EA202190607A1 - Химерный антигенный рецептор для bcma на основе однодоменного антитела и его применение - Google Patents

Химерный антигенный рецептор для bcma на основе однодоменного антитела и его применение

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EA202190607A1
EA202190607A1 EA202190607A EA202190607A EA202190607A1 EA 202190607 A1 EA202190607 A1 EA 202190607A1 EA 202190607 A EA202190607 A EA 202190607A EA 202190607 A EA202190607 A EA 202190607A EA 202190607 A1 EA202190607 A1 EA 202190607A1
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Prior art keywords
bcma
application
single domain
domain antibody
antigenic receptor
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EA202190607A
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English (en)
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Цзихуай Чфан
Хунцзянь Ли
Хунчан Су
Чаолэман Бао
Цзунпэй Сун
Цинхуа Цай
Ицзинь Дин
Чжибо Цай
Original Assignee
Шэньчжэнь Преджин Байофарма Ко., Лтд.
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Application filed by Шэньчжэнь Преджин Байофарма Ко., Лтд. filed Critical Шэньчжэнь Преджин Байофарма Ко., Лтд.
Publication of EA202190607A1 publication Critical patent/EA202190607A1/ru

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Abstract

Химерный антигенный рецептор (CAR) и его применение, где CAR включает BCMA-связывающий домен, трансмембранный домен, один или более костимулирующих доменов и внутриклеточный сигнальный домен, где BCMA-связывающий домен содержит определяющие комплементарность участки тяжелой цепи HCDR1-3, и аминокислотные последовательности HCDR1-3 последовательно приведены в SEQ ID NO: 1-3.
EA202190607A 2018-08-24 2019-07-10 Химерный антигенный рецептор для bcma на основе однодоменного антитела и его применение EA202190607A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201810972053.8A CN109134665B (zh) 2018-08-24 2018-08-24 一种基于单域抗体的bcma嵌合抗原受体及应用
PCT/CN2019/095505 WO2020038146A1 (zh) 2018-08-24 2019-07-10 一种基于单域抗体的bcma嵌合抗原受体及应用

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EA202190607A1 true EA202190607A1 (ru) 2021-05-28

