BR112020004935A8 - Composição farmacêutica compreendendo um anticorpo que se liga especificamente a n-terminal de lisil-trna sintetase como princípio ativo para prevenção ou tratamento de doença relacionada com migração celular - Google Patents

Composição farmacêutica compreendendo um anticorpo que se liga especificamente a n-terminal de lisil-trna sintetase como princípio ativo para prevenção ou tratamento de doença relacionada com migração celular

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Publication number
BR112020004935A8
BR112020004935A8 BR112020004935A BR112020004935A BR112020004935A8 BR 112020004935 A8 BR112020004935 A8 BR 112020004935A8 BR 112020004935 A BR112020004935 A BR 112020004935A BR 112020004935 A BR112020004935 A BR 112020004935A BR 112020004935 A8 BR112020004935 A8 BR 112020004935A8
Authority
BR
Brazil
Prior art keywords
antibody
lysyl
prevention
pharmaceutical composition
treatment
Prior art date
Application number
BR112020004935A
Other languages
English (en)
Other versions
BR112020004935A2 (pt
Inventor
Hoon Kwon Nam
Young Lee Jin
Kim Sunghoon
Original Assignee
Medicinal Bioconvergence Res Ct
Biocontac Co Ltd
Zymedi Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medicinal Bioconvergence Res Ct, Biocontac Co Ltd, Zymedi Co Ltd filed Critical Medicinal Bioconvergence Res Ct
Publication of BR112020004935A2 publication Critical patent/BR112020004935A2/pt
Publication of BR112020004935A8 publication Critical patent/BR112020004935A8/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5029—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on cell motility
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/9015—Ligases (6)

Abstract

COMPOSIÇÃO FARMACÊUTICA COMPREENDENDO UM ANTICORPO QUE SE KIGA ESPECIFICAMENTE A N-TERMINAL DE LISIL-TRNA SINTETASE COMO PRINCÍPIO ATIVO PARA PREVENÇÃO OU TRATAMENTO DE DOENÇA RELACIONADA COM MIGRAÇÃO CELULAR. A presente invenção refere-se a um novo uso de um anticorpo que se liga especificamente aoN-terminal da lisil-tRNA sintetase e mais particularmente, a uma composição farmacêutica compreendendo um anticorpo que se liga especificamente a um epítopo incluindo a sequência da SEQ ID NO: 117 no domínio N-terminalda lisil-tRNA sintetase (KRS) ou um fragmento funcional do mesmo como um princípio ativo para prevenir e tratar uma doença relacionada à migração de células imunes. Um anticorpo específico para o N-terminal da KRS fornecido pela presente invenção pode regular a migração de células imunes, exibindo assim efeitos muito notáveis na prevenção, alívio e tratamento de doenças relacionadas à migração de células imunes.
BR112020004935A 2017-09-15 2018-09-17 Composição farmacêutica compreendendo um anticorpo que se liga especificamente a n-terminal de lisil-trna sintetase como princípio ativo para prevenção ou tratamento de doença relacionada com migração celular BR112020004935A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20170118917 2017-09-15
PCT/KR2018/010903 WO2019054819A1 (ko) 2017-09-15 2018-09-17 라이실 tRNA 합성효소 N-말단에 특이적으로 결합하는 항체를 유효성분으로 포함하는 면역세포 이동 관련 질환의 예방 또는 치료용 약학적 조성물

Publications (2)

Publication Number Publication Date
BR112020004935A2 BR112020004935A2 (pt) 2022-04-19
BR112020004935A8 true BR112020004935A8 (pt) 2022-07-05

Family

ID=65723723

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112020004935A BR112020004935A8 (pt) 2017-09-15 2018-09-17 Composição farmacêutica compreendendo um anticorpo que se liga especificamente a n-terminal de lisil-trna sintetase como princípio ativo para prevenção ou tratamento de doença relacionada com migração celular

Country Status (10)

