JP7170030B2 - キナーゼを調節する化合物の製剤 - Google Patents

キナーゼを調節する化合物の製剤 Download PDF

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JP7170030B2
JP7170030B2 JP2020502185A JP2020502185A JP7170030B2 JP 7170030 B2 JP7170030 B2 JP 7170030B2 JP 2020502185 A JP2020502185 A JP 2020502185A JP 2020502185 A JP2020502185 A JP 2020502185A JP 7170030 B2 JP7170030 B2 JP 7170030B2
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compound
disease
composition
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cancer
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JP2020528884A5 (cg-RX-API-DMAC7.html
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プラブハ・エヌ・イブラヒム
ハミド・レザエイ
ゲイリー・コナード・バイザー
倫有 加茂
浩 山小瀬
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Plexxikon Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Biochemistry (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2020502185A 2017-07-25 2018-07-24 キナーゼを調節する化合物の製剤 Active JP7170030B2 (ja)

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Application Number Priority Date Filing Date Title
US201762536574P 2017-07-25 2017-07-25
US62/536,574 2017-07-25
PCT/US2018/043433 WO2019023198A1 (en) 2017-07-25 2018-07-24 FORMULATION OF A COMPOUND MODULATING KINASES

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JP2020528884A JP2020528884A (ja) 2020-10-01
JP2020528884A5 JP2020528884A5 (cg-RX-API-DMAC7.html) 2021-09-02
JP7170030B2 true JP7170030B2 (ja) 2022-11-11

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US (3) US10435404B2 (cg-RX-API-DMAC7.html)
EP (1) EP3658189A1 (cg-RX-API-DMAC7.html)
JP (1) JP7170030B2 (cg-RX-API-DMAC7.html)
KR (1) KR102615829B1 (cg-RX-API-DMAC7.html)
CN (1) CN110944670B (cg-RX-API-DMAC7.html)
AU (1) AU2018307910B2 (cg-RX-API-DMAC7.html)
BR (1) BR112019028235B1 (cg-RX-API-DMAC7.html)
CA (1) CA3070505C (cg-RX-API-DMAC7.html)
TW (1) TWI805599B (cg-RX-API-DMAC7.html)
WO (1) WO2019023198A1 (cg-RX-API-DMAC7.html)

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JP7636646B2 (ja) 2019-04-09 2025-02-27 オプナ バイオ ソシエテ アノニム Ｅｐ３００またはｃｂｐの調節のための縮合アジンおよびその適応
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AU2021327375A1 (en) 2020-08-21 2023-03-16 Opna Bio SA Combinational drug anticancer therapies
KR20230088761A (ko) 2020-10-13 2023-06-20 베링거 인겔하임 인터내셔날 게엠베하 재가공하는 방법
CN115925700B (zh) * 2022-11-21 2025-02-18 罗欣药业(上海)有限公司 一种酪氨酸激酶抑制剂的晶型及其制备方法
JP2026502949A (ja) 2022-12-30 2026-01-27 アヴィセンナ バイオサイエンシズ インコーポレイテッド アザインドールｒｏｃｋ阻害剤

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