AU2018282038B2 - Anti TRBC1 antigen binding domains - Google Patents

Anti TRBC1 antigen binding domains Download PDF

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Publication number
AU2018282038B2
AU2018282038B2 AU2018282038A AU2018282038A AU2018282038B2 AU 2018282038 B2 AU2018282038 B2 AU 2018282038B2 AU 2018282038 A AU2018282038 A AU 2018282038A AU 2018282038 A AU2018282038 A AU 2018282038A AU 2018282038 B2 AU2018282038 B2 AU 2018282038B2
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AU2018282038A1 (en
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Shaun CORDOBA
Ram JHA
Wen Chean LIM
Shimobi ONUOHA
Simon Thomas
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Autolus Ltd
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Autolus Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • C12N5/0634—Cells from the blood or the immune system
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    • G—PHYSICS
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07—ORGANIC CHEMISTRY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
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AU2018282038A 2017-06-09 2018-06-08 Anti TRBC1 antigen binding domains Active AU2018282038B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1709203.2 2017-06-09
GBGB1709203.2A GB201709203D0 (en) 2017-06-09 2017-06-09 Antigen-binding domain
PCT/GB2018/051570 WO2018224844A1 (en) 2017-06-09 2018-06-08 Anti trbc1 antigen binding domains

Publications (2)

Publication Number Publication Date
AU2018282038A1 AU2018282038A1 (en) 2019-12-12
AU2018282038B2 true AU2018282038B2 (en) 2025-03-27

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AU2018282038A Active AU2018282038B2 (en) 2017-06-09 2018-06-08 Anti TRBC1 antigen binding domains

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US (3) US11440961B2 (enExample)
EP (1) EP3635006A1 (enExample)
JP (3) JP7177794B2 (enExample)
KR (1) KR102743539B1 (enExample)
CN (2) CN110741018B (enExample)
AU (1) AU2018282038B2 (enExample)
BR (1) BR112019025990A2 (enExample)
CA (1) CA3065006A1 (enExample)
CL (1) CL2019003536A1 (enExample)
CO (1) CO2019013614A2 (enExample)
CU (1) CU24663B1 (enExample)
GB (1) GB201709203D0 (enExample)
IL (1) IL270731B2 (enExample)
MX (1) MX2019013387A (enExample)
MY (1) MY205039A (enExample)
PE (1) PE20191717A1 (enExample)
PH (1) PH12019502785A1 (enExample)
WO (1) WO2018224844A1 (enExample)
ZA (1) ZA201907524B (enExample)

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