JP7346460B2 - アンジオテンシノーゲン（ＡＧＴ）ｉＲＮＡ組成物及びその使用方法 - Google Patents

アンジオテンシノーゲン（ＡＧＴ）ｉＲＮＡ組成物及びその使用方法 Download PDF

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JP7346460B2
JP7346460B2 JP2020564197A JP2020564197A JP7346460B2 JP 7346460 B2 JP7346460 B2 JP 7346460B2 JP 2020564197 A JP2020564197 A JP 2020564197A JP 2020564197 A JP2020564197 A JP 2020564197A JP 7346460 B2 JP7346460 B2 JP 7346460B2
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hypertension
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JP2021522841A (ja
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ドナルド・フォスター
グレゴリー・ヒンクル
マーク・ケイ・シュリーゲル
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Alnylam Pharmaceuticals Inc
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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JP2020564197A 2018-05-14 2019-05-14 アンジオテンシノーゲン（ＡＧＴ）ｉＲＮＡ組成物及びその使用方法 Active JP7346460B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023144091A JP7721606B2 (ja) 2018-05-14 2023-09-06 アンジオテンシノーゲン（ＡＧＴ）ｉＲＮＡ組成物及びその使用方法
JP2025126796A JP2025179045A (ja) 2018-05-14 2025-07-30 アンジオテンシノーゲン（ＡＧＴ）ｉＲＮＡ組成物及びその使用方法

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201862671094P 2018-05-14 2018-05-14
US62/671,094 2018-05-14
US201862727141P 2018-09-05 2018-09-05
US62/727,141 2018-09-05
US201962816996P 2019-03-12 2019-03-12
US62/816,996 2019-03-12
PCT/US2019/032150 WO2019222166A1 (en) 2018-05-14 2019-05-14 Angiotensinogen (agt) irna compositions and methods of use thereof

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JP2023144091A Division JP7721606B2 (ja) 2018-05-14 2023-09-06 アンジオテンシノーゲン（ＡＧＴ）ｉＲＮＡ組成物及びその使用方法

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JP2021522841A JP2021522841A (ja) 2021-09-02
JP2021522841A5 JP2021522841A5 (https=) 2022-05-12
JPWO2019222166A5 JPWO2019222166A5 (https=) 2022-05-12
JP7346460B2 true JP7346460B2 (ja) 2023-09-19

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JP2023144091A Active JP7721606B2 (ja) 2018-05-14 2023-09-06 アンジオテンシノーゲン（ＡＧＴ）ｉＲＮＡ組成物及びその使用方法
JP2025126796A Pending JP2025179045A (ja) 2018-05-14 2025-07-30 アンジオテンシノーゲン（ＡＧＴ）ｉＲＮＡ組成物及びその使用方法

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JP2025126796A Pending JP2025179045A (ja) 2018-05-14 2025-07-30 アンジオテンシノーゲン（ＡＧＴ）ｉＲＮＡ組成物及びその使用方法

