. Such inhibitors are useful for the diagnosis and control of renin-dependent hypertension.
PCT/US1987/002264 1986-09-30 1987-09-10 Renin inhibitory peptides having novel c-terminal moieties WO1988002374A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP87505681A JPH02500025A (en) 1986-09-30 1987-09-10 Renin inhibitory peptide with a novel C-terminal group
DK290588A DK290588A (en) 1986-09-30 1988-05-27 PURE-INHIBITED PEPTID

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US91349086A 1986-09-30 1986-09-30
US913,490 1986-09-30
US92583086A 1986-10-30 1986-10-30
US925,830 1986-10-30
US707987A 1987-01-27 1987-01-27
US007,079 1987-01-27

Publications (2)

Publication Number Publication Date
WO1988002374A2 WO1988002374A2 (en) 1988-04-07
WO1988002374A3 true WO1988002374A3 (en) 1988-08-11

Family

ID=27358265

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1987/002264 WO1988002374A2 (en) 1986-09-30 1987-09-10 Renin inhibitory peptides having novel c-terminal moieties

Country Status (5)

Country Link
EP (1) EP0321497A1 (en)
JP (1) JPH02500025A (en)
AU (1) AU7968687A (en)
DK (1) DK290588A (en)
WO (1) WO1988002374A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU619222B2 (en) * 1987-10-21 1992-01-23 Upjohn Company, The Renin inhibitors containing a (1-amino-2-hydroxy-2- heterocyclic)ethyl moiety
DE3814325A1 (en) * 1988-04-28 1989-11-09 Merck Patent Gmbh AMINOSAEUREDERIVATE
SE8802428D0 (en) * 1988-06-28 1988-06-28 Haessle Ab NEW COMPOUNDS
AU4035189A (en) * 1988-08-19 1990-03-23 Upjohn Company, The Renin inhibitory peptides containing suleptanic acid or derivatives thereof
US5164388A (en) * 1988-10-19 1992-11-17 Abbott Laboratories Heterocyclic peptide renin inhibitors
US5554783A (en) * 1989-05-23 1996-09-10 Abbott Laboratories Retroviral protease inhibiting compounds
US5354866A (en) * 1989-05-23 1994-10-11 Abbott Laboratories Retroviral protease inhibiting compounds
US5696270A (en) * 1989-05-23 1997-12-09 Abbott Laboratories Intermediate for making retroviral protease inhibiting compounds
US5643878A (en) * 1991-09-12 1997-07-01 Ciba-Geigy Corporation 5-amino-4-hydroxyhexanoic acid derivatives
TW217410B (en) * 1992-04-01 1993-12-11 Ciba Geigy
KR100187990B1 (en) * 1992-12-29 1999-06-01 스티븐 에프. 웨인스톡 Retroviral protease inhibiting compounds
US5786500A (en) * 1993-10-22 1998-07-28 Abbott Laboratories Process for the preparation of a substituted 2.5-diamino-3-hydroxyhexane
US5491253A (en) * 1993-10-22 1996-02-13 Abbott Laboratories Process for the preparation of a substituted 2,5-diamino-3-hydroxyhexane
ATE220661T1 (en) * 1994-10-19 2002-08-15 Novartis Erfind Verwalt Gmbh ANTIVIRAL ETHERS OF ASPARTATE PROTEASE SUBSTRATE ISOSTERS

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0111266A2 (en) * 1982-12-03 1984-06-20 Ciba-Geigy Ag Substituted tetrapeptides
EP0163237A2 (en) * 1984-05-29 1985-12-04 Merck & Co. Inc. Di- and tri-peptidal renin inhibitors
EP0173481A2 (en) * 1984-08-06 1986-03-05 The Upjohn Company Peptides

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0111266A2 (en) * 1982-12-03 1984-06-20 Ciba-Geigy Ag Substituted tetrapeptides
EP0163237A2 (en) * 1984-05-29 1985-12-04 Merck & Co. Inc. Di- and tri-peptidal renin inhibitors
EP0173481A2 (en) * 1984-08-06 1986-03-05 The Upjohn Company Peptides

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Chemical Abstracts, volume 105, no. 3, 21 July 1986, (Columbus, Ohio, US), J.A. Fehrentz et al.: "Synthesis of aldehydic peptides inhibiting renin", see page 676, abstract 24605p & Int. J. Pept. Protein Res. 1985, 26(3), 236-41 *
Journal of Medicinal Chemistry, volume 30, August 1987, American Chemical Society, (Washington, DC, US), S.H. Rosenberg et al.: "Novel renin inhibitors containing analogues of statine retro-inverted at the C-termini: specificity at the P2 histidine site 1,2", pages 1224-1228 *

Also Published As

Publication number Publication date
AU7968687A (en) 1988-04-21
DK290588D0 (en) 1988-05-27
WO1988002374A2 (en) 1988-04-07
DK290588A (en) 1988-05-27
EP0321497A1 (en) 1989-06-28
JPH02500025A (en) 1990-01-11

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