CU20190099A7 - Dominio de unión a antígeno anti-trbc1, y receptor de antígeno quimérico, anticuerpo, acoplador biespecífico de células t y conjugado anticuerpo-fármaco que comprenden el mismo - Google Patents
Dominio de unión a antígeno anti-trbc1, y receptor de antígeno quimérico, anticuerpo, acoplador biespecífico de células t y conjugado anticuerpo-fármaco que comprenden el mismoInfo
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- CU20190099A7 CU20190099A7 CU2019000099A CU20190099A CU20190099A7 CU 20190099 A7 CU20190099 A7 CU 20190099A7 CU 2019000099 A CU2019000099 A CU 2019000099A CU 20190099 A CU20190099 A CU 20190099A CU 20190099 A7 CU20190099 A7 CU 20190099A7
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- Prior art keywords
- seq
- antibody
- antigen
- binding domain
- bispecific
- Prior art date
Links
- 239000000427 antigen Substances 0.000 title abstract 3
- 102000036639 antigens Human genes 0.000 title abstract 3
- 108091007433 antigens Proteins 0.000 title abstract 3
- 102000006306 Antigen Receptors Human genes 0.000 title 1
- 108010083359 Antigen Receptors Proteins 0.000 title 1
- 239000000611 antibody drug conjugate Substances 0.000 title 1
- 229940049595 antibody-drug conjugate Drugs 0.000 title 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 2
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940127121 immunoconjugate Drugs 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- A—HUMAN NECESSITIES
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- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
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- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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- A61K39/4631—Chimeric Antigen Receptors [CAR]
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- A61K39/4632—T-cell receptors [TCR]; antibody T-cell receptor constructs
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- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
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- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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Abstract
<p>La presente invención proporciona un dominio de unión a antígeno anti-TRBC1 el cual comprende:</p> <p>a) un dominio VH que tiene una secuencia de aminoácidos que se selecciona de SEQ ID No. 9, SEQ ID No. 10, SEQ ID No. 11, SEQ ID No. 12, SEQ ID No. 13, SEQ ID No. 14, SEQ ID No. 15, SEQ ID No. 16, SEQ ID No. 17 y SEQ ID No. 18; y</p> <p>b) un dominio VL que tiene una secuencia de aminoácidos que se selecciona de SEQ ID No. 19, SEQ ID No. 20, SEQ ID No. 21, SEQ ID No. 22, SEQ ID No. 23, SEQ ID No. 24, SEQ ID No. 25, SEQ ID No. 26, SEQ ID No. 27, SEQ ID No. 28, SEQ ID No. 29, SEQ ID No. 30, SEQ ID No. 31, SEQ ID No. 32, SEQ ID No. 33, SEQ ID No. 34.</p> <p>La presente invención también proporciona un receptor de antígeno quimérico, un anticuerpo, un acoplador biespecífico de células T y un conjugado anticuerpo-fármaco que comprende a dicho dominio de unión a antígeno anti-TRBC1.</p>
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1709203.2A GB201709203D0 (en) | 2017-06-09 | 2017-06-09 | Antigen-binding domain |
PCT/GB2018/051570 WO2018224844A1 (en) | 2017-06-09 | 2018-06-08 | Anti trbc1 antigen binding domains |
Publications (2)
Publication Number | Publication Date |
---|---|
CU20190099A7 true CU20190099A7 (es) | 2020-10-20 |
CU24663B1 CU24663B1 (es) | 2023-05-11 |
Family
ID=59358238
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CU2019000099A CU24663B1 (es) | 2017-06-09 | 2018-06-08 | Dominio de unión a antígeno anti-trbc1, receptor de antígeno quimérico, anticuerpo y acoplador biespecífico de células t que comprenden el mismo |
Country Status (17)
Country | Link |
---|---|
US (3) | US11440961B2 (es) |
EP (1) | EP3635006A1 (es) |
JP (2) | JP7177794B2 (es) |
KR (1) | KR20200015713A (es) |
AU (1) | AU2018282038A1 (es) |
BR (1) | BR112019025990A2 (es) |
CA (1) | CA3065006A1 (es) |
CL (1) | CL2019003536A1 (es) |
CO (1) | CO2019013614A2 (es) |
CU (1) | CU24663B1 (es) |
GB (1) | GB201709203D0 (es) |
IL (1) | IL270731B2 (es) |
MX (1) | MX2019013387A (es) |
PE (1) | PE20191717A1 (es) |
PH (1) | PH12019502785A1 (es) |
WO (1) | WO2018224844A1 (es) |
ZA (1) | ZA201907524B (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
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US20230027993A1 (en) * | 2014-03-05 | 2023-01-26 | Autolus Limited | Methods |
US11385233B2 (en) | 2015-03-05 | 2022-07-12 | Autolus Limited | Methods of depleting malignant T-cells |
GB201709203D0 (en) * | 2017-06-09 | 2017-07-26 | Autolus Ltd | Antigen-binding domain |
GB201800298D0 (en) | 2018-01-09 | 2018-02-21 | Autolus Ltd | Method |