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US (3) US11015201B2 (https=)
EP (2) EP4324520A3 (https=)
JP (3) JP7346460B2 (https=)
KR (2) KR20250171473A (https=)
CN (4) CN118685406A (https=)
AU (2) AU2019269418B2 (https=)
BR (1) BR112020022943A2 (https=)
CA (2) CA3100003A1 (https=)
CL (3) CL2020002865A1 (https=)
CO (1) CO2020015314A2 (https=)
DK (1) DK3794122T5 (https=)
ES (1) ES2967713T3 (https=)
FI (1) FI3794122T3 (https=)
HR (1) HRP20231412T1 (https=)
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IL (2) IL292877B2 (https=)
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PE (1) PE20210114A1 (https=)
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RS (1) RS64812B1 (https=)
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SI (1) SI3794122T1 (https=)
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CA3215908A1 (en) 2014-05-22 2015-11-26 Alnylam Pharmaceuticals, Inc. Angiotensinogen (agt) irna compositions and methods of use thereof
TWI851574B (zh) 2018-05-14 2024-08-11 美商阿尼拉製藥公司 血管收縮素原（ＡＧＴ）ｉＲＮＡ組成物及其使用方法
KR20220115946A (ko) * 2019-11-13 2022-08-19 알닐람 파마슈티칼스 인코포레이티드 안지오텐시노겐 (agt) 관련 장애를 치료하기 위한 방법 및 조성물
WO2021231552A1 (en) * 2020-05-12 2021-11-18 Duke University Compositions and methods for controlling blood pressure
IL310295A (en) * 2021-08-04 2024-03-01 Alnylam Pharmaceuticals Inc iRNA compositions and methods for silencing angiotensinogen (AGT)
US20240401045A1 (en) * 2021-10-01 2024-12-05 Adarx Pharmaceuticals, Inc. Angiotensinogen-modulating compositions and methods of use thereof
CN120775847A (zh) * 2021-10-20 2025-10-14 厦门甘宝利生物医药有限公司 Agt抑制剂及其用途
IL312811A (en) * 2021-11-16 2024-07-01 Shanghai Argo Biopharmaceutical Co Ltd Composition and method for inhibiting angiotensinogen (agt) protein expression
US20250197853A1 (en) * 2021-11-19 2025-06-19 Tuojie Biotech (Shanghai) Co., Ltd. Sirna targeting angiotensinogen and pharmaceutical use of sirna
WO2023138650A1 (zh) * 2022-01-20 2023-07-27 上海拓界生物医药科技有限公司 一种dsRNA、其应用及制备方法
WO2023155909A1 (zh) * 2022-02-18 2023-08-24 南京明德新药研发有限公司 三氮唑核苷类似物及其作为嵌入基团的应用
TW202405171A (zh) * 2022-04-01 2024-02-01 美商雅迪克斯製藥公司 血管收縮素原調節組合物及其使用方法
CN119546764A (zh) 2022-04-29 2025-02-28 默化(无锡)生物科技有限公司 一类含核苷酸类似物的双链RNAi类似物的缀合物
CN117264948B (zh) * 2022-06-14 2024-05-10 广州必贝特医药股份有限公司 抑制血管紧张素原基因表达的RNAi抑制剂及其应用
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KR20250046303A (ko) * 2022-08-05 2025-04-02 사네진 바이오 유에스에이 인크. 안지오텐시노겐 (agt)을 표적화하는 이중 가닥 rna 및 그의 사용 방법
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WO2024234831A1 (zh) * 2023-05-15 2024-11-21 苏州时安生物技术有限公司 一种用于调节血管紧张素原基因表达的双链rna、其缀合物、药物组合物及用途
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CN121399258A (zh) * 2023-07-06 2026-01-23 大睿生物医药科技(上海)有限公司 调控AGT表达的dsRNA分子
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TW202509216A (zh) * 2023-07-14 2025-03-01 大陸商北京安龍生物醫藥有限公司 靶向血管收縮素原的寡核苷酸及其用途
IL325820A (en) * 2023-08-16 2026-03-01 Chengdu Gowell Biopharmaceutical Co Ltd SIRNA, SIRNA suffix, pharmaceutical composition and their use
CN119585432B (zh) * 2023-08-22 2025-08-12 成都先衍生物技术有限公司 一种靶向AGT基因表达的siRNA及其缀合物和用途
CN119040325B (zh) * 2023-09-18 2025-07-18 广州必贝特医药股份有限公司 用于同时抑制两个靶基因表达的siRNA、药物及其应用
CN119876130A (zh) * 2023-10-23 2025-04-25 广东东阳光药业股份有限公司 一种新型的双链siRNA、其缀合物及其用途
WO2025097040A1 (en) * 2023-11-03 2025-05-08 Ionis Pharmaceuticals, Inc. Methods and compositions for reducing angiotensinogen
CN120005876A (zh) * 2023-11-15 2025-05-16 纳肽得(青岛)生物医药有限公司 抑制血管紧张素原表达的siRNA及其用途
WO2025128614A1 (en) 2023-12-12 2025-06-19 Alnylam Pharmaceuticals, Inc. Methods and compositions for treating an angiotensinogen- (agt-) associated disorder
WO2025130862A1 (zh) * 2023-12-18 2025-06-26 广东东阳光药业股份有限公司 一种新型的双链siRNA、其缀合物及其用途
CN120350001A (zh) * 2024-01-22 2025-07-22 尧唐(上海)生物科技有限公司 靶向AGT基因的gRNA及其应用
WO2026026829A1 (zh) * 2024-07-31 2026-02-05 苏州吉玛基因股份有限公司 靶向血管紧张素原的双链rna分子、其修饰物和应用
CN118685411B (zh) * 2024-08-27 2024-11-05 苏州炫景生物科技有限公司 抑制agt基因表达的双链寡核苷酸、其缀合物及用途
WO2026050125A1 (en) 2024-08-28 2026-03-05 Alnylam Pharmaceuticals, Inc. Methods and compositions for treating an angiotensinogen- (agt-) associated disorder
CN119040330B (zh) * 2024-11-01 2025-03-04 北京悦康科创医药科技股份有限公司 一种调控AGT基因表达的siRNA及其用途

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