RU2018130094A - Композиции, содержащие сульфорафан или предшественник сульфорафана и экстракт или порошок молочного чертополоха - Google Patents
Композиции, содержащие сульфорафан или предшественник сульфорафана и экстракт или порошок молочного чертополоха Download PDFInfo
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- 239000000203 mixture Substances 0.000 title claims 12
- 239000000284 extract Substances 0.000 title claims 6
- SUVMJBTUFCVSAD-UHFFFAOYSA-N sulforaphane Chemical compound CS(=O)CCCCN=C=S SUVMJBTUFCVSAD-UHFFFAOYSA-N 0.000 title claims 5
- 235000013365 dairy product Nutrition 0.000 title 1
- 206010009944 Colon cancer Diseases 0.000 claims 8
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims 8
- 239000011885 synergistic combination Substances 0.000 claims 8
- 238000000034 method Methods 0.000 claims 7
- SEBFKMXJBCUCAI-UHFFFAOYSA-N NSC 227190 Natural products C1=C(O)C(OC)=CC(C2C(OC3=CC=C(C=C3O2)C2C(C(=O)C3=C(O)C=C(O)C=C3O2)O)CO)=C1 SEBFKMXJBCUCAI-UHFFFAOYSA-N 0.000 claims 6
- SEBFKMXJBCUCAI-HKTJVKLFSA-N silibinin Chemical compound C1=C(O)C(OC)=CC([C@@H]2[C@H](OC3=CC=C(C=C3O2)[C@@H]2[C@H](C(=O)C3=C(O)C=C(O)C=C3O2)O)CO)=C1 SEBFKMXJBCUCAI-HKTJVKLFSA-N 0.000 claims 6
- 235000011299 Brassica oleracea var botrytis Nutrition 0.000 claims 5
- 235000017647 Brassica oleracea var italica Nutrition 0.000 claims 5
- 240000003259 Brassica oleracea var. botrytis Species 0.000 claims 5
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 4
- 108010024636 Glutathione Proteins 0.000 claims 4
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 claims 4
- 208000029742 colonic neoplasm Diseases 0.000 claims 4
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 claims 4
- 239000002552 dosage form Substances 0.000 claims 4
- 229960003180 glutathione Drugs 0.000 claims 4
- 229940096421 milk thistle extract Drugs 0.000 claims 4
- 235000020727 milk thistle extract Nutrition 0.000 claims 4
- 239000000843 powder Substances 0.000 claims 4
- 229950000628 silibinin Drugs 0.000 claims 4
- 235000014899 silybin Nutrition 0.000 claims 4
- RUQCCAGSFPUGSZ-OBWQKADXSA-N Glucoraphanin Natural products C[S@](=O)CCCCC(=NS(=O)(=O)O)S[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O RUQCCAGSFPUGSZ-OBWQKADXSA-N 0.000 claims 3
- GMMLNKINDDUDCF-JRWRFYLSSA-N [(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] (1e)-5-[(r)-methylsulfinyl]-n-sulfooxypentanimidothioate Chemical compound C[S@@](=O)CCCC\C(=N/OS(O)(=O)=O)S[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O GMMLNKINDDUDCF-JRWRFYLSSA-N 0.000 claims 3
- WCGUUGGRBIKTOS-GPOJBZKASA-N (3beta)-3-hydroxyurs-12-en-28-oic acid Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CC[C@@H](C)[C@H](C)[C@H]5C4=CC[C@@H]3[C@]21C WCGUUGGRBIKTOS-GPOJBZKASA-N 0.000 claims 2
- SUVMJBTUFCVSAD-JTQLQIEISA-N 4-Methylsulfinylbutyl isothiocyanate Natural products C[S@](=O)CCCCN=C=S SUVMJBTUFCVSAD-JTQLQIEISA-N 0.000 claims 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 2
- 240000007154 Coffea arabica Species 0.000 claims 2
- 235000007460 Coffea arabica Nutrition 0.000 claims 2
- 235000010469 Glycine max Nutrition 0.000 claims 2
- 244000068988 Glycine max Species 0.000 claims 2
- 229920002683 Glycosaminoglycan Polymers 0.000 claims 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims 2
- 244000025272 Persea americana Species 0.000 claims 2
- 235000008673 Persea americana Nutrition 0.000 claims 2
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 claims 2
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 claims 2
- -1 amino carbohydrate Chemical class 0.000 claims 2
- 229920002770 condensed tannin Polymers 0.000 claims 2
- 235000012754 curcumin Nutrition 0.000 claims 2
- 229940109262 curcumin Drugs 0.000 claims 2
- 239000004148 curcumin Substances 0.000 claims 2
- VFLDPWHFBUODDF-UHFFFAOYSA-N diferuloylmethane Natural products C1=C(O)C(OC)=CC(C=CC(=O)CC(=O)C=CC=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-UHFFFAOYSA-N 0.000 claims 2
- 235000013399 edible fruits Nutrition 0.000 claims 2
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 claims 2
- 229910052749 magnesium Inorganic materials 0.000 claims 2
- 239000011777 magnesium Substances 0.000 claims 2
- 235000001055 magnesium Nutrition 0.000 claims 2
- 229940068065 phytosterols Drugs 0.000 claims 2
- 229960001285 quercetin Drugs 0.000 claims 2
- 235000005875 quercetin Nutrition 0.000 claims 2
- 229960004245 silymarin Drugs 0.000 claims 2
- 235000017700 silymarin Nutrition 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 229960005559 sulforaphane Drugs 0.000 claims 2
- 235000015487 sulforaphane Nutrition 0.000 claims 2
- 229940096998 ursolic acid Drugs 0.000 claims 2
- PLSAJKYPRJGMHO-UHFFFAOYSA-N ursolic acid Natural products CC1CCC2(CCC3(C)C(C=CC4C5(C)CCC(O)C(C)(C)C5CCC34C)C2C1C)C(=O)O PLSAJKYPRJGMHO-UHFFFAOYSA-N 0.000 claims 2
- 229940088594 vitamin Drugs 0.000 claims 2
- 229930003231 vitamin Natural products 0.000 claims 2
- 235000013343 vitamin Nutrition 0.000 claims 2
- 239000011782 vitamin Substances 0.000 claims 2
- 150000003722 vitamin derivatives Chemical class 0.000 claims 2
- 235000010323 ascorbic acid Nutrition 0.000 claims 1
- 229960005070 ascorbic acid Drugs 0.000 claims 1
- 239000011668 ascorbic acid Substances 0.000 claims 1
- 108010058651 thioglucosidase Proteins 0.000 claims 1
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- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
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Claims (15)
1. Композиция для перорального введения для увеличения содержания глутатиона при лечении рака прямой кишки или рака толстой кишки, содержащая синергитическую комбинацию сульфорафана и экстракта молочного чертополоха, стандартизованного до содержания от 20 до около 35 вес.% силибинина.
