AU2019289217B2 - Bridged compounds as agonists of the muscarinic M1 and/or M4 receptor - Google Patents

Bridged compounds as agonists of the muscarinic M1 and/or M4 receptor Download PDF

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Publication number
AU2019289217B2
AU2019289217B2 AU2019289217A AU2019289217A AU2019289217B2 AU 2019289217 B2 AU2019289217 B2 AU 2019289217B2 AU 2019289217 A AU2019289217 A AU 2019289217A AU 2019289217 A AU2019289217 A AU 2019289217A AU 2019289217 B2 AU2019289217 B2 AU 2019289217B2
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Prior art keywords
oxa
carboxylate
azabicyclo
nonane
optionally substituted
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AU2019289217A1 (en
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Giles Albert Brown
Benjamin Gerald TEHAN
Barry John Teobald
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Nxera Pharma UK Ltd
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Nxera Pharma UK Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2019289217A 2018-06-22 2019-06-24 Bridged compounds as agonists of the muscarinic M1 and/or M4 receptor Active AU2019289217B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1810239.2A GB201810239D0 (en) 2018-06-22 2018-06-22 Pharmaceutical compounds
GB1810239.2 2018-06-22
PCT/GB2019/051780 WO2019243851A1 (en) 2018-06-22 2019-06-24 Bridged compounds as agonists of the muscarinic m1 and/or m4 receptor

Publications (2)

Publication Number Publication Date
AU2019289217A1 AU2019289217A1 (en) 2021-01-14
AU2019289217B2 true AU2019289217B2 (en) 2023-08-17

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Family Applications (1)

Application Number Title Priority Date Filing Date
AU2019289217A Active AU2019289217B2 (en) 2018-06-22 2019-06-24 Bridged compounds as agonists of the muscarinic M1 and/or M4 receptor

Country Status (10)

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US (2) US10787447B2 (enExample)
EP (1) EP3810614B1 (enExample)
JP (1) JP7317054B2 (enExample)
CN (1) CN112585143B (enExample)
AU (1) AU2019289217B2 (enExample)
CA (1) CA3104222A1 (enExample)
ES (1) ES2984420T3 (enExample)
GB (1) GB201810239D0 (enExample)
TW (1) TWI822803B (enExample)
WO (1) WO2019243851A1 (enExample)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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GB201513743D0 (en) * 2015-08-03 2015-09-16 Heptares Therapeutics Ltd Muscarinic agonists
GB201519352D0 (en) 2015-11-02 2015-12-16 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201617454D0 (en) 2016-10-14 2016-11-30 Heptares Therapeutics Limited Pharmaceutical compounds
WO2018229542A1 (en) * 2017-06-09 2018-12-20 Adama Makhteshim Ltd. Formulation for seed treatment comprising fluensulfone
GB201810239D0 (en) 2018-06-22 2018-08-08 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201819961D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201819960D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds
GB202020191D0 (en) * 2020-12-18 2021-02-03 Heptares Therapeutics Ltd Pharmaceutical compounds

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Also Published As

Publication number Publication date
US10787447B2 (en) 2020-09-29
AU2019289217A1 (en) 2021-01-14
TW202019922A (zh) 2020-06-01
JP7317054B2 (ja) 2023-07-28
TWI822803B (zh) 2023-11-21
US20210002271A1 (en) 2021-01-07
EP3810614A1 (en) 2021-04-28
JP2021528446A (ja) 2021-10-21
CN112585143B (zh) 2024-11-12
EP3810614C0 (en) 2024-03-27
CA3104222A1 (en) 2019-12-26
CN112585143A (zh) 2021-03-30
US20200002328A1 (en) 2020-01-02
US11773090B2 (en) 2023-10-03
EP3810614B1 (en) 2024-03-27
WO2019243851A1 (en) 2019-12-26
ES2984420T3 (es) 2024-10-29
GB201810239D0 (en) 2018-08-08

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