JP7158104B2 - Ｎｋ細胞ベースの療法で使用するためのｈｄａｃ阻害剤 - Google Patents

Ｎｋ細胞ベースの療法で使用するためのｈｄａｃ阻害剤 Download PDF

Info

Publication number
JP7158104B2
JP7158104B2 JP2019522629A JP2019522629A JP7158104B2 JP 7158104 B2 JP7158104 B2 JP 7158104B2 JP 2019522629 A JP2019522629 A JP 2019522629A JP 2019522629 A JP2019522629 A JP 2019522629A JP 7158104 B2 JP7158104 B2 JP 7158104B2
Authority
JP
Japan
Prior art keywords
day
less
administered
cells
certain embodiments
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2019522629A
Other languages
English (en)
Japanese (ja)
Other versions
JP2019522054A5 (enExample
JP2019522054A (ja
Inventor
エヌ． ウッディ，ジェームズ
スン－シオン，パトリック
Original Assignee
ビラクタ セラピューティクス，インク．
ナントクエスト，インク．
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ビラクタ セラピューティクス，インク．, ナントクエスト，インク． filed Critical ビラクタ セラピューティクス，インク．
Publication of JP2019522054A publication Critical patent/JP2019522054A/ja
Publication of JP2019522054A5 publication Critical patent/JP2019522054A5/ja
Application granted granted Critical
Publication of JP7158104B2 publication Critical patent/JP7158104B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/15—Depsipeptides; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/46—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/51—Stomach
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2019522629A 2016-07-15 2017-07-14 Ｎｋ細胞ベースの療法で使用するためのｈｄａｃ阻害剤 Active JP7158104B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662362959P 2016-07-15 2016-07-15
US62/362,959 2016-07-15
PCT/US2017/042222 WO2018013975A1 (en) 2016-07-15 2017-07-14 Hdac inhibitors for use with nk cell based therapies

Publications (3)

Publication Number Publication Date
JP2019522054A JP2019522054A (ja) 2019-08-08
JP2019522054A5 JP2019522054A5 (enExample) 2020-08-06
JP7158104B2 true JP7158104B2 (ja) 2022-10-21

Family

ID=60952218

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2019522629A Active JP7158104B2 (ja) 2016-07-15 2017-07-14 Ｎｋ細胞ベースの療法で使用するためのｈｄａｃ阻害剤
JP2019522627A Active JP7373991B2 (ja) 2016-07-15 2017-07-14 免疫療法で使用するためのヒストン脱アセチル化酵素阻害剤
JP2022032796A Pending JP2022088404A (ja) 2016-07-15 2022-03-03 免疫療法で使用するためのヒストン脱アセチル化酵素阻害剤

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2019522627A Active JP7373991B2 (ja) 2016-07-15 2017-07-14 免疫療法で使用するためのヒストン脱アセチル化酵素阻害剤
JP2022032796A Pending JP2022088404A (ja) 2016-07-15 2022-03-03 免疫療法で使用するためのヒストン脱アセチル化酵素阻害剤

Country Status (6)

