JP7339946B2 - ２－（５－メトキシイソクロマン－１－イル）－４，５－ジヒドロ－１ｈ－イミダゾールおよびその硫酸水素塩の製造方法 - Google Patents

２－（５－メトキシイソクロマン－１－イル）－４，５－ジヒドロ－１ｈ－イミダゾールおよびその硫酸水素塩の製造方法 Download PDF

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JP7339946B2
JP7339946B2 JP2020529522A JP2020529522A JP7339946B2 JP 7339946 B2 JP7339946 B2 JP 7339946B2 JP 2020529522 A JP2020529522 A JP 2020529522A JP 2020529522 A JP2020529522 A JP 2020529522A JP 7339946 B2 JP7339946 B2 JP 7339946B2
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methoxyisochroman
ethyl
give
dihydro
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JP2021504418A5 (enExample
JP2021504418A (ja
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ライチネン、イルポ
レスキネン、ミッコ
メケレ、ミッコ
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Orion Oyj
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/76—Benzo[c]pyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Epoxy Resins (AREA)
  • Detergent Compositions (AREA)
JP2020529522A 2017-12-01 2018-11-30 ２－（５－メトキシイソクロマン－１－イル）－４，５－ジヒドロ－１ｈ－イミダゾールおよびその硫酸水素塩の製造方法 Active JP7339946B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FI20176085 2017-12-01
FI20176085 2017-12-01
PCT/FI2018/050864 WO2019106238A1 (en) 2017-12-01 2018-11-30 Process for the preparation of 2-(5-methoxyisochroman-1 -yl)-4,5-dihydro-1 h-imidazole and the hydrogensulfate salt thereof

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JP2021504418A JP2021504418A (ja) 2021-02-15
JP2021504418A5 JP2021504418A5 (enExample) 2023-07-13
JP7339946B2 true JP7339946B2 (ja) 2023-09-06

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KR (1) KR102718536B1 (enExample)
CN (1) CN111630049B (enExample)
AU (1) AU2018376872B2 (enExample)
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Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE112020003658T5 (de) 2019-07-31 2022-05-19 Hyundai Motor Company Sdn-basiertes eindringungsverhinderungsverfahren für ein fahrzeuginternesnetz und system, das dieses verfahren verwendet
KR20230159515A (ko) * 2021-03-19 2023-11-21 오리온 코포레이션 타시피미딘 제형 및 이의 용도
JP2025502480A (ja) * 2022-01-24 2025-01-24 オリオン コーポレーション イソクロマン－イミダゾール構造のアルファ－２ａアドレナリン受容体アゴニストの新規な硫酸塩形
WO2023148431A1 (en) 2022-02-04 2023-08-10 Orion Corporation Novel salt forms of isochroman-imidazole structured alpha-2a adrenoceptor agonist
JP2025531623A (ja) 2022-09-28 2025-09-22 オリオン コーポレーション タシピミジンおよびｃｙｐ２ｄ６阻害薬の併用療法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015512438A (ja) 2012-04-02 2015-04-27 オリオン コーポレーション 新規なアルファ２アドレナリン受容体アゴニスト

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6410562B1 (en) * 1998-12-18 2002-06-25 Eli Lilly And Company Hypoglycemic imidazoline compounds

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015512438A (ja) 2012-04-02 2015-04-27 オリオン コーポレーション 新規なアルファ２アドレナリン受容体アゴニスト

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ANA M REVERDITO; ET AL，SYNTHESIS AND SYNTHETIC APPLICATIONS OF 1-ARYL-2-ALKYL-4,5-DIHYDRO-1H-IMIDAZOLES，SYNTHETIC COMMUNICATIONS，TAYLOR & FRANCIS，2011年10月27日，VOL:42, NR:14,，PAGE(S):2083 - 2097，http://dx.doi.org/10.1080/00397911.2011.552155
Neef, Gunter; Eder, Ulrich; Sauer, Gerhard，One-step conversions of esters to 2-imidazolines, benzimidazzoles, and benzothiazoles by alminum organic reagents，Journal of Organic Chemistry，1981年，46(13),，2824-2826
WENDY A LOUGHLIN; ET AL，CYCLODEHYDRATION OF N-(AMINOALKYL)BENZAMIDES UNDER MILD CONDITIONS WITH A HENDRICKSON REAGENT ANALOGUE，JOURNAL OF ORGANIC CHEMISTRY，ACS PUBLICATIONS，2013年06月27日，VOL:78, NR:14,，PAGE(S):7356 - 7361，http://dx.doi.org/10.1021/jo401082q

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US11352346B2 (en) 2022-06-07
HUE059849T2 (hu) 2023-01-28
US20200308152A1 (en) 2020-10-01
RU2020121597A3 (enExample) 2022-01-04
EP3717476B1 (en) 2022-08-03
LT3717476T (lt) 2022-09-26
AU2018376872B2 (en) 2023-12-07
CN111630049A (zh) 2020-09-04
IL274931A (en) 2020-07-30
ES2927193T3 (es) 2022-11-03
HRP20221247T1 (hr) 2022-12-09
EP3717476A1 (en) 2020-10-07
BR112020010617A2 (pt) 2020-11-10
RU2020121597A (ru) 2022-01-04
KR102718536B1 (ko) 2024-10-21
PT3717476T (pt) 2022-08-23
SI3717476T1 (sl) 2022-10-28
IL274931B2 (en) 2023-11-01
WO2019106238A1 (en) 2019-06-06
JP2021504418A (ja) 2021-02-15
CA3083734A1 (en) 2019-06-06
AU2018376872A1 (en) 2020-07-16
PL3717476T3 (pl) 2022-11-21
IL274931B1 (en) 2023-07-01
KR20200095519A (ko) 2020-08-10
CN111630049B (zh) 2023-06-20
DK3717476T3 (da) 2022-09-05
ZA202003981B (en) 2021-07-28

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