EA202090450A1 - Антагонисты рецептора кортикотропин-рилизинг фактора - Google Patents
Антагонисты рецептора кортикотропин-рилизинг фактораInfo
- Publication number
- EA202090450A1 EA202090450A1 EA202090450A EA202090450A EA202090450A1 EA 202090450 A1 EA202090450 A1 EA 202090450A1 EA 202090450 A EA202090450 A EA 202090450A EA 202090450 A EA202090450 A EA 202090450A EA 202090450 A1 EA202090450 A1 EA 202090450A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- corticotropin
- receptor antagonists
- releasing factor
- dimethylpyrazolo
- ethylpropyl
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A61K9/4825—Proteins, e.g. gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Данное изобретение предлагает новые фармацевтические композиции, содержащие 3-(4-хлор-2-(морфолин-4-ил)тиазол-5-ил)-7-(1-этилпропил)-2,5-диметилпиразоло[1,5-a]пиримидин и способы их применения для лечения врожденной гиперплазии коры надпочечников (ВГКН).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762545406P | 2017-08-14 | 2017-08-14 | |
PCT/US2018/046760 WO2019036503A1 (en) | 2017-08-14 | 2018-08-14 | CORTICOTROPIN RELEASE FACTOR RECEPTOR ANTAGONISTS |
Publications (1)
Publication Number | Publication Date |
---|---|
EA202090450A1 true EA202090450A1 (ru) | 2020-09-24 |
Family
ID=65362494
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA202090450A EA202090450A1 (ru) | 2017-08-14 | 2018-08-14 | Антагонисты рецептора кортикотропин-рилизинг фактора |
Country Status (11)
Country | Link |
---|---|
US (8) | US20210361664A1 (ru) |
EP (1) | EP3628005A4 (ru) |
JP (2) | JP7398963B2 (ru) |
KR (1) | KR20200040761A (ru) |
CN (1) | CN110996943A (ru) |
AU (2) | AU2018317398A1 (ru) |
BR (1) | BR112020002967A2 (ru) |
CA (1) | CA3064464A1 (ru) |
EA (1) | EA202090450A1 (ru) |
MX (2) | MX2019015320A (ru) |
WO (1) | WO2019036503A1 (ru) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2936974A1 (en) | 2014-01-21 | 2015-07-30 | Neurocrine Biosciences, Inc. | Crf1 receptor antagonists for the treatment of congenital adrenal hyperplasia |
CN110996943A (zh) | 2017-08-14 | 2020-04-10 | 云杉生物科学公司 | 促肾上腺皮质激素释放因子受体拮抗剂 |
MX2020011344A (es) * | 2018-04-27 | 2021-02-09 | Spruce Biosciences Inc | Métodos para tratar tumores en reposo suprarrenales testiculares y de ovarios. |
BR112022000956A2 (pt) * | 2019-07-19 | 2022-04-05 | Spruce Biosciences Inc | Métodos de tratamento da hiperplasia adrenal congênita |
AU2021324839B2 (en) | 2020-08-12 | 2024-02-29 | Spruce Biosciences, Inc. | Methods and compositions for treating polycystic ovary syndrome |
WO2022046905A1 (en) * | 2020-08-26 | 2022-03-03 | Neurocrine Biosciences, Inc. | Crf receptor antagonists and methods of use |
US11708372B2 (en) | 2021-11-19 | 2023-07-25 | Spruce Biosciences, Inc. | Crystalline composition of tildacerfont and methods of use and preparation thereof |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060078623A1 (en) * | 2004-08-13 | 2006-04-13 | Emisphere Technologies, Inc. | Pharmaceutical formulations containing microparticles or nanoparticles of a delivery agent |
CA2663511C (en) * | 2006-09-20 | 2012-12-04 | Eli Lilly And Company | Thiazole pyrazolopyrimidines as crf1 receptor antagonists |