Country Link
US (3) US12427152B2 (enExample)
EP (4) EP4596053A3 (enExample)
JP (3) JP7158104B2 (enExample)
CN (2) CN109715173A (enExample)
GB (2) GB2567093A (enExample)
WO (2) WO2018013962A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109715173A (zh) 2016-07-15 2019-05-03 维拉克塔治疗公司 供基于nk细胞的疗法使用的hdac抑制剂
IL266918B2 (en) 2016-12-07 2024-03-01 Agenus Inc Anti-ctla-4 antibodies and methods of use thereof
US20200368280A1 (en) * 2018-01-12 2020-11-26 Viracta Therapeutics, Inc. Epigenetic modifiers for use in cellular immunotherapy
CA3100282A1 (en) 2018-06-19 2019-12-26 Nantcell, Inc. Hiv treatment compositions and methods
CN109306341B (zh) * 2018-09-12 2022-01-28 华东师范大学 Hdac11基因干扰的嵌合抗原受体t细胞及其应用
KR102533540B1 (ko) 2018-10-31 2023-05-17 난트퀘스트, 인크. Pd-l1 키메라 항원 수용체-발현 nk 세포에 의한 pd-l1-양성 악성종양의 제거(elimination of pd-l1-positive malignancies by pd-l1 chimeric antigen receptor-expressing nk cells)
PH12021552997A1 (en) 2019-05-31 2023-08-14 Viracta Subsidiary Inc Methods of treating virally associated cancers with histone deacetylase inhibitors
WO2021037128A1 (zh) * 2019-08-28 2021-03-04 深圳微芯生物科技股份有限公司 一种西达本胺药物组合物及其应用
JP2022552642A (ja) * 2019-10-07 2022-12-19 ヴィラクタ サブシディアリー，インク． 副作用が軽減されたｈｄａｃ治療の調剤
CN113302307B (zh) 2019-11-26 2024-04-05 南克维斯特公司 原代nk car构建体和方法
EP4069229A4 (en) 2019-12-05 2024-02-07 Viracta Subsidiary, Inc. Hdac inhibitor solid state forms
CN111358777A (zh) * 2020-02-24 2020-07-03 军事科学院军事医学研究院环境医学与作业医学研究所 一种提高外周血单个核细胞线粒体功能的方法和应用
IL302289A (en) * 2020-10-28 2023-06-01 Viracta Subsidiary Inc Hdac inhibitor solid state forms
CN113502265B (zh) * 2021-05-25 2024-05-28 昭泰英基生物医药（香港）有限公司 将t细胞重编程为类nk细胞的诱导剂及其应用
WO2023003972A1 (en) * 2021-07-21 2023-01-26 Viracta Subsidiary, Inc. Cancer treatment combinations
WO2023247770A1 (en) * 2022-06-23 2023-12-28 Eximmium Biotechnologies Gmbh Treatment or prevention of a medical condition associated with a herpes virus infection
WO2024254774A1 (zh) * 2023-06-14 2024-12-19 香港北恒生物科技有限公司 免疫细胞联合疗法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015010096A1 (en) 2013-07-18 2015-01-22 Baylor College Of Medicine Method of enhancing potency of immune cells
WO2016109668A1 (en) 2014-12-31 2016-07-07 Anthrogenesis Corporation Methods of treating hematological disorders, solid tumors, or infectious diseases using natural killer cells

