JP7728178B2 - （ｓ）－１－（４－フルオロフェニル）－１－（２－（４－（６－（１－メチル－１ｈ－ピラゾール－４－イル）ピロロ［２，１－ｆ］［１、２，４］トリアジン－４－イル）ピペラジニル）－ピリミジン－５－イル）エタン－１－アミンの結晶形態及び製造方法 - Google Patents

（ｓ）－１－（４－フルオロフェニル）－１－（２－（４－（６－（１－メチル－１ｈ－ピラゾール－４－イル）ピロロ［２，１－ｆ］［１、２，４］トリアジン－４－イル）ピペラジニル）－ピリミジン－５－イル）エタン－１－アミンの結晶形態及び製造方法

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JP7728178B2
JP7728178B2 JP2021560265A JP2021560265A JP7728178B2 JP 7728178 B2 JP7728178 B2 JP 7728178B2 JP 2021560265 A JP2021560265 A JP 2021560265A JP 2021560265 A JP2021560265 A JP 2021560265A JP 7728178 B2 JP7728178 B2 JP 7728178B2
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compound
crystalline form
powder
ray diffraction
diffraction pattern
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JP2022526438A (ja
JP2022526438A5 (https=
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ウェートジグ，ジョシュア・ディー
マー，ブレントン
ハインリック，ブライアン
ウィルキー，ゴードン
マッキーカーン，ローレン
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ブループリント メディシンズ コーポレイション
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2021560265A 2019-04-12 2020-04-10 （ｓ）－１－（４－フルオロフェニル）－１－（２－（４－（６－（１－メチル－１ｈ－ピラゾール－４－イル）ピロロ［２，１－ｆ］［１、２，４］トリアジン－４－イル）ピペラジニル）－ピリミジン－５－イル）エタン－１－アミンの結晶形態及び製造方法 Active JP7728178B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962833527P 2019-04-12 2019-04-12
US62/833,527 2019-04-12
US201962844575P 2019-05-07 2019-05-07
US62/844,575 2019-05-07
US202062990269P 2020-03-16 2020-03-16
US62/990,269 2020-03-16
PCT/US2020/027724 WO2020210669A1 (en) 2019-04-12 2020-04-10 Crystalline forms of (s)-1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1h-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazinyl)-pyrimidin-5-yl)ethan-1-amine and methods of making

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JP2022526438A JP2022526438A (ja) 2022-05-24
JP2022526438A5 JP2022526438A5 (https=) 2023-04-18
JP7728178B2 true JP7728178B2 (ja) 2025-08-22

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US (5) US12060354B2 (https=)
EP (2) EP4302761A3 (https=)
JP (1) JP7728178B2 (https=)
CN (1) CN113966334B (https=)
CA (2) CA3296895A1 (https=)
DK (1) DK3856341T3 (https=)
ES (1) ES2966512T3 (https=)
FI (1) FI3856341T3 (https=)
HR (1) HRP20231533T1 (https=)
HU (1) HUE064283T2 (https=)
IL (2) IL287148A (https=)
LT (1) LT3856341T (https=)
MA (1) MA53759A (https=)
PL (1) PL3856341T3 (https=)
PT (1) PT3856341T (https=)
RS (1) RS64881B1 (https=)
SI (1) SI3856341T1 (https=)
SM (1) SMT202300447T1 (https=)
TW (1) TWI845657B (https=)
WO (1) WO2020210669A1 (https=)

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ES2966512T3 (es) 2019-04-12 2024-04-22 Blueprint Medicines Corp Formas cristalinas de (S)-1-(4-fluorofenil)-1-(2-(4-(6-(1-metil-1H-pirazol-4-il)pirrolo[2,1-f][1,2,4]triazin-4-il)piperazinil)-pirimidin-5-il)etan-1-amina y métodos de elaboración
CN114341138A (zh) * 2019-07-09 2022-04-12 桑多斯股份公司 口服可用的选择性kit和pdgfr激酶抑制剂的晶型
GB201915447D0 (en) * 2019-10-24 2019-12-11 Johnson Matthey Plc Polymorphs of avapritinib and methods of preparing the polymorphs
WO2021183709A1 (en) 2020-03-11 2021-09-16 Teva Czech Industries S.R.O Solid state forms of avapritinib and process for preparation thereof
WO2021257522A1 (en) 2020-06-17 2021-12-23 Teva Czech Industries S.R.O Solid state forms of avapritinib salts
HU231413B1 (hu) * 2021-02-26 2023-08-28 Egis Gyógyszergyár Zrt. Eljárás avapritinib és intermedierek előállítására
AU2022231009A1 (en) 2021-03-03 2023-09-21 Blueprint Medicines Corporation Synthetic methods and intermediates for producing compounds for treating kit- and pdgfra-mediated diseases
HU231755B1 (hu) * 2022-08-11 2026-02-28 Egis Gyógyszergyár Zrt. Új avapritinib sók és előállítási eljárásaik
US20240382493A1 (en) * 2023-05-18 2024-11-21 Blueprint Medicines Corporation Methods for treating systemic mastocytosis and gastrointestinal stromal tumors
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US20210147433A1 (en) 2021-05-20
IL287148A (en) 2021-12-01
US11964980B2 (en) 2024-04-23
US12252494B2 (en) 2025-03-18
LT3856341T (lt) 2023-12-27
CN113966334A (zh) 2022-01-21
HRP20231533T1 (hr) 2024-03-01
EP4302761A2 (en) 2024-01-10
US20260116883A1 (en) 2026-04-30
TW202104232A (zh) 2021-02-01
PT3856341T (pt) 2023-12-12
US11999744B2 (en) 2024-06-04
IL324301A (en) 2025-12-01
US20230271971A1 (en) 2023-08-31
DK3856341T3 (da) 2023-12-04
TWI845657B (zh) 2024-06-21
SI3856341T1 (sl) 2024-02-29
ES2966512T3 (es) 2024-04-22
US12060354B2 (en) 2024-08-13
JP2022526438A (ja) 2022-05-24
CA3296895A1 (en) 2026-03-02
PL3856341T3 (pl) 2024-03-04
EP3856341B1 (en) 2023-09-06
EP4302761A3 (en) 2024-03-27
FI3856341T3 (fi) 2023-11-30
CA3136707A1 (en) 2020-10-15
HUE064283T2 (hu) 2024-02-28
WO2020210669A1 (en) 2020-10-15
US20240132510A1 (en) 2024-04-25
RS64881B1 (sr) 2023-12-29
CN113966334B (zh) 2025-01-21
US20230124801A1 (en) 2023-04-20
EP3856341A1 (en) 2021-08-04
SMT202300447T1 (it) 2024-01-10
MA53759A (fr) 2021-08-04

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