CO2020004801A2 - Uso de suplementos de aminoácidos para mejorar la síntesis de proteínas musculares - Google Patents
Uso de suplementos de aminoácidos para mejorar la síntesis de proteínas muscularesInfo
- Publication number
- CO2020004801A2 CO2020004801A2 CONC2020/0004801A CO2020004801A CO2020004801A2 CO 2020004801 A2 CO2020004801 A2 CO 2020004801A2 CO 2020004801 A CO2020004801 A CO 2020004801A CO 2020004801 A2 CO2020004801 A2 CO 2020004801A2
- Authority
- CO
- Colombia
- Prior art keywords
- protein synthesis
- amino acid
- muscle protein
- muscle
- improve muscle
- Prior art date
Links
- 102000008934 Muscle Proteins Human genes 0.000 title abstract 4
- 108010074084 Muscle Proteins Proteins 0.000 title abstract 4
- 238000001243 protein synthesis Methods 0.000 title abstract 4
- 230000014616 translation Effects 0.000 title abstract 4
- 235000005550 amino acid supplement Nutrition 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 4
- 241000124008 Mammalia Species 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 210000003205 muscle Anatomy 0.000 abstract 2
- 230000000638 stimulation Effects 0.000 abstract 2
- 230000001195 anabolic effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000004220 muscle function Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/175—Amino acids
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4172—Imidazole-alkanecarboxylic acids, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/316—Foods, ingredients or supplements having a functional effect on health having an effect on regeneration or building of ligaments or muscles
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/02—Acid
- A23V2250/06—Amino acid
- A23V2250/0624—Histidine
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/02—Acid
- A23V2250/06—Amino acid
- A23V2250/0626—Isoleucine
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/02—Acid
- A23V2250/06—Amino acid
- A23V2250/0628—Leucine
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/02—Acid
- A23V2250/06—Amino acid
- A23V2250/063—Lysine
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/02—Acid
- A23V2250/06—Amino acid
- A23V2250/0632—Methionine
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/02—Acid
- A23V2250/06—Amino acid
- A23V2250/0638—Phenylalanine
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/02—Acid
- A23V2250/06—Amino acid
- A23V2250/0648—Threonine
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/02—Acid
- A23V2250/06—Amino acid
- A23V2250/065—Tryptophan
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/02—Acid
- A23V2250/06—Amino acid
- A23V2250/0654—Valine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Nutrition Science (AREA)
- Mycology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
RESUMEN La presente invención abarca una composición de aminoácidos para estimular síntesis de proteínas musculares. Además, la presente descripción hace referencia, en términos generales, al uso de una composición de aminoácidos anabólicos para la estimulación de la síntesis de proteínas musculares. En particular, se describen composiciones y métodos para utilizarlos para la prevención y/o tratamiento de una pérdida de cualquiera de masa muscular, fuerza muscular, función muscular y función física, o cualquier combinación de estas, en un mamífero, especialmente un mamífero adulto. También se proporcionan kits que comprenden una composición para la estimulación de la síntesis de proteínas musculares y, en determinadas modalidades, instrucciones para su administración.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762580861P | 2017-11-02 | 2017-11-02 | |