Family Cites Families (158)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3471513A (en) 1966-11-01 1969-10-07 Searle & Co 2-(2-carboxyethyl)-5-phenyl-1-pyrrole-butyric acid and congeners
BE789077A (fr) 1971-09-22 1973-01-15 Nitto Boseki Co Ltd Procede de preparation de derives de pyrimidine
JPS5327252B2 (enExample) 1973-04-17 1978-08-07
US4026895A (en) 1973-09-08 1977-05-31 Eisai Co., Ltd. 1,3-Benzodioxol derivatives
FR2300551A2 (fr) 1975-02-17 1976-09-10 Fabre Sa Pierre Nouveaux
GB1498903A (en) 1974-03-25 1978-01-25 Fabre Sa Pierre Aromatic keto-acids and their derivatives
GB1484413A (en) 1974-04-18 1977-09-01 Kissei Pharmaceutical Aromatic amidocarboxylic acid derivatives
DE2456958A1 (de) 1974-12-03 1976-06-16 Basf Ag 3-(p-biphenylyl)-butyronitril und seine anwendung als arzneimittel
US4031243A (en) 1975-07-03 1977-06-21 Juste, S.A. Quimico-Farmaceutica 2-(4-Isobutyl phenyl)butyric acid, salts thereof, and pharmaceutical compositions containing the same
GB1518764A (en) 1976-03-17 1978-07-26 Soc D Etudes Prod Chimique Isobutyramides their preparation and therapeutic composititions containing them
US4176193A (en) 1977-03-17 1979-11-27 Societe D'etudes De Produits Chimiques Therapeutic isobutyramides
US4732914A (en) 1978-02-13 1988-03-22 The Upjohn Company Prostacyclin analogs
US4234599A (en) 1978-10-04 1980-11-18 Scott Eugene J Van Treatment of skin keratoses with α-hydroxy acids and related compounds
FR2508797B1 (fr) 1981-07-03 1986-03-14 Charles Chany Medicament comprenant le produit de la reaction d'un acide carboxylique en c1 a c6 sur un amino-acide basique
US4704402A (en) 1982-06-12 1987-11-03 University Of Pittsburgh Method of treating sickle cell anemia
GB2126082A (en) 1982-08-12 1984-03-21 Heinrich Schulze Pharmaceutical preparations having analgetic and cytostatic activity
US4894364A (en) 1983-10-26 1990-01-16 Greer Sheldon B Method and materials for sensitizing neoplastic tissue to radiation
US4851229A (en) 1983-12-01 1989-07-25 Alza Corporation Composition comprising a therapeutic agent and a modulating agent
US4671901A (en) 1984-01-26 1987-06-09 Oral-D Orally effective ion chelators
CA1249968A (en) 1984-04-05 1989-02-14 Kazuo Kigasawa Ointment base
US4747825A (en) 1984-06-29 1988-05-31 Ferring Laboratories, Inc. Apparatus and methodology for pulsed administration of growth promoting agents
US4613616A (en) 1984-07-20 1986-09-23 Research Corporation Polymeric iron chelators
JPS61155358A (ja) 1984-12-21 1986-07-15 Suntory Ltd ジアリール酪酸誘導体
JPS61180740A (ja) 1985-02-05 1986-08-13 Asahi Chem Ind Co Ltd 新規なフエニル酢酸又はフエニルチオ酢酸誘導体とそれを有効成分とする植物生育調節剤
US4735967A (en) 1985-05-28 1988-04-05 Neesby Torben E Method for desensitizing the gastrointestinal tract from food allergies
DE3534743A1 (de) 1985-09-28 1987-04-02 Beiersdorf Ag Hydrocortisondiester enthaltende o/w-creme
GB8607683D0 (en) 1986-03-27 1986-04-30 Ici Plc Anti-tumor agents
US4751244A (en) 1986-04-04 1988-06-14 Merck & Co., Inc. Compounds useful in treating sickle cell anemia
US4731381A (en) 1986-04-04 1988-03-15 Merck & Co., Inc. Method of treating a person for sickle cell anemia
US4699926A (en) 1986-04-04 1987-10-13 Merck & Co., Inc. Compounds useful in treating sickle cell anemia
US4948592A (en) 1986-05-09 1990-08-14 Alza Corporation Pulsed drug delivery
US4723958A (en) 1986-05-23 1988-02-09 Merck & Co., Inc. Pulsatile drug delivery system
US4822821A (en) 1986-10-10 1989-04-18 Children's Hospital Medical Center Of Northern California Method for augmenting fetal hemoglobin
US5025029A (en) 1986-10-10 1991-06-18 Children's Hospital Medical Center Of Northern California Method for augmenting fetal hemoglobin
US4965251A (en) 1987-04-03 1990-10-23 The Board Of Regents Of The University Of Washington Pulse treatment of hemoglobinopathies with erythropoietin
US4853388A (en) 1987-05-15 1989-08-01 Pearlman Dale L Method for treating psoriasis with cytotoxic agents
