JP7109132B2 - スルホラファン及び/又はスルホラファン前駆体を含有してなるブロッコリー抽出物または粉末を含む組成物 - Google Patents
スルホラファン及び/又はスルホラファン前駆体を含有してなるブロッコリー抽出物または粉末を含む組成物 Download PDFInfo
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- JP7109132B2 JP7109132B2 JP2020168976A JP2020168976A JP7109132B2 JP 7109132 B2 JP7109132 B2 JP 7109132B2 JP 2020168976 A JP2020168976 A JP 2020168976A JP 2020168976 A JP2020168976 A JP 2020168976A JP 7109132 B2 JP7109132 B2 JP 7109132B2
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- sulforaphane
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- milk thistle
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Description
グルコラファニン含有ブロッコリー抽出物(約12重量%)、50mg~5g、
ミロシナーゼ含有凍結乾燥ブロッコリースプラウト粉末、25mg~500mg
アスコルビン酸、5mg~500mg
オオアザミ抽出物(約20重量%~35重量%シリビニン)、25mg~5g
カラム:Waters社BEHアミド、1.7μm粒径;2.1mm×100mm
移動相:20%の10mM酢酸アンモニウム、pH5.0;80%アセトニトリル;
分離モード:イソクラティック
カラム温度:70℃
流速:0.7ml/分
上記の条件によって、スルホラファン前駆体、グルコラファニンを含めた5種の典型的なアブラナ科グルコシノレート分離が可能となる。
Claims (11)
- 直腸癌または結腸癌を治療、予防し、その発生を低減し、その症状を減少させ、その二次再発を低減させるための経口投与可能な薬剤組成物であって、有効成分として、
スルホラファンおよび/またはスルホラファン前駆体を含有してなるブロッコリー抽出物または粉末と、そして
シリマリン及び/又はシリビニンを含有してなるオオアザミ抽出物または粉末と、
の組合せからなり、これら有効成分相互間の相乗作用が発現される量で前記ブロッコリー抽出物または粉末及び前記オオアザミ抽出物または粉末が配合された経口投与可能な薬剤組成物。
- 腸溶コーティング剤または錠剤である請求項1に記載の薬剤組成物。
- シリマリンを含むオオアザミ抽出物を含む請求項1に記載の経口投与可能な薬剤組成物。
- シリビニンを含むオオアザミ抽出物を含む請求項1に記載の経口投与可能な薬剤組成物。
- ケルセチン、アミノ糖、グリコサミノグリカン、アボカド/ダイズ不けん化物、ビタミン、コーヒー果実、マグネシウム、シリマリン、プロアントシアニジン、ウルソール酸、クルクミン、フィトステロール、フィトスタノールおよびS‐アデノシルメチオニン(SAMe)からなる群から選択される1種以上のさらなる成分をさらに含む、請求項1に記載の経口投与可能な薬剤組成物。
- 肝臓癌、前立腺癌、脳腫瘍、肺癌、腎臓癌、結腸癌、乳癌、食道癌、膵臓癌または卵巣癌の一つの癌またはそれ以上の癌を治療、予防し、その発症を低減し、その症状を減少させ、及び/又はその二次再発を低減するための経口投与可能な薬剤組成物であって、有効成分として、スルホラファンおよび/またはスルホラファン前駆体を含有してなるブロッコリー抽出物または粉末と、そしてシリマリン及び/ 又はシリビニンを含有してなるオオアザミ抽出物または粉末との組合せからなり、これら有効成分相互間の相乗作用が発現される量で前記ブロッコリー抽出物または粉末及び前記オオアザミ抽出物または粉末が配合された経口投与可能な薬剤組成物。
- グルタチオンレベルを増大させるための経口投与可能な薬剤組成物であって、有効成分として、スルホラファンおよび/またはスルホラファン前駆体を含有してなるブロッコリー抽出物または粉末と、そしてシリマリン及び/ 又はシリビニンを含有してなるオオアザミ抽出物または粉末との組合せからなり、これら有効成分相互間の相乗作用が発現される量で前記ブロッコリー抽出物または粉末及び前記オオアザミ抽出物または粉末が配合された経口投与可能な薬剤組成物。
- 非アルコール性脂肪性肝疾患(NAFLD)を治療、予防し、その発生を低減し、その症状を減少させ、及び/又はその二次再発を低減させるための経口投与可能な薬剤組成物であって、有効成分として、スルホラファンおよび/またはスルホラファン前駆体を含有してなるブロッコリー抽出物または粉末と、そしてシリマリン及び/又はシリビニンを含有してなるオオアザミ抽出物または粉末との組合せからなり、これら有効成分相互間の相乗作用が発現される量で前記ブロッコリー抽出物または粉末及び前記オオアザミ抽出物または粉末が配合された経口投与可能な薬剤組成物。
- シリマリンを含有してなるオオアザミ抽出物を含む請求項8に記載の経口投与可能な薬剤組成物。
- シリビニンを含有してなるオオアザミ抽出物を含む請求項8に記載の経口投与可能な薬剤組成物。
- ケルセチン、アミノ糖、グリコサミノグリカン、アボカド/ダイズ不けん化物、ビタミン、コーヒー果実、マグネシウム、シリマリン、プロアントシアニジン、ウルソール酸、クルクミン、フィトステロールおよびフィトスタノールからなる群から選択される1種以上のさらなる成分をさらに含む、請求項8に記載の経口投与可能な薬剤組成物。
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US201261668342P | 2012-07-05 | 2012-07-05 | |
US201261668386P | 2012-07-05 | 2012-07-05 | |
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US61/668,342 | 2012-07-05 | ||
US61/668,386 | 2012-07-05 | ||
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JP2022022783A Pending JP2022059053A (ja) | 2012-07-05 | 2022-02-17 | グルコラファニンまたはスルホラファンおよびキノコ抽出物または粉末を含む組成物 |
JP2022113426A Active JP7458443B2 (ja) | 2012-07-05 | 2022-07-14 | スルホラファン及び/又はスルホラファンの誘導体及びオオアザミ抽出物又は粉末を含む組成物 |
JP2023208549A Pending JP2024023619A (ja) | 2012-07-05 | 2023-12-11 | スルホラファン前駆体のスルホラファンへの変換を促進する方法 |
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