| PCT/US2018/058937 WO2019090061A1 (en) | 2017-11-02 | 2018-11-02 | Use of amino acid supplementation for improved muscle protein synthesis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO2020004801A2 true CO2020004801A2 (es) | 2020-05-05 |
Family
ID=66332726
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CONC2020/0004801A CO2020004801A2 (es) | 2017-11-02 | 2020-04-17 | Uso de suplementos de aminoácidos para mejorar la síntesis de proteínas musculares |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US11273138B2 (es) |
| EP (1) | EP3703516A4 (es) |
| JP (3) | JP7529566B2 (es) |
| KR (2) | KR20250036934A (es) |
| CN (2) | CN111295102A (es) |
| CA (1) | CA3079518C (es) |
| CO (1) | CO2020004801A2 (es) |
| MX (1) | MX2020004397A (es) |
| MY (1) | MY209392A (es) |
| SG (1) | SG11202003370VA (es) |
| WO (1) | WO2019090061A1 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3703516A4 (en) | 2017-11-02 | 2021-08-18 | BioVentures, LLC | USE OF AMINO ACID SUPPLEMENTATION FOR IMPROVED MUSCLE PROTEIN SYNTHESIS |
| EP3980002A1 (en) * | 2019-06-07 | 2022-04-13 | Société des Produits Nestlé S.A. | Compositions and methods using one or more autophagy-inducing amino acids to potentiate musculoskeletal effect of one or more anabolic amino acids |
| US20220296550A1 (en) * | 2019-06-20 | 2022-09-22 | Societe Des Produits Nestle S.A. | Compositions and methods to potentiate musculoskeletal effect of one or more anabolic amino acids |
| AU2021249461B2 (en) * | 2020-04-01 | 2026-03-19 | Société des Produits Nestlé S.A. | Compositions containing amino acids and methods of using such compositions for treating sarcopenia |
| EP4701445A1 (en) * | 2023-04-28 | 2026-03-04 | Orivian Inc. | A dietary supplement combination and use thereof for improving muscle performance |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4851226A (en) | 1987-11-16 | 1989-07-25 | Mcneil Consumer Products Company | Chewable medicament tablet containing means for taste masking |
| DE3916903A1 (de) | 1989-05-24 | 1991-02-28 | Leopold Pharma Gmbh | Waessrige zusammensetzung fuer die parenterale ernaehrung |
| ATE192037T1 (de) * | 1989-12-29 | 2000-05-15 | Braun Medical Inc | Verwendung von arginin als immunstimulator |
| US5075114A (en) | 1990-05-23 | 1991-12-24 | Mcneil-Ppc, Inc. | Taste masking and sustained release coatings for pharmaceuticals |
| CA2128820A1 (en) | 1993-07-27 | 1995-01-28 | Walter G. Gowan, Jr. | Rapidly disintegrating pharmaceutical dosage form and process for preparation thereof |
| US5817329A (en) | 1997-02-28 | 1998-10-06 | Gardiner; Paul T. | Nutritional supplement for increased muscle size and strength for body builders |
| AU2001248129A1 (en) | 2000-04-17 | 2001-10-30 | Befa Handelsgesellschaft M.B.H. | Method for determining the concentration of carnitine in fluids |
| US20040087490A1 (en) | 2002-09-20 | 2004-05-06 | Troup John P. | Nutritional compositions |
| US7288570B2 (en) | 2002-12-20 | 2007-10-30 | Nutricia N.V. | Stimulation of in vivo production of proteins |
| JPWO2005104873A1 (ja) | 2004-04-28 | 2008-03-13 | 大塚製薬株式会社 | アミノ酸含有食品 |
| US20100267831A1 (en) * | 2005-03-29 | 2010-10-21 | Hisamine Kobayashi | Amino Acid-Containing Composition for Preventing or Remedying Decrease in the Skeletal Muscle of Aged People |
| JPWO2007023999A1 (ja) | 2005-08-24 | 2009-03-05 | 味の素株式会社 | アミノ酸含有酸性飲料及びその製造方法 |
| EP2032697A1 (en) | 2006-06-26 | 2009-03-11 | DSMIP Assets B.V. | Peptidylarginine deiminase and uses thereof in the production of citrullinated proteins and peptides |
| US20080268038A1 (en) | 2007-04-26 | 2008-10-30 | Wolfe Robert R | Compositions and Approaches for Increasing Diet Induced Thermogenesis, Inducing Weight Loss and Maintaining Muscle Mass and Strength |
