PT3856341T - Formas cristalinas de (s)-1-(4-fluorofenil)-1-(2-(4-(6-(1- metil-1h-pirazol-4-il)pirrolo[2,1-f][1,2,4]triazin-4- il)piperazinil)pirimidin-5-il)etan-1-amina e métodos de preparação - Google Patents

Formas cristalinas de (s)-1-(4-fluorofenil)-1-(2-(4-(6-(1- metil-1h-pirazol-4-il)pirrolo[2,1-f][1,2,4]triazin-4- il)piperazinil)pirimidin-5-il)etan-1-amina e métodos de preparação

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Publication number
PT3856341T
PT3856341T PT207229360T PT20722936T PT3856341T PT 3856341 T PT3856341 T PT 3856341T PT 207229360 T PT207229360 T PT 207229360T PT 20722936 T PT20722936 T PT 20722936T PT 3856341 T PT3856341 T PT 3856341T
Authority
PT
Portugal
Prior art keywords
ethan
triazin
pyrrolo
pyrazol
pyrimidin
Prior art date
Application number
PT207229360T
Other languages
English (en)
Original Assignee
Blueprint Medicines Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Blueprint Medicines Corp filed Critical Blueprint Medicines Corp
Publication of PT3856341T publication Critical patent/PT3856341T/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PT207229360T 2019-04-12 2020-04-10 Formas cristalinas de (s)-1-(4-fluorofenil)-1-(2-(4-(6-(1- metil-1h-pirazol-4-il)pirrolo[2,1-f][1,2,4]triazin-4- il)piperazinil)pirimidin-5-il)etan-1-amina e métodos de preparação PT3856341T (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962833527P 2019-04-12 2019-04-12
US201962844575P 2019-05-07 2019-05-07
US202062990269P 2020-03-16 2020-03-16

Publications (1)

Publication Number Publication Date
PT3856341T true PT3856341T (pt) 2023-12-12

Family

ID=70476546

Family Applications (1)

Application Number Title Priority Date Filing Date
PT207229360T PT3856341T (pt) 2019-04-12 2020-04-10 Formas cristalinas de (s)-1-(4-fluorofenil)-1-(2-(4-(6-(1- metil-1h-pirazol-4-il)pirrolo[2,1-f][1,2,4]triazin-4- il)piperazinil)pirimidin-5-il)etan-1-amina e métodos de preparação

Country Status (18)

Country Link
US (4) US20210147433A1 (pt)
EP (2) EP3856341B1 (pt)
JP (1) JP2022526438A (pt)
CN (1) CN113966334A (pt)
CA (1) CA3136707A1 (pt)
DK (1) DK3856341T3 (pt)
ES (1) ES2966512T3 (pt)
FI (1) FI3856341T3 (pt)
HR (1) HRP20231533T1 (pt)
HU (1) HUE064283T2 (pt)
IL (1) IL287148A (pt)
LT (1) LT3856341T (pt)
MA (1) MA53759A (pt)
PL (1) PL3856341T3 (pt)
PT (1) PT3856341T (pt)
RS (1) RS64881B1 (pt)
SI (1) SI3856341T1 (pt)
WO (1) WO2020210669A1 (pt)

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US20230103724A1 (en) 2020-03-11 2023-04-06 Teva Czech Industries S.R.O Solid state forms of avapritinib and process for preparation thereof
US20230279009A1 (en) 2020-06-17 2023-09-07 Teva Czech Industries S.R.O Solid state forms of avapritinib salts
HU231413B1 (hu) * 2021-02-26 2023-08-28 Egis Gyógyszergyár Zrt. Eljárás avapritinib és intermedierek előállítására
IL305611A (en) 2021-03-03 2023-11-01 Blueprint Medicines Corp Synthetic methods and intermediates for the production of compounds for the treatment of PDGFRA-mediated diseases and kits
HUP2200323A1 (hu) * 2022-08-11 2024-02-28 Egyt Gyogyszervegyeszeti Gyar Új avapritinib sók és elõállítási eljárásaik

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Also Published As

Publication number Publication date
TW202104232A (zh) 2021-02-01
EP4302761A2 (en) 2024-01-10
US20230124801A1 (en) 2023-04-20
US11999744B2 (en) 2024-06-04
US20240132510A1 (en) 2024-04-25
MA53759A (fr) 2021-08-04
FI3856341T3 (fi) 2023-11-30
LT3856341T (lt) 2023-12-27
IL287148A (en) 2021-12-01
EP3856341B1 (en) 2023-09-06
US20210147433A1 (en) 2021-05-20
JP2022526438A (ja) 2022-05-24
DK3856341T3 (da) 2023-12-04
EP4302761A3 (en) 2024-03-27
CA3136707A1 (en) 2020-10-15
HRP20231533T1 (hr) 2024-03-01
WO2020210669A1 (en) 2020-10-15
HUE064283T2 (hu) 2024-02-28
EP3856341A1 (en) 2021-08-04
CN113966334A (zh) 2022-01-21
US11964980B2 (en) 2024-04-23
ES2966512T3 (es) 2024-04-22
US20230271971A1 (en) 2023-08-31
PL3856341T3 (pl) 2024-03-04
RS64881B1 (sr) 2023-12-29
SI3856341T1 (sl) 2024-02-29

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