US4820711A (en) 1987-05-15 1989-04-11 Pearlman Dale L Method for treating actinic keratosis with cytotoxic agents
US4849426A (en) 1987-05-15 1989-07-18 Pearlman Dale L Method for treating actinic keratosis with cytotoxic agents
FR2633929B2 (fr) 1987-09-25 1995-05-24 Picardie Universite Derives non toxiques de l'acide n-butyrique, presentant des actions therapeutiques retardees
US5032507A (en) 1987-11-13 1991-07-16 The Salk Institute For Biological Studies Potentiation of erythropoiesis
DE3742222A1 (de) 1987-12-12 1989-06-22 Basf Ag (2r)-aryloxy-3-n-butyroyloxy-propan-2-ole
US4880624A (en) 1988-03-18 1989-11-14 The Board Of Trustees Of The University Of Illinois Volatile attractants for diabrotica species
GB8912700D0 (en) 1989-06-02 1989-07-19 Shell Int Research Herbicidal compounds
DE68914197T2 (de) 1988-06-20 1994-11-10 Ihara Chemical Ind Co Alkansäurederivate und herbizide Mittel.
US4958592A (en) 1988-08-22 1990-09-25 General Electric Company Resistance heater for diamond production by CVD
US4925873A (en) 1988-09-01 1990-05-15 E. R. Squibb & Sons, Inc. Method of treating skin injuries using thromboxane A2 receptor antagonists
US4997815A (en) 1988-11-01 1991-03-05 Children's Hospital Medical Center Of Northern California Method for augmenting fetal hemoglobin by treatment with activin and/or inhibin
US5137734A (en) 1989-03-22 1992-08-11 Dana Farber Cancer Institute Angiogenic monoglycerides
US5039703A (en) 1989-11-16 1991-08-13 Breuer Richard I Method for treating inflammatory bowel disorders
GB8929070D0 (en) 1989-12-22 1990-02-28 Fujisawa Pharmaceutical Co Peptide compounds,processes for preparation thereof and pharmaceutical composition comprising the same
US5674898A (en) 1990-03-05 1997-10-07 Genzyme Corporation Methods and therapeutic compositions for treating cystic fibrosis
US5258367A (en) 1990-06-29 1993-11-02 University Of Florida Uteroferrin and rose proteins for stimulating hematopoietic cells
US5216004A (en) 1990-09-13 1993-06-01 Children's Hospital Medical Center Of North California Method for preventing malaria
US5100647A (en) 1990-10-02 1992-03-31 The Trustees Of The University Of Pennsylvania Method and formulations for the therapy of cystic fibrosis, Bartter's syndrome and secretory diarrheas, and for diuretic treatment
US5674912A (en) 1991-03-01 1997-10-07 Warner-Lambert Company Sunscreen-wound healing compositions and methods for preparing and using same
US5851828A (en) 1991-03-07 1998-12-22 The General Hospital Corporation Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells
US5270458A (en) 1991-04-02 1993-12-14 The Trustees Of Princeton University Nucleic acids encoding fragments of hematopoietic stem cell receptor flk-2
US5199942A (en) 1991-06-07 1993-04-06 Immunex Corporation Method for improving autologous transplantation
US5635532A (en) 1991-10-21 1997-06-03 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Compositions and methods for therapy and prevention of pathologies including cancer, AIDS and anemia
EP0567613B1 (en) 1991-10-21 2002-02-20 The Government of the United States of America, as represented by the Secretary, Department of Health and Human Services Compositions for therapy and prevention of cancer
US5605930A (en) 1991-10-21 1997-02-25 The United States Of America As Represented By The Department Of Health And Human Services Compositions and methods for treating and preventing pathologies including cancer
DE69327432T2 (de) 1992-02-07 2000-05-18 Kaken Pharmaceutical Co., Ltd. Heilmittel für wunden und hämorrhoiden
CA2090283A1 (en) 1992-02-28 1993-08-29 Nobuyuki Hamanaka Phenoxyacetic acid derivatives
US5366996A (en) 1992-12-07 1994-11-22 Elford Howard L Method of treating hemoglobinopathies
US5403590A (en) 1992-12-21 1995-04-04 New England Deaconess Hospital Corporation Method of pulsatile drug infusion
