KR102718536B1 - 2-(5-메톡시이소크로만-1-일)-4,5-디하이드로-1h-이미다졸 및 이의 하이드로젠설페이트 염의 제조방법 - Google Patents

2-(5-메톡시이소크로만-1-일)-4,5-디하이드로-1h-이미다졸 및 이의 하이드로젠설페이트 염의 제조방법 Download PDF

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KR102718536B1
KR102718536B1 KR1020207019100A KR20207019100A KR102718536B1 KR 102718536 B1 KR102718536 B1 KR 102718536B1 KR 1020207019100 A KR1020207019100 A KR 1020207019100A KR 20207019100 A KR20207019100 A KR 20207019100A KR 102718536 B1 KR102718536 B1 KR 102718536B1
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methoxyisochroman
chemical formula
formula
ethyl
carboxylate
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KR20200095519A (ko
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일포 라이티넨
미코 레스키넨
미코 매켈래
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오리온 코포레이션
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/76—Benzo[c]pyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Epoxy Resins (AREA)
  • Detergent Compositions (AREA)
KR1020207019100A 2017-12-01 2018-11-30 2-(5-메톡시이소크로만-1-일)-4,5-디하이드로-1h-이미다졸 및 이의 하이드로젠설페이트 염의 제조방법 Active KR102718536B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FI20176085 2017-12-01
FI20176085 2017-12-01
PCT/FI2018/050864 WO2019106238A1 (en) 2017-12-01 2018-11-30 Process for the preparation of 2-(5-methoxyisochroman-1 -yl)-4,5-dihydro-1 h-imidazole and the hydrogensulfate salt thereof

Publications (2)

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KR20200095519A KR20200095519A (ko) 2020-08-10
KR102718536B1 true KR102718536B1 (ko) 2024-10-21

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KR1020207019100A Active KR102718536B1 (ko) 2017-12-01 2018-11-30 2-(5-메톡시이소크로만-1-일)-4,5-디하이드로-1h-이미다졸 및 이의 하이드로젠설페이트 염의 제조방법

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US (1) US11352346B2 (enExample)
EP (1) EP3717476B1 (enExample)
JP (1) JP7339946B2 (enExample)
KR (1) KR102718536B1 (enExample)
CN (1) CN111630049B (enExample)
AU (1) AU2018376872B2 (enExample)
BR (1) BR112020010617A2 (enExample)
CA (1) CA3083734A1 (enExample)
DK (1) DK3717476T3 (enExample)
ES (1) ES2927193T3 (enExample)
HR (1) HRP20221247T1 (enExample)
HU (1) HUE059849T2 (enExample)
IL (1) IL274931B2 (enExample)
LT (1) LT3717476T (enExample)
PL (1) PL3717476T3 (enExample)
PT (1) PT3717476T (enExample)
SI (1) SI3717476T1 (enExample)
WO (1) WO2019106238A1 (enExample)
ZA (1) ZA202003981B (enExample)

Families Citing this family (5)

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WO2021020935A1 (ko) 2019-07-31 2021-02-04 현대자동차주식회사 차량 내부 네트워크에 대한 sdn 기반의 침입 대응 방법 및 이를 이용한 시스템
AU2022236605A1 (en) * 2021-03-19 2023-11-02 Orion Corporation Tasipimidine formulations and use thereof
JP2025502480A (ja) 2022-01-24 2025-01-24 オリオン コーポレーション イソクロマン－イミダゾール構造のアルファ－２ａアドレナリン受容体アゴニストの新規な硫酸塩形
AU2023215667A1 (en) 2022-02-04 2024-09-12 Orion Corporation Novel salt forms of isochroman-imidazole structured alpha-2a adrenoceptor agonist
JP2025531623A (ja) 2022-09-28 2025-09-22 オリオン コーポレーション タシピミジンおよびｃｙｐ２ｄ６阻害薬の併用療法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6410562B1 (en) * 1998-12-18 2002-06-25 Eli Lilly And Company Hypoglycemic imidazoline compounds
AR090557A1 (es) * 2012-04-02 2014-11-19 Orion Corp DERIVADOS IMIDAZOLICOS AGONISTAS ADRENERGICOS a2

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
The Journal of Organic Chemistry, 2013, 제78권, 페이지 7356-7361

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Publication number Publication date
IL274931B2 (en) 2023-11-01
US20200308152A1 (en) 2020-10-01
RU2020121597A (ru) 2022-01-04
HRP20221247T1 (hr) 2022-12-09
WO2019106238A1 (en) 2019-06-06
CN111630049B (zh) 2023-06-20
BR112020010617A2 (pt) 2020-11-10
IL274931A (en) 2020-07-30
HUE059849T2 (hu) 2023-01-28
AU2018376872A1 (en) 2020-07-16
RU2020121597A3 (enExample) 2022-01-04
CN111630049A (zh) 2020-09-04
DK3717476T3 (da) 2022-09-05
EP3717476A1 (en) 2020-10-07
JP7339946B2 (ja) 2023-09-06
KR20200095519A (ko) 2020-08-10
US11352346B2 (en) 2022-06-07
SI3717476T1 (sl) 2022-10-28
LT3717476T (lt) 2022-09-26
AU2018376872B2 (en) 2023-12-07
IL274931B1 (en) 2023-07-01
JP2021504418A (ja) 2021-02-15
ZA202003981B (en) 2021-07-28
ES2927193T3 (es) 2022-11-03
PL3717476T3 (pl) 2022-11-21
PT3717476T (pt) 2022-08-23
CA3083734A1 (en) 2019-06-06
EP3717476B1 (en) 2022-08-03

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