JP7761578B2 - シクロスポリン誘導体の調製 - Google Patents

シクロスポリン誘導体の調製

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Publication number
JP7761578B2
JP7761578B2 JP2022556477A JP2022556477A JP7761578B2 JP 7761578 B2 JP7761578 B2 JP 7761578B2 JP 2022556477 A JP2022556477 A JP 2022556477A JP 2022556477 A JP2022556477 A JP 2022556477A JP 7761578 B2 JP7761578 B2 JP 7761578B2
Authority
JP
Japan
Prior art keywords
compound
alkyl
formula
equivalents
copper
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2022556477A
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English (en)
Japanese (ja)
Other versions
JP2023518776A5 (https=
JP2023518776A (ja
Inventor
チン‐ポン マック，
ファシュー マー，
ダオフェイ リー，
シャオ ユー，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Farsight Medical Technology Shanghai Co Ltd
Original Assignee
Farsight Medical Technology Shanghai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farsight Medical Technology Shanghai Co Ltd filed Critical Farsight Medical Technology Shanghai Co Ltd
Publication of JP2023518776A publication Critical patent/JP2023518776A/ja
Publication of JP2023518776A5 publication Critical patent/JP2023518776A5/ja
Application granted granted Critical
Publication of JP7761578B2 publication Critical patent/JP7761578B2/ja
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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Analytical Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2022556477A 2020-03-26 2021-03-25 シクロスポリン誘導体の調製 Active JP7761578B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN2020081295 2020-03-26
CNPCT/CN2020/081295 2020-03-26
CNPCT/CN2021/078391 2021-03-01
CN2021078391 2021-03-01
PCT/CN2021/083016 WO2021190604A1 (en) 2020-03-26 2021-03-25 Preparation of cyclosporin derivatives

Publications (3)

Publication Number Publication Date
JP2023518776A JP2023518776A (ja) 2023-05-08
JP2023518776A5 JP2023518776A5 (https=) 2024-04-05
JP7761578B2 true JP7761578B2 (ja) 2025-10-28

Family

ID=77891510

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2022556477A Active JP7761578B2 (ja) 2020-03-26 2021-03-25 シクロスポリン誘導体の調製
JP2022556478A Active JP7776435B2 (ja) 2020-03-26 2021-03-25 シクロフィリン阻害剤およびその使用

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2022556478A Active JP7776435B2 (ja) 2020-03-26 2021-03-25 シクロフィリン阻害剤およびその使用

Country Status (11)

Country Link
US (3) US20230174583A1 (https=)
EP (2) EP4126905A4 (https=)
JP (2) JP7761578B2 (https=)
KR (2) KR20220158761A (https=)
CN (2) CN115335389A (https=)
AU (1) AU2021240762A1 (https=)
BR (1) BR112022018929A2 (https=)
CA (2) CA3172601A1 (https=)
IL (1) IL296586B1 (https=)
MX (1) MX2022011697A (https=)
WO (2) WO2021190601A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111449050A (zh) * 2019-01-20 2020-07-28 睿诺医疗科技（上海）有限公司 环孢菌素类似物及其用途
AU2020363688A1 (en) 2019-10-12 2022-04-21 Farsight Medical Technology (Shanghai) Co., Ltd. Treatment and prevention of nephrotoxin-induced kidney injuries
IL296586B1 (en) * 2020-03-26 2026-04-01 Farsight Medical Tech Shanghai Co Ltd Cyclophilin inhibitors and their uses
AU2021256222A1 (en) 2020-04-15 2022-10-06 Farsight Medical Technology (Shanghai) Co., Ltd. Prevention and treatment of organ injuries
GB202207348D0 (en) * 2022-05-19 2022-07-06 Cypralis Ltd Macrocyclic compounds and uses thereof
WO2024183651A1 (en) * 2023-03-03 2024-09-12 Farsight Medical Technology (Shanghai) Co., Ltd. Treatment and prevention of agent‐induced liver conditions or diseases
KR20260018851A (ko) * 2023-06-02 2026-02-09 파사이트 메디컬 테크놀로지 (상하이) 컴퍼니 리미티드 사이클로필린 저해제 및 그 용도

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012516850A (ja) 2009-01-30 2012-07-26 エナンタ ファーマシューティカルズ インコーポレイテッド Ｃ型肝炎感染を予防または治療するためのシクロスポリンアナログ
JP2013136597A (ja) 2001-10-19 2013-07-11 Isotechnika Pharma Inc シクロスポリン類似体混合物及びそれらの免疫調整剤としての使用
WO2019016572A1 (en) 2017-07-21 2019-01-24 Cypralis Ltd CICLOSPORINE ANALOGUES AND USES THEREOF

Family Cites Families (28)

