JP7274725B2 - 慢性疲労症候群の治療剤 - Google Patents
慢性疲労症候群の治療剤 Download PDFInfo
- Publication number
- JP7274725B2 JP7274725B2 JP2018559624A JP2018559624A JP7274725B2 JP 7274725 B2 JP7274725 B2 JP 7274725B2 JP 2018559624 A JP2018559624 A JP 2018559624A JP 2018559624 A JP2018559624 A JP 2018559624A JP 7274725 B2 JP7274725 B2 JP 7274725B2
- Authority
- JP
- Japan
- Prior art keywords
- chronic fatigue
- wasabi
- present
- therapeutic agent
- fatigue syndrome
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000003814 drug Substances 0.000 title claims description 81
- 206010008874 Chronic Fatigue Syndrome Diseases 0.000 title claims description 47
- 208000029766 myalgic encephalomeyelitis/chronic fatigue syndrome Diseases 0.000 title claims description 47
- 229940124597 therapeutic agent Drugs 0.000 title claims description 29
- 235000000760 Wasabia japonica Nutrition 0.000 claims description 71
- 206010016256 fatigue Diseases 0.000 claims description 42
- 208000001640 Fibromyalgia Diseases 0.000 claims description 27
- 238000011282 treatment Methods 0.000 claims description 25
- 239000000284 extract Substances 0.000 claims description 24
- 229940079593 drug Drugs 0.000 claims description 21
- XQZVZULJKVALRI-UHFFFAOYSA-N 1-isothiocyanato-6-(methylsulfinyl)hexane Chemical compound CS(=O)CCCCCCN=C=S XQZVZULJKVALRI-UHFFFAOYSA-N 0.000 claims description 20
- 238000000605 extraction Methods 0.000 claims description 17
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 15
- 241000196324 Embryophyta Species 0.000 claims description 10
- 239000004089 psychotropic agent Substances 0.000 claims description 9
- 150000003839 salts Chemical class 0.000 claims description 9
- 229940001470 psychoactive drug Drugs 0.000 claims description 8
- 238000006911 enzymatic reaction Methods 0.000 claims description 5
- 239000003242 anti bacterial agent Substances 0.000 claims description 4
- 229940088710 antibiotic agent Drugs 0.000 claims description 4
- 229920001353 Dextrin Polymers 0.000 claims description 2
- 239000004375 Dextrin Substances 0.000 claims description 2
- 229940124599 anti-inflammatory drug Drugs 0.000 claims description 2
- 235000019425 dextrin Nutrition 0.000 claims description 2
- 239000012254 powdered material Substances 0.000 claims description 2
- 241001293164 Eutrema japonicum Species 0.000 claims 5
- 244000195452 Wasabia japonica Species 0.000 description 66
- 235000013305 food Nutrition 0.000 description 38
- 239000000047 product Substances 0.000 description 28
- 239000002537 cosmetic Substances 0.000 description 27
- 238000000034 method Methods 0.000 description 27
- 230000002265 prevention Effects 0.000 description 21
- 230000003449 preventive effect Effects 0.000 description 19
- 201000010099 disease Diseases 0.000 description 17
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 17
- 230000006872 improvement Effects 0.000 description 14
- 239000000203 mixture Substances 0.000 description 14
- 239000004480 active ingredient Substances 0.000 description 13
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 12
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 12
- 239000000654 additive Substances 0.000 description 12
- 208000024891 symptom Diseases 0.000 description 12
- 230000036541 health Effects 0.000 description 11
- ZOJBYZNEUISWFT-UHFFFAOYSA-N allyl isothiocyanate Chemical compound C=CCN=C=S ZOJBYZNEUISWFT-UHFFFAOYSA-N 0.000 description 10
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 9
- 239000007788 liquid Substances 0.000 description 9
- 150000002540 isothiocyanates Chemical class 0.000 description 8
- 230000000069 prophylactic effect Effects 0.000 description 7
- 239000002904 solvent Substances 0.000 description 7
