JP7317054B2 - ムスカリンｍ１および／またはｍ４受容体のアゴニストとしての架橋化合物 - Google Patents

ムスカリンｍ１および／またはｍ４受容体のアゴニストとしての架橋化合物 Download PDF

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JP7317054B2
JP7317054B2 JP2020571690A JP2020571690A JP7317054B2 JP 7317054 B2 JP7317054 B2 JP 7317054B2 JP 2020571690 A JP2020571690 A JP 2020571690A JP 2020571690 A JP2020571690 A JP 2020571690A JP 7317054 B2 JP7317054 B2 JP 7317054B2
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oxa
carboxylate
azabicyclo
nonane
optionally substituted
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JP2021528446A (ja
JP2021528446A5 (enExample
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ブラウン，ジャイルズ・アルバート
テオバルド，バリー・ジョン
テハン，ベンジャミン・ジェラルド
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Nxera Pharma UK Ltd
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Heptares Therapeutics Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2020571690A 2018-06-22 2019-06-24 ムスカリンｍ１および／またはｍ４受容体のアゴニストとしての架橋化合物 Active JP7317054B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1810239.2A GB201810239D0 (en) 2018-06-22 2018-06-22 Pharmaceutical compounds
GB1810239.2 2018-06-22
PCT/GB2019/051780 WO2019243851A1 (en) 2018-06-22 2019-06-24 Bridged compounds as agonists of the muscarinic m1 and/or m4 receptor

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JP2021528446A JP2021528446A (ja) 2021-10-21
JP2021528446A5 JP2021528446A5 (enExample) 2022-06-30
JP7317054B2 true JP7317054B2 (ja) 2023-07-28

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US (2) US10787447B2 (enExample)
EP (1) EP3810614B1 (enExample)
JP (1) JP7317054B2 (enExample)
CN (1) CN112585143B (enExample)
AU (1) AU2019289217B2 (enExample)
CA (1) CA3104222A1 (enExample)
ES (1) ES2984420T3 (enExample)
GB (1) GB201810239D0 (enExample)
TW (1) TWI822803B (enExample)
WO (1) WO2019243851A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2619829T3 (es) 2011-11-18 2017-06-27 Heptares Therapeutics Limited Agonistas del receptor muscarínico M1
GB201404922D0 (en) 2014-03-19 2014-04-30 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201513743D0 (en) * 2015-08-03 2015-09-16 Heptares Therapeutics Ltd Muscarinic agonists
GB201519352D0 (en) 2015-11-02 2015-12-16 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201617454D0 (en) 2016-10-14 2016-11-30 Heptares Therapeutics Limited Pharmaceutical compounds
WO2018229542A1 (en) * 2017-06-09 2018-12-20 Adama Makhteshim Ltd. Formulation for seed treatment comprising fluensulfone
GB201810239D0 (en) 2018-06-22 2018-08-08 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201819961D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201819960D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds
GB202020191D0 (en) * 2020-12-18 2021-02-03 Heptares Therapeutics Ltd Pharmaceutical compounds

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JP2018508562A (ja) 2015-03-19 2018-03-29 ヘプタレス セラピューティクス リミテッドＨｅｐｔａｒｅｓ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｌｉｍｉｔｅｄ ムスカリンｍ１受容体及び／またはｍ４受容体のアゴニストとしてのスピロ環状化合物
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Also Published As

Publication number Publication date
US10787447B2 (en) 2020-09-29
AU2019289217A1 (en) 2021-01-14
TW202019922A (zh) 2020-06-01
TWI822803B (zh) 2023-11-21
US20210002271A1 (en) 2021-01-07
EP3810614A1 (en) 2021-04-28
JP2021528446A (ja) 2021-10-21
AU2019289217B2 (en) 2023-08-17
CN112585143B (zh) 2024-11-12
EP3810614C0 (en) 2024-03-27
CA3104222A1 (en) 2019-12-26
CN112585143A (zh) 2021-03-30
US20200002328A1 (en) 2020-01-02
US11773090B2 (en) 2023-10-03
EP3810614B1 (en) 2024-03-27
WO2019243851A1 (en) 2019-12-26
ES2984420T3 (es) 2024-10-29
GB201810239D0 (en) 2018-08-08

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