JP7146900B2 - 溶解度が向上したアピゲニンを含む脱毛緩和組成物 - Google Patents
溶解度が向上したアピゲニンを含む脱毛緩和組成物 Download PDFInfo
- Publication number
- JP7146900B2 JP7146900B2 JP2020507990A JP2020507990A JP7146900B2 JP 7146900 B2 JP7146900 B2 JP 7146900B2 JP 2020507990 A JP2020507990 A JP 2020507990A JP 2020507990 A JP2020507990 A JP 2020507990A JP 7146900 B2 JP7146900 B2 JP 7146900B2
- Authority
- JP
- Japan
- Prior art keywords
- apigenin
- hair loss
- composition
- weight
- hair
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000203 mixture Substances 0.000 title claims description 83
- KZNIFHPLKGYRTM-UHFFFAOYSA-N apigenin Chemical compound C1=CC(O)=CC=C1C1=CC(=O)C2=C(O)C=C(O)C=C2O1 KZNIFHPLKGYRTM-UHFFFAOYSA-N 0.000 title claims description 67
- XADJWCRESPGUTB-UHFFFAOYSA-N apigenin Natural products C1=CC(O)=CC=C1C1=CC(=O)C2=CC(O)=C(O)C=C2O1 XADJWCRESPGUTB-UHFFFAOYSA-N 0.000 title claims description 67
- 229940117893 apigenin Drugs 0.000 title claims description 67
- 235000008714 apigenin Nutrition 0.000 title claims description 67
- 201000004384 Alopecia Diseases 0.000 title claims description 57
- 208000024963 hair loss Diseases 0.000 title claims description 57
- 230000003676 hair loss Effects 0.000 title claims description 57
- 230000000116 mitigating effect Effects 0.000 claims description 47
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 41
- 229920005862 polyol Polymers 0.000 claims description 17
- 150000003077 polyols Chemical class 0.000 claims description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- SWQUTKGVXGTROS-UHFFFAOYSA-N bis(2-ethoxyethyl) butanedioate Chemical compound CCOCCOC(=O)CCC(=O)OCCOCC SWQUTKGVXGTROS-UHFFFAOYSA-N 0.000 claims description 9
- 229940119676 diethoxyethyl succinate Drugs 0.000 claims description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 8
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 6
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 4
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 4
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims description 4
- ZXEKIIBDNHEJCQ-UHFFFAOYSA-N isobutanol Chemical compound CC(C)CO ZXEKIIBDNHEJCQ-UHFFFAOYSA-N 0.000 claims description 4
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims description 3
- 230000001256 tonic effect Effects 0.000 claims description 3
- 229940058015 1,3-butylene glycol Drugs 0.000 claims description 2
- DKMROQRQHGEIOW-UHFFFAOYSA-N Diethyl succinate Chemical compound CCOC(=O)CCC(=O)OCC DKMROQRQHGEIOW-UHFFFAOYSA-N 0.000 claims description 2
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- 235000019437 butane-1,3-diol Nutrition 0.000 claims description 2
- 125000004432 carbon atom Chemical group C* 0.000 claims description 2
- 239000000049 pigment Substances 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 239000003755 preservative agent Substances 0.000 claims description 2
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical compound CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 claims description 2
- KWABLUYIOFEZOY-UHFFFAOYSA-N dioctyl butanedioate Chemical compound CCCCCCCCOC(=O)CCC(=O)OCCCCCCCC KWABLUYIOFEZOY-UHFFFAOYSA-N 0.000 claims 1
- 239000002304 perfume Substances 0.000 claims 1
- 239000003921 oil Substances 0.000 description 32
- 230000000052 comparative effect Effects 0.000 description 14
- 238000004519 manufacturing process Methods 0.000 description 14
- 210000004761 scalp Anatomy 0.000 description 8
- 230000000694 effects Effects 0.000 description 5
- 230000003779 hair growth Effects 0.000 description 5
- 238000001556 precipitation Methods 0.000 description 5
- KBPLFHHGFOOTCA-UHFFFAOYSA-N 1-Octanol Chemical compound CCCCCCCCO KBPLFHHGFOOTCA-UHFFFAOYSA-N 0.000 description 4