- OGYHCBGORZWBPH-UHFFFAOYSA-N 1-isothiocyanato-7-(methylsulfinyl)heptane Chemical compound CS(=O)CCCCCCCN=C=S OGYHCBGORZWBPH-UHFFFAOYSA-N 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 206010025482 malaise Diseases 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 240000003291 Armoracia rusticana Species 0.000 description 5
- 235000011330 Armoracia rusticana Nutrition 0.000 description 5
- 235000016720 allyl isothiocyanate Nutrition 0.000 description 5
- 239000002775 capsule Substances 0.000 description 5
- 238000001035 drying Methods 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 239000008187 granular material Substances 0.000 description 5
- -1 methanol or ethanol Chemical compound 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 239000006188 syrup Substances 0.000 description 5
- 235000020357 syrup Nutrition 0.000 description 5
- 230000001225 therapeutic effect Effects 0.000 description 5
- IUUQPVQTAUKPPB-UHFFFAOYSA-N 1-isothiocyanato-5-(methylsulfinyl)pentane Chemical group CS(=O)CCCCCN=C=S IUUQPVQTAUKPPB-UHFFFAOYSA-N 0.000 description 4
- YIBXPFAXPUDDTK-UHFFFAOYSA-N 1-isothiocyanato-6-(methylsulfanyl)hexane Chemical compound CSCCCCCCN=C=S YIBXPFAXPUDDTK-UHFFFAOYSA-N 0.000 description 4
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
- 240000002791 Brassica napus Species 0.000 description 4
- 235000011299 Brassica oleracea var botrytis Nutrition 0.000 description 4
- 240000003259 Brassica oleracea var. botrytis Species 0.000 description 4
- 206010019233 Headaches Diseases 0.000 description 4
- 235000017879 Nasturtium officinale Nutrition 0.000 description 4
- 240000005407 Nasturtium officinale Species 0.000 description 4
- 244000088415 Raphanus sativus Species 0.000 description 4
- 235000006140 Raphanus sativus var sativus Nutrition 0.000 description 4
- 230000000996 additive effect Effects 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 231100000869 headache Toxicity 0.000 description 4
- 239000003960 organic solvent Substances 0.000 description 4
- 229920005862 polyol Polymers 0.000 description 4
- 150000003077 polyols Chemical class 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 239000003826 tablet Substances 0.000 description 4
- BCRXKWOQVFKZAG-UHFFFAOYSA-N 8-(methylsulfinyl)octyl isothiocyanate Chemical compound CS(=O)CCCCCCCCN=C=S BCRXKWOQVFKZAG-UHFFFAOYSA-N 0.000 description 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- NMLUOJBSAYAYEM-WIBUTAKZSA-N Hirsutin Natural products CC[C@@H]1CN2CCc3c([nH]c4ccccc34)[C@H]2C[C@H]1C(=COC)C(=O)OC NMLUOJBSAYAYEM-WIBUTAKZSA-N 0.000 description 3
- 230000002354 daily effect Effects 0.000 description 3
- 230000003247 decreasing effect Effects 0.000 description 3
- 229960002496 duloxetine hydrochloride Drugs 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 239000000499 gel Substances 0.000 description 3
- 230000035876 healing Effects 0.000 description 3
- 235000013402 health food Nutrition 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- JFTURWWGPMTABQ-UHFFFAOYSA-N n,n-dimethyl-3-naphthalen-1-yloxy-3-thiophen-2-ylpropan-1-amine Chemical compound C=1C=CC2=CC=CC=C2C=1OC(CCN(C)C)C1=CC=CS1 JFTURWWGPMTABQ-UHFFFAOYSA-N 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 235000019198 oils Nutrition 0.000 description 3
- 229920001542 oligosaccharide Polymers 0.000 description 3
- 150000002482 oligosaccharides Chemical class 0.000 description 3
- 238000000746 purification Methods 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- SUVMJBTUFCVSAD-SNVBAGLBSA-N (R)-sulforaphane Chemical group C[S@@](=O)CCCCN=C=S SUVMJBTUFCVSAD-SNVBAGLBSA-N 0.000 description 2
- LDIRGNDMTOGVRB-UHFFFAOYSA-N 1-Isothiocyanato-7-(methylthio)heptane Chemical group CSCCCCCCCN=C=S LDIRGNDMTOGVRB-UHFFFAOYSA-N 0.000 description 2
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 2
- SUVMJBTUFCVSAD-JTQLQIEISA-N 4-Methylsulfinylbutyl isothiocyanate Chemical group C[S@](=O)CCCCN=C=S SUVMJBTUFCVSAD-JTQLQIEISA-N 0.000 description 2