US8153962B2 (en) * | 2008-12-24 | 2012-04-10 | Quest Diagnostics Investments Incorporated | Mass spectrometry assay for congenital adrenal hyperplasia |
ES2710149T3 (es) * | 2009-12-31 | 2019-04-23 | Marius Pharmaceuticals Llc | Modulación de la solubilidad, la estabilidad, la absorción, el metabolismo y el perfil farmacocinético de los fármacos lipófilos por esteroles |
CA2936974A1 (en) * | 2014-01-21 | 2015-07-30 | Neurocrine Biosciences, Inc. | Crf1 receptor antagonists for the treatment of congenital adrenal hyperplasia |
CN110996943A (zh) | 2017-08-14 | 2020-04-10 | 云杉生物科学公司 | 促肾上腺皮质激素释放因子受体拮抗剂 |
-
2018
- 2018-08-14 CN CN201880038569.3A patent/CN110996943A/zh active Pending
- 2018-08-14 CA CA3064464A patent/CA3064464A1/en active Pending
- 2018-08-14 BR BR112020002967-0A patent/BR112020002967A2/pt unknown
- 2018-08-14 JP JP2019572817A patent/JP7398963B2/ja active Active
- 2018-08-14 WO PCT/US2018/046760 patent/WO2019036503A1/en unknown
- 2018-08-14 US US16/639,541 patent/US20210361664A1/en not_active Abandoned
- 2018-08-14 EA EA202090450A patent/EA202090450A1/ru unknown
- 2018-08-14 EP EP18846689.0A patent/EP3628005A4/en active Pending
- 2018-08-14 KR KR1020207004095A patent/KR20200040761A/ko active Search and Examination
- 2018-08-14 MX MX2019015320A patent/MX2019015320A/es unknown
- 2018-08-14 AU AU2018317398A patent/AU2018317398A1/en not_active Abandoned
-
2019
- 2019-04-18 US US16/388,620 patent/US10849908B2/en active Active
- 2019-12-16 MX MX2023000501A patent/MX2023000501A/es unknown
-
2020
- 2020-10-05 US US17/063,592 patent/US11344557B2/en active Active
- 2020-10-22 US US17/078,054 patent/US11007201B2/en active Active
-
2021
- 2021-06-25 US US17/359,411 patent/US11351177B2/en active Active
- 2021-06-25 US US17/359,414 patent/US11311549B2/en active Active
-
2022
- 2022-01-27 US US17/586,228 patent/US20220143037A1/en not_active Abandoned
- 2022-12-09 US US18/078,649 patent/US20230321112A1/en active Pending
-
2023
- 2023-01-13 AU AU2023200189A patent/AU2023200189B2/en active Active
- 2023-09-08 JP JP2023146415A patent/JP2024001014A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
US20210015827A1 (en) | 2021-01-21 |
US11007201B2 (en) | 2021-05-18 |
US20210361664A1 (en) | 2021-11-25 |
EP3628005A4 (en) | 2021-01-20 |
US20230321112A1 (en) | 2023-10-12 |
WO2019036503A1 (en) | 2019-02-21 |
AU2018317398A1 (en) | 2019-11-21 |
US10849908B2 (en) | 2020-12-01 |
US20230414627A1 (en) | 2023-12-28 |
JP7398963B2 (ja) | 2023-12-15 |
MX2023000501A (es) | 2023-02-13 |
US20210322430A1 (en) | 2021-10-21 |
MX2019015320A (es) | 2020-07-20 |
CN110996943A (zh) | 2020-04-10 |
US11311549B2 (en) | 2022-04-26 |
AU2023200189A1 (en) | 2023-02-16 |
JP2024001014A (ja) | 2024-01-09 |
US20190262349A1 (en) | 2019-08-29 |
AU2023200189B2 (en) | 2024-02-22 |
US20210322431A1 (en) | 2021-10-21 |
US20220143037A1 (en) | 2022-05-12 |
BR112020002967A2 (pt) | 2020-08-11 |
US11344557B2 (en) | 2022-05-31 |
US11351177B2 (en) | 2022-06-07 |
US20210038609A1 (en) | 2021-02-11 |
CA3064464A1 (en) | 2019-02-21 |
KR20200040761A (ko) | 2020-04-20 |
EP3628005A1 (en) | 2020-04-01 |
JP2020530831A (ja) | 2020-10-29 |
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