JP7190425B2 - 肝細胞癌の治療のための併用療法 - Google Patents

肝細胞癌の治療のための併用療法 Download PDF

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JP7190425B2
JP7190425B2 JP2019511500A JP2019511500A JP7190425B2 JP 7190425 B2 JP7190425 B2 JP 7190425B2 JP 2019511500 A JP2019511500 A JP 2019511500A JP 2019511500 A JP2019511500 A JP 2019511500A JP 7190425 B2 JP7190425 B2 JP 7190425B2
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pharmaceutically acceptable
pyrimidin
amino
cdk4
inhibitor
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JP2019528302A5 (https=
JP2019528302A (ja
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アナンド セルヴァラジ，
ピーター スミス，
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Eisai R&D Management Co Ltd
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Eisai R&D Management Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2019511500A 2016-08-23 2017-08-23 肝細胞癌の治療のための併用療法 Active JP7190425B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662378455P 2016-08-23 2016-08-23
US62/378,455 2016-08-23
PCT/US2017/048183 WO2018039324A1 (en) 2016-08-23 2017-08-23 Combination therapies for the treatment of hepatocellular carcinoma

Publications (3)

Publication Number Publication Date
JP2019528302A JP2019528302A (ja) 2019-10-10
JP2019528302A5 JP2019528302A5 (https=) 2020-09-24
JP7190425B2 true JP7190425B2 (ja) 2022-12-15

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JP2019511500A Active JP7190425B2 (ja) 2016-08-23 2017-08-23 肝細胞癌の治療のための併用療法

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US (1) US20190175598A1 (https=)
EP (1) EP3503923B1 (https=)
JP (1) JP7190425B2 (https=)
KR (1) KR102466192B1 (https=)
CN (1) CN109803684B (https=)
AU (1) AU2017315357B2 (https=)
BR (1) BR112019003722A2 (https=)
CA (1) CA3034875C (https=)
ES (1) ES2966469T3 (https=)
IL (1) IL264950B2 (https=)
MX (1) MX2019002115A (https=)
RU (1) RU2769251C2 (https=)
SG (1) SG11201901472TA (https=)
WO (1) WO2018039324A1 (https=)

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EP3738084A4 (en) 2018-01-08 2021-11-17 G1 Therapeutics, Inc. SUPERIOR G1T38 DOSING SCHEMES
EP4309656A3 (en) 2018-05-14 2024-02-28 Pfizer Inc. Oral solution formulation
TW202128174A (zh) * 2019-10-09 2021-08-01 美商G1治療公司 失調之纖維母細胞生長因子受體訊息傳遞的癌症之標靶性治療
JP2023533903A (ja) * 2020-05-15 2023-08-07 エーザイ・アール・アンド・ディー・マネジメント株式会社 Ｆｇｆｒ４阻害剤の経口製剤によるがんの治療方法
JP2025520303A (ja) 2022-05-30 2025-07-03 石▲薬▼集▲團▼中奇制▲薬▼技▲術▼（石家庄）有限公司 癌治療用の医薬組み合わせ物および医薬組成物
TW202523318A (zh) * 2023-11-30 2025-06-16 大陸商石藥集團中奇製藥技術（石家莊）有限公司 聯合治療腫瘤的藥物

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WO2016025650A1 (en) 2014-08-13 2016-02-18 Celgene Avilomics Research, Inc. Combinations of an erk inhibitor and a cdk4/6 inhibitor and related methods
JP2018511635A (ja) 2015-04-14 2018-04-26 エーザイ・アール・アンド・ディー・マネジメント株式会社 結晶性ｆｇｆｒ４阻害剤化合物およびその使用

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IL264950B2 (en) 2024-01-01
EP3503923A1 (en) 2019-07-03
KR20190040996A (ko) 2019-04-19
MX2019002115A (es) 2019-07-08
US20190175598A1 (en) 2019-06-13
RU2769251C2 (ru) 2022-03-29
AU2017315357B2 (en) 2022-12-01
JP2019528302A (ja) 2019-10-10
AU2017315357A1 (en) 2019-02-28
CN109803684A (zh) 2019-05-24
RU2019108259A3 (https=) 2020-11-24
CA3034875A1 (en) 2018-03-01
ES2966469T3 (es) 2024-04-22
BR112019003722A2 (pt) 2019-05-28
CA3034875C (en) 2024-05-28
CN109803684B (zh) 2022-08-23
KR102466192B1 (ko) 2022-11-14
EP3503923B1 (en) 2023-10-04
IL264950B1 (en) 2023-09-01
RU2019108259A (ru) 2020-09-25
WO2018039324A1 (en) 2018-03-01
SG11201901472TA (en) 2019-03-28
IL264950A (en) 2019-05-30

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