CA3083734A1 - Process for the preparation of 2-(5-methoxyisochroman-1 -yl)-4,5-dihydro-1 h-imidazole and the hydrogensulfate salt thereof - Google Patents

Process for the preparation of 2-(5-methoxyisochroman-1 -yl)-4,5-dihydro-1 h-imidazole and the hydrogensulfate salt thereof Download PDF

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Publication number
CA3083734A1
CA3083734A1 CA3083734A CA3083734A CA3083734A1 CA 3083734 A1 CA3083734 A1 CA 3083734A1 CA 3083734 A CA3083734 A CA 3083734A CA 3083734 A CA3083734 A CA 3083734A CA 3083734 A1 CA3083734 A1 CA 3083734A1
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CA
Canada
Prior art keywords
formula
methoxyisochroman
ethyl
compound
carboxylate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3083734A
Other languages
English (en)
French (fr)
Inventor
Ilpo Laitinen
Mikko Leskinen
Mikko Makela
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Orion Oyj
Original Assignee
Orion Oyj
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Oyj filed Critical Orion Oyj
Publication of CA3083734A1 publication Critical patent/CA3083734A1/en
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/76—Benzo[c]pyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Epoxy Resins (AREA)
  • Detergent Compositions (AREA)
CA3083734A 2017-12-01 2018-11-30 Process for the preparation of 2-(5-methoxyisochroman-1 -yl)-4,5-dihydro-1 h-imidazole and the hydrogensulfate salt thereof Pending CA3083734A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FI20176085 2017-12-01
FI20176085 2017-12-01
PCT/FI2018/050864 WO2019106238A1 (en) 2017-12-01 2018-11-30 Process for the preparation of 2-(5-methoxyisochroman-1 -yl)-4,5-dihydro-1 h-imidazole and the hydrogensulfate salt thereof

Publications (1)

Publication Number Publication Date
CA3083734A1 true CA3083734A1 (en) 2019-06-06

Family

ID=64746580

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3083734A Pending CA3083734A1 (en) 2017-12-01 2018-11-30 Process for the preparation of 2-(5-methoxyisochroman-1 -yl)-4,5-dihydro-1 h-imidazole and the hydrogensulfate salt thereof

Country Status (19)

Country Link
US (1) US11352346B2 (enExample)
EP (1) EP3717476B1 (enExample)
JP (1) JP7339946B2 (enExample)
KR (1) KR102718536B1 (enExample)
CN (1) CN111630049B (enExample)
AU (1) AU2018376872B2 (enExample)
BR (1) BR112020010617A2 (enExample)
CA (1) CA3083734A1 (enExample)
DK (1) DK3717476T3 (enExample)
ES (1) ES2927193T3 (enExample)
HR (1) HRP20221247T1 (enExample)
HU (1) HUE059849T2 (enExample)
IL (1) IL274931B2 (enExample)
LT (1) LT3717476T (enExample)
PL (1) PL3717476T3 (enExample)
PT (1) PT3717476T (enExample)
SI (1) SI3717476T1 (enExample)
WO (1) WO2019106238A1 (enExample)
ZA (1) ZA202003981B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021020935A1 (ko) 2019-07-31 2021-02-04 현대자동차주식회사 차량 내부 네트워크에 대한 sdn 기반의 침입 대응 방법 및 이를 이용한 시스템
AU2022236605A1 (en) * 2021-03-19 2023-11-02 Orion Corporation Tasipimidine formulations and use thereof
JP2025502480A (ja) 2022-01-24 2025-01-24 オリオン コーポレーション イソクロマン－イミダゾール構造のアルファ－２ａアドレナリン受容体アゴニストの新規な硫酸塩形
AU2023215667A1 (en) 2022-02-04 2024-09-12 Orion Corporation Novel salt forms of isochroman-imidazole structured alpha-2a adrenoceptor agonist
JP2025531623A (ja) 2022-09-28 2025-09-22 オリオン コーポレーション タシピミジンおよびｃｙｐ２ｄ６阻害薬の併用療法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6410562B1 (en) * 1998-12-18 2002-06-25 Eli Lilly And Company Hypoglycemic imidazoline compounds
AR090557A1 (es) * 2012-04-02 2014-11-19 Orion Corp DERIVADOS IMIDAZOLICOS AGONISTAS ADRENERGICOS a2

Also Published As

Publication number Publication date
IL274931B2 (en) 2023-11-01
US20200308152A1 (en) 2020-10-01
RU2020121597A (ru) 2022-01-04
HRP20221247T1 (hr) 2022-12-09
WO2019106238A1 (en) 2019-06-06
CN111630049B (zh) 2023-06-20
BR112020010617A2 (pt) 2020-11-10
IL274931A (en) 2020-07-30
HUE059849T2 (hu) 2023-01-28
AU2018376872A1 (en) 2020-07-16
RU2020121597A3 (enExample) 2022-01-04
CN111630049A (zh) 2020-09-04
DK3717476T3 (da) 2022-09-05
EP3717476A1 (en) 2020-10-07
JP7339946B2 (ja) 2023-09-06
KR20200095519A (ko) 2020-08-10
US11352346B2 (en) 2022-06-07
SI3717476T1 (sl) 2022-10-28
LT3717476T (lt) 2022-09-26
AU2018376872B2 (en) 2023-12-07
IL274931B1 (en) 2023-07-01
JP2021504418A (ja) 2021-02-15
ZA202003981B (en) 2021-07-28
ES2927193T3 (es) 2022-11-03
PL3717476T3 (pl) 2022-11-21
KR102718536B1 (ko) 2024-10-21
PT3717476T (pt) 2022-08-23
EP3717476B1 (en) 2022-08-03

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