WO1995011699A1 (en) 1993-10-29 1995-05-04 The Trustees Of Boston University Physiologically stable compositions of butyric acid, and butyric acid salts and derivatives as anti-neoplastic agents
US5827642A (en) 1994-08-31 1998-10-27 Fred Hutchinson Cancer Research Center Rapid expansion method ("REM") for in vitro propagation of T lymphocytes
US6011000A (en) 1995-03-03 2000-01-04 Perrine; Susan P. Compositions for the treatment of blood disorders
AU6714396A (en) 1995-07-28 1997-02-26 Trustees Of Boston University Methods and compositions for treating cell proliferative disorders
US5763488A (en) 1995-10-30 1998-06-09 Vertex Pharmaceuticals Incorporated Methods and compositions using butyrate esters of threitol
ATE476496T1 (de) 1996-03-04 2010-08-15 Calyx Bio Ventures Inc Modifizierte schnellvermehrungsmethode ('modified-rem') zur in vitro vermehrung von t-lymphozyten
WO1997037004A1 (en) 1996-03-30 1997-10-09 Boehringer Mannheim Gmbh Method for the production of activated marked tumor-specific t cells and use thereof in treatment of tumors
US6403647B1 (en) 1996-07-26 2002-06-11 Susan P. Perrine Pulsed administration of compositions for the treatment of blood disorders
US6197743B1 (en) 1996-07-26 2001-03-06 The Trustees Of Boston University Compositions and methods for the treatment of viral disorders
EP2298350A3 (en) 1996-07-26 2011-06-08 Susan P. Perrine Composition comprising an inducing agent and an anti-viral agent for the treatment of viral disorders
US5939456A (en) 1996-07-26 1999-08-17 Perrine; Susan P. Pulsed administration of compositions for the treatment of blood disorders
US6043389A (en) 1997-03-11 2000-03-28 Mor Research Applications, Ltd. Hydroxy and ether-containing oxyalkylene esters and uses thereof
US6030961A (en) 1997-03-11 2000-02-29 Bar-Ilan Research & Development Co., Ltd. Oxyalkylene phosphate compounds and uses thereof
US5932545A (en) 1997-03-17 1999-08-03 Abbott Laboratories Antiangiogenic drug to treat cancer, arthritis and retinopathy
US6231880B1 (en) 1997-05-30 2001-05-15 Susan P. Perrine Compositions and administration of compositions for the treatment of blood disorders
CA2324426A1 (en) 1998-02-11 1999-08-19 Douglas V. Faller Compositions and methods for the treatment of cystic fibrosis
US7541184B2 (en) 2000-02-24 2009-06-02 Invitrogen Corporation Activation and expansion of cells
US20030134341A1 (en) 2001-09-19 2003-07-17 Medcell Biologics, Llc. Th1 cell adoptive immunotherapy
US7745140B2 (en) 2002-01-03 2010-06-29 The Trustees Of The University Of Pennsylvania Activation and expansion of T-cells using an engineered multivalent signaling platform as a research tool
US8946295B2 (en) 2002-07-25 2015-02-03 Sunny Pharmtech Inc. Histone hyperacetylating agents for promoting wound healing and preventing scar formation
DE602005016683D1 (de) 2004-07-10 2009-10-29 Fox Chase Cancer Ct Genetisch modifizierte, menschliche, natürliche killerzellenlinien:
WO2006017214A2 (en) 2004-07-12 2006-02-16 Merck & Co., Inc. Inhibitors of histone deacetylase
US20060069060A1 (en) 2004-09-27 2006-03-30 Sanjeev Redkar Salts of decitabine
US7135833B2 (en) * 2004-11-30 2006-11-14 Rockwell Automation Technologies, Inc. Motor control for flux-reduced braking
FR2881746B1 (fr) 2005-02-07 2007-04-13 Centre Nat Rech Scient Epitopes t cd4+des antigenes de latence de type i et ii du virus epstein-barr aptes a etre reconnus par la majorite des individus de la population caucasienne et leurs applications
GB0509225D0 (en) 2005-05-05 2005-06-15 Chroma Therapeutics Ltd Inhibitors of enzymatic activity
EP2418278A3 (en) 2005-05-09 2012-07-04 Ono Pharmaceutical Co., Ltd. Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics
GB0510204D0 (en) * 2005-05-19 2005-06-22 Chroma Therapeutics Ltd Enzyme inhibitors
US20080075692A1 (en) 2006-05-09 2008-03-27 Perrine Susan P Methods for treating blood disorders
WO2008028193A2 (en) 2006-09-01 2008-03-06 Pharmion Corporation Colon-targeted oral formulations of cytidine analogs
