JPH023662A - ホスホリパーゼ基質、およびホスホリパーゼを光学的に定量する方法および試薬 - Google Patents

ホスホリパーゼ基質、およびホスホリパーゼを光学的に定量する方法および試薬

Info

Publication number
JPH023662A
JPH023662A JP1046717A JP4671789A JPH023662A JP H023662 A JPH023662 A JP H023662A JP 1046717 A JP1046717 A JP 1046717A JP 4671789 A JP4671789 A JP 4671789A JP H023662 A JPH023662 A JP H023662A
Authority
JP
Japan
Prior art keywords
group
tables
formulas
alkyl
atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1046717A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0466864B2 (enExample
Inventor
Martina Junius
マルチナ・ユニウス
Ulrich Neumann
ウルリヒ・ノイマン
Der Eltz Herbert Von
ヘルベルト・フオン・デル・エルツ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Publication of JPH023662A publication Critical patent/JPH023662A/ja
Publication of JPH0466864B2 publication Critical patent/JPH0466864B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C305/00—Esters of sulfuric acids
    • C07C305/02—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C305/04—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton being acyclic and saturated
    • C07C305/10—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton being acyclic and saturated being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/11—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/12—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/44—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Detergent Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP1046717A 1988-03-04 1989-03-01 ホスホリパーゼ基質、およびホスホリパーゼを光学的に定量する方法および試薬 Granted JPH023662A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3807123.1 1988-03-04
DE3807123A DE3807123A1 (de) 1988-03-04 1988-03-04 Substrate fuer phospholipasen

Publications (2)

Publication Number Publication Date
JPH023662A true JPH023662A (ja) 1990-01-09
JPH0466864B2 JPH0466864B2 (enExample) 1992-10-26

Family

ID=6348884

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1046717A Granted JPH023662A (ja) 1988-03-04 1989-03-01 ホスホリパーゼ基質、およびホスホリパーゼを光学的に定量する方法および試薬

Country Status (10)

Country Link
US (1) US5091527A (enExample)
EP (1) EP0331167B1 (enExample)
JP (1) JPH023662A (enExample)
AT (1) ATE78484T1 (enExample)
AU (1) AU600869B2 (enExample)
CA (1) CA1337656C (enExample)
DE (2) DE3807123A1 (enExample)
ES (1) ES2034437T3 (enExample)
GR (1) GR3005766T3 (enExample)
ZA (1) ZA891607B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04248996A (ja) * 1990-09-20 1992-09-04 Boehringer Mannheim Gmbh 体液中のホスホリパーゼの測定法

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69029269T2 (de) * 1989-08-29 1997-05-28 The Regents Of The University Of California, Berkeley, Calif. Neue inhibitoren für hydrolytische enzyme und substrate und bestimmungsverfahren, selbige einschliessende verfahren und testsätze
US5308766A (en) * 1989-08-29 1994-05-03 The Regents Of The University Of California Hydrolytic enzyme inhibitors/inactivators and methods for using same
US5352673A (en) * 1989-08-29 1994-10-04 Dennis Edward A Prodrugs
DE19622224A1 (de) 1996-02-16 1997-08-21 Max Planck Gesellschaft Phosphatidyloligoglycerine
JP4220603B2 (ja) * 1998-12-02 2009-02-04 アルフレッサファーマ株式会社 血小板活性化因子アセチルヒドロラーゼ活性の測定方法
EP1305323A1 (en) * 2000-07-25 2003-05-02 Eli Lilly And Company Chromogenic compound
US8071740B2 (en) 2000-11-17 2011-12-06 Vascular Biogenics Ltd. Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis
AU2003222427B8 (en) * 2000-11-17 2010-04-29 Vascular Biogenics Ltd. Promoters exhibiting endothelial cell specificity and methods of using same
US6838452B2 (en) 2000-11-24 2005-01-04 Vascular Biogenics Ltd. Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis
AU2002307793B2 (en) 2001-10-19 2007-01-25 Vascular Biogenics Ltd. Polynucleotide constructs, pharmaceutical compositions and methods for targeted downregulation of angiogenesis and anticancer therapy
JP4812751B2 (ja) * 2004-04-16 2011-11-09 グラクソ グループ リミテッド Ｌｐ−ＰＬＡ２活性およびＬｐ−ＰＬＡ２活性阻害を検出する方法
US20150017671A1 (en) 2004-04-16 2015-01-15 Yaping Shou Methods for detecting lp-pla2 activity and inhibition of lp-pla2 activity
US7807847B2 (en) 2004-07-09 2010-10-05 Vascular Biogenics Ltd. Process for the preparation of oxidized phospholipids
US9006217B2 (en) 2007-01-09 2015-04-14 Vascular Biogenics Ltd. High-purity phospholipids
US8569529B2 (en) 2007-01-09 2013-10-29 Vascular Biogenics Ltd. High-purity phospholipids
EP2826369A3 (en) 2008-11-06 2015-03-18 Vascular Biogenics Ltd. Oxidized lipid compounds and uses thereof
US20140283157A1 (en) 2013-03-15 2014-09-18 Diadexus, Inc. Lipoprotein-associated phospholipase a2 antibody compositions and methods of use
US9771385B2 (en) 2014-11-26 2017-09-26 Vascular Biogenics Ltd. Oxidized lipids
WO2016084023A1 (en) 2014-11-26 2016-06-02 Vascular Biogenics Ltd. Oxidized lipids and treatment or prevention of fibrosis

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4493832A (en) * 1981-07-03 1985-01-15 Fujisawa Pharmaceutical Co., Ltd. Certain glycerol-phosphoryl choline derivatives, compositions containing same and method of using same
US4485045A (en) * 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
FR2517310A1 (fr) * 1981-11-27 1983-06-03 Unilever Nv Derives d'a-glycerophosphatidester, procede pour leur preparation, composition cosmetique ou pharmaceutique les contenant
JPS5931786A (ja) * 1982-08-16 1984-02-20 Hidetoshi Tsuchida ホスフアチジルコリン型リン脂質化合物
DE3516001A1 (de) * 1985-05-03 1986-11-06 Boehringer Mannheim Gmbh, 6800 Mannheim Lipasefarbtest
EP0225129B1 (en) * 1985-11-29 1989-05-24 Takeda Chemical Industries, Ltd. Phospholipid derivatives, their production and use
AU607698B2 (en) * 1986-03-24 1991-03-14 Macquarie University Antigenic analogues of platelet activating factor (paf)
IL84387A0 (en) * 1987-11-06 1990-02-09 Rapaport Erich Pharmaceutical compositions containing a substituted phosphatide

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04248996A (ja) * 1990-09-20 1992-09-04 Boehringer Mannheim Gmbh 体液中のホスホリパーゼの測定法

Also Published As

Publication number Publication date
GR3005766T3 (enExample) 1993-06-07
JPH0466864B2 (enExample) 1992-10-26
ES2034437T3 (es) 1993-04-01
CA1337656C (en) 1995-11-28
ZA891607B (en) 1989-11-29
EP0331167A3 (en) 1989-11-15
EP0331167B1 (de) 1992-07-22
AU3094389A (en) 1989-09-07
ATE78484T1 (de) 1992-08-15
AU600869B2 (en) 1990-08-23
DE58901860D1 (en) 1992-08-27
EP0331167A2 (de) 1989-09-06
US5091527A (en) 1992-02-25
DE3807123A1 (de) 1989-09-14

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