AU2017315357B2 - Combination therapies for the treatment of hepatocellular carcinoma - Google Patents

Combination therapies for the treatment of hepatocellular carcinoma Download PDF

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Publication number
AU2017315357B2
AU2017315357B2 AU2017315357A AU2017315357A AU2017315357B2 AU 2017315357 B2 AU2017315357 B2 AU 2017315357B2 AU 2017315357 A AU2017315357 A AU 2017315357A AU 2017315357 A AU2017315357 A AU 2017315357A AU 2017315357 B2 AU2017315357 B2 AU 2017315357B2
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AU
Australia
Prior art keywords
pharmaceutically acceptable
pyrimidin
amino
acceptable salt
inhibitor
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AU2017315357A
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English (en)
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AU2017315357A1 (en
Inventor
Anand SELVARAJ
Peter Smith
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Eisai R&D Management Co Ltd
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Eisai R&D Management Co Ltd
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Publication of AU2017315357A1 publication Critical patent/AU2017315357A1/en
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2017315357A 2016-08-23 2017-08-23 Combination therapies for the treatment of hepatocellular carcinoma Active AU2017315357B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662378455P 2016-08-23 2016-08-23
US62/378,455 2016-08-23
PCT/US2017/048183 WO2018039324A1 (en) 2016-08-23 2017-08-23 Combination therapies for the treatment of hepatocellular carcinoma

Publications (2)

Publication Number Publication Date
AU2017315357A1 AU2017315357A1 (en) 2019-02-28
AU2017315357B2 true AU2017315357B2 (en) 2022-12-01

Family

ID=59772765

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2017315357A Active AU2017315357B2 (en) 2016-08-23 2017-08-23 Combination therapies for the treatment of hepatocellular carcinoma

Country Status (14)

Country Link
US (1) US20190175598A1 (https=)
EP (1) EP3503923B1 (https=)
JP (1) JP7190425B2 (https=)
KR (1) KR102466192B1 (https=)
CN (1) CN109803684B (https=)
AU (1) AU2017315357B2 (https=)
BR (1) BR112019003722A2 (https=)
CA (1) CA3034875C (https=)
ES (1) ES2966469T3 (https=)
IL (1) IL264950B2 (https=)
MX (1) MX2019002115A (https=)
RU (1) RU2769251C2 (https=)
SG (1) SG11201901472TA (https=)
WO (1) WO2018039324A1 (https=)

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MX2020007312A (es) 2018-01-08 2021-01-08 G1 Therapeutics Inc Regimenes de dosificacion superior de g1t38.
ES2968899T3 (es) 2018-05-14 2024-05-14 Pfizer Formulación de la solución oral
TW202128174A (zh) * 2019-10-09 2021-08-01 美商G1治療公司 失調之纖維母細胞生長因子受體訊息傳遞的癌症之標靶性治療
JP2023533903A (ja) * 2020-05-15 2023-08-07 エーザイ・アール・アンド・ディー・マネジメント株式会社 Ｆｇｆｒ４阻害剤の経口製剤によるがんの治療方法
CN117479958A (zh) 2022-05-30 2024-01-30 石药集团中奇制药技术（石家庄）有限公司 用于治疗癌症的药物组合和药物组合物
WO2025113607A1 (zh) * 2023-11-30 2025-06-05 石药集团中奇制药技术（石家庄）有限公司 联合治疗肿瘤的药物

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Also Published As

Publication number Publication date
RU2019108259A (ru) 2020-09-25
SG11201901472TA (en) 2019-03-28
IL264950A (en) 2019-05-30
CN109803684A (zh) 2019-05-24
KR102466192B1 (ko) 2022-11-14
AU2017315357A1 (en) 2019-02-28
BR112019003722A2 (pt) 2019-05-28
EP3503923A1 (en) 2019-07-03
IL264950B2 (en) 2024-01-01
IL264950B1 (en) 2023-09-01
JP2019528302A (ja) 2019-10-10
KR20190040996A (ko) 2019-04-19
JP7190425B2 (ja) 2022-12-15
CN109803684B (zh) 2022-08-23
RU2019108259A3 (https=) 2020-11-24
WO2018039324A1 (en) 2018-03-01
CA3034875A1 (en) 2018-03-01
EP3503923B1 (en) 2023-10-04
CA3034875C (en) 2024-05-28
RU2769251C2 (ru) 2022-03-29
ES2966469T3 (es) 2024-04-22
MX2019002115A (es) 2019-07-08
US20190175598A1 (en) 2019-06-13

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