EA202090450A1 - Антагонисты рецептора кортикотропин-рилизинг фактора - Google Patents

Антагонисты рецептора кортикотропин-рилизинг фактора

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Publication number
EA202090450A1
EA202090450A1 EA202090450A EA202090450A EA202090450A1 EA 202090450 A1 EA202090450 A1 EA 202090450A1 EA 202090450 A EA202090450 A EA 202090450A EA 202090450 A EA202090450 A EA 202090450A EA 202090450 A1 EA202090450 A1 EA 202090450A1
Authority
EA
Eurasian Patent Office
Prior art keywords
corticotropin
receptor antagonists
releasing factor
dimethylpyrazolo
ethylpropyl
Prior art date
Application number
EA202090450A
Other languages
English (en)
Inventor
Алексис Ховертон
Хал Гербер
Михаэль Хуанг
Original Assignee
Спрюс Биосайнсес, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=65362494&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA202090450(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Спрюс Биосайнсес, Инк. filed Critical Спрюс Биосайнсес, Инк.
Publication of EA202090450A1 publication Critical patent/EA202090450A1/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A61K9/4825—Proteins, e.g. gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Данное изобретение предлагает новые фармацевтические композиции, содержащие 3-(4-хлор-2-(морфолин-4-ил)тиазол-5-ил)-7-(1-этилпропил)-2,5-диметилпиразоло[1,5-a]пиримидин и способы их применения для лечения врожденной гиперплазии коры надпочечников (ВГКН).
EA202090450A 2017-08-14 2018-08-14 Антагонисты рецептора кортикотропин-рилизинг фактора EA202090450A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762545406P 2017-08-14 2017-08-14
PCT/US2018/046760 WO2019036503A1 (en) 2017-08-14 2018-08-14 CORTICOTROPIN RELEASE FACTOR RECEPTOR ANTAGONISTS

Publications (1)

Publication Number Publication Date
EA202090450A1 true EA202090450A1 (ru) 2020-09-24

Family

ID=65362494

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202090450A EA202090450A1 (ru) 2017-08-14 2018-08-14 Антагонисты рецептора кортикотропин-рилизинг фактора

Country Status (11)

Country Link
US (8) US20210361664A1 (ru)
EP (1) EP3628005A4 (ru)
JP (2) JP7398963B2 (ru)
KR (1) KR20200040761A (ru)
CN (1) CN110996943A (ru)
AU (2) AU2018317398A1 (ru)
BR (1) BR112020002967A2 (ru)
CA (1) CA3064464A1 (ru)
EA (1) EA202090450A1 (ru)
MX (2) MX2019015320A (ru)
WO (1) WO2019036503A1 (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2936974A1 (en) 2014-01-21 2015-07-30 Neurocrine Biosciences, Inc. Crf1 receptor antagonists for the treatment of congenital adrenal hyperplasia
CN110996943A (zh) 2017-08-14 2020-04-10 云杉生物科学公司 促肾上腺皮质激素释放因子受体拮抗剂
MX2020011344A (es) * 2018-04-27 2021-02-09 Spruce Biosciences Inc Métodos para tratar tumores en reposo suprarrenales testiculares y de ovarios.
BR112022000956A2 (pt) * 2019-07-19 2022-04-05 Spruce Biosciences Inc Métodos de tratamento da hiperplasia adrenal congênita
AU2021324839B2 (en) 2020-08-12 2024-02-29 Spruce Biosciences, Inc. Methods and compositions for treating polycystic ovary syndrome
WO2022046905A1 (en) * 2020-08-26 2022-03-03 Neurocrine Biosciences, Inc. Crf receptor antagonists and methods of use
US11708372B2 (en) 2021-11-19 2023-07-25 Spruce Biosciences, Inc. Crystalline composition of tildacerfont and methods of use and preparation thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060078623A1 (en) * 2004-08-13 2006-04-13 Emisphere Technologies, Inc. Pharmaceutical formulations containing microparticles or nanoparticles of a delivery agent
CA2663511C (en) * 2006-09-20 2012-12-04 Eli Lilly And Company Thiazole pyrazolopyrimidines as crf1 receptor antagonists
US8153962B2 (en) * 2008-12-24 2012-04-10 Quest Diagnostics Investments Incorporated Mass spectrometry assay for congenital adrenal hyperplasia
ES2710149T3 (es) * 2009-12-31 2019-04-23 Marius Pharmaceuticals Llc Modulación de la solubilidad, la estabilidad, la absorción, el metabolismo y el perfil farmacocinético de los fármacos lipófilos por esteroles
CA2936974A1 (en) * 2014-01-21 2015-07-30 Neurocrine Biosciences, Inc. Crf1 receptor antagonists for the treatment of congenital adrenal hyperplasia
CN110996943A (zh) 2017-08-14 2020-04-10 云杉生物科学公司 促肾上腺皮质激素释放因子受体拮抗剂

Also Published As

Publication number Publication date
US20210015827A1 (en) 2021-01-21
US11007201B2 (en) 2021-05-18
US20210361664A1 (en) 2021-11-25
EP3628005A4 (en) 2021-01-20
US20230321112A1 (en) 2023-10-12
WO2019036503A1 (en) 2019-02-21
AU2018317398A1 (en) 2019-11-21
US10849908B2 (en) 2020-12-01
US20230414627A1 (en) 2023-12-28
JP7398963B2 (ja) 2023-12-15
MX2023000501A (es) 2023-02-13
US20210322430A1 (en) 2021-10-21
MX2019015320A (es) 2020-07-20
CN110996943A (zh) 2020-04-10
US11311549B2 (en) 2022-04-26
AU2023200189A1 (en) 2023-02-16
JP2024001014A (ja) 2024-01-09
US20190262349A1 (en) 2019-08-29
AU2023200189B2 (en) 2024-02-22
US20210322431A1 (en) 2021-10-21
US20220143037A1 (en) 2022-05-12
BR112020002967A2 (pt) 2020-08-11
US11344557B2 (en) 2022-05-31
US11351177B2 (en) 2022-06-07
US20210038609A1 (en) 2021-02-11
CA3064464A1 (en) 2019-02-21
KR20200040761A (ko) 2020-04-20
EP3628005A1 (en) 2020-04-01
JP2020530831A (ja) 2020-10-29

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