GB201817172D0 (en) | 2018-10-22 | 2018-12-05 | Autolus Ltd | Antibody |
US20220041718A1 (en) * | 2018-10-31 | 2022-02-10 | Autolus Limited | Binding domain |
WO2020172571A1 (en) * | 2019-02-21 | 2020-08-27 | Elstar Therapeutics, Inc. | Multifunctional molecules that bind to t cell related cancer cells and uses thereof |
GB202004263D0 (en) * | 2020-03-24 | 2020-05-06 | Autolus Ltd | Antibody conjugate |
GB202005216D0 (en) | 2020-04-08 | 2020-05-20 | Autolus Ltd | Cell |
JP2021175722A (ja) | 2020-04-22 | 2021-11-04 | 住友化学株式会社 | 塩、酸発生剤、レジスト組成物及びレジストパターンの製造方法 |
EP4139363A1 (en) * | 2020-04-24 | 2023-03-01 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to t cell related cancer cells and uses thereof |
JP2022008152A (ja) | 2020-06-25 | 2022-01-13 | 住友化学株式会社 | 塩、酸発生剤、レジスト組成物及びレジストパターンの製造方法 |
JP2022013736A (ja) | 2020-07-01 | 2022-01-18 | 住友化学株式会社 | 塩、酸発生剤、レジスト組成物及びレジストパターンの製造方法 |
JP2022123839A (ja) | 2021-02-12 | 2022-08-24 | 住友化学株式会社 | 塩、酸発生剤、レジスト組成物及びレジストパターンの製造方法 |
WO2022177889A1 (en) * | 2021-02-17 | 2022-08-25 | The Johns Hopkins University | Methods and materials for treating clonal t cell expansions |
JP2022164583A (ja) | 2021-04-15 | 2022-10-27 | 住友化学株式会社 | 塩、酸発生剤、レジスト組成物及びレジストパターンの製造方法 |
JP2022164585A (ja) | 2021-04-15 | 2022-10-27 | 住友化学株式会社 | 塩、酸発生剤、レジスト組成物及びレジストパターンの製造方法 |
US20230004084A1 (en) | 2021-05-06 | 2023-01-05 | Sumitomo Chemical Company, Limited | Salt, acid generator, resist composition and method for producing resist pattern |
CN114181971A (zh) * | 2021-11-22 | 2022-03-15 | 东莞市麦亘生物科技有限公司 | 一种靶向trbc1 car-t细胞的制备方法与应用 |
WO2024085182A1 (ja) * | 2022-10-18 | 2024-04-25 | Meiji Seikaファルマ株式会社 | T細胞性腫瘍の治療剤 |
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---|---|---|---|---|
CA2484182A1 (en) | 2002-04-29 | 2003-11-13 | Genpat77 Pharmacogenetics Ag | Novel antibody binding tcr and tirc7 and its use in therapy and diagnosis |
RU2355703C2 (ru) | 2002-10-09 | 2009-05-20 | Медиджен Лимитед | Одноцепочечные рекомбинантные т-клеточные рецепторы |
GB0304068D0 (en) | 2003-02-22 | 2003-03-26 | Avidex Ltd | Substances |
WO2013074916A1 (en) | 2011-11-18 | 2013-05-23 | Board Of Regents, The University Of Texas System | Car+ t cells genetically modified to eliminate expression of t- cell receptor and/or hla |
GB201206559D0 (en) | 2012-04-13 | 2012-05-30 | Ucl Business Plc | Polypeptide |
US11385233B2 (en) | 2015-03-05 | 2022-07-12 | Autolus Limited | Methods of depleting malignant T-cells |
PT3125934T (pt) | 2014-03-05 | 2019-12-16 | Ucl Business Plc | Recetor de antigénio quimérico (car) com domínios de ligação a antigénio para a região constante beta do recetor de células t |
GB201405845D0 (en) | 2014-04-01 | 2014-05-14 | Ucl Business Plc | Signalling system |
GB201415347D0 (en) | 2014-08-29 | 2014-10-15 | Ucl Business Plc | Signalling system |
GB201501936D0 (en) | 2015-02-05 | 2015-03-25 | Ucl Business Plc | Signalling system |
GB201503133D0 (en) | 2015-02-24 | 2015-04-08 | Ucl Business Plc And Syncona Partners Llp | Chimeric protein |
GB201709203D0 (en) * | 2017-06-09 | 2017-07-26 | Autolus Ltd | Antigen-binding domain |
GB201800298D0 (en) | 2018-01-09 | 2018-02-21 | Autolus Ltd | Method |
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2017
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2018
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- 2018-06-08 BR BR112019025990-2A patent/BR112019025990A2/pt unknown
- 2018-06-08 MX MX2019013387A patent/MX2019013387A/es unknown
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- 2018-06-08 US US16/620,370 patent/US11440961B2/en active Active
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2019
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2022
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BR112019025990A2 (pt) | 2020-07-07 |
CO2019013614A2 (es) | 2020-04-01 |
EP3635006A1 (en) | 2020-04-15 |
MX2019013387A (es) | 2020-08-31 |
PH12019502785A1 (en) | 2020-09-14 |
JP2022159473A (ja) | 2022-10-17 |
IL270731B1 (en) | 2023-11-01 |
US11440961B2 (en) | 2022-09-13 |
US20230053849A1 (en) | 2023-02-23 |
ZA201907524B (en) | 2023-04-26 |
CL2019003536A1 (es) | 2020-05-08 |
US20220098300A1 (en) | 2022-03-31 |
JP2020527027A (ja) | 2020-09-03 |
PE20191717A1 (es) | 2019-12-06 |
CA3065006A1 (en) | 2018-12-13 |
RU2019136753A3 (es) | 2021-09-27 |
US20200140549A1 (en) | 2020-05-07 |
AU2018282038A1 (en) | 2019-12-12 |
IL270731B2 (en) | 2024-03-01 |
US11434293B2 (en) | 2022-09-06 |
CU24663B1 (es) | 2023-05-11 |
WO2018224844A1 (en) | 2018-12-13 |
RU2019136753A (ru) | 2021-07-09 |
KR20200015713A (ko) | 2020-02-12 |
CN110741018A (zh) | 2020-01-31 |
JP7177794B2 (ja) | 2022-11-24 |
IL270731A (en) | 2020-01-30 |
GB201709203D0 (en) | 2017-07-26 |
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