2. Композиция для перорального введения по п. 1, в которой композиция содержит энтеросолюбильную лекарственную форму.
3. Композиция для перорального введения по п. 1, дополнительно содержащая один или более дополнительных компонентов, выбранных из группы, состоящей из: кверцетина, аминоуглевода, гликозоаминогликана, неомыляемых веществ на основе авокадо и соевых бобов, витамина, плодов кофейного дерева, магния, силимарина, проантоцианидинов, урсоловой кислоты, куркумина, фитостиролов и фитостанолов.
4. Композиция для перорального введения по п. 1, в которой композиция содержит экстракт брокколи, стандартизованный до содержания 12 вес.% глюкорафанина.
5. Способ увеличения содержания глутатиона при лечении рака прямой кишки или рака толстой кишки, содержащий введение субъекту, нуждающемуся в этом, синергетической комбинации сульфорафана и экстракта молочного чертополоха, стандартизованного до содержания от 20 до около 35 вес.% силибинина.
6. Способ по п. 5, содержащий введение синергетической комбинации в энтеросолюбильной лекарственной форме.
7. Композиция для перорального введения для увеличения содержания глутатиона при лечении рака прямой кишки или рака толстой кишки, содержащая синергитическую комбинацию экстракта или порошка брокколи и экстракта молочного чертополоха, стандартизованного до содержания от 20 до около 35 вес.% силибинина.
8. Композиция для перорального введения по п. 7, в которой композиция содержит энтеросолюбильную лекарственную форму.
9. Композиция для перорального введения по п. 7, дополнительно содержащая один или более дополнительных компонентов, выбранных из группы, состоящей из: кверцетина, аминоуглевода, гликозоаминогликана, неомыляемых веществ на основе авокадо и соевых бобов, витамина, плодов кофейного дерева, магния, силимарина, проантоцианидинов, урсоловой кислоты, куркумина, фитостиролов и фитостанолов.
10. Композиция для перорального введения по п. 7, в которой экстракт или порошок брокколи стандартизован до содержания 12 вес.% глюкорафанина.
11. Способ увеличения содержания глутатиона при лечении рака прямой кишки или рака толстой кишки, содержащий введение субъекту, нуждающемуся в этом, синергетической комбинации экстракта или порошка брокколи и экстракта молочного чертополоха, стандартизованного до содержания от 20 до около 35 вес.% силибинина.
12. Способ по п. 11, содержащий введение синергетической комбинации в энтеросолюбильной лекарственной форме.
13. Способ по п.11, включающий стандартизацию экстракта или порошка брокколи до содержания 12 вес.% глюкорафанина.
14. Способ по п.11, в котором синергитическая комбинация дополнительно содержит мирозиназу.
15. Способ по п.11, в котором синергитическая комбинация дополнительно содержит аскорбиновую кислоту.
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| US201261668328P | 2012-07-05 | 2012-07-05 | |
| US201261668386P | 2012-07-05 | 2012-07-05 | |
| US201261668374P | 2012-07-05 | 2012-07-05 | |
| US201261668364P | 2012-07-05 | 2012-07-05 | |
| US201261668342P | 2012-07-05 | 2012-07-05 | |
| US201261668396P | 2012-07-05 | 2012-07-05 | |
| US61/668,396 | 2012-07-05 | ||
| US61/668,342 | 2012-07-05 | ||
| US61/668,374 | 2012-07-05 | ||
| US61/668,328 | 2012-07-05 | ||
| US61/668,386 | 2012-07-05 | ||
| US61/668,364 | 2012-07-05 | ||
| US201361794417P | 2013-03-15 | 2013-03-15 | |
| US61/794,417 | 2013-03-15 |
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| RU2015103499A Division RU2666953C2 (ru) | 2012-07-05 | 2013-07-03 | Композиции, содержащие сульфорафан или предшественник сульфорафана и экстракт или порошок молочного чертополоха |
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| RU2018130094A true RU2018130094A (ru) | 2018-10-04 |
| RU2018130094A3 RU2018130094A3 (ru) | 2022-04-19 |
| RU2785683C2 RU2785683C2 (ru) | 2022-12-12 |
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