Country Link
US (1) US11965038B2 (pt)
EP (1) EP3682898A4 (pt)
JP (1) JP2020534273A (pt)
KR (1) KR102163465B1 (pt)
CN (1) CN111629752B (pt)
AU (1) AU2018332491B2 (pt)
BR (1) BR112020004935A8 (pt)
CA (1) CA3084461A1 (pt)
RU (1) RU2749591C1 (pt)
WO (1) WO2019054819A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3058117C (en) 2017-03-27 2023-10-17 Medicinal Bioconvergence Research Center Antibody binding specifically to n-terminal region of lysyl-trna synthetase exposed on cell membrane
AU2018332491B2 (en) * 2017-09-15 2022-04-14 Zymedi Co., Ltd. Pharmaceutical composition comprising antibody binding specifically to lysyl-tRNA synthetase N-terminus as effective ingredient for preventing or treating immune cell migration-related disease
EP3882272A4 (en) * 2018-09-17 2022-10-12 Zymedi Co., Ltd. ANTIBODIES SPECIFICALLY BINDING TO AN N-TERMINAL DOMAIN OF LYSYL-ARNT SYNTHETASE EXPOSED ON AN EXTRACELLULAR MEMBRANE

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GB9928136D0 (en) * 1999-11-29 2000-01-26 Rose Marlene L Organ rejection and associated conditions
KR100961392B1 (ko) 2008-04-15 2010-06-07 이화여자대학교 산학협력단 항체 파지 표면제시 라이브러리 제조방법, 상기 방법에의해 제조된 항체 파지 표면제시 라이브러리, 상기 항체파지 표면제시 라이브러리 유전자를 포함한 파지미드 벡터
RU2465330C1 (ru) * 2008-08-18 2012-10-27 Сеул Нэшнл Юниверсити Индастри Фаундейшн СПОСОБ ИНГИБИРОВАНИЯ МЕТАСТАЗИРОВАНИЯ ЗЛОКАЧЕСТВЕННОЙ ОПУХОЛИ ИЛИ МИГРАЦИИ ЗЛОКАЧЕСТВЕННЫХ КЛЕТОК ПОСРЕДСТВОМ СНИЖЕНИЯ КЛЕТОЧНОГО УРОВНЯ ЛИЗИЛ-тРНК-СИНТЕТАЗЫ (ВАРИАНТЫ), КОМПОЗИЦИЯ И ПРИМЕНЕНИЕ ВЕКТОРА ЭКСПРЕССИИ ИЛИ АНТИТЕЛА ПРОТИВ KRS ДЛЯ ИНГИБИРОВАНИЯ МЕТАСТАЗИРОВАНИЯ ЗЛОКАЧЕСТВЕННОЙ ОПУХОЛИ ИЛИ МИГРАЦИИ ЗЛОКАЧЕСТВЕННЫХ КЛЕТОК
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CA3058117C (en) * 2017-03-27 2023-10-17 Medicinal Bioconvergence Research Center Antibody binding specifically to n-terminal region of lysyl-trna synthetase exposed on cell membrane
AU2018332491B2 (en) 2017-09-15 2022-04-14 Zymedi Co., Ltd. Pharmaceutical composition comprising antibody binding specifically to lysyl-tRNA synthetase N-terminus as effective ingredient for preventing or treating immune cell migration-related disease

Also Published As

Publication number Publication date
EP3682898A1 (en) 2020-07-22
AU2018332491B2 (en) 2022-04-14
JP2020534273A (ja) 2020-11-26
KR20190031189A (ko) 2019-03-25
CN111629752B (zh) 2024-03-29
CA3084461A1 (en) 2019-03-21
RU2749591C1 (ru) 2021-06-15
KR102163465B1 (ko) 2020-10-07
BR112020004935A2 (pt) 2022-04-19
WO2019054819A1 (ko) 2019-03-21
EP3682898A4 (en) 2021-09-29
CN111629752A (zh) 2020-09-04
US20210070880A1 (en) 2021-03-11
US11965038B2 (en) 2024-04-23
AU2018332491A1 (en) 2020-04-30

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Legal Events

Date Code Title Description
B12F Other appeals [chapter 12.6 patent gazette]
B25A Requested transfer of rights approved

Owner name: BIOCONTAC CO., LTD. (KR)

B25A Requested transfer of rights approved

Owner name: ZYMEDI CO., LTD. (KR)