JP7177794B2 - 抗ｔｒｂｃ１抗原結合ドメイン - Google Patents

抗ｔｒｂｃ１抗原結合ドメイン Download PDF

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JP7177794B2
JP7177794B2 JP2019567333A JP2019567333A JP7177794B2 JP 7177794 B2 JP7177794 B2 JP 7177794B2 JP 2019567333 A JP2019567333 A JP 2019567333A JP 2019567333 A JP2019567333 A JP 2019567333A JP 7177794 B2 JP7177794 B2 JP 7177794B2
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cell
cells
trbc1
cell lymphoma
seq
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JP2020527027A5 (enExample
JP2020527027A (ja
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ショーン コルドバ，
サイモン トーマス，
シモビ オヌオハ，
ラム ジャー，
ウェン チェアン リム，
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オートラス リミテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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JP2019567333A 2017-06-09 2018-06-08 抗ｔｒｂｃ１抗原結合ドメイン Active JP7177794B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022130014A JP2022159473A (ja) 2017-06-09 2022-08-17 抗ｔｒｂｃ１抗原結合ドメイン
JP2025081388A JP2025107475A (ja) 2017-06-09 2025-05-14 抗ｔｒｂｃ１抗原結合ドメイン

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GB1709203.2 2017-06-09
GBGB1709203.2A GB201709203D0 (en) 2017-06-09 2017-06-09 Antigen-binding domain
PCT/GB2018/051570 WO2018224844A1 (en) 2017-06-09 2018-06-08 Anti trbc1 antigen binding domains

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JP2020527027A JP2020527027A (ja) 2020-09-03
JP2020527027A5 JP2020527027A5 (enExample) 2021-04-30
JP7177794B2 true JP7177794B2 (ja) 2022-11-24

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JP2022130014A Withdrawn JP2022159473A (ja) 2017-06-09 2022-08-17 抗ｔｒｂｃ１抗原結合ドメイン
JP2025081388A Pending JP2025107475A (ja) 2017-06-09 2025-05-14 抗ｔｒｂｃ１抗原結合ドメイン

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JP2025081388A Pending JP2025107475A (ja) 2017-06-09 2025-05-14 抗ｔｒｂｃ１抗原結合ドメイン

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US (3) US11440961B2 (enExample)
EP (1) EP3635006A1 (enExample)
JP (3) JP7177794B2 (enExample)
KR (1) KR102743539B1 (enExample)
CN (2) CN110741018B (enExample)
AU (1) AU2018282038B2 (enExample)
BR (1) BR112019025990A2 (enExample)
CA (1) CA3065006A1 (enExample)
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022159473A (ja) * 2017-06-09 2022-10-17 オートラス リミテッド 抗ｔｒｂｃ１抗原結合ドメイン

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US11385233B2 (en) 2015-03-05 2022-07-12 Autolus Limited Methods of depleting malignant T-cells
US11982672B2 (en) 2014-03-05 2024-05-14 Autolus Limited Methods
GB201800298D0 (en) 2018-01-09 2018-02-21 Autolus Ltd Method
WO2019139987A1 (en) 2018-01-09 2019-07-18 Elstar Therapeutics, Inc. Calreticulin binding constructs and engineered t cells for the treatment of diseases
US12152073B2 (en) 2018-03-14 2024-11-26 Marengo Therapeutics, Inc. Multifunctional molecules that bind to calreticulin and uses thereof
CN112955465A (zh) 2018-07-03 2021-06-11 马伦戈治疗公司 抗tcr抗体分子及其用途
GB201812650D0 (en) 2018-08-03 2018-09-19 Autolus Ltd Molecular assessment of TRBC usage
GB201817172D0 (en) 2018-10-22 2018-12-05 Autolus Ltd Antibody
GB201817822D0 (en) 2018-10-31 2018-12-19 Autolus Ltd Binding domain
WO2020172605A1 (en) 2019-02-21 2020-08-27 Elstar Therapeutics, Inc. Antibody molecules that bind to nkp30 and uses thereof
JP7710373B2 (ja) * 2019-02-21 2025-07-18 マレンゴ・セラピューティクス，インコーポレーテッド Ｔ細胞関連のがん細胞に結合する多機能性分子およびその使用
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