GB0619753D0 (en) 2006-10-06 2006-11-15 Chroma Therapeutics Ltd Enzyme inhibitors
CN103275067B (zh) 2006-10-28 2015-09-02 梅特希尔基因公司 组蛋白脱乙酰酶抑制剂
JP5043120B2 (ja) 2006-10-30 2012-10-10 クロマ セラピューティクス リミテッド ヒストンデアセチラーゼの阻害剤としてのヒドロキサメート
WO2008097654A1 (en) 2007-02-08 2008-08-14 Merck & Co., Inc. Methods of using saha for treating hiv infection
WO2009067453A1 (en) 2007-11-19 2009-05-28 Syndax Pharmaceuticals, Inc. Combinations of hdac inhibitors and proteasome inhibitors
US8383099B2 (en) 2009-08-28 2013-02-26 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Adoptive cell therapy with young T cells
WO2011038224A1 (en) 2009-09-24 2011-03-31 Trustees Of Boston University Methods for treating viral disorders
US8491927B2 (en) 2009-12-02 2013-07-23 Nimble Epitech, Llc Pharmaceutical composition containing a hypomethylating agent and a histone deacetylase inhibitor
MA33899B1 (fr) 2009-12-08 2013-01-02 Hemaquest Pharmaceuticals Inc Procedes et regimes a faible dose pour des troubles des globules rouges
WO2011113013A2 (en) 2010-03-11 2011-09-15 Hemaquest Pharmaceuticals, Inc. Methods and compositions for treating viral or virally-induced conditions
PH12013501201A1 (en) 2010-12-09 2013-07-29 Univ Pennsylvania Use of chimeric antigen receptor-modified t cells to treat cancer
WO2012099973A2 (en) 2011-01-18 2012-07-26 The Trustees Of The University Of Pennsylvania Compositions and methods for treating cancer
WO2012120262A1 (en) 2011-03-09 2012-09-13 Larsson Pia Compounds and methods for improving impaired endogenous fibrinolysis using histone deacetylase inhibitors
EP3381454A1 (en) 2011-09-02 2018-10-03 Syndax Pharmaceuticals Inc. Methods for the treatment of breast cancer
EP2755648B1 (en) 2011-09-13 2017-03-08 Pharmacyclics LLC Formulations of histone deacetylase inhibitor in combination with bendamustine and uses thereof
US9708384B2 (en) 2011-09-22 2017-07-18 The Trustees Of The University Of Pennsylvania Universal immune receptor expressed by T cells for the targeting of diverse and multiple antigens
EP2763670B1 (en) 2011-10-03 2018-12-05 Universite Libre De Bruxelles Reactivation of hiv-1 gene expression to treat persistent hiv infection
CN102391359B (zh) 2011-11-17 2014-07-16 南京优科生物医药研究有限公司 组蛋白去乙酰化酶抑制剂及其合成方法和制药用途
BR112014013709A2 (pt) * 2011-12-08 2017-08-22 Fund Sales Métodos, composições farmaceuticas, e kits, para tratar cânceres resitentes às antiprogestinas
WO2013110280A1 (en) 2012-01-27 2013-08-01 Aarhus Universitet Panobinostat for use in the treatment of hiv-1
US20150099012A1 (en) 2012-03-02 2015-04-09 Erasmus University Medical Center Rotterdam Methods for activating retrovirus in latent infected cells, and compounds for use therein
WO2013149026A2 (en) 2012-03-30 2013-10-03 The Johns Hopkins University Use of n-(4-((3-(2-amino-4-pyrimidinyl) -2-pyridinyl)oxy)phenyl)-4-(4-methyl -2-thienyl)-1-phthalazinamine in combination with histone deacetylase inhibitors for treatment of cancer
JP6431478B2 (ja) 2012-06-01 2018-11-28 ドレクセル ユニバーシティ Ｂ型肝炎ウイルスのｃｃｃｄｎａの転写の調節
CN102793693A (zh) 2012-09-07 2012-11-28 天津医科大学 伏立诺他在制备治疗自身免疫及炎症性疾病药物方面的应用
US9415070B2 (en) 2012-11-09 2016-08-16 Massachusetts Institute Of Technology Methods and compositions for localized delivery of agents to virally infected cells and tissues
BR112015021576A2 (pt) 2013-03-15 2017-10-10 Dana Farber Cancer Inst Inc peptídeos terapêuticos
CN103232474A (zh) 2013-04-16 2013-08-07 中国药科大学 组蛋白去乙酰化酶抑制剂
WO2015095410A1 (en) 2013-12-17 2015-06-25 Genentech, Inc. Methods of treating cancer using pd-1 axis binding antagonists and an anti-cd20 antibody
KR102313381B1 (ko) 2013-12-19 2021-10-14 퓨어테인 바이오사이언스, 엘엘씨. 동물을 치료하기 위한 방법
JOP20200096A1 (ar) * 2014-01-31 2017-06-16 Children’S Medical Center Corp جزيئات جسم مضاد لـ tim-3 واستخداماتها
US20150320754A1 (en) 2014-04-16 2015-11-12 Infinity Pharmaceuticals, Inc. Combination therapies
CN104083763A (zh) 2014-07-16 2014-10-08 中国人民解放军军事医学科学院野战输血研究所 组蛋白去乙酰化酶抑制剂在制备潜伏病毒激活剂中的应用
RU2555474C1 (ru) 2014-09-09 2015-07-10 Государственное бюджетное образовательное учреждение высшего профессионального образования "Ростовский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ГБОУ ВПО РостГМУ Минздрава России) Способ лечения эпштейна-барр вирусной инфекции у детей с вич-инфекцией
US10813952B2 (en) * 2014-11-14 2020-10-27 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services NK cells with an increased antibody-dependent cellular toxicity (ADCC) against tumors
TWI595006B (zh) * 2014-12-09 2017-08-11 禮納特神經系統科學公司 抗ｐｄ－１抗體類和使用彼等之方法
WO2016153839A1 (en) 2015-03-20 2016-09-29 Merck Sharp & Dohme Corp. Combination of a pd-1 antagonist and vorinostat for treating cancer
US20170021002A1 (en) * 2015-05-18 2017-01-26 Batu Biologics, Inc. Augmentation of cancer and cancer endothelial vaccine immunogenicity by histone deacetylase inhibitors
CN107708741A (zh) * 2015-06-12 2018-02-16 免疫医疗公司 用嵌合抗原受体(car)构建体和表达car构建体的t细胞(car‑t)或nk细胞(car‑nk)进行的疾病疗法
EP3310168B1 (en) 2015-06-19 2024-08-21 Trustees of Boston University Combinations of a nucleoside analog and an inducing agent for use in treating herpesvirus-induced conditions
SMT202100131T1 (it) * 2015-07-14 2021-05-07 Bristol Myers Squibb Co Metodo di trattamento di un cancro usando un inibitore di checkpoint immunitari; anticorpo che si lega al recettore della morte programmata-1 (pd-1) o al ligando della morte programmata 1 (pd-l1)
CN105055386A (zh) 2015-08-12 2015-11-18 天津医科大学总医院 伏立诺他用于制备免疫调节药物的应用
EP3345002A4 (en) 2015-09-02 2019-05-08 Syndax Pharmaceuticals Inc. SELECTION OF PATIENTS FOR COMBINATION THERAPY
WO2017053823A1 (en) 2015-09-25 2017-03-30 Pharmacyclics Llc Treatment using hdac inhibitors and immunotherapy
ITUB20155193A1 (it) 2015-11-03 2017-05-03 Italfarmaco Spa Sospensioni orali di Givinostat fisicamente e chimicamente stabili
JP2018537536A (ja) * 2015-12-09 2018-12-20 ナント ホールディングス アイピー エルエルシーＮａｎｔ Ｈｏｌｄｉｎｇｓ ＩＰ， ＬＬＣ Ｈｅｒ２陽性転移性乳癌の治療のための組成物および方法
US20190183870A1 (en) 2016-01-05 2019-06-20 The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services Combination of histone deacetylase inhibitor and immunotherapy
CN105647946B (zh) * 2016-03-18 2019-09-20 江苏普瑞康生物医药科技有限公司 一种基于FcγRⅢa的嵌合基因及其用途
TWI808055B (zh) * 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
EA201892587A1 (ru) 2016-05-20 2019-04-30 Биохэйвен Фармасьютикал Холдинг Компани Лтд. Использование глутамат-модулирующих средств вместе с иммунотерапией для лечения рака
CN116376812A (zh) 2016-05-25 2023-07-04 国家医疗保健研究所 治疗癌症的方法和组合物
CN109789190A (zh) * 2016-06-30 2019-05-21 河谷控股Ip有限责任公司 Nant癌症疫苗
CN109715173A (zh) 2016-07-15 2019-05-03 维拉克塔治疗公司 供基于nk细胞的疗法使用的hdac抑制剂
EP3532077A4 (en) * 2016-10-28 2020-06-10 Nant Holdings IP, LLC Avatar dendritic cells: the neoantigen natural killer t-cell chemo immuno radiation composition inducing immunogenic cell death
US10799536B2 (en) * 2016-12-09 2020-10-13 Onk Therapeutics Limited Method of treating multiple myeloma using natural killer cells expressing a chimeric antigen receptor for CD38
US20200270574A1 (en) * 2017-09-29 2020-08-27 Nantcell, Inc. CD1d and TCR-NKT Cells
TW201922282A (zh) 2017-10-13 2019-06-16 大陸商江蘇恆瑞醫藥股份有限公司 Ｐｄ-１抗體和表觀遺傳調節劑聯合在製備治療腫瘤的藥物中的用途
US11756651B2 (en) * 2018-01-04 2023-09-12 Nantomics Llc Method of treating a tumor in a patient based on an immune gene expression
US20200368280A1 (en) 2018-01-12 2020-11-26 Viracta Therapeutics, Inc. Epigenetic modifiers for use in cellular immunotherapy
CN112533613A (zh) 2018-02-06 2021-03-19 通用医疗公司 作为肿瘤免疫应答的生物标志物的重复rna
WO2019195420A1 (en) * 2018-04-04 2019-10-10 Nant Holding IP, LLC Advanced avartar dendritic cells
US11823773B2 (en) * 2018-04-13 2023-11-21 Nant Holdings Ip, Llc Nant cancer vaccine strategies
WO2023003972A1 (en) 2021-07-21 2023-01-26 Viracta Subsidiary, Inc. Cancer treatment combinations