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US (1) US20220218746A1 (ru)
EP (1) EP3842462A4 (ru)
JP (1) JP7237287B2 (ru)
KR (1) KR102223873B1 (ru)
CN (1) CN109134665B (ru)
AU (1) AU2019325036B2 (ru)
BR (1) BR112021003408A2 (ru)
CA (1) CA3109320C (ru)
EA (1) EA202190607A1 (ru)
SG (1) SG11202101685XA (ru)
WO (1) WO2020038146A1 (ru)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3845244A4 (en) * 2018-08-24 2022-09-07 Shenzhen Pregene Biopharma Co. Ltd. ANTI-BCMA SINGLE DOMAIN ANTIBODIES AND THEIR USE
CN109134665B (zh) * 2018-08-24 2021-06-11 上海先博生物科技有限公司 一种基于单域抗体的bcma嵌合抗原受体及应用
CN109678961A (zh) * 2019-01-15 2019-04-26 深圳市南科生物工程有限公司 一种基于bmca纳米抗体序列的嵌合抗原受体的构建方法及其应用
US20220144948A1 (en) * 2019-01-29 2022-05-12 Shanghai Jiao Tong University Chimeric antigen receptor and use thereof
CN109942708B (zh) * 2019-03-28 2021-01-05 上海科棋药业科技有限公司 一种抗bcma的单域抗体及其应用
CN111171160B (zh) * 2020-02-14 2022-05-17 四川大学华西医院 基于TGF-β改造的嵌合抗原受体及其修饰的免疫细胞
CN111333729B (zh) * 2020-03-17 2022-12-06 深圳市南科生物工程有限公司 抗b细胞成熟抗原的纳米抗体及应用
CN111848798B (zh) * 2020-07-27 2022-05-13 源道隆（苏州）医学科技有限公司 可结合bcma的纳米抗体及其应用
CN111909271B (zh) * 2020-08-12 2021-03-23 深圳市茵冠生物科技有限公司 一种基于单域抗体的bcma嵌合抗原受体及其应用
CN111925451B (zh) * 2020-10-12 2021-01-29 佑仁细胞工程(浙江)有限公司 一种靶向bcma的嵌合抗原受体(car)及其应用
CN112592927B (zh) * 2020-12-22 2024-06-11 上海科棋药业科技有限公司 一种同时靶向cd19和bcma的双靶点嵌合抗原受体及其应用
CN116390954A (zh) * 2020-12-29 2023-07-04 宁波茂行生物医药科技有限公司 靶向bcma的单域抗体
CN113087798B (zh) * 2020-12-31 2022-05-24 北京艺妙神州医药科技有限公司 一种抗bcma的抗体及其应用
CN114149505B (zh) * 2021-01-12 2022-11-04 北京门罗生物科技有限公司 治疗b细胞相关疾病的免疫细胞、制备方法及其应用
CN112830971B (zh) * 2021-02-08 2022-07-29 华道(上海)生物医药有限公司 一种抗bcma的抗原结合片段及其应用
CN113265001B (zh) * 2021-02-08 2022-07-29 华道(上海)生物医药有限公司 一种抗b细胞成熟抗原的纳米抗体及其应用
CN117924497A (zh) * 2021-03-22 2024-04-26 浙江纳米抗体技术中心有限公司 一种靶向bcma的纳米抗体及其应用
JP2024517719A (ja) * 2021-04-27 2024-04-23 オリセル セラピューティクス カンパニー リミテッド Ｂｃｍａを標的としたキメラ型抗原受容体及びその応用
WO2023098846A1 (zh) * 2021-12-03 2023-06-08 江苏先声药业有限公司 抗bcma纳米抗体及其应用
CN114195896B (zh) * 2021-12-06 2022-07-05 东莞清实生物科技有限公司 一种基于单域抗体的bcma嵌合抗原受体及其应用
US20240009309A1 (en) * 2022-07-05 2024-01-11 Neomics Pharmaceuticals Llc Chimeric antigen receptor comprising bcma nanobody linked to a chimeric intracellular signaling domain
CN117384299B (zh) * 2022-11-01 2024-04-30 邦恩泰(山东)生物医药科技集团股份有限公司 靶向bcma和/或fcrh5的嵌合抗原受体、car-t细胞及其应用
CN117186228B (zh) * 2022-12-06 2024-03-22 成都赛恩吉诺生物科技有限公司 包含长cdr3序列的抗人bcma纳米抗体的双特异性抗体及应用
CN116239692B (zh) * 2023-01-13 2023-11-17 北京艺妙神州医药科技有限公司 分离的抗体、包含该抗体的car及其用途
CN116396389B (zh) * 2023-05-05 2024-01-23 成都优赛诺生物科技有限公司 一种靶向bcma的单域抗体、嵌合抗原受体及其应用
CN117534763B (zh) * 2023-12-28 2024-03-26 康维众和(中山)生物药业有限公司 抗bcma的纳米抗体及其制备方法与应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104126009B (zh) * 2011-10-07 2019-05-10 国立大学法人三重大学 嵌合抗原受体
EP3131927B8 (en) * 2014-04-14 2020-12-23 Cellectis Bcma (cd269) specific chimeric antigen receptors for cancer immunotherapy
RU2751660C2 (ru) * 2014-07-21 2021-07-15 Новартис Аг Лечение злокачественного новообразования с использованием гуманизированного химерного антигенного рецептора против всма
US20170226216A1 (en) * 2014-07-24 2017-08-10 Bluebird Bio, Inc. Bcma chimeric antigen receptors
CN113698497A (zh) * 2014-12-05 2021-11-26 纪念斯隆-凯特琳癌症中心 靶向b-细胞成熟抗原的嵌合抗原受体及其用途
CN107207598B (zh) * 2014-12-12 2020-12-08 蓝鸟生物公司 Bcma嵌合抗原受体
US20180094280A1 (en) * 2015-03-20 2018-04-05 Bluebird Bio, Inc. Vector formulations
PL3331910T3 (pl) * 2015-08-03 2020-05-18 Engmab Sàrl Przeciwciała monoklonalne przeciwko ludzkiemu antygenowi dojrzewania limfocytów B (BCMA)
CN105384825B (zh) * 2015-08-11 2018-06-01 南京传奇生物科技有限公司 一种基于单域抗体的双特异性嵌合抗原受体及其应用
JP7054924B2 (ja) * 2015-09-23 2022-04-15 サイトイミューン セラピューティクス， インコーポレイテッド 免疫療法のためのｆｌｔ３指向ｃａｒ細胞
US11090334B2 (en) * 2016-01-29 2021-08-17 Med Manor Organics (P) Ltd. Chimeric antigen receptor specific to b-cell maturation antigen, a recombinant expression vector and a method thereof
CN105777911B (zh) * 2016-04-12 2019-07-02 上海优卡迪生物医药科技有限公司 抗bcma嵌合抗原受体、编码基因、重组表达载体及其构建方法和应用
CN105837693A (zh) * 2016-05-30 2016-08-10 李斯文 一种基于bcma的抗原嵌合受体及其制备方法和应用
CA3032498A1 (en) * 2016-08-02 2018-02-08 TCR2 Therapeutics Inc. Compositions and methods for tcr reprogramming using fusion proteins
KR20240005168A (ko) * 2016-11-04 2024-01-11 2세븐티 바이오, 인코포레이티드 항-bcma car t 세포 조성물
CN106749678A (zh) * 2017-01-09 2017-05-31 北京普瑞金科技有限公司 Her2 car重组慢病毒载体及其构建方法与应用
CN109134665B (zh) * 2018-08-24 2021-06-11 上海先博生物科技有限公司 一种基于单域抗体的bcma嵌合抗原受体及应用

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CA3109320A1 (en) 2020-02-27
US20220218746A1 (en) 2022-07-14
EP3842462A4 (en) 2022-05-04
WO2020038146A1 (zh) 2020-02-27
CN109134665A (zh) 2019-01-04
JP7237287B2 (ja) 2023-03-13
SG11202101685XA (en) 2021-03-30
KR20200023165A (ko) 2020-03-04
CA3109320C (en) 2023-10-31
EP3842462A1 (en) 2021-06-30
AU2019325036B2 (en) 2023-10-05
AU2019325036A1 (en) 2021-04-22
KR102223873B1 (ko) 2021-03-08
CN109134665B (zh) 2021-06-11
BR112021003408A2 (pt) 2021-05-18

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