JP7656589B2 - エストロゲン受容体分解物質としてのテトラヒドロナフタレン誘導体を用いて乳癌を治療する方法 - Google Patents

エストロゲン受容体分解物質としてのテトラヒドロナフタレン誘導体を用いて乳癌を治療する方法 Download PDF

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JP7656589B2
JP7656589B2 JP2022513440A JP2022513440A JP7656589B2 JP 7656589 B2 JP7656589 B2 JP 7656589B2 JP 2022513440 A JP2022513440 A JP 2022513440A JP 2022513440 A JP2022513440 A JP 2022513440A JP 7656589 B2 JP7656589 B2 JP 7656589B2
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formula
effective amount
palbociclib
pharmaceutical composition
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JP2022546471A (ja
JP2022546471A5 (enExample
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アンドリュー ピー． クルー
ジョン フラナガン
シェリル マキシーン ゴウ
ロイヤル ジェイ． ザ サード ハスケル
マルシア ドーガン ムーア
ユミン チアン
イアン チャールズ アンソニー タイラー
ジン ワン
シン チェン
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Arvinas Operations Inc
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
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JP2022513440A 2019-08-26 2020-08-24 エストロゲン受容体分解物質としてのテトラヒドロナフタレン誘導体を用いて乳癌を治療する方法 Active JP7656589B2 (ja)

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JP2025048187A JP2025094174A (ja) 2019-08-26 2025-03-24 エストロゲン受容体分解物質としてのテトラヒドロナフタレン誘導体を用いて乳癌を治療する方法

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US201962891648P 2019-08-26 2019-08-26
US62/891,648 2019-08-26
US201962924653P 2019-10-22 2019-10-22
US62/924,653 2019-10-22
US201962942663P 2019-12-02 2019-12-02
US62/942,663 2019-12-02
US202063023067P 2020-05-11 2020-05-11
US63/023,067 2020-05-11
PCT/US2020/047693 WO2021041348A1 (en) 2019-08-26 2020-08-24 Methods of treating breast cancer with tetrahydronaphthalene derivatives as estrogen receptor degraders

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JP2025048187A Pending JP2025094174A (ja) 2019-08-26 2025-03-24 エストロゲン受容体分解物質としてのテトラヒドロナフタレン誘導体を用いて乳癌を治療する方法

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KR (1) KR20220054347A (enExample)
CN (2) CN114667147B (enExample)
AU (2) AU2020336309B2 (enExample)
BR (1) BR112022003490A2 (enExample)
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CN116234803B (zh) * 2019-12-23 2026-06-30 冰洲石生物科技公司 用于治疗癌症的雌激素受体降解剂和细胞周期蛋白依赖性激酶抑制剂的组合
AU2021342287A1 (en) 2020-09-14 2023-04-13 Arvinas Operations, Inc. Crystalline forms of a compound for the targeted degradation of estrogen receptor
IL303143A (en) * 2020-12-14 2023-07-01 Arvinas Operations Inc Methods of treating breast cancer with tetrahydronaphthalene derivatives as estrogen receptor degraders
JP2024512544A (ja) * 2021-03-29 2024-03-19 江▲蘇▼恒瑞医▲薬▼股▲フン▼有限公司 テトラヒドロナフタレン系化合物、その製造方法及びその医薬的応用
CN115611909A (zh) * 2021-07-12 2023-01-17 江苏恒瑞医药股份有限公司 四氢萘类化合物、其制备方法及其在医药上的应用
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EP4554948A1 (en) * 2022-07-12 2025-05-21 Regents of the University of Michigan Tetrahydronaphthalene derivatives as estrogen receptor degraders
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JP2025533592A (ja) * 2022-09-29 2025-10-07 江▲蘇▼恒瑞医▲薬▼股▲フン▼有限公司 テトラリン系誘導体の薬学的に許容される塩、結晶型及び調製方法
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WO2024167904A1 (en) 2023-02-07 2024-08-15 Arvinas Operations, Inc. Dosage regimens of estrogen receptor degraders in combination with an mtor inhibitor
TW202440096A (zh) 2023-03-24 2024-10-16 美商亞文納營運公司 雌激素受體降解劑之給藥方案
JP2026519559A (ja) 2023-06-02 2026-06-16 ファイザー・インク エストロゲン受容体分解薬およびｃｄｋ４阻害剤の組合せ
JP2026518466A (ja) 2023-06-02 2026-06-08 アルビナス・オペレーションズ・インコーポレイテッド エストロゲン受容体分解剤とａｋｔ阻害剤との組み合わせ
WO2024258856A1 (en) 2023-06-12 2024-12-19 Arvinas Operations, Inc. Solid oral dosage forms of estrogen receptor degraders
WO2025006569A1 (en) 2023-06-27 2025-01-02 Arvinas Operations, Inc. Combinations of estrogen receptor degraders and cdk7 inhibitors for the treatment of cancer
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WO2025240252A1 (en) * 2024-05-13 2025-11-20 Beta Pharma, Inc. Estrogen receptor degraders as treatments for breast cancer
WO2026044127A1 (en) 2024-08-22 2026-02-26 Arvinas Operations, Inc. Administration of cyp3a inhibitors in the treatment of cancer
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