- 230000008901 benefit Effects 0.000 description 3
- 239000002537 cosmetic Substances 0.000 description 3
- 239000010696 ester oil Substances 0.000 description 3
- 230000007794 irritation Effects 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 2
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 2
- 230000008236 biological pathway Effects 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 229930003935 flavonoid Natural products 0.000 description 2
- 150000002215 flavonoids Chemical class 0.000 description 2
- 235000017173 flavonoids Nutrition 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 235000011090 malic acid Nutrition 0.000 description 2
- 239000001630 malic acid Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000005192 partition Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 description 1
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 description 1
- BJXKHCXZXUPUHC-UHFFFAOYSA-N 4-(2-ethoxyethoxy)-4-oxobutanoic acid Chemical compound CCOCCOC(=O)CCC(O)=O BJXKHCXZXUPUHC-UHFFFAOYSA-N 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- -1 alkyl malate Chemical compound 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 210000004958 brain cell Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- PKPOVTYZGGYDIJ-UHFFFAOYSA-N dioctyl carbonate Chemical compound CCCCCCCCOC(=O)OCCCCCCCC PKPOVTYZGGYDIJ-UHFFFAOYSA-N 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- DLAHAXOYRFRPFQ-UHFFFAOYSA-N dodecyl benzoate Chemical compound CCCCCCCCCCCCOC(=O)C1=CC=CC=C1 DLAHAXOYRFRPFQ-UHFFFAOYSA-N 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 230000003648 hair appearance Effects 0.000 description 1
- 229940124563 hair growth stimulant Drugs 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- XJNUECKWDBNFJV-UHFFFAOYSA-N hexadecyl 2-ethylhexanoate Chemical compound CCCCCCCCCCCCCCCCOC(=O)C(CC)CCCC XJNUECKWDBNFJV-UHFFFAOYSA-N 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 229940049920 malate Drugs 0.000 description 1
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 1
- 229940055577 oleyl alcohol Drugs 0.000 description 1
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000013076 target substance Substances 0.000 description 1
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020170125657A KR102417319B1 (ko) | 2017-09-28 | 2017-09-28 | 용해도가 향상된 아피게닌을 포함하는 탈모 완화 조성물 |
| KR10-2017-0125657 | 2017-09-28 | ||
| PCT/KR2018/010747 WO2019066325A2 (ko) | 2017-09-28 | 2018-09-13 | 용해도가 향상된 아피게닌을 포함하는 탈모 완화 조성물 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020535115A JP2020535115A (ja) | 2020-12-03 |
| JP7146900B2 true JP7146900B2 (ja) | 2022-10-04 |
Family
ID=65903372
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020507990A Active JP7146900B2 (ja) | 2017-09-28 | 2018-09-13 | 溶解度が向上したアピゲニンを含む脱毛緩和組成物 |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JP7146900B2 (zh) |
| KR (1) | KR102417319B1 (zh) |
| CN (1) | CN111194208B (zh) |
| TW (1) | TWI793178B (zh) |
| WO (1) | WO2019066325A2 (zh) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20210142254A (ko) | 2020-05-18 | 2021-11-25 | (주)아모레퍼시픽 | 아피게닌의 용출률이 개선된 식품 조성물 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015120847A (ja) | 2013-12-24 | 2015-07-02 | 花王株式会社 | 吸水性樹脂及びその製造方法 |
| JP2015221761A (ja) | 2014-05-22 | 2015-12-10 | 株式会社 沖縄リサーチセンター | ポリメトキシフラボノイド溶解組成物及びその製造方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060067905A1 (en) * | 2005-04-01 | 2006-03-30 | Sederma Sas | Formulations and method for treating baldness |
| JP5089887B2 (ja) | 2006-01-23 | 2012-12-05 | 日本精化株式会社 | 生理活性物質含有複合体 |
