JP7731196B2 - 抗Ｃ１ｓ抗体および使用方法 - Google Patents

抗Ｃ１ｓ抗体および使用方法

Info

Publication number
JP7731196B2
JP7731196B2 JP2020526341A JP2020526341A JP7731196B2 JP 7731196 B2 JP7731196 B2 JP 7731196B2 JP 2020526341 A JP2020526341 A JP 2020526341A JP 2020526341 A JP2020526341 A JP 2020526341A JP 7731196 B2 JP7731196 B2 JP 7731196B2
Authority
JP
Japan
Prior art keywords
antibody
seq
sequence
hvr
antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2020526341A
Other languages
English (en)
Japanese (ja)
Other versions
JP2021502967A (ja
Inventor
シュー フェン
太一 倉持
優 村岡
徳行 高橋
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of JP2021502967A publication Critical patent/JP2021502967A/ja
Priority to JP2023100458A priority Critical patent/JP2023116744A/ja
Application granted granted Critical
Publication of JP7731196B2 publication Critical patent/JP7731196B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mycology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2020526341A 2017-11-14 2018-11-14 抗Ｃ１ｓ抗体および使用方法 Active JP7731196B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023100458A JP2023116744A (ja) 2017-11-14 2023-06-20 抗Ｃ１ｓ抗体および使用方法

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2017219507 2017-11-14
JP2017219507 2017-11-14
JP2018188765 2018-10-04
JP2018188765 2018-10-04
PCT/JP2018/042054 WO2019098212A1 (en) 2017-11-14 2018-11-14 Anti-c1s antibodies and methods of use

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023100458A Division JP2023116744A (ja) 2017-11-14 2023-06-20 抗Ｃ１ｓ抗体および使用方法

Publications (2)

Publication Number Publication Date
JP2021502967A JP2021502967A (ja) 2021-02-04
JP7731196B2 true JP7731196B2 (ja) 2025-08-29

Family

ID=66539588

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2020526341A Active JP7731196B2 (ja) 2017-11-14 2018-11-14 抗Ｃ１ｓ抗体および使用方法
JP2023100458A Pending JP2023116744A (ja) 2017-11-14 2023-06-20 抗Ｃ１ｓ抗体および使用方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2023100458A Pending JP2023116744A (ja) 2017-11-14 2023-06-20 抗Ｃ１ｓ抗体および使用方法

Country Status (5)

Country Link
US (1) US12084513B2 (https=)
EP (2) EP4640703A3 (https=)
JP (2) JP7731196B2 (https=)
CN (1) CN111556895B (https=)
WO (1) WO2019098212A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023116744A (ja) * 2017-11-14 2023-08-22 中外製薬株式会社 抗Ｃ１ｓ抗体および使用方法

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014030750A1 (ja) 2012-08-24 2014-02-27 中外製薬株式会社 マウスFcγRII特異的Fc抗体
CN105246914B (zh) 2013-04-02 2021-08-27 中外制药株式会社 Fc区变体
EP4696320A2 (en) * 2019-05-15 2026-02-18 Chugai Seiyaku Kabushiki Kaisha Anti-c1s antibody
CA3153207A1 (en) * 2019-10-16 2021-04-22 Chugai Seiyaku Kabushiki Kaisha An antibody, a pharmaceutical composition, and a method
AR125344A1 (es) * 2021-04-15 2023-07-05 Chugai Pharmaceutical Co Ltd Anticuerpo anti-c1s
CN117769434A (zh) * 2021-05-20 2024-03-26 黛安瑟斯医疗运营公司 与C1s结合的抗体和其用途
CN120757653A (zh) 2021-07-13 2025-10-10 迈威(美国)生物治疗有限公司 抗c1s抗体和其用途
JP7753313B2 (ja) * 2022-10-18 2025-10-14 中外製薬株式会社 抗Ｃ１ｓ抗体の使用
WO2025129535A1 (en) * 2023-12-20 2025-06-26 Dianthus Therapeutics Opco, Inc. Pharmaceutical compositions comprising antibodies for treatment of c1s mediated disorders and methods of using the same

Citations (4)

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Publication number Priority date Publication date Assignee Title
WO2009125825A1 (ja) 2008-04-11 2009-10-15 中外製薬株式会社 複数分子の抗原に繰り返し結合する抗原結合分子
JP2016503400A (ja) 2012-10-25 2016-02-04 トゥルー・ノース・セラピューティクス・インコーポレイテッド 抗補体Ｃ１ｓ抗体とそれらの用途
JP2016505240A (ja) 2012-11-02 2016-02-25 トゥルー・ノース・セラピューティクス・インコーポレイテッド 抗補体Ｃ１ｓ抗体とそれらの用途
JP2017509312A (ja) 2014-12-19 2017-04-06 中外製薬株式会社 抗ｃ５抗体および使用方法

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