AU2018376872B2 - Process for the preparation of 2-(5-methoxyisochroman-1 -yl)-4,5-dihydro-1 H-imidazole and the hydrogensulfate salt thereof - Google Patents

Process for the preparation of 2-(5-methoxyisochroman-1 -yl)-4,5-dihydro-1 H-imidazole and the hydrogensulfate salt thereof Download PDF

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AU2018376872B2
AU2018376872B2 AU2018376872A AU2018376872A AU2018376872B2 AU 2018376872 B2 AU2018376872 B2 AU 2018376872B2 AU 2018376872 A AU2018376872 A AU 2018376872A AU 2018376872 A AU2018376872 A AU 2018376872A AU 2018376872 B2 AU2018376872 B2 AU 2018376872B2
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formula
methoxyisochroman
ethyl
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carboxylate
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AU2018376872A1 (en
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Ilpo Laitinen
Mikko Leskinen
Mikko MÄKELÄ
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Orion Oyj
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Orion Oyj
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/76—Benzo[c]pyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Epoxy Resins (AREA)
  • Detergent Compositions (AREA)
AU2018376872A 2017-12-01 2018-11-30 Process for the preparation of 2-(5-methoxyisochroman-1 -yl)-4,5-dihydro-1 H-imidazole and the hydrogensulfate salt thereof Active AU2018376872B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FI20176085 2017-12-01
FI20176085 2017-12-01
PCT/FI2018/050864 WO2019106238A1 (en) 2017-12-01 2018-11-30 Process for the preparation of 2-(5-methoxyisochroman-1 -yl)-4,5-dihydro-1 h-imidazole and the hydrogensulfate salt thereof

Publications (2)

Publication Number Publication Date
AU2018376872A1 AU2018376872A1 (en) 2020-07-16
AU2018376872B2 true AU2018376872B2 (en) 2023-12-07

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AU2018376872A Active AU2018376872B2 (en) 2017-12-01 2018-11-30 Process for the preparation of 2-(5-methoxyisochroman-1 -yl)-4,5-dihydro-1 H-imidazole and the hydrogensulfate salt thereof

Country Status (19)

Country Link
US (1) US11352346B2 (enExample)
EP (1) EP3717476B1 (enExample)
JP (1) JP7339946B2 (enExample)
KR (1) KR102718536B1 (enExample)
CN (1) CN111630049B (enExample)
AU (1) AU2018376872B2 (enExample)
BR (1) BR112020010617A2 (enExample)
CA (1) CA3083734A1 (enExample)
DK (1) DK3717476T3 (enExample)
ES (1) ES2927193T3 (enExample)
HR (1) HRP20221247T1 (enExample)
HU (1) HUE059849T2 (enExample)
IL (1) IL274931B2 (enExample)
LT (1) LT3717476T (enExample)
PL (1) PL3717476T3 (enExample)
PT (1) PT3717476T (enExample)
SI (1) SI3717476T1 (enExample)
WO (1) WO2019106238A1 (enExample)
ZA (1) ZA202003981B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021020935A1 (ko) 2019-07-31 2021-02-04 현대자동차주식회사 차량 내부 네트워크에 대한 sdn 기반의 침입 대응 방법 및 이를 이용한 시스템
AU2022236605A1 (en) * 2021-03-19 2023-11-02 Orion Corporation Tasipimidine formulations and use thereof
JP2025502480A (ja) 2022-01-24 2025-01-24 オリオン コーポレーション イソクロマン－イミダゾール構造のアルファ－２ａアドレナリン受容体アゴニストの新規な硫酸塩形
AU2023215667A1 (en) 2022-02-04 2024-09-12 Orion Corporation Novel salt forms of isochroman-imidazole structured alpha-2a adrenoceptor agonist
JP2025531623A (ja) 2022-09-28 2025-09-22 オリオン コーポレーション タシピミジンおよびｃｙｐ２ｄ６阻害薬の併用療法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6410562B1 (en) * 1998-12-18 2002-06-25 Eli Lilly And Company Hypoglycemic imidazoline compounds
WO2013150173A1 (en) * 2012-04-02 2013-10-10 Orion Corporation New alpha2 adrenoceptor agonists

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6410562B1 (en) * 1998-12-18 2002-06-25 Eli Lilly And Company Hypoglycemic imidazoline compounds
WO2013150173A1 (en) * 2012-04-02 2013-10-10 Orion Corporation New alpha2 adrenoceptor agonists

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Neef "One-Step Conversions of Esters to 2-Imidazolines, Benzimidazoles, and Benzothiazoles by Aluminum Organic Reagents" J. Org. Chem. 1981, 46, 2824. *

Also Published As

Publication number Publication date
IL274931B2 (en) 2023-11-01
US20200308152A1 (en) 2020-10-01
RU2020121597A (ru) 2022-01-04
HRP20221247T1 (hr) 2022-12-09
WO2019106238A1 (en) 2019-06-06
CN111630049B (zh) 2023-06-20
BR112020010617A2 (pt) 2020-11-10
IL274931A (en) 2020-07-30
HUE059849T2 (hu) 2023-01-28
AU2018376872A1 (en) 2020-07-16
RU2020121597A3 (enExample) 2022-01-04
CN111630049A (zh) 2020-09-04
DK3717476T3 (da) 2022-09-05
EP3717476A1 (en) 2020-10-07
JP7339946B2 (ja) 2023-09-06
KR20200095519A (ko) 2020-08-10
US11352346B2 (en) 2022-06-07
SI3717476T1 (sl) 2022-10-28
LT3717476T (lt) 2022-09-26
IL274931B1 (en) 2023-07-01
JP2021504418A (ja) 2021-02-15
ZA202003981B (en) 2021-07-28
ES2927193T3 (es) 2022-11-03
PL3717476T3 (pl) 2022-11-21
KR102718536B1 (ko) 2024-10-21
PT3717476T (pt) 2022-08-23
CA3083734A1 (en) 2019-06-06
EP3717476B1 (en) 2022-08-03

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