JP7546596B2 - ヘテロ環式化合物ならびに蠕虫感染および疾患におけるその使用 - Google Patents
ヘテロ環式化合物ならびに蠕虫感染および疾患におけるその使用 Download PDFInfo
- Publication number
- JP7546596B2 JP7546596B2 JP2021563666A JP2021563666A JP7546596B2 JP 7546596 B2 JP7546596 B2 JP 7546596B2 JP 2021563666 A JP2021563666 A JP 2021563666A JP 2021563666 A JP2021563666 A JP 2021563666A JP 7546596 B2 JP7546596 B2 JP 7546596B2
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- compound
- pharma
- stereoisomer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/732—Pectin
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962839552P | 2019-04-26 | 2019-04-26 | |
| US62/839,552 | 2019-04-26 | ||
| PCT/US2020/029805 WO2020219871A1 (en) | 2019-04-26 | 2020-04-24 | Heterocyclic compounds and their use for treatment of helminthic infections and diseases |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022529541A JP2022529541A (ja) | 2022-06-22 |
| JP2022529541A5 JP2022529541A5 (https=) | 2023-04-13 |
| JPWO2020219871A5 JPWO2020219871A5 (https=) | 2023-04-13 |
| JP7546596B2 true JP7546596B2 (ja) | 2024-09-06 |
Family
ID=70775481
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021563666A Active JP7546596B2 (ja) | 2019-04-26 | 2020-04-24 | ヘテロ環式化合物ならびに蠕虫感染および疾患におけるその使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US11505548B2 (https=) |
| EP (1) | EP3959207A1 (https=) |
| JP (1) | JP7546596B2 (https=) |
| KR (1) | KR102939516B1 (https=) |
| CN (1) | CN114072395A (https=) |
| WO (1) | WO2020219871A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2019301510B2 (en) | 2018-07-09 | 2024-06-13 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Anthelminthic heterocyclic compounds |
| CA3133100A1 (en) | 2019-03-19 | 2020-09-24 | Boehringer Ingelheim Animal Health USA Inc. | Anthelmintic aza-benzothiophene and aza-benzofuran compounds |
| US11505548B2 (en) * | 2019-04-26 | 2022-11-22 | Celgene Corporation | Heterocyclic compounds and their use for treatment of helminthic infections and diseases |
| EP4077322A1 (en) | 2019-12-18 | 2022-10-26 | Intervet International B.V. | Anthelmintic compounds comprising azaindoles structure |
| AU2020406093A1 (en) | 2019-12-18 | 2022-06-16 | Intervet International B.V. | Anthelmintic compounds comprising a quinoline structure |
| KR20230028268A (ko) | 2020-05-29 | 2023-02-28 | 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 | 구충성 헤테로시클릭 화합물 |
| KR20230043904A (ko) | 2020-07-24 | 2023-03-31 | 엘랑코 유에스 인코포레이티드 | 이속사졸린 화합물 및 이의 중간체의 제조 공정 |
| CN116744917A (zh) | 2020-09-04 | 2023-09-12 | 礼蓝美国公司 | 适口调配物 |
| US20240025891A1 (en) * | 2020-10-23 | 2024-01-25 | Celgene Corporation | Heterocyclic compounds and their use for treatment of helminthic infections and diseases |
| US20240043446A1 (en) | 2020-12-11 | 2024-02-08 | Intervet Inc. | Anthelmintic compounds comprising a thienopyridine structure |
| CN112500324B (zh) * | 2020-12-12 | 2022-05-13 | 浙江大学衢州研究院 | 制备硫代酰胺类化合物的方法 |
| US20240148744A1 (en) * | 2021-02-09 | 2024-05-09 | Celgene Corporation | Sulfonamides and their use for treatment of helminthic infections and diseases |
