DE3807123A1 - Substrate fuer phospholipasen - Google Patents

Substrate fuer phospholipasen

Info

Publication number
DE3807123A1
DE3807123A1 DE3807123A DE3807123A DE3807123A1 DE 3807123 A1 DE3807123 A1 DE 3807123A1 DE 3807123 A DE3807123 A DE 3807123A DE 3807123 A DE3807123 A DE 3807123A DE 3807123 A1 DE3807123 A1 DE 3807123A1
Authority
DE
Germany
Prior art keywords
acid
phospholipase
glycero
substrate
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE3807123A
Other languages
German (de)
English (en)
Inventor
Martina Dipl Chem Dr Re Junius
Ulrich Dr Rer Nat Neumann
Herbert Von Der Dr Rer Na Eltz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Priority to DE3807123A priority Critical patent/DE3807123A1/de
Priority to CA000590628A priority patent/CA1337656C/en
Priority to JP1046717A priority patent/JPH023662A/ja
Priority to AT89103660T priority patent/ATE78484T1/de
Priority to DE8989103660T priority patent/DE58901860D1/de
Priority to AU30943/89A priority patent/AU600869B2/en
Priority to US07/318,075 priority patent/US5091527A/en
Priority to ES198989103660T priority patent/ES2034437T3/es
Priority to ZA891607A priority patent/ZA891607B/xx
Priority to EP89103660A priority patent/EP0331167B1/de
Publication of DE3807123A1 publication Critical patent/DE3807123A1/de
Priority to GR920401478T priority patent/GR3005766T3/el
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C305/00—Esters of sulfuric acids
    • C07C305/02—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C305/04—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton being acyclic and saturated
    • C07C305/10—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton being acyclic and saturated being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/11—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/12—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/44—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Detergent Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE3807123A 1988-03-04 1988-03-04 Substrate fuer phospholipasen Withdrawn DE3807123A1 (de)

Priority Applications (11)

Application Number Priority Date Filing Date Title
DE3807123A DE3807123A1 (de) 1988-03-04 1988-03-04 Substrate fuer phospholipasen
CA000590628A CA1337656C (en) 1988-03-04 1989-02-09 Substrates for phospholipases
JP1046717A JPH023662A (ja) 1988-03-04 1989-03-01 ホスホリパーゼ基質、およびホスホリパーゼを光学的に定量する方法および試薬
AU30943/89A AU600869B2 (en) 1988-03-04 1989-03-02 Substrates for phospholipases
DE8989103660T DE58901860D1 (en) 1988-03-04 1989-03-02 Substrate fuer phospholipasen.
AT89103660T ATE78484T1 (de) 1988-03-04 1989-03-02 Substrate fuer phospholipasen.
US07/318,075 US5091527A (en) 1988-03-04 1989-03-02 Substrate for phospholipase
ES198989103660T ES2034437T3 (es) 1988-03-04 1989-03-02 Substrato de fosfolipasa.
ZA891607A ZA891607B (en) 1988-03-04 1989-03-02 Substrates for phospholipases
EP89103660A EP0331167B1 (de) 1988-03-04 1989-03-02 Substrate für Phospholipasen
GR920401478T GR3005766T3 (enExample) 1988-03-04 1992-09-24

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3807123A DE3807123A1 (de) 1988-03-04 1988-03-04 Substrate fuer phospholipasen

Publications (1)

Publication Number Publication Date
DE3807123A1 true DE3807123A1 (de) 1989-09-14

Family

ID=6348884

Family Applications (2)

Application Number Title Priority Date Filing Date
DE3807123A Withdrawn DE3807123A1 (de) 1988-03-04 1988-03-04 Substrate fuer phospholipasen
DE8989103660T Expired - Lifetime DE58901860D1 (en) 1988-03-04 1989-03-02 Substrate fuer phospholipasen.

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE8989103660T Expired - Lifetime DE58901860D1 (en) 1988-03-04 1989-03-02 Substrate fuer phospholipasen.

Country Status (10)

