MX2019015320A - Antagonistas del receptor del factor liberador de corticotropina. - Google Patents

Antagonistas del receptor del factor liberador de corticotropina.

Info

Publication number
MX2019015320A
MX2019015320A MX2019015320A MX2019015320A MX2019015320A MX 2019015320 A MX2019015320 A MX 2019015320A MX 2019015320 A MX2019015320 A MX 2019015320A MX 2019015320 A MX2019015320 A MX 2019015320A MX 2019015320 A MX2019015320 A MX 2019015320A
Authority
MX
Mexico
Prior art keywords
receptor antagonists
factor receptor
releasing factor
corticotropin releasing
dimethylpyrazolo
Prior art date
Application number
MX2019015320A
Other languages
English (en)
Inventor
Alexis Howerton
Hal Gerber
Michael Huang
Original Assignee
Spruce Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=65362494&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2019015320(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Spruce Biosciences Inc filed Critical Spruce Biosciences Inc
Publication of MX2019015320A publication Critical patent/MX2019015320A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A61K9/4825—Proteins, e.g. gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente invención proporciona nuevas composiciones farmacéuticas que comprenden 3-(4-cloro-2-(morfolin-4-il)tiazol-5- il)-7-(1-etilpropil)-2,5-dimetilpirazolo(1,5-a)pirimidina y métodos para el uso de la misma para el tratamiento de la hiperplasia suprarrenal congénita (CAH).
MX2019015320A 2017-08-14 2018-08-14 Antagonistas del receptor del factor liberador de corticotropina. MX2019015320A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762545406P 2017-08-14 2017-08-14
PCT/US2018/046760 WO2019036503A1 (en) 2017-08-14 2018-08-14 CORTICOTROPIN RELEASE FACTOR RECEPTOR ANTAGONISTS

Publications (1)

Publication Number Publication Date
MX2019015320A true MX2019015320A (es) 2020-07-20

Family

ID=65362494

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2019015320A MX2019015320A (es) 2017-08-14 2018-08-14 Antagonistas del receptor del factor liberador de corticotropina.
MX2023000501A MX2023000501A (es) 2017-08-14 2019-12-16 Antagonistas del receptor del factor liberador de corticotropina.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2023000501A MX2023000501A (es) 2017-08-14 2019-12-16 Antagonistas del receptor del factor liberador de corticotropina.

Country Status (11)

Country Link
US (8) US20210361664A1 (es)
EP (1) EP3628005A4 (es)
JP (2) JP7398963B2 (es)
KR (1) KR20200040761A (es)
CN (1) CN110996943A (es)
AU (2) AU2018317398A1 (es)
BR (1) BR112020002967A2 (es)
CA (1) CA3064464A1 (es)
EA (1) EA202090450A1 (es)
MX (2) MX2019015320A (es)
WO (1) WO2019036503A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015112642A1 (en) 2014-01-21 2015-07-30 Neurocrine Biosciences, Inc. Crf1 receptor antagonists for the treatment of congenital adrenal hyperplasia
MX2019015320A (es) 2017-08-14 2020-07-20 Spruce Biosciences Inc Antagonistas del receptor del factor liberador de corticotropina.
JP7427655B2 (ja) * 2018-04-27 2024-02-05 スプルース バイオサイエンシーズ，インク． 精巣副腎残存腫瘍および卵巣副腎残存腫瘍を処置するための方法
BR112022000956A2 (pt) 2019-07-19 2022-04-05 Spruce Biosciences Inc Métodos de tratamento da hiperplasia adrenal congênita
WO2022036123A1 (en) * 2020-08-12 2022-02-17 Spruce Biosciences, Inc. Methods and compositions for treating polycystic ovary syndrome
WO2022046905A1 (en) * 2020-08-26 2022-03-03 Neurocrine Biosciences, Inc. Crf receptor antagonists and methods of use
US11708372B2 (en) 2021-11-19 2023-07-25 Spruce Biosciences, Inc. Crystalline composition of tildacerfont and methods of use and preparation thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060078623A1 (en) * 2004-08-13 2006-04-13 Emisphere Technologies, Inc. Pharmaceutical formulations containing microparticles or nanoparticles of a delivery agent
PL2094709T3 (pl) 2006-09-20 2011-02-28 Lilly Co Eli Tiazolopirazolopirymidyny jako antagoniści receptora crf1
EP3486648A3 (en) * 2008-12-24 2019-08-07 Quest Diagnostics Investments Incorporated Mass spectrometry assay for congenital adrenal hyperplasia
WO2015112642A1 (en) 2014-01-21 2015-07-30 Neurocrine Biosciences, Inc. Crf1 receptor antagonists for the treatment of congenital adrenal hyperplasia
MX2019015320A (es) 2017-08-14 2020-07-20 Spruce Biosciences Inc Antagonistas del receptor del factor liberador de corticotropina.

Also Published As

Publication number Publication date
BR112020002967A2 (pt) 2020-08-11
EP3628005A1 (en) 2020-04-01
US20220143037A1 (en) 2022-05-12
US20210322431A1 (en) 2021-10-21
EP3628005A4 (en) 2021-01-20
US20210038609A1 (en) 2021-02-11
US20210361664A1 (en) 2021-11-25
WO2019036503A1 (en) 2019-02-21
US11351177B2 (en) 2022-06-07
US20230414627A1 (en) 2023-12-28
US11344557B2 (en) 2022-05-31
US20230321112A1 (en) 2023-10-12
US10849908B2 (en) 2020-12-01
JP2020530831A (ja) 2020-10-29
AU2023200189A1 (en) 2023-02-16
JP7398963B2 (ja) 2023-12-15
MX2023000501A (es) 2023-02-13
US20210322430A1 (en) 2021-10-21
JP2024001014A (ja) 2024-01-09
CN110996943A (zh) 2020-04-10
US20190262349A1 (en) 2019-08-29
US20210015827A1 (en) 2021-01-21
AU2018317398A1 (en) 2019-11-21
US11311549B2 (en) 2022-04-26
KR20200040761A (ko) 2020-04-20
AU2023200189B2 (en) 2024-02-22
CA3064464A1 (en) 2019-02-21
EA202090450A1 (ru) 2020-09-24
US11007201B2 (en) 2021-05-18

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