| UY39995A (es) | 2021-11-01 | 2023-05-15 | Boehringer Ingelheim Vetmedica GmbH | Compuestos de pirrolopiridazina como antihelmínticos |
| CN115819429A (zh) * | 2022-12-13 | 2023-03-21 | 成都睿智化学研究有限公司 | 一种5-氯-2,3-二氢呋喃[2,3-c]吡啶的合成方法 |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000508295A (ja) | 1995-11-08 | 2000-07-04 | メルク エンド カンパニー インコーポレーテッド | 農薬製剤 |
| JP2002532497A (ja) | 1998-12-17 | 2002-10-02 | アベンティス・クロップサイエンス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | ４−トリフルオロメチル−３−オキサジアゾリルピリジン、その製造方法、その化合物を含有する薬剤、および農薬としてのその使用 |
| JP2003519081A (ja) | 1998-08-11 | 2003-06-17 | バイエルクロップサイエンス株式会社 | 殺線虫性及び駆虫性ピラゾール類 |
| JP2008527043A (ja) | 2005-01-19 | 2008-07-24 | ブリストル−マイヤーズ スクイブ カンパニー | 血栓塞栓障害治療用のｐ２ｙ１受容体阻害剤としての２−フェノキシ−ｎ−（１，３，４−チアジアゾール−２−イル）ピリジン−３−アミン誘導体および関連化合物 |
| JP2008280335A (ja) | 2007-04-11 | 2008-11-20 | Sumitomo Chemical Co Ltd | アミド化合物の製造方法 |
| JP2014503528A (ja) | 2010-12-14 | 2014-02-13 | エレクトロプホレトイクス リミテッド | カゼインキナーゼ１δ（ＣＫ１δ）阻害剤及びタウオパチーなどの神経変性疾患の治療におけるその使用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA879329B (en) * | 1986-12-12 | 1988-06-13 | Ciba-Geigy Ag | Pesticides |
| US4871753A (en) | 1986-12-12 | 1989-10-03 | Ciba-Geigy Corporation | 3-Phenyl-5-trifluoromethyl-1,2,4-oxadiazole compounds which are useful pesticides |
| ES2140543T3 (es) | 1993-08-13 | 2000-03-01 | Zeneca Ltd | Derivados de tia- y oxadiazol y su uso como fungicidas o insecticidas. |
| US5614470A (en) | 1994-04-01 | 1997-03-25 | Sankyo Company, Limited | 13-substituted milbemycin derivatives, their preparation and their use |
| JP3689462B2 (ja) * | 1994-11-17 | 2005-08-31 | 三共アグロ株式会社 | 殺虫活性を有する１３位置換ミルベマイシン誘導体 |
| CN1915016B (zh) | 1995-11-08 | 2010-12-22 | 默沙东公司 | 农药制剂 |
| TW201210597A (en) * | 2010-06-09 | 2012-03-16 | Gilead Sciences Inc | Inhibitors of hepatitis C virus |
| US11505548B2 (en) * | 2019-04-26 | 2022-11-22 | Celgene Corporation | Heterocyclic compounds and their use for treatment of helminthic infections and diseases |
-
2020
- 2020-04-24 US US16/858,410 patent/US11505548B2/en active Active
- 2020-04-24 WO PCT/US2020/029805 patent/WO2020219871A1/en not_active Ceased
- 2020-04-24 CN CN202080046747.4A patent/CN114072395A/zh active Pending
- 2020-04-24 KR KR1020217038203A patent/KR102939516B1/ko active Active
- 2020-04-24 JP JP2021563666A patent/JP7546596B2/ja active Active
- 2020-04-24 EP EP20726997.8A patent/EP3959207A1/en active Pending
-
2022
- 2022-10-04 US US17/960,046 patent/US12338235B2/en active Active
-
2025
- 2025-05-16 US US19/211,032 patent/US20250276967A1/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000508295A (ja) | 1995-11-08 | 2000-07-04 | メルク エンド カンパニー インコーポレーテッド | 農薬製剤 |
| JP2003519081A (ja) | 1998-08-11 | 2003-06-17 | バイエルクロップサイエンス株式会社 | 殺線虫性及び駆虫性ピラゾール類 |
| JP2002532497A (ja) | 1998-12-17 | 2002-10-02 | アベンティス・クロップサイエンス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | ４−トリフルオロメチル−３−オキサジアゾリルピリジン、その製造方法、その化合物を含有する薬剤、および農薬としてのその使用 |
| JP2008527043A (ja) | 2005-01-19 | 2008-07-24 | ブリストル−マイヤーズ スクイブ カンパニー | 血栓塞栓障害治療用のｐ２ｙ１受容体阻害剤としての２−フェノキシ−ｎ−（１，３，４−チアジアゾール−２−イル）ピリジン−３−アミン誘導体および関連化合物 |
| JP2008280335A (ja) | 2007-04-11 | 2008-11-20 | Sumitomo Chemical Co Ltd | アミド化合物の製造方法 |