| US8637569B2 (en) * | 2009-10-22 | 2014-01-28 | Api Genesis, Llc | Methods of increasing solubility of poorly soluble compounds and methods of making and using formulations of such compounds |
| ES2766877T3 (es) * | 2012-12-21 | 2020-06-15 | Oreal | Composición cosmética |
| KR102466224B1 (ko) * | 2015-12-02 | 2022-11-10 | 킨지루시 가부시키 가이샤 | 육모ㆍ발모 촉진제 |
| CN107158386A (zh) * | 2017-05-31 | 2017-09-15 | 段新方 | 预防和治疗脱发的药物 |
-
2017
- 2017-09-28 KR KR1020170125657A patent/KR102417319B1/ko active IP Right Grant
-
2018
- 2018-09-13 WO PCT/KR2018/010747 patent/WO2019066325A2/ko active Application Filing
- 2018-09-13 CN CN201880063434.2A patent/CN111194208B/zh active Active
- 2018-09-13 JP JP2020507990A patent/JP7146900B2/ja active Active
- 2018-09-25 TW TW107133678A patent/TWI793178B/zh active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015120847A (ja) | 2013-12-24 | 2015-07-02 | 花王株式会社 | 吸水性樹脂及びその製造方法 |
| JP2015221761A (ja) | 2014-05-22 | 2015-12-10 | 株式会社 沖縄リサーチセンター | ポリメトキシフラボノイド溶解組成物及びその製造方法 |
Non-Patent Citations (1)
| Title |
|---|
| Hair Serum, MINTEL GNPD [ONLINE]， 2015.11，[検索日 2022.03.30]インターネット：<URL:https://www.gnpd.com/sinatra>，(Database accession no.3597873) |
Also Published As
| Publication number | Publication date |
|---|---|
| TW201919591A (zh) | 2019-06-01 |
| TWI793178B (zh) | 2023-02-21 |
| CN111194208B (zh) | 2023-03-31 |
| KR102417319B1 (ko) | 2022-07-06 |
| JP2020535115A (ja) | 2020-12-03 |
| WO2019066325A2 (ko) | 2019-04-04 |
| KR20190036592A (ko) | 2019-04-05 |
| WO2019066325A3 (ko) | 2019-05-23 |
| CN111194208A (zh) | 2020-05-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6528194B2 (ja) | ミノキシジル含有外用液剤および外用液剤の製造方法 | |
| KR101466650B1 (ko) | 폴리올 및 유화제를 포함하는 저 자극 및 고 보습성 수중유형 화장료 조성물 및 그 제조방법 | |
| JP6944878B2 (ja) | 組成物 | |
| US5977188A (en) | Humectant and an endermic liniment | |
| JP3661706B2 (ja) | 皮膚外用剤 | |
| WO2009014327A2 (en) | Liquid body cleanser composition | |
| CN100581533C (zh) | 一种润肤霜及其制备方法 | |
| JP2008120717A (ja) | 化粧用組成物 | |
| JP7146900B2 (ja) | 溶解度が向上したアピゲニンを含む脱毛緩和組成物 | |
| KR101702648B1 (ko) | 피부 외용제용 보존제, 이를 포함하는 화장료 조성물 및 약학 조성물 | |
| KR101956155B1 (ko) | 데아닌 유도체를 함유하는 피부 외용제 조성물 | |
| KR102463133B1 (ko) | 고함량의 우레아를 포함하는 화장료 조성물 | |
| KR20160075356A (ko) | 발한 억제 조성물 | |
| JP2019210250A (ja) | イソペンチルジオールを含有する防腐剤組成物 | |
| EP3226827B2 (en) | Aluminium-free antiperspirant/deodorant compositions and method of preparing the same | |
| US20130323332A1 (en) | Hand and body moisturizing serum | |
| EP2353579B1 (en) | Deodorant composition | |
| KR101301168B1 (ko) | 오일 겔화제로서 트리베헤닌을 포함하는 유중수형 유화메이크업 화장료 조성물 | |
| JP2003073242A (ja) | 脱色剤組成物及び染毛剤組成物 | |
| Askarov et al. | Chemical composition of deonica dezodorant | |
| KR102223208B1 (ko) | 백탁현상이 방지되는 주름 개선용 화장료 조성물 | |
| JP5154283B2 (ja) | 皮膚外用剤 | |
| JP2008184395A (ja) | 制汗・消臭化粧料およびその製造方法 | |
| BR102019027804A2 (pt) | composição antitranspirante, uso cosmético e método de aplicação da mesma | |
| DE102014213228A1 (de) | Schweißhemmende kosmetische Mittel mit speziellen Proteinen aus Süßgräsern der Gattung Triticum und/oder Oryza und/oder Avena, welche keine Halogenide und/oder Hydroxyhalogenide von Aluminium und/oder Zirconium enthalten |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20210624 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20220224 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20220405 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20220615 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20220913 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20220921 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 7146900 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |