JPH01279838A - 塩化リゾチーム含有歯肉炎・歯槽膿漏用貼付剤 - Google Patents
塩化リゾチーム含有歯肉炎・歯槽膿漏用貼付剤Info
- Publication number
- JPH01279838A JPH01279838A JP63108053A JP10805388A JPH01279838A JP H01279838 A JPH01279838 A JP H01279838A JP 63108053 A JP63108053 A JP 63108053A JP 10805388 A JP10805388 A JP 10805388A JP H01279838 A JPH01279838 A JP H01279838A
- Authority
- JP
- Japan
- Prior art keywords
- film
- parts
- weight
- lysozyme chloride
- chloride
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 title claims abstract description 58
- 102000016943 Muramidase Human genes 0.000 title claims abstract description 54
- 108010014251 Muramidase Proteins 0.000 title claims abstract description 54
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 title claims abstract description 54
- 239000004325 lysozyme Substances 0.000 title claims abstract description 54
- 229960000274 lysozyme Drugs 0.000 title claims abstract description 54
- 235000010335 lysozyme Nutrition 0.000 title claims abstract description 54
- 208000007565 gingivitis Diseases 0.000 title claims abstract description 17
- 201000001245 periodontitis Diseases 0.000 title claims abstract description 16
- 239000011505 plaster Substances 0.000 title abstract 3
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims abstract description 38
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims abstract description 19
- 229960000458 allantoin Drugs 0.000 claims abstract description 19
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims abstract description 9
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims abstract description 9
- FUWUEFKEXZQKKA-UHFFFAOYSA-N beta-thujaplicin Chemical compound CC(C)C=1C=CC=C(O)C(=O)C=1 FUWUEFKEXZQKKA-UHFFFAOYSA-N 0.000 claims abstract description 6
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 4
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims abstract description 4
- TUFYVOCKVJOUIR-UHFFFAOYSA-N alpha-Thujaplicin Natural products CC(C)C=1C=CC=CC(=O)C=1O TUFYVOCKVJOUIR-UHFFFAOYSA-N 0.000 claims abstract description 3
- 229930007845 β-thujaplicin Natural products 0.000 claims abstract description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 12
- -1 tesitdesitin Chemical compound 0.000 claims description 7
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 6
- 229920002125 Sokalan® Polymers 0.000 claims description 6
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 6
- 239000011780 sodium chloride Substances 0.000 claims description 6
- 229920001577 copolymer Polymers 0.000 claims description 5
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 5
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 claims description 4
- 229920000623 Cellulose acetate phthalate Polymers 0.000 claims description 4
- 229940081734 cellulose acetate phthalate Drugs 0.000 claims description 4
- 229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 claims description 4
- 229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 claims description 4
- 239000001525 mentha piperita l. herb oil Substances 0.000 claims description 4
- 235000019477 peppermint oil Nutrition 0.000 claims description 4
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 claims description 4
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 3
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 3
- 108010010803 Gelatin Proteins 0.000 claims description 3
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 claims description 3
- 229920000569 Gum karaya Polymers 0.000 claims description 3
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 3
- 241000934878 Sterculia Species 0.000 claims description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 3
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 3
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 3
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 claims description 3
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 claims description 3
- 239000008273 gelatin Substances 0.000 claims description 3
- 229920000159 gelatin Polymers 0.000 claims description 3
- 235000019322 gelatine Nutrition 0.000 claims description 3
- 235000011852 gelatine desserts Nutrition 0.000 claims description 3
- 235000010494 karaya gum Nutrition 0.000 claims description 3
- 239000000231 karaya gum Substances 0.000 claims description 3
- 229940039371 karaya gum Drugs 0.000 claims description 3
- 229920000609 methyl cellulose Polymers 0.000 claims description 3
- 239000001923 methylcellulose Substances 0.000 claims description 3
- 235000010981 methylcellulose Nutrition 0.000 claims description 3
- 229960002900 methylcellulose Drugs 0.000 claims description 3
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 claims description 3
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 3
- 235000010413 sodium alginate Nutrition 0.000 claims description 3
- 239000000661 sodium alginate Substances 0.000 claims description 3
- 229940005550 sodium alginate Drugs 0.000 claims description 3
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 claims description 3
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 claims description 2
- 235000007866 Chamaemelum nobile Nutrition 0.000 claims description 2
- WJLVQTJZDCGNJN-UHFFFAOYSA-N Chlorhexidine hydrochloride Chemical compound Cl.Cl.C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 WJLVQTJZDCGNJN-UHFFFAOYSA-N 0.000 claims description 2
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims description 2
- MPDGHEJMBKOTSU-UHFFFAOYSA-N Glycyrrhetinsaeure Natural products C12C(=O)C=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C MPDGHEJMBKOTSU-UHFFFAOYSA-N 0.000 claims description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 2
- 244000042664 Matricaria chamomilla Species 0.000 claims description 2
- 235000007232 Matricaria chamomilla Nutrition 0.000 claims description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims description 2
- 229920002472 Starch Polymers 0.000 claims description 2
- 239000005844 Thymol Substances 0.000 claims description 2
- 229960000686 benzalkonium chloride Drugs 0.000 claims description 2
- 229960005274 benzocaine Drugs 0.000 claims description 2
- BLFLLBZGZJTVJG-UHFFFAOYSA-N benzocaine Chemical compound CCOC(=O)C1=CC=C(N)C=C1 BLFLLBZGZJTVJG-UHFFFAOYSA-N 0.000 claims description 2
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims description 2
- 229940105329 carboxymethylcellulose Drugs 0.000 claims description 2
- 229960001927 cetylpyridinium chloride Drugs 0.000 claims description 2
- 229960004504 chlorhexidine hydrochloride Drugs 0.000 claims description 2
- IVHBBMHQKZBJEU-UHFFFAOYSA-N cinchocaine hydrochloride Chemical compound [Cl-].C1=CC=CC2=NC(OCCCC)=CC(C(=O)NCC[NH+](CC)CC)=C21 IVHBBMHQKZBJEU-UHFFFAOYSA-N 0.000 claims description 2
- HWDGVJUIHRPKFR-UHFFFAOYSA-I copper;trisodium;18-(2-carboxylatoethyl)-20-(carboxylatomethyl)-12-ethenyl-7-ethyl-3,8,13,17-tetramethyl-17,18-dihydroporphyrin-21,23-diide-2-carboxylate Chemical compound [Na+].[Na+].[Na+].[Cu+2].N1=C(C(CC([O-])=O)=C2C(C(C)C(C=C3C(=C(C=C)C(=C4)[N-]3)C)=N2)CCC([O-])=O)C(=C([O-])[O-])C(C)=C1C=C1C(CC)=C(C)C4=N1 HWDGVJUIHRPKFR-UHFFFAOYSA-I 0.000 claims description 2
- 229960001378 dequalinium chloride Drugs 0.000 claims description 2
- LTNZEXKYNRNOGT-UHFFFAOYSA-N dequalinium chloride Chemical compound [Cl-].[Cl-].C1=CC=C2[N+](CCCCCCCCCC[N+]3=C4C=CC=CC4=C(N)C=C3C)=C(C)C=C(N)C2=C1 LTNZEXKYNRNOGT-UHFFFAOYSA-N 0.000 claims description 2
- 229940045574 dibucaine hydrochloride Drugs 0.000 claims description 2
- 229960000520 diphenhydramine Drugs 0.000 claims description 2
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 claims description 2
- 229960003720 enoxolone Drugs 0.000 claims description 2
- IAIWVQXQOWNYOU-FPYGCLRLSA-N nitrofural Chemical compound NC(=O)N\N=C\C1=CC=C([N+]([O-])=O)O1 IAIWVQXQOWNYOU-FPYGCLRLSA-N 0.000 claims description 2
- 229960001907 nitrofurazone Drugs 0.000 claims description 2
- WGVIBWRLLMUUAJ-UHFFFAOYSA-N o-[2-(diethylamino)ethyl] 4-amino-2-hexoxybenzenecarbothioate Chemical compound CCCCCCOC1=CC(N)=CC=C1C(=S)OCCN(CC)CC WGVIBWRLLMUUAJ-UHFFFAOYSA-N 0.000 claims description 2
- 229960003742 phenol Drugs 0.000 claims description 2
- 235000019422 polyvinyl alcohol Nutrition 0.000 claims description 2
- 229940079841 sodium copper chlorophyllin Drugs 0.000 claims description 2
- 235000013758 sodium copper chlorophyllin Nutrition 0.000 claims description 2
- 239000008107 starch Substances 0.000 claims description 2
- 235000019698 starch Nutrition 0.000 claims description 2
- 229940032147 starch Drugs 0.000 claims description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims description 2
- 229960000790 thymol Drugs 0.000 claims description 2
- 229940098465 tincture Drugs 0.000 claims description 2
- 229940042585 tocopherol acetate Drugs 0.000 claims description 2
- 239000000230 xanthan gum Substances 0.000 claims description 2
- 235000010493 xanthan gum Nutrition 0.000 claims description 2
- 229920001285 xanthan gum Polymers 0.000 claims description 2
- 229940082509 xanthan gum Drugs 0.000 claims description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- 239000001856 Ethyl cellulose Substances 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 235000019325 ethyl cellulose Nutrition 0.000 claims 1
- 229920001249 ethyl cellulose Polymers 0.000 claims 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 1
- 229940086735 succinate Drugs 0.000 claims 1
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 claims 1
- 210000000214 mouth Anatomy 0.000 abstract description 14
- 230000003110 anti-inflammatory effect Effects 0.000 abstract description 6
- 230000000694 effects Effects 0.000 abstract description 6
- 229920000639 hydroxypropylmethylcellulose acetate succinate Polymers 0.000 abstract description 5
- 230000002439 hemostatic effect Effects 0.000 abstract description 3
- 241000894006 Bacteria Species 0.000 abstract description 2
- 206010030113 Oedema Diseases 0.000 abstract description 2
- 235000010418 carrageenan Nutrition 0.000 abstract description 2
- 229920001525 carrageenan Polymers 0.000 abstract description 2
- 210000002784 stomach Anatomy 0.000 abstract description 2
- 208000024891 symptom Diseases 0.000 abstract description 2
- 208000010266 Aggressive Periodontitis Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 108010025899 gelatin film Proteins 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 230000002934 lysing effect Effects 0.000 abstract 1
- 201000006727 periodontosis Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 239000010408 film Substances 0.000 description 144
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 48
- 239000012790 adhesive layer Substances 0.000 description 26
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 22
- 239000010410 layer Substances 0.000 description 21
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 19
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 16
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 15
- 230000001070 adhesive effect Effects 0.000 description 10
- 229960003511 macrogol Drugs 0.000 description 10
- 239000000203 mixture Substances 0.000 description 9
- 238000004090 dissolution Methods 0.000 description 8
- 238000001035 drying Methods 0.000 description 8
- 235000011187 glycerol Nutrition 0.000 description 8
- 239000002904 solvent Substances 0.000 description 7
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- 239000004480 active ingredient Substances 0.000 description 6
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 5
- 239000000853 adhesive Substances 0.000 description 5
- 230000007721 medicinal effect Effects 0.000 description 5
- 208000028169 periodontal disease Diseases 0.000 description 5
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 5
- 229920001800 Shellac Polymers 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 238000010828 elution Methods 0.000 description 4
- 239000004208 shellac Substances 0.000 description 4
- 229940113147 shellac Drugs 0.000 description 4
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 4
- 235000013874 shellac Nutrition 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- 239000004014 plasticizer Substances 0.000 description 3
- 238000011084 recovery Methods 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 230000001420 bacteriolytic effect Effects 0.000 description 2
- 239000006189 buccal tablet Substances 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 230000003111 delayed effect Effects 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 229940088598 enzyme Drugs 0.000 description 2
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- 230000002401 inhibitory effect Effects 0.000 description 2
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- 230000003239 periodontal effect Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
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- 229920001817 Agar Polymers 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 235000008331 Pinus X rigitaeda Nutrition 0.000 description 1
- 235000011613 Pinus brutia Nutrition 0.000 description 1
- 241000018646 Pinus brutia Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
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- 238000000576 coating method Methods 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 230000000593 degrading effect Effects 0.000 description 1
- ACYGYJFTZSAZKR-UHFFFAOYSA-J dicalcium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Ca+2].[Ca+2].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O ACYGYJFTZSAZKR-UHFFFAOYSA-J 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 230000009931 harmful effect Effects 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 229920003112 high viscosity grade hydroxypropyl cellulose Polymers 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 238000003475 lamination Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000002101 lytic effect Effects 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 210000002200 mouth mucosa Anatomy 0.000 description 1
- 230000001338 necrotic effect Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000012744 reinforcing agent Substances 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 229960002668 sodium chloride Drugs 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- 239000010937 tungsten Substances 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63108053A JPH01279838A (ja) | 1988-04-30 | 1988-04-30 | 塩化リゾチーム含有歯肉炎・歯槽膿漏用貼付剤 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63108053A JPH01279838A (ja) | 1988-04-30 | 1988-04-30 | 塩化リゾチーム含有歯肉炎・歯槽膿漏用貼付剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH01279838A true JPH01279838A (ja) | 1989-11-10 |
| JPH059412B2 JPH059412B2 (ru) | 1993-02-04 |
Family
ID=14474723
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63108053A Granted JPH01279838A (ja) | 1988-04-30 | 1988-04-30 | 塩化リゾチーム含有歯肉炎・歯槽膿漏用貼付剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH01279838A (ru) |
Cited By (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5192802A (en) * | 1991-09-25 | 1993-03-09 | Mcneil-Ppc, Inc. | Bioadhesive pharmaceutical carrier |
| US5578315A (en) * | 1993-12-01 | 1996-11-26 | Rutgers, The State University Of New Jersey | Mucosal adhesive device for long-acting delivery of pharmaceutical combinations in oral cavity |
| JP2001505884A (ja) * | 1996-12-16 | 2001-05-08 | エルティエス ローマン テラピー−ズュステーメ アーゲー | 個々に投薬でき、液体に接触すると急速に分解する活性物質含有および特に芳香物含有膜状投与形態 |
| JP2003514009A (ja) * | 1999-11-12 | 2003-04-15 | エルテーエス ローマン テラピー−ジステーメ アーゲー | 薬理学的活性物質またはその他の物質の二相放出用薄膜製剤 |
| WO2005120455A1 (en) * | 2004-06-12 | 2005-12-22 | Passion For Life Healthcare Limited | Soluble strip for oral or topical administration |