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015010096A1 (en) 2013-07-18 2015-01-22 Baylor College Of Medicine Method of enhancing potency of immune cells
WO2016109668A1 (en) 2014-12-31 2016-07-07 Anthrogenesis Corporation Methods of treating hematological disorders, solid tumors, or infectious diseases using natural killer cells

Also Published As

Publication number Publication date
EP3484489A4 (en) 2020-04-01
GB2567093A (en) 2019-04-03
GB201901327D0 (en) 2019-03-20
EP4596053A2 (en) 2025-08-06
GB2567362B (en) 2022-04-20
GB201901338D0 (en) 2019-03-20
CN109803661A (zh) 2019-05-24
EP3484478A1 (en) 2019-05-22
JP2022088404A (ja) 2022-06-14
JP7373991B2 (ja) 2023-11-06
US20230149413A1 (en) 2023-05-18
EP3484489B1 (en) 2025-06-18
GB2567362A (en) 2019-04-10
CN109715173A (zh) 2019-05-03
US12427152B2 (en) 2025-09-30
WO2018013962A1 (en) 2018-01-18
US20190290646A1 (en) 2019-09-26
WO2018013975A1 (en) 2018-01-18
EP3484478B1 (en) 2025-11-05
JP2019525957A (ja) 2019-09-12
EP3484478A4 (en) 2020-04-01
EP3484489A1 (en) 2019-05-22
JP2019522054A (ja) 2019-08-08
EP4650005A2 (en) 2025-11-19
US20190216818A1 (en) 2019-07-18
EP4596053A3 (en) 2025-10-15

Similar Documents

Publication Publication Date Title
JP7158104B2 (ja) Ｎｋ細胞ベースの療法で使用するためのｈｄａｃ阻害剤
Haines et al. ONCR-177, an oncolytic HSV-1 designed to potently activate systemic antitumor immunity
JP7654708B2 (ja) がんを治療するための、腫瘍溶解性ウイルスの単独又はチェックポイント阻害剤との組み合わせでの使用
León et al. Prolonged antigen presentation by immune complex–binding dendritic cells programs the proliferative capacity of memory CD8 T cells
JP2019531722A (ja) ウイルス特異的ｔ細胞の活性化および拡大のためのプラットフォーム
EP3217993A1 (en) Treatment of cancer by infusion of oncolytic herpes simplex virus to the blood
Dasari et al. Prophylactic and therapeutic strategies for Epstein–Barr virus-associated diseases: emerging strategies for clinical development
Ding et al. New biologic therapy for systemic lupus erythematosus
KR20170095270A (ko) 안정한 동결된 단순 포진 바이러스 제제
AU2011295845A1 (en) EBV-specific cytotoxic T-lymphocytes for the treatment of locoregional nasopharyngeal carcinoma (NPC)
US20200368280A1 (en) Epigenetic modifiers for use in cellular immunotherapy
HK40007642A (en) Hdac inhibitors for use with nk cell based therapies
HK40007642B (en) Hdac inhibitors for use with nk cell based therapies
WO2023102328A2 (en) Treatment of cd30-positive cancer
Heckman et al. Retraction: Fast‐tracked CTL: Rapid induction of potent anti‐tumor killer T cells in situ
Burchett et al. A universal boosting strategy for adoptive T cell therapy using a paired vaccine/chimeric antigen receptor
Fresnay et al. Bone marrow vaccination: A novel approach to enhance antigen specific antitumor immunity
Bhatt Therapy for B-cell Lymphoma

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20190408

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20200622

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20200625

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20200626

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20210628

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20210927

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20211223

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20220207

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20220502

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20220817

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20220912

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20221004

R150 Certificate of patent or registration of utility model

Ref document number: 7158104

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250