JP7699927B2 - 抗ｔｒｅｍ－１抗体およびその使用 - Google Patents

抗ｔｒｅｍ－１抗体およびその使用 Download PDF

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Publication number
JP7699927B2
JP7699927B2 JP2020553642A JP2020553642A JP7699927B2 JP 7699927 B2 JP7699927 B2 JP 7699927B2 JP 2020553642 A JP2020553642 A JP 2020553642A JP 2020553642 A JP2020553642 A JP 2020553642A JP 7699927 B2 JP7699927 B2 JP 7699927B2
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Prior art keywords
antibody
trem
seq
heavy chain
antibodies
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Japanese (ja)
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JPWO2019195126A5 (enExample
JP2021519594A (ja
Inventor
アチャル パシン
マイケル エル ゴスラン
アーロン ピー ヤムニウク
デレック エー ホームズ
グオドン チェン
プリヤンカ アプルヴァ マディア
リチャード ユチェン ホアン
スティーブン マイケル カール
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Pain & Pain Management (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2020553642A 2018-04-02 2019-04-01 抗ｔｒｅｍ－１抗体およびその使用 Active JP7699927B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023039342A JP2023080074A (ja) 2018-04-02 2023-03-14 抗ｔｒｅｍ－１抗体およびその使用

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862651605P 2018-04-02 2018-04-02
US62/651,605 2018-04-02
PCT/US2019/025100 WO2019195126A1 (en) 2018-04-02 2019-04-01 Anti-trem-1 antibodies and uses thereof

Related Child Applications (1)

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JP2023039342A Division JP2023080074A (ja) 2018-04-02 2023-03-14 抗ｔｒｅｍ－１抗体およびその使用

Publications (3)

Publication Number Publication Date
JP2021519594A JP2021519594A (ja) 2021-08-12
JPWO2019195126A5 JPWO2019195126A5 (enExample) 2022-06-30
JP7699927B2 true JP7699927B2 (ja) 2025-06-30

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JP2020553642A Active JP7699927B2 (ja) 2018-04-02 2019-04-01 抗ｔｒｅｍ－１抗体およびその使用
JP2023039342A Pending JP2023080074A (ja) 2018-04-02 2023-03-14 抗ｔｒｅｍ－１抗体およびその使用

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Country Status (24)

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US (4) US11155618B2 (enExample)
EP (1) EP3774902A1 (enExample)
JP (2) JP7699927B2 (enExample)
CN (1) CN111936520A (enExample)
AR (1) AR117566A1 (enExample)
AU (2) AU2019248547B2 (enExample)
CA (1) CA3092387A1 (enExample)
CL (1) CL2020002367A1 (enExample)
CO (1) CO2020013466A2 (enExample)
CR (2) CR20250022A (enExample)
EA (1) EA202092302A1 (enExample)
EC (1) ECSP20061469A (enExample)
IL (1) IL277678B (enExample)
JO (1) JOP20200240A1 (enExample)
MA (1) MA52190A (enExample)
MX (1) MX2020010204A (enExample)
MY (1) MY206833A (enExample)
PE (1) PE20201343A1 (enExample)
PH (1) PH12020551619A1 (enExample)
SA (1) SA520420262B1 (enExample)
SG (1) SG11202009625WA (enExample)
TW (2) TWI790370B (enExample)
UA (1) UA129672C2 (enExample)
WO (1) WO2019195126A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201700250WA (en) * 2014-07-17 2017-02-27 Novo Nordisk As Site directed mutagenesis of trem-1 antibodies for decreasing viscosity
JOP20190248A1 (ar) 2017-04-21 2019-10-20 Amgen Inc بروتينات ربط مولد ضد trem2 واستخداماته
CA3092387A1 (en) 2018-04-02 2019-10-10 Bristol-Myers Squibb Company Anti-trem-1 antibodies and uses thereof
CN114174536A (zh) * 2019-07-15 2022-03-11 百时美施贵宝公司 抗trem-1抗体及其用途
CN117642428A (zh) * 2021-05-03 2024-03-01 Ucb生物制药有限责任公司 抗体
CN114948849A (zh) * 2022-05-13 2022-08-30 苏州大学附属第一医院 一种含trem1抑制剂的微针、微针系统及其制备方法
AU2024257984A1 (en) 2023-04-21 2025-10-02 Celsius Therapeutics, Inc. Anti-trem1 antibody agents, compositions, and uses thereof
WO2025048517A1 (ko) * 2023-08-31 2025-03-06 충북대학교 산학협력단 Ｃｈｉ３ｌ１에 특이적인 인간 단일클론항체를 포함하는 아토피 피부염 예방 또는 치료용 조성물
WO2025199118A1 (en) * 2024-03-18 2025-09-25 Willow Neuroscience, Inc. Anti-trem1 antibody constructs, compositions comprising anti-trem1 antibody constructs and methods of using anti-trem1 antibody constructs

Citations (4)

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Publication number Priority date Publication date Assignee Title
WO2015098813A1 (ja) 2013-12-24 2015-07-02 アステラス製薬株式会社 新規抗ヒトｂｄｃａ－２抗体
JP2015527064A (ja) 2012-07-13 2015-09-17 ロシュ グリクアート アクチェンゲゼルシャフト 二重特異性抗ｖｅｇｆ／抗ａｎｇ−２抗体及び眼血管疾患の処置におけるそれらの使用
JP2016533395A (ja) 2013-10-04 2016-10-27 エフ−スター バイオテクノロジー リミテッド がんバイオマーカー及びその使用
JP2017522325A (ja) 2014-07-17 2017-08-10 ノヴォ ノルディスク アクティーゼルスカブ 粘度を低下させるためのｔｒｅｍ−１抗体の部位特異的変異誘発

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CO2020013466A2 (es) 2020-11-10
EA202092302A1 (ru) 2021-02-02
MA52190A (fr) 2021-02-17
AU2025242161A1 (en) 2025-10-23
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TW202003570A (zh) 2020-01-16
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