JP7700036B2 - 酸性ｐＨでＶＩＳＴＡと結合する抗体 - Google Patents

酸性ｐＨでＶＩＳＴＡと結合する抗体 Download PDF

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Publication number
JP7700036B2
JP7700036B2 JP2021500886A JP2021500886A JP7700036B2 JP 7700036 B2 JP7700036 B2 JP 7700036B2 JP 2021500886 A JP2021500886 A JP 2021500886A JP 2021500886 A JP2021500886 A JP 2021500886A JP 7700036 B2 JP7700036 B2 JP 7700036B2
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Prior art keywords
seq
amino acid
vista
acid sequence
antibody
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JP2021500886A
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English (en)
Japanese (ja)
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JP2022513421A (ja
JP2022513421A5 (https=
JPWO2020014327A5 (https=
Inventor
ロバート・ジェイ・ジョンストン
アルビンド・ラジパル
ポール・オー・シェパード
ルイス・ボルジェス
アンドリュー・ランキン
キース・サドゥーン・バージャット
アラン・ジェイ・コーマン
シャオディ・デン
リン・ホイ・スー
ジンジャー・レイクストロー
ジェイソン・アール・ピンクニー
デイビッド・エイ・クリットン
グオドン・チェン
リチャード・ワイ・ホアン
エカテリーナ・ジー・デヤノバ
マイケル・キグリー
ハディア・レマー
アクバル・ナイーム
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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Publication of JPWO2020014327A5 publication Critical patent/JPWO2020014327A5/ja
Priority to JP2024095011A priority Critical patent/JP2024147543A/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74—Inducing cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2021500886A 2018-07-11 2019-07-10 酸性ｐＨでＶＩＳＴＡと結合する抗体 Active JP7700036B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024095011A JP2024147543A (ja) 2018-07-11 2024-06-12 酸性ｐＨでＶＩＳＴＡと結合する抗体

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201862696622P 2018-07-11 2018-07-11
US62/696,622 2018-07-11
US201862733450P 2018-09-19 2018-09-19
US62/733,450 2018-09-19
US201962826330P 2019-03-29 2019-03-29
US62/826,330 2019-03-29
PCT/US2019/041154 WO2020014327A2 (en) 2018-07-11 2019-07-10 Antibodies binding to vista at acidic ph

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2024095011A Division JP2024147543A (ja) 2018-07-11 2024-06-12 酸性ｐＨでＶＩＳＴＡと結合する抗体

Publications (4)

Publication Number Publication Date
JP2022513421A JP2022513421A (ja) 2022-02-08
JP2022513421A5 JP2022513421A5 (https=) 2022-07-19
JPWO2020014327A5 JPWO2020014327A5 (https=) 2022-07-19
JP7700036B2 true JP7700036B2 (ja) 2025-06-30

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Family Applications (2)

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JP2021500886A Active JP7700036B2 (ja) 2018-07-11 2019-07-10 酸性ｐＨでＶＩＳＴＡと結合する抗体
JP2024095011A Pending JP2024147543A (ja) 2018-07-11 2024-06-12 酸性ｐＨでＶＩＳＴＡと結合する抗体

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JP2024095011A Pending JP2024147543A (ja) 2018-07-11 2024-06-12 酸性ｐＨでＶＩＳＴＡと結合する抗体

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Country Link
US (1) US12091462B2 (https=)
EP (1) EP3820902A2 (https=)
JP (2) JP7700036B2 (https=)
KR (1) KR20210031722A (https=)
CN (2) CN121203021A (https=)
AU (1) AU2019301120A1 (https=)
BR (1) BR112021000303A2 (https=)
CA (1) CA3104536A1 (https=)
CL (5) CL2021000012A1 (https=)
CO (1) CO2021000046A2 (https=)
IL (1) IL279944A (https=)
MX (1) MX2021000213A (https=)
PE (1) PE20210687A1 (https=)
SG (1) SG11202100102VA (https=)
TW (1) TW202028235A (https=)
WO (1) WO2020014327A2 (https=)

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EP3568159A4 (en) 2017-01-11 2020-08-05 Bristol-Myers Squibb Company PSGL-1 ANTAGONISTS AND THEIR USES
KR102715540B1 (ko) 2017-03-14 2024-10-08 파이브 프라임 테라퓨틱스, 인크. 산성 pH에서 VISTA에 결합하는 항체
BR112020019083A2 (pt) 2018-03-21 2020-12-29 Five Prime Therapeutics, Inc. Anticorpos, ácido nucleico, composições, célula e métodos para preparar um anticorpo, para tratar câncer, para tratar uma doença infecciosa, para tratar uma inflamação, para a identificação de um anticorpo, para melhorar a eficácia antitumoral de um anticorpo, para melhorar a farmacocinética de um anticorpo, para selecionar um anticorpo, para melhorar a eficácia de anticorpos, para isolar anticorpos, para detectar vista em uma amostra e para tratar câncer
BR112021000303A2 (pt) * 2018-07-11 2021-04-13 Five Prime Therapeutics, Inc. Anticorpos que se ligam a vista em ph ácido
EP4031575A1 (en) * 2019-09-19 2022-07-27 Bristol-Myers Squibb Company Antibodies binding to vista at acidic ph
WO2022178203A1 (en) * 2021-02-18 2022-08-25 Kineta, Inc. Anti-vista antibodies and uses thereof
EP4429769A1 (en) * 2021-11-09 2024-09-18 Sensei Biotherapeutics, Inc. Anti-vista antibodies and uses thereof

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