| JP2014503528A (ja) | 2010-12-14 | 2014-02-13 | エレクトロプホレトイクス リミテッド | カゼインキナーゼ１δ（ＣＫ１δ）阻害剤及びタウオパチーなどの神経変性疾患の治療におけるその使用 |
Non-Patent Citations (1)
| Title |
|---|
| SANTUS, Maria et al.，Synthesis of 1,3,4-thiadiazole derivatives with potential tuberculostatic activity，ACTA POLONIAE PHARMACEUTICA，1988年，vol.45, no.3，p.219-24 |
Also Published As
| Publication number | Publication date |
|---|---|
| US12338235B2 (en) | 2025-06-24 |
| US20200339559A1 (en) | 2020-10-29 |
| US11505548B2 (en) | 2022-11-22 |
| JP2022529541A (ja) | 2022-06-22 |
| US20250276967A1 (en) | 2025-09-04 |
| WO2020219871A1 (en) | 2020-10-29 |
| KR102939516B1 (ko) | 2026-03-16 |
| KR20220027822A (ko) | 2022-03-08 |
| CN114072395A (zh) | 2022-02-18 |
| US20230146944A1 (en) | 2023-05-11 |
| EP3959207A1 (en) | 2022-03-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7546596B2 (ja) | ヘテロ環式化合物ならびに蠕虫感染および疾患におけるその使用 | |
| AU2009288618B2 (en) | Aminotriazolopyridines and their use as kinase inhibitors | |
| US20240025891A1 (en) | Heterocyclic compounds and their use for treatment of helminthic infections and diseases | |
| AU2004309279B2 (en) | Thiazole derivative | |
| CA2954488C (en) | Pyridone derivative having tetrahydropyranylmethyl group | |
| ES2828503T3 (es) | Bloqueadores de los canales de sodio, método de preparación de los mismos y uso de los mismos | |
| BRPI0707816A2 (pt) | inibidores de pi - 3 quinase e mÉtodos de uso | |
| TW201331181A (zh) | 經改質之４－苯基－吡啶衍生物 | |
| JP7451569B2 (ja) | ヒストン脱アセチル化酵素６阻害剤としての１，３，４－オキサジアゾールホモフタルイミド誘導体化合物、およびそれを含む薬剤学的組成物 | |
| AU2015317332A1 (en) | Inhibiting the transient receptor potential A1 ion channel | |
| KR102940213B1 (ko) | Nadph 산화효소 저해제로서의 신규한 화합물 | |
| TW202220987A (zh) | 經取代雜環化合物及其治療用途 | |
| EP3294728A1 (en) | Substituted quinoxaline derivatives | |
| US20240148744A1 (en) | Sulfonamides and their use for treatment of helminthic infections and diseases | |
| KR20230127271A (ko) | 헤테로시클릭 화합물 및 기생충성 질환을 위한 그의용도 | |
| TR201808301T4 (tr) | Sülfonilindol türevleri ve bunların hazırlanma metotları. | |
| CA3103068A1 (en) | Triazolotriazine derivatives as a2a receptor antagonists | |
| HK40068974A (en) | Heterocyclic compounds and their use for treatment of helminthic infections and diseases | |
| TWI921912B (zh) | Fgfr抑制劑及其使用方法 | |
| CA3189672A1 (en) | Copper complexes for treatment of neurodegenerative disorders | |
| EA049463B1 (ru) | Соединения пиридазинонов и их применения | |
| TW202540100A (zh) | 作為parp1抑制劑之化合物及包含其之醫藥組合物 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7424 Effective date: 20220307 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20230405 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20230405 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20240312 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20240314 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20240528 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20240806 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20240827 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 7546596 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |