JP7149076B2 - ブルトン型チロシンキナーゼ阻害剤の薬学的製剤 - Google Patents

ブルトン型チロシンキナーゼ阻害剤の薬学的製剤 Download PDF

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JP7149076B2
JP7149076B2 JP2017541753A JP2017541753A JP7149076B2 JP 7149076 B2 JP7149076 B2 JP 7149076B2 JP 2017541753 A JP2017541753 A JP 2017541753A JP 2017541753 A JP2017541753 A JP 2017541753A JP 7149076 B2 JP7149076 B2 JP 7149076B2
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ibrutinib
tablet formulation
solid tablet
microcrystalline cellulose
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JP2018507200A5 (enExample
JP2018507200A (ja
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アトラリ，ハリシャ
チョン，チン，ワー
キュール，ロバート
タン，ヘオウ
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ファーマサイクリックス エルエルシー
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Inorganic Chemistry (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2017541753A 2015-03-03 2016-03-02 ブルトン型チロシンキナーゼ阻害剤の薬学的製剤 Active JP7149076B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022106400A JP2022141701A (ja) 2015-03-03 2022-06-30 ブルトン型チロシンキナーゼ阻害剤の薬学的製剤
JP2024129576A JP2024170405A (ja) 2015-03-03 2024-08-05 ブルトン型チロシンキナーゼ阻害剤の薬学的製剤

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562127717P 2015-03-03 2015-03-03
US62/127,717 2015-03-03
US201562193518P 2015-07-16 2015-07-16
US62/193,518 2015-07-16
PCT/US2016/020467 WO2016141068A1 (en) 2015-03-03 2016-03-02 Pharmaceutical formulations of bruton's tyrosine kinase inhibtor

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JP2022106400A Division JP2022141701A (ja) 2015-03-03 2022-06-30 ブルトン型チロシンキナーゼ阻害剤の薬学的製剤

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JP2018507200A JP2018507200A (ja) 2018-03-15
JP2018507200A5 JP2018507200A5 (enExample) 2019-04-25
JP7149076B2 true JP7149076B2 (ja) 2022-10-06

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JP2017541753A Active JP7149076B2 (ja) 2015-03-03 2016-03-02 ブルトン型チロシンキナーゼ阻害剤の薬学的製剤
JP2022106400A Pending JP2022141701A (ja) 2015-03-03 2022-06-30 ブルトン型チロシンキナーゼ阻害剤の薬学的製剤
JP2024129576A Pending JP2024170405A (ja) 2015-03-03 2024-08-05 ブルトン型チロシンキナーゼ阻害剤の薬学的製剤

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JP2022106400A Pending JP2022141701A (ja) 2015-03-03 2022-06-30 ブルトン型チロシンキナーゼ阻害剤の薬学的製剤
JP2024129576A Pending JP2024170405A (ja) 2015-03-03 2024-08-05 ブルトン型チロシンキナーゼ阻害剤の薬学的製剤

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US (9) US9655857B2 (enExample)
EP (2) EP3265084B1 (enExample)
JP (3) JP7149076B2 (enExample)
KR (2) KR20250016514A (enExample)
CN (4) CN107427498A (enExample)
AU (4) AU2016226279B2 (enExample)
BR (2) BR122023020985A2 (enExample)
CA (3) CA3177995A1 (enExample)
DK (1) DK3265084T3 (enExample)
ES (1) ES2971597T3 (enExample)
FI (1) FI3265084T3 (enExample)
HR (1) HRP20240231T1 (enExample)
HU (1) HUE065703T2 (enExample)
IL (3) IL315294A (enExample)
LT (1) LT3265084T (enExample)
MD (1) MD3265084T2 (enExample)
MX (5) MX394784B (enExample)
NZ (1) NZ734446A (enExample)
PL (1) PL3265084T3 (enExample)
PT (1) PT3265084T (enExample)
RS (1) RS65234B1 (enExample)
RU (1) RU2017133990A (enExample)
SG (2) SG10202102078VA (enExample)
SI (1) SI3265084T1 (enExample)
SM (1) SMT202400074T1 (enExample)
TW (6) TWI810588B (enExample)
WO (1) WO2016141068A1 (enExample)
ZA (1) ZA201907661B (enExample)

Cited By (1)

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JP2022141701A (ja) * 2015-03-03 2022-09-29 ファーマサイクリックス エルエルシー ブルトン型チロシンキナーゼ阻害剤の薬学的製剤

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US9545407B2 (en) * 2014-08-07 2017-01-17 Pharmacyclics Llc Formulations of a bruton's tyrosine kinase inhibitor
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FI3405177T3 (fi) * 2016-01-19 2026-06-03 Janssen Pharmaceutica Nv Btk:n estäjää käsittäviä formulaatioita/koostumuksia
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