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EP0194972B1 (en) 1985-03-11 1992-07-29 Sandoz Ag Novel cyclosporins
FI111730B (fi) 1990-11-02 2003-09-15 Novartis Ag Menetelmä ei-immunosuppressiivisen syklosporiinin valmistamiseksi
AU750245B2 (en) * 1997-10-08 2002-07-11 Aurinia Phamaceuticals Inc. Deuterated cyclosporine analogs and their use as immunomodulating agents
CN1205220C (zh) 1998-06-12 2005-06-08 斯－凯穆公司 新颖的环孢菌素
US6809077B2 (en) 2001-10-12 2004-10-26 Enanta Pharmaceuticals, Inc. Cyclosporin analogs for the treatment of autoimmune diseases
US7538084B2 (en) 2003-03-17 2009-05-26 Amr Technology, Inc. Cyclosporins
SI1802650T1 (sl) 2004-10-01 2012-03-30 Scynexis Inc Eter in tioeter substituirani ciklosporinski derivati za zdravljenje in preventivo pred infekcijami s hepatitisom c
ZA200703157B (en) * 2004-10-01 2008-08-27 Scynexis Inc 3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis C infection
EP2023918B1 (en) * 2006-05-19 2011-03-23 Scynexis, Inc. Cyclosporins for the treatment and prevention of ocular disorders
WO2008143996A1 (en) * 2007-05-18 2008-11-27 Scynexis, Inc. New chemical processes
AU2009276241A1 (en) 2008-07-30 2010-02-04 Ciclofilin Pharmaceuticals Corp. Nonimmunosuppressive cyclosporine analogue molecules
US8481483B2 (en) 2009-02-19 2013-07-09 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
WO2011082289A1 (en) * 2009-12-30 2011-07-07 Scynexis Inc. Cyclosporine analogues
WO2012009715A2 (en) * 2010-07-16 2012-01-19 S&T Global Inc. Novel cyclosporin derivatives for the treatment and prevention of a viral infection
US9890198B2 (en) * 2010-12-03 2018-02-13 S&T Global Inc. Cyclosporin derivatives and uses thereof
BR112013014890B1 (pt) 2010-12-15 2023-10-24 Contravir Pharmaceuticals, Inc Composto análogo de moléculas pertencentes à família ciclosporina, composição farmacêutica compreendendo o mesmo, uso terapêutico ou profilático do referido composto e processos para a preparação dos mesmos
DE102011111991A1 (de) * 2011-08-30 2013-02-28 Lead Discovery Center Gmbh Neue Cyclosporin-Derivate
GB201217560D0 (en) 2012-10-02 2012-11-14 Mitopharm Ltd Novel cyclic depsipeptide compounds and their uses
US20140212381A1 (en) * 2012-10-19 2014-07-31 Scynexis, Inc. Macrocycles
GB201222455D0 (en) * 2012-12-13 2013-01-30 Perioc Ltd Novel pharmaceutical formulations and their use in the treatment of periodontaldisease
GB201414806D0 (en) 2014-08-20 2014-10-01 Ucl Business Plc Cyclosporin conjugates
WO2017004304A1 (en) * 2015-06-30 2017-01-05 Cypralis Limited Novel macrocycles
CN106902346A (zh) * 2015-12-23 2017-06-30 中美华世通生物医药科技（武汉）有限公司 药物组合物及其制药用途
CN106902347A (zh) * 2015-12-23 2017-06-30 中美华世通生物医药科技（武汉）有限公司 亲环孢素抑制剂的用途
CN118324867A (zh) * 2016-05-17 2024-07-12 美国科技环球有限公司 新型环孢菌素衍生物及其用途
WO2020037530A1 (en) * 2018-08-22 2020-02-27 Waterstone Pharmaceuticals (Wuhan) Co., Ltd. Crystalline form of compound and uses thereof in medicine
CN111449050A (zh) * 2019-01-20 2020-07-28 睿诺医疗科技（上海）有限公司 环孢菌素类似物及其用途
IL296586B1 (en) * 2020-03-26 2026-04-01 Farsight Medical Tech Shanghai Co Ltd Cyclophilin inhibitors and their uses

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013136597A (ja) 2001-10-19 2013-07-11 Isotechnika Pharma Inc シクロスポリン類似体混合物及びそれらの免疫調整剤としての使用
JP2012516850A (ja) 2009-01-30 2012-07-26 エナンタ ファーマシューティカルズ インコーポレイテッド Ｃ型肝炎感染を予防または治療するためのシクロスポリンアナログ
WO2019016572A1 (en) 2017-07-21 2019-01-24 Cypralis Ltd CICLOSPORINE ANALOGUES AND USES THEREOF

Also Published As

Publication number Publication date
EP4126905A1 (en) 2023-02-08
JP2023518777A (ja) 2023-05-08
MX2022011697A (es) 2022-10-07
TW202144379A (zh) 2021-12-01
US20230174583A1 (en) 2023-06-08
JP7776435B2 (ja) 2025-11-26
US20240352074A1 (en) 2024-10-24
EP4126904A4 (en) 2024-05-29
IL296586A (en) 2022-11-01
CN115335389A (zh) 2022-11-11
IL296586B1 (en) 2026-04-01
CN115298199A (zh) 2022-11-04
US20230110497A1 (en) 2023-04-13
US12522634B2 (en) 2026-01-13
KR20220158760A (ko) 2022-12-01
BR112022018929A2 (pt) 2022-12-06
JP2023518776A (ja) 2023-05-08
AU2021240762A1 (en) 2022-10-06
CA3172601A1 (en) 2021-09-30
WO2021190601A1 (en) 2021-09-30
EP4126904A1 (en) 2023-02-08
CA3172535A1 (en) 2021-09-30
WO2021190604A1 (en) 2021-09-30
US12060440B2 (en) 2024-08-13
KR20220158761A (ko) 2022-12-01
EP4126905A4 (en) 2024-05-29

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