| JP2006510611A (ja) * | 2002-11-13 | 2006-03-30 | エルテーエス ローマン テラピー−ジステーメ アーゲー | 多層経粘膜的治療システム |
| JP2006117600A (ja) * | 2004-10-22 | 2006-05-11 | Nippon Zettoc Co Ltd | 口腔内装着器具用洗浄剤及び口腔内装着器具用表面処理剤 |
| JP2007326808A (ja) * | 2006-06-07 | 2007-12-20 | Matsutani Chem Ind Ltd | 口腔衛生用可食性フィルム |
| USRE42126E1 (en) | 1999-07-02 | 2011-02-08 | The Procter & Gamble Company | Delivery system for oral care compositions comprising organosiloxane resins using a removable backing strip |
| JP2012533522A (ja) * | 2009-07-17 | 2012-12-27 | クロクス テクノロジーズ インコーポレイテッド | 口腔内消毒および口腔疾患の処置のための酸化剤、光増感剤および創傷治癒剤の組み合わせ |
| US8986719B2 (en) | 2005-11-09 | 2015-03-24 | Klox Technologies Inc. | Teeth whitening compositions and methods |
| US9345648B2 (en) | 2006-11-09 | 2016-05-24 | Klox Technologies Inc. | Photoactivatable oxygen-evolving compositions and methods for teeth whitening |
| US9375446B2 (en) | 2008-11-07 | 2016-06-28 | Klox Technologies Inc. | Oxidatitive photoactivated skin rejeuvenation composition comprising hyaluronic acid, glucosamine, or allantoin |
| US9554976B2 (en) | 2002-09-11 | 2017-01-31 | The Procter & Gamble Company | Tooth whitening product |
| US9655829B2 (en) | 2012-09-14 | 2017-05-23 | Valeant Pharmaceuticals International, Inc. | Compositions and methods for teeth whitening |
| CN107106512A (zh) * | 2015-11-25 | 2017-08-29 | 缇碧艾姆株式会社 | 口腔止血及伤口保护膜 |
| US10130706B2 (en) | 2013-03-14 | 2018-11-20 | Klox Technologies Inc. | Biophotonic materials and uses thereof |
| US10207029B2 (en) | 2014-04-01 | 2019-02-19 | Klox Technologies Inc. | Tissue filler compositions and methods of use |
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| US10285916B2 (en) | 2012-10-17 | 2019-05-14 | The Procter & Gamble Company | Strip for the delivery of an oral care active and methods for applying oral care actives |
| US10881736B2 (en) | 2013-07-03 | 2021-01-05 | Klox Technologies Inc. | Biophotonic compositions comprising a chromophore and a gelling agent for treating wounds |
| US11116841B2 (en) | 2012-04-20 | 2021-09-14 | Klox Technologies Inc. | Biophotonic compositions, kits and methods |
| US11421349B2 (en) | 2014-10-31 | 2022-08-23 | Klox Technologies Inc. | Photoactivatable fibers and fabric media |
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| JPS61280423A (ja) * | 1985-06-05 | 1986-12-11 | Kiyuukiyuu Yakuhin Kogyo Kk | 口腔内粘膜貼付剤 |
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Cited By (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5314915A (en) * | 1991-09-25 | 1994-05-24 | Mcneil-Ppc, Inc. | Bioadhesive pharmaceutical carrier |
| US5462749A (en) * | 1991-09-25 | 1995-10-31 | Mcnell-Ppc, Inc. | Bioadhesive pharmaceutical carrier |
| US5192802A (en) * | 1991-09-25 | 1993-03-09 | Mcneil-Ppc, Inc. | Bioadhesive pharmaceutical carrier |
| US5578315A (en) * | 1993-12-01 | 1996-11-26 | Rutgers, The State University Of New Jersey | Mucosal adhesive device for long-acting delivery of pharmaceutical combinations in oral cavity |
| JP2001505884A (ja) * | 1996-12-16 | 2001-05-08 | エルティエス ローマン テラピー−ズュステーメ アーゲー | 個々に投薬でき、液体に接触すると急速に分解する活性物質含有および特に芳香物含有膜状投与形態 |
| USRE42126E1 (en) | 1999-07-02 | 2011-02-08 | The Procter & Gamble Company | Delivery system for oral care compositions comprising organosiloxane resins using a removable backing strip |
| JP4825385B2 (ja) * | 1999-11-12 | 2011-11-30 | エルテーエス ローマン テラピー−ジステーメ アーゲー | 薬理学的活性物質またはその他の物質の二相放出用薄膜製剤 |
| JP2003514009A (ja) * | 1999-11-12 | 2003-04-15 | エルテーエス ローマン テラピー−ジステーメ アーゲー | 薬理学的活性物質またはその他の物質の二相放出用薄膜製剤 |
| US9554976B2 (en) | 2002-09-11 | 2017-01-31 | The Procter & Gamble Company | Tooth whitening product |
| US10493016B2 (en) | 2002-09-11 | 2019-12-03 | The Procter & Gamble Company | Tooth whitening product |
| JP2006510611A (ja) * | 2002-11-13 | 2006-03-30 | エルテーエス ローマン テラピー−ジステーメ アーゲー | 多層経粘膜的治療システム |
| JP4653488B2 (ja) * | 2002-11-13 | 2011-03-16 | エルテーエス ローマン テラピー−ジステーメ アーゲー | 多層経粘膜的治療システム |
| WO2005120455A1 (en) * | 2004-06-12 | 2005-12-22 | Passion For Life Healthcare Limited | Soluble strip for oral or topical administration |
| JP2006117600A (ja) * | 2004-10-22 | 2006-05-11 | Nippon Zettoc Co Ltd | 口腔内装着器具用洗浄剤及び口腔内装着器具用表面処理剤 |
| US8986719B2 (en) | 2005-11-09 | 2015-03-24 | Klox Technologies Inc. | Teeth whitening compositions and methods |
| JP2007326808A (ja) * | 2006-06-07 | 2007-12-20 | Matsutani Chem Ind Ltd | 口腔衛生用可食性フィルム |
| US9345648B2 (en) | 2006-11-09 | 2016-05-24 | Klox Technologies Inc. | Photoactivatable oxygen-evolving compositions and methods for teeth whitening |
| US10485986B2 (en) | 2008-11-07 | 2019-11-26 | Klox Technologies Inc. | Methods and compositions for treatment of pigmented lesions |
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| US11691025B2 (en) | 2008-11-07 | 2023-07-04 | Klox Technologies Inc. | Methods and compositions for reversing or mitigating skin aging |
| US11020609B2 (en) | 2008-11-07 | 2021-06-01 | Klox Technologies Inc. | Methods and compositions for treatment of pigmented lesions |
| US9375446B2 (en) | 2008-11-07 | 2016-06-28 | Klox Technologies Inc. | Oxidatitive photoactivated skin rejeuvenation composition comprising hyaluronic acid, glucosamine, or allantoin |
| US10322179B2 (en) | 2009-07-17 | 2019-06-18 | Klox Technologies Inc. | Combination of an oxidant, a photosensitizer and a wound healing agent for oral disinfection and treatment of oral disease |
| US10471147B2 (en) | 2009-07-17 | 2019-11-12 | Klox Technologies Inc. | Combination of an oxidant, a photosensitizer and a wound healing agent for oral disinfection and treatment of oral disease |
| US9603929B2 (en) | 2009-07-17 | 2017-03-28 | Klox Technologies Inc. | Combination of an oxidant, a photosensitizer and a wound healing agent for oral disinfecton and treatment of oral disease |
| US11141482B2 (en) | 2009-07-17 | 2021-10-12 | Klox Technologies Inc. | Combination of an oxidant, a photosensitizer and a wound healing agent for oral disinfection and treatment of oral disease |
| JP2012533522A (ja) * | 2009-07-17 | 2012-12-27 | クロクス テクノロジーズ インコーポレイテッド | 口腔内消毒および口腔疾患の処置のための酸化剤、光増感剤および創傷治癒剤の組み合わせ |
| US8986746B2 (en) | 2009-07-17 | 2015-03-24 | Klox Technologies Inc. | Combination of an oxidant, a photosensitizer and a wound healing agent for oral disinfection and treatment of oral disease |
| US11116841B2 (en) | 2012-04-20 | 2021-09-14 | Klox Technologies Inc. | Biophotonic compositions, kits and methods |
| US10213373B2 (en) | 2012-04-20 | 2019-02-26 | Klox Technologies, Inc. | Chromophore combinations for biophotonic uses |
| US9655829B2 (en) | 2012-09-14 | 2017-05-23 | Valeant Pharmaceuticals International, Inc. | Compositions and methods for teeth whitening |
| US10285916B2 (en) | 2012-10-17 | 2019-05-14 | The Procter & Gamble Company | Strip for the delivery of an oral care active and methods for applying oral care actives |
| US10130706B2 (en) | 2013-03-14 | 2018-11-20 | Klox Technologies Inc. | Biophotonic materials and uses thereof |
| US11324823B2 (en) | 2013-03-14 | 2022-05-10 | Klox Technologies Inc. | Biophotonic materials and uses thereof |
| US10881736B2 (en) | 2013-07-03 | 2021-01-05 | Klox Technologies Inc. | Biophotonic compositions comprising a chromophore and a gelling agent for treating wounds |
| US10772990B2 (en) | 2014-04-01 | 2020-09-15 | Klox Technologies Inc. | Tissue filler compositions and methods of use |
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| US11421349B2 (en) | 2014-10-31 | 2022-08-23 | Klox Technologies Inc. | Photoactivatable fibers and fabric media |
| CN107106512A (zh) * | 2015-11-25 | 2017-08-29 | 缇碧艾姆株式会社 | 口腔止血及伤口保护膜 |
| JP2018538233A (ja) * | 2015-11-25 | 2018-12-27 | ティービーエム カンパニーＴｂｍ Ｃｏｍｐａｎｙ | 口腔止血及び創傷保護フィルム |
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| Publication number | Publication date |
|---|---|
| JPH059412B2 (ru) | 1993-02-04 |
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