- SKIHGKNFJKJXPX-UHFFFAOYSA-N 4-isothiocyanato-1-butene Chemical group C=CCCN=C=S SKIHGKNFJKJXPX-UHFFFAOYSA-N 0.000 description 2
- DBISBKDNOKIADM-UHFFFAOYSA-N 5-isothiocyanato-1-pentene Chemical group C=CCCCN=C=S DBISBKDNOKIADM-UHFFFAOYSA-N 0.000 description 2
- BFBMDZOSZQDEKW-UHFFFAOYSA-N 8-(methylthio)octylisothiocyanate Chemical group CSCCCCCCCCN=C=S BFBMDZOSZQDEKW-UHFFFAOYSA-N 0.000 description 2
- HBVIMVJTUQNSEP-UHFFFAOYSA-N Berteroin Chemical group CSCCCCCN=C=S HBVIMVJTUQNSEP-UHFFFAOYSA-N 0.000 description 2
- 244000178993 Brassica juncea Species 0.000 description 2
- 235000011332 Brassica juncea Nutrition 0.000 description 2
- 235000008537 Brassica juncea var. integrifolia Nutrition 0.000 description 2
- 240000007124 Brassica oleracea Species 0.000 description 2
- 235000003899 Brassica oleracea var acephala Nutrition 0.000 description 2
- 235000011301 Brassica oleracea var capitata Nutrition 0.000 description 2
- 235000004221 Brassica oleracea var gemmifera Nutrition 0.000 description 2
- 235000017647 Brassica oleracea var italica Nutrition 0.000 description 2
- 235000001169 Brassica oleracea var oleracea Nutrition 0.000 description 2
- 244000308368 Brassica oleracea var. gemmifera Species 0.000 description 2
- 235000010149 Brassica rapa subsp chinensis Nutrition 0.000 description 2
- 235000000536 Brassica rapa subsp pekinensis Nutrition 0.000 description 2
- 241000499436 Brassica rapa subsp. pekinensis Species 0.000 description 2
- 235000004977 Brassica sinapistrum Nutrition 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 229920000858 Cyclodextrin Polymers 0.000 description 2
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 2
- 239000004278 EU approved seasoning Substances 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 2
- 208000000112 Myalgia Diseases 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 2
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- SUVMJBTUFCVSAD-UHFFFAOYSA-N Sulforathane Chemical group CS(=O)CCCCN=C=S SUVMJBTUFCVSAD-UHFFFAOYSA-N 0.000 description 2
- ZMZDMBWJUHKJPS-UHFFFAOYSA-M Thiocyanate anion Chemical compound [S-]C#N ZMZDMBWJUHKJPS-UHFFFAOYSA-M 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- 229930003779 Vitamin B12 Natural products 0.000 description 2
- 229930003268 Vitamin C Natural products 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 238000005273 aeration Methods 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 235000013361 beverage Nutrition 0.000 description 2
- LIMQQADUEULBSO-UHFFFAOYSA-N butyl isothiocyanate Chemical group CCCCN=C=S LIMQQADUEULBSO-UHFFFAOYSA-N 0.000 description 2
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 2
- 239000008116 calcium stearate Substances 0.000 description 2
- 235000013539 calcium stearate Nutrition 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 description 2
- AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 description 2
- 235000008504 concentrate Nutrition 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 239000003925 fat Substances 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000011194 food seasoning agent Nutrition 0.000 description 2
- 238000004817 gas chromatography Methods 0.000 description 2
- 239000007903 gelatin capsule Substances 0.000 description 2
- ZMZDMBWJUHKJPS-UHFFFAOYSA-N hydrogen thiocyanate Natural products SC#N ZMZDMBWJUHKJPS-UHFFFAOYSA-N 0.000 description 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 235000015110 jellies Nutrition 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 238000000199 molecular distillation Methods 0.000 description 2
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 2
- 229930014626 natural product Natural products 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 2
- 230000035807 sensation Effects 0.000 description 2
