IL264950B2 - Combined treatments for the treatment of malignant liver cell carcinoma - Google Patents
Combined treatments for the treatment of malignant liver cell carcinomaInfo
- Publication number
- IL264950B2 IL264950B2 IL264950A IL26495019A IL264950B2 IL 264950 B2 IL264950 B2 IL 264950B2 IL 264950 A IL264950 A IL 264950A IL 26495019 A IL26495019 A IL 26495019A IL 264950 B2 IL264950 B2 IL 264950B2
- Authority
- IL
- Israel
- Prior art keywords
- pharmaceutically acceptable
- pyrimidin
- acceptable salt
- amino
- ethylpiperazin
- Prior art date
Links
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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| US201662378455P | 2016-08-23 | 2016-08-23 | |
| PCT/US2017/048183 WO2018039324A1 (en) | 2016-08-23 | 2017-08-23 | Combination therapies for the treatment of hepatocellular carcinoma |
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| IL264950A IL264950A (en) | 2019-05-30 |
| IL264950B1 IL264950B1 (en) | 2023-09-01 |
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| EP (1) | EP3503923B1 (https=) |
| JP (1) | JP7190425B2 (https=) |
| KR (1) | KR102466192B1 (https=) |
| CN (1) | CN109803684B (https=) |
| AU (1) | AU2017315357B2 (https=) |
| BR (1) | BR112019003722A2 (https=) |
| CA (1) | CA3034875C (https=) |
| ES (1) | ES2966469T3 (https=) |
| IL (1) | IL264950B2 (https=) |
| MX (1) | MX2019002115A (https=) |
| RU (1) | RU2769251C2 (https=) |
| SG (1) | SG11201901472TA (https=) |
| WO (1) | WO2018039324A1 (https=) |
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| MX2020007312A (es) | 2018-01-08 | 2021-01-08 | G1 Therapeutics Inc | Regimenes de dosificacion superior de g1t38. |
| ES2968899T3 (es) | 2018-05-14 | 2024-05-14 | Pfizer | Formulación de la solución oral |
| TW202128174A (zh) * | 2019-10-09 | 2021-08-01 | 美商G1治療公司 | 失調之纖維母細胞生長因子受體訊息傳遞的癌症之標靶性治療 |
| JP2023533903A (ja) * | 2020-05-15 | 2023-08-07 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | Ｆｇｆｒ４阻害剤の経口製剤によるがんの治療方法 |
| CN117479958A (zh) | 2022-05-30 | 2024-01-30 | 石药集团中奇制药技术（石家庄）有限公司 | 用于治疗癌症的药物组合和药物组合物 |
| WO2025113607A1 (zh) * | 2023-11-30 | 2025-06-05 | 石药集团中奇制药技术（石家庄）有限公司 | 联合治疗肿瘤的药物 |
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| WO2016168331A1 (en) * | 2015-04-14 | 2016-10-20 | Eisai R&D Management Co., Ltd. | Crystalline fgfr4 inhibitor compound and uses thereof |
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| DE19959546A1 (de) | 1999-12-09 | 2001-06-21 | Rhone Poulenc Rorer Gmbh | Pharmazeutische Zubereitung zur Behandlung von Tumorerkrankungen |
| CA2397593C (en) | 2000-01-18 | 2009-11-10 | Aventis Pharmaceuticals Inc. | Pseudopolymorph of (-)-cis-2-(2-chlorophenyl)-5,7-dihydroxy-8[4r-(3s-hydroxy-1-methyl)piperidinyl]-4h-1-benzopyran-4-one |
| ATE284400T1 (de) | 2000-01-18 | 2004-12-15 | Aventis Pharma Inc | Ethanolsolvat von (-)-cis-2-(2-chlorphenyl)-5,7- dihydroxy-8- (4r-(3s-hydroxy-1- methyl)piperidinyl)-4h-1-benzopyran-4-on |
| WO2002022133A1 (en) | 2000-09-12 | 2002-03-21 | Virginia Commonwealth University | Promotion of adoptosis in cancer cells by co-administration of cyclin dependent kinase inhibitors and cellular differentiation agents |
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2017
- 2017-08-23 CN CN201780062334.3A patent/CN109803684B/zh active Active
- 2017-08-23 AU AU2017315357A patent/AU2017315357B2/en active Active
- 2017-08-23 ES ES17761701T patent/ES2966469T3/es active Active
- 2017-08-23 KR KR1020197008327A patent/KR102466192B1/ko active Active
- 2017-08-23 WO PCT/US2017/048183 patent/WO2018039324A1/en not_active Ceased
- 2017-08-23 US US16/324,643 patent/US20190175598A1/en not_active Abandoned
- 2017-08-23 EP EP17761701.6A patent/EP3503923B1/en active Active
- 2017-08-23 RU RU2019108259A patent/RU2769251C2/ru active
- 2017-08-23 JP JP2019511500A patent/JP7190425B2/ja active Active
- 2017-08-23 IL IL264950A patent/IL264950B2/en unknown
- 2017-08-23 BR BR112019003722A patent/BR112019003722A2/pt not_active Application Discontinuation
- 2017-08-23 CA CA3034875A patent/CA3034875C/en active Active
- 2017-08-23 MX MX2019002115A patent/MX2019002115A/es unknown
- 2017-08-23 SG SG11201901472TA patent/SG11201901472TA/en unknown
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Also Published As
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|---|---|
| RU2019108259A (ru) | 2020-09-25 |
| SG11201901472TA (en) | 2019-03-28 |
| IL264950A (en) | 2019-05-30 |
| CN109803684A (zh) | 2019-05-24 |
| KR102466192B1 (ko) | 2022-11-14 |
| AU2017315357A1 (en) | 2019-02-28 |
| BR112019003722A2 (pt) | 2019-05-28 |
| EP3503923A1 (en) | 2019-07-03 |
| IL264950B1 (en) | 2023-09-01 |
| JP2019528302A (ja) | 2019-10-10 |
| KR20190040996A (ko) | 2019-04-19 |
| JP7190425B2 (ja) | 2022-12-15 |
| CN109803684B (zh) | 2022-08-23 |
| RU2019108259A3 (https=) | 2020-11-24 |
| WO2018039324A1 (en) | 2018-03-01 |
| AU2017315357B2 (en) | 2022-12-01 |
| CA3034875A1 (en) | 2018-03-01 |
| EP3503923B1 (en) | 2023-10-04 |
| CA3034875C (en) | 2024-05-28 |
| RU2769251C2 (ru) | 2022-03-29 |
| ES2966469T3 (es) | 2024-04-22 |
| MX2019002115A (es) | 2019-07-08 |
| US20190175598A1 (en) | 2019-06-13 |
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