JP7511241B2 - リシル-tRNA合成酵素N末端に特異的に結合する抗体を有効成分として含む免疫細胞の遊走関連疾患の予防又は治療用薬学的組成物 - Google Patents
リシル-tRNA合成酵素N末端に特異的に結合する抗体を有効成分として含む免疫細胞の遊走関連疾患の予防又は治療用薬学的組成物 Download PDFInfo
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A61P35/04—Antineoplastic agents specific for metastasis
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- C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
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- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G01N33/5029—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on cell motility
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- G—PHYSICS
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- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/9015—Ligases (6)
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- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
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- Molecular Biology (AREA)
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- Veterinary Medicine (AREA)
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- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
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- Hematology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
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- Tropical Medicine & Parasitology (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2017-0118917 | 2017-09-15 | ||
| KR20170118917 | 2017-09-15 | ||
| PCT/KR2018/010903 WO2019054819A1 (ko) | 2017-09-15 | 2018-09-17 | 라이실 tRNA 합성효소 N-말단에 특이적으로 결합하는 항체를 유효성분으로 포함하는 면역세포 이동 관련 질환의 예방 또는 치료용 약학적 조성물 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020534273A JP2020534273A (ja) | 2020-11-26 |
| JP2020534273A5 JP2020534273A5 (https=) | 2022-05-30 |
| JP7511241B2 true JP7511241B2 (ja) | 2024-07-05 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020515025A Active JP7511241B2 (ja) | 2017-09-15 | 2018-09-17 | リシル-tRNA合成酵素N末端に特異的に結合する抗体を有効成分として含む免疫細胞の遊走関連疾患の予防又は治療用薬学的組成物 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US11965038B2 (https=) |
| EP (1) | EP3682898A4 (https=) |
| JP (1) | JP7511241B2 (https=) |
| KR (1) | KR102163465B1 (https=) |
| CN (1) | CN111629752B (https=) |
| AU (1) | AU2018332491B2 (https=) |
| BR (1) | BR112020004935A8 (https=) |
| CA (1) | CA3084461C (https=) |
| RU (1) | RU2749591C1 (https=) |
| WO (1) | WO2019054819A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112019020166A2 (pt) | 2017-03-27 | 2020-06-30 | Medicinal Bioconvergence Research Center | anticorpo que se liga especificamente a região n-terminal de lisil-trna sintetase exposta na membrana celular |
| CA3084461C (en) | 2017-09-15 | 2025-06-17 | Zymedi Co., Ltd. | PHARMACEUTICAL COMPOSITION COMPRISING AN ANTIBODY THAT BINDS SPECIFICALLY TO THE N-TERMINAL END OF LYSYL TRANSFER RIBONUCLE ACID (NTRNA) SYNTHETASE AS AN ACTIVE INGREDIENT FOR THE PREVENTION OR TREATMENT OF A DISEASE RELATED TO IMMUNE CELL MIGRATION |
| WO2020060156A1 (ko) * | 2018-09-17 | 2020-03-26 | 재단법인 의약바이오컨버젼스연구단 | 세포 외막에 노출되는 라이실-tRNA 합성효소 N-말단 영역에 특이적으로 결합하는 항체 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012500256A (ja) | 2008-08-18 | 2012-01-05 | ソウル ナショナル ユニバーシティー インダストリー ファウンデーション | ライシルtRNA合成酵素の細胞内水準を調節して癌転移又は癌細胞の移動を調節する方法 |
| JP2017502672A (ja) | 2013-12-30 | 2017-01-26 | メディシナル バイオコンバージェンス リサーチ センター | 抗krsモノクロナル抗体及びこれの用途 |
| JP7345181B2 (ja) | 2017-03-27 | 2023-09-15 | ザイメディ カンパニー リミテッド | 細胞外膜に露出されるリシル-tRNA合成酵素N-末端領域に特異的に結合する抗体 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9928136D0 (en) * | 1999-11-29 | 2000-01-26 | Rose Marlene L | Organ rejection and associated conditions |