Country Link
US (1) US5091527A (enExample)
EP (1) EP0331167B1 (enExample)
JP (1) JPH023662A (enExample)
AT (1) ATE78484T1 (enExample)
AU (1) AU600869B2 (enExample)
CA (1) CA1337656C (enExample)
DE (2) DE3807123A1 (enExample)
ES (1) ES2034437T3 (enExample)
GR (1) GR3005766T3 (enExample)
ZA (1) ZA891607B (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3100057B2 (ja) * 1989-08-29 2000-10-16 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 新規な加水分解酵素阻害剤及び基質、並びにこれらを用いた分析方法及びキット
US5308766A (en) * 1989-08-29 1994-05-03 The Regents Of The University Of California Hydrolytic enzyme inhibitors/inactivators and methods for using same
US5352673A (en) * 1989-08-29 1994-10-04 Dennis Edward A Prodrugs
DE4029845A1 (de) * 1990-09-20 1992-03-26 Boehringer Mannheim Gmbh Verfahren zur bestimmung von phospholipase in koerperfluessigkeiten
DE19622224A1 (de) 1996-02-16 1997-08-21 Max Planck Gesellschaft Phosphatidyloligoglycerine
JP4220603B2 (ja) * 1998-12-02 2009-02-04 アルフレッサファーマ株式会社 血小板活性化因子アセチルヒドロラーゼ活性の測定方法
WO2002002570A1 (en) * 2000-07-25 2002-01-10 Eli Lilly And Company Chromogenic compound
US8071740B2 (en) * 2000-11-17 2011-12-06 Vascular Biogenics Ltd. Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis
AU2003222427B8 (en) * 2000-11-17 2010-04-29 Vascular Biogenics Ltd. Promoters exhibiting endothelial cell specificity and methods of using same
US6838452B2 (en) 2000-11-24 2005-01-04 Vascular Biogenics Ltd. Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis
KR100866117B1 (ko) 2001-10-19 2008-10-31 바스큘라 바이오제닉스 리미티드 혈관형성의 표적화 억제조절 및 항암 치료를 위한폴리뉴클레오타이드 작제물, 약학적 조성물 및 방법
US20150017671A1 (en) 2004-04-16 2015-01-15 Yaping Shou Methods for detecting lp-pla2 activity and inhibition of lp-pla2 activity
US7741020B2 (en) * 2004-04-16 2010-06-22 Glaxo Group Limited Methods for detecting Lp-PLA2 activity and inhibition of Lp-PLA2 activity
US7807847B2 (en) 2004-07-09 2010-10-05 Vascular Biogenics Ltd. Process for the preparation of oxidized phospholipids
US8569529B2 (en) 2007-01-09 2013-10-29 Vascular Biogenics Ltd. High-purity phospholipids
US9006217B2 (en) 2007-01-09 2015-04-14 Vascular Biogenics Ltd. High-purity phospholipids
CA2740726A1 (en) * 2008-11-06 2010-05-14 Vascular Biogenics Ltd. Oxidized lipid compounds and uses thereof
US20140283157A1 (en) 2013-03-15 2014-09-18 Diadexus, Inc. Lipoprotein-associated phospholipase a2 antibody compositions and methods of use
US9771385B2 (en) 2014-11-26 2017-09-26 Vascular Biogenics Ltd. Oxidized lipids
CN106999506A (zh) 2014-11-26 2017-08-01 脉管生物生长有限公司 氧化脂质以及纤维化的治疗或预防

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4493832A (en) * 1981-07-03 1985-01-15 Fujisawa Pharmaceutical Co., Ltd. Certain glycerol-phosphoryl choline derivatives, compositions containing same and method of using same
US4485045A (en) * 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
FR2517310A1 (fr) * 1981-11-27 1983-06-03 Unilever Nv Derives d'a-glycerophosphatidester, procede pour leur preparation, composition cosmetique ou pharmaceutique les contenant
JPS5931786A (ja) * 1982-08-16 1984-02-20 Hidetoshi Tsuchida ホスフアチジルコリン型リン脂質化合物
DE3516001A1 (de) * 1985-05-03 1986-11-06 Boehringer Mannheim Gmbh, 6800 Mannheim Lipasefarbtest
EP0225129B1 (en) * 1985-11-29 1989-05-24 Takeda Chemical Industries, Ltd. Phospholipid derivatives, their production and use
AU607698B2 (en) * 1986-03-24 1991-03-14 Macquarie University Antigenic analogues of platelet activating factor (paf)
IL84387A0 (en) * 1987-11-06 1990-02-09 Rapaport Erich Pharmaceutical compositions containing a substituted phosphatide

Also Published As

Publication number Publication date
JPH023662A (ja) 1990-01-09
EP0331167A3 (en) 1989-11-15
US5091527A (en) 1992-02-25
AU3094389A (en) 1989-09-07
JPH0466864B2 (enExample) 1992-10-26
ES2034437T3 (es) 1993-04-01
GR3005766T3 (enExample) 1993-06-07
ATE78484T1 (de) 1992-08-15
EP0331167B1 (de) 1992-07-22
AU600869B2 (en) 1990-08-23
CA1337656C (en) 1995-11-28
EP0331167A2 (de) 1989-09-06
DE58901860D1 (en) 1992-08-27
ZA891607B (en) 1989-11-29

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Legal Events

Date Code Title Description
8139 Disposal/non-payment of the annual fee