| US7790688B2 (en) | 2008-01-11 | 2010-09-07 | Healthspan Solutions, Llc | Compositions and methods for increasing muscle mass, strength, and functional performance in the elderly |
| SG177334A1 (en) | 2009-06-24 | 2012-02-28 | Japan Tobacco Inc | Modified biotin-conjugated protein |
| WO2011078654A1 (en) * | 2009-12-24 | 2011-06-30 | N.V. Nutricia | Low-caloric high-protein nutritional composition for the stimulation of muscle protein synthesis |
| WO2012005568A1 (en) | 2010-07-07 | 2012-01-12 | N.V. Nutricia | Nutritional composition for the stimulation of muscle protein synthesis |
| WO2012037311A1 (en) | 2010-09-17 | 2012-03-22 | Maine Natural Health, Inc. | Compositions containing omega-3 oil and uses thereof |
| US9364463B2 (en) * | 2011-11-18 | 2016-06-14 | Board Of Trustees Of The University Of Arkansas | Use of amino acid supplementation for improved muscle recovery |
| US9597367B2 (en) * | 2013-04-19 | 2017-03-21 | Bioventures, Llc | Methods for improving muscle and heart function |
| US20140357576A1 (en) | 2013-05-31 | 2014-12-04 | Nestec S.A. | Methods for enhancement of muscle protein synthesis |
| SG11201602012RA (en) * | 2013-09-25 | 2016-04-28 | Pronutria Inc | Compositions and formulations for maintaining and increasing muscle mass, strength, and performance and methods of production and use thereof |
| US10888571B2 (en) | 2015-12-18 | 2021-01-12 | Lonza Consumer Health Inc. | Method and composition for increasing muscle protein synthesis and/or functional strength in mammals |
| EP3703516A4 (en) | 2017-11-02 | 2021-08-18 | BioVentures, LLC | USE OF AMINO ACID SUPPLEMENTATION FOR IMPROVED MUSCLE PROTEIN SYNTHESIS |
-
2018
- 2018-11-02 EP EP18874200.1A patent/EP3703516A4/en active Pending
- 2018-11-02 KR KR1020257006226A patent/KR20250036934A/ko active Pending
- 2018-11-02 MX MX2020004397A patent/MX2020004397A/es unknown
- 2018-11-02 JP JP2020521298A patent/JP7529566B2/ja active Active
- 2018-11-02 WO PCT/US2018/058937 patent/WO2019090061A1/en not_active Ceased
- 2018-11-02 KR KR1020207011303A patent/KR102775380B1/ko active Active
- 2018-11-02 CN CN201880070954.6A patent/CN111295102A/zh active Pending
- 2018-11-02 US US16/761,175 patent/US11273138B2/en active Active
- 2018-11-02 CN CN202311374241.8A patent/CN118178404A/zh active Pending
- 2018-11-02 MY MYPI2020001940A patent/MY209392A/en unknown
- 2018-11-02 CA CA3079518A patent/CA3079518C/en active Active
- 2018-11-02 SG SG11202003370VA patent/SG11202003370VA/en unknown
-
2020
- 2020-04-17 CO CONC2020/0004801A patent/CO2020004801A2/es unknown
-
2023
- 2023-08-14 JP JP2023131779A patent/JP7716119B2/ja active Active
-
2025
- 2025-03-11 JP JP2025037938A patent/JP2025090715A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20200253908A1 (en) | 2020-08-13 |
| RU2020117917A3 (es) | 2022-02-04 |
| JP2023154042A (ja) | 2023-10-18 |
| MY209392A (en) | 2025-07-07 |
| CN118178404A (zh) | 2024-06-14 |
| JP7529566B2 (ja) | 2024-08-06 |
| CA3079518C (en) | 2025-05-13 |
| CN111295102A (zh) | 2020-06-16 |
| US11273138B2 (en) | 2022-03-15 |
| MX2020004397A (es) | 2020-08-06 |
| BR112020007447A2 (pt) | 2020-12-08 |
| SG11202003370VA (en) | 2020-05-28 |
| RU2020117917A (ru) | 2021-12-02 |
| KR20200083977A (ko) | 2020-07-09 |
| JP2021501746A (ja) | 2021-01-21 |
| WO2019090061A1 (en) | 2019-05-09 |
| JP7716119B2 (ja) | 2025-07-31 |
| JP2025090715A (ja) | 2025-06-17 |
| EP3703516A4 (en) | 2021-08-18 |
| KR102775380B1 (ko) | 2025-03-04 |
| CA3079518A1 (en) | 2019-05-09 |
| KR20250036934A (ko) | 2025-03-14 |
| EP3703516A1 (en) | 2020-09-09 |
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