| KR100961392B1 (ko) | 2008-04-15 | 2010-06-07 | 이화여자대학교 산학협력단 | 항체 파지 표면제시 라이브러리 제조방법, 상기 방법에의해 제조된 항체 파지 표면제시 라이브러리, 상기 항체파지 표면제시 라이브러리 유전자를 포함한 파지미드 벡터 |
| RU2465330C1 (ru) * | 2008-08-18 | 2012-10-27 | Сеул Нэшнл Юниверсити Индастри Фаундейшн | СПОСОБ ИНГИБИРОВАНИЯ МЕТАСТАЗИРОВАНИЯ ЗЛОКАЧЕСТВЕННОЙ ОПУХОЛИ ИЛИ МИГРАЦИИ ЗЛОКАЧЕСТВЕННЫХ КЛЕТОК ПОСРЕДСТВОМ СНИЖЕНИЯ КЛЕТОЧНОГО УРОВНЯ ЛИЗИЛ-тРНК-СИНТЕТАЗЫ (ВАРИАНТЫ), КОМПОЗИЦИЯ И ПРИМЕНЕНИЕ ВЕКТОРА ЭКСПРЕССИИ ИЛИ АНТИТЕЛА ПРОТИВ KRS ДЛЯ ИНГИБИРОВАНИЯ МЕТАСТАЗИРОВАНИЯ ЗЛОКАЧЕСТВЕННОЙ ОПУХОЛИ ИЛИ МИГРАЦИИ ЗЛОКАЧЕСТВЕННЫХ КЛЕТОК |
| KR101009501B1 (ko) * | 2008-10-10 | 2011-01-18 | 서울대학교산학협력단 | 항-라이실 티알엔에이 합성효소 항체 및 항-라미닌 수용체 항체를 유효성분으로 포함하는 암 진단용 조성물 |
| US9127268B2 (en) * | 2009-12-11 | 2015-09-08 | Atyr Pharma, Inc. | Aminoacyl tRNA synthetases for modulating inflammation |
| CA2800281C (en) * | 2010-06-01 | 2021-01-12 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of lysyl-trna synthetases |
| US11111396B2 (en) | 2014-10-17 | 2021-09-07 | C3 Nano, Inc. | Transparent films with control of light hue using nanoscale colorants |
| US10050713B2 (en) | 2015-03-02 | 2018-08-14 | Futurewei Technologies, Inc. | Optical transceiver using duplex media, self-homodyne detection (SHD), coherent detection, and uncooled laser |
| KR20180069146A (ko) | 2016-12-14 | 2018-06-25 | 만도헬라일렉트로닉스(주) | 주차 조향 보조 시스템 및 그 제어방법 |
| CA3084461C (en) * | 2017-09-15 | 2025-06-17 | Zymedi Co., Ltd. | PHARMACEUTICAL COMPOSITION COMPRISING AN ANTIBODY THAT BINDS SPECIFICALLY TO THE N-TERMINAL END OF LYSYL TRANSFER RIBONUCLE ACID (NTRNA) SYNTHETASE AS AN ACTIVE INGREDIENT FOR THE PREVENTION OR TREATMENT OF A DISEASE RELATED TO IMMUNE CELL MIGRATION |
-
2018
- 2018-09-17 CA CA3084461A patent/CA3084461C/en active Active
- 2018-09-17 KR KR1020180111060A patent/KR102163465B1/ko active Active
- 2018-09-17 JP JP2020515025A patent/JP7511241B2/ja active Active
- 2018-09-17 AU AU2018332491A patent/AU2018332491B2/en active Active
- 2018-09-17 US US16/646,240 patent/US11965038B2/en active Active
- 2018-09-17 WO PCT/KR2018/010903 patent/WO2019054819A1/ko not_active Ceased
- 2018-09-17 CN CN201880074372.5A patent/CN111629752B/zh active Active
- 2018-09-17 BR BR112020004935A patent/BR112020004935A8/pt unknown
- 2018-09-17 EP EP18856914.9A patent/EP3682898A4/en active Pending
- 2018-09-17 RU RU2020113539A patent/RU2749591C1/ru active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012500256A (ja) | 2008-08-18 | 2012-01-05 | ソウル ナショナル ユニバーシティー インダストリー ファウンデーション | ライシルtRNA合成酵素の細胞内水準を調節して癌転移又は癌細胞の移動を調節する方法 |
| JP2017502672A (ja) | 2013-12-30 | 2017-01-26 | メディシナル バイオコンバージェンス リサーチ センター | 抗krsモノクロナル抗体及びこれの用途 |
| JP7345181B2 (ja) | 2017-03-27 | 2023-09-15 | ザイメディ カンパニー リミテッド | 細胞外膜に露出されるリシル-tRNA合成酵素N-末端領域に特異的に結合する抗体 |
Non-Patent Citations (1)
| Title |
|---|
| Nature Chemical Biology、2014年発行、Vol.10、No.1、pp.29-34 |
Also Published As
| Publication number | Publication date |
|---|---|
| BR112020004935A8 (pt) | 2022-07-05 |
| AU2018332491B2 (en) | 2022-04-14 |
| CN111629752B (zh) | 2024-03-29 |
| KR102163465B1 (ko) | 2020-10-07 |
| CA3084461A1 (en) | 2019-03-21 |
| CA3084461C (en) | 2025-06-17 |
| US20210070880A1 (en) | 2021-03-11 |
| EP3682898A4 (en) | 2021-09-29 |
| BR112020004935A2 (pt) | 2022-04-19 |
| CN111629752A (zh) | 2020-09-04 |
| RU2749591C1 (ru) | 2021-06-15 |
| EP3682898A1 (en) | 2020-07-22 |
| WO2019054819A1 (ko) | 2019-03-21 |
| KR20190031189A (ko) | 2019-03-25 |
| AU2018332491A1 (en) | 2020-04-30 |
| US11965038B2 (en) | 2024-04-23 |
| JP2020534273A (ja) | 2020-11-26 |
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