- 235000019615 sensations Nutrition 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000000829 suppository Substances 0.000 description 2
- 244000117494 takana Species 0.000 description 2
- 239000002562 thickening agent Substances 0.000 description 2
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 2
- 235000015112 vegetable and seed oil Nutrition 0.000 description 2
- 239000008158 vegetable oil Substances 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 235000019163 vitamin B12 Nutrition 0.000 description 2
- 239000011715 vitamin B12 Substances 0.000 description 2
- 239000011718 vitamin C Substances 0.000 description 2
- 235000019154 vitamin C Nutrition 0.000 description 2
- 239000001993 wax Substances 0.000 description 2
- NWZSZGALRFJKBT-KNIFDHDWSA-N (2s)-2,6-diaminohexanoic acid;(2s)-2-hydroxybutanedioic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O.NCCCC[C@H](N)C(O)=O NWZSZGALRFJKBT-KNIFDHDWSA-N 0.000 description 1
- SCYULBFZEHDVBN-UHFFFAOYSA-N 1,1-Dichloroethane Chemical compound CC(Cl)Cl SCYULBFZEHDVBN-UHFFFAOYSA-N 0.000 description 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 1
- GLQPTZAAUROJMO-UHFFFAOYSA-N 4-(3,4-dimethoxyphenyl)benzaldehyde Chemical compound C1=C(OC)C(OC)=CC=C1C1=CC=C(C=O)C=C1 GLQPTZAAUROJMO-UHFFFAOYSA-N 0.000 description 1
- WRFHVMFZOJHYGN-UHFFFAOYSA-N 6-isothiocyanatohex-1-ene Chemical group C=CCCCCN=C=S WRFHVMFZOJHYGN-UHFFFAOYSA-N 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 208000008035 Back Pain Diseases 0.000 description 1
- 235000011293 Brassica napus Nutrition 0.000 description 1
- 235000001171 Brassica oleracea var gongylodes Nutrition 0.000 description 1
- 235000000540 Brassica rapa subsp rapa Nutrition 0.000 description 1
- 241000219193 Brassicaceae Species 0.000 description 1
- 241000195940 Bryophyta Species 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- QMMFVYPAHWMCMS-UHFFFAOYSA-N Dimethyl sulfide Chemical compound CSC QMMFVYPAHWMCMS-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 208000008771 Lymphadenopathy Diseases 0.000 description 1
- 206010028836 Neck pain Diseases 0.000 description 1
- 206010039101 Rhinorrhoea Diseases 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 235000013334 alcoholic beverage Nutrition 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 229940035676 analgesics Drugs 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 230000001430 anti-depressive effect Effects 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000002180 anti-stress Effects 0.000 description 1
- 239000000935 antidepressant agent Substances 0.000 description 1
- 229940005513 antidepressants Drugs 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 125000005135 aryl sulfinyl group Chemical group 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 235000015895 biscuits Nutrition 0.000 description 1
- 239000007844 bleaching agent Substances 0.000 description 1
- 235000008429 bread Nutrition 0.000 description 1
- 239000012267 brine Substances 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- CSNJTIWCTNEOSW-UHFFFAOYSA-N carbamothioylsulfanyl carbamodithioate Chemical compound NC(=S)SSC(N)=S CSNJTIWCTNEOSW-UHFFFAOYSA-N 0.000 description 1
- 235000014171 carbonated beverage Nutrition 0.000 description 1
- 229940085927 celecoxib 100 mg Drugs 0.000 description 1
- 235000010980 cellulose Nutrition 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 229960003405 ciprofloxacin Drugs 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 235000014510 cooky Nutrition 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000003889 eye drop Substances 0.000 description 1
- 229940012356 eye drops Drugs 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 235000010855 food raising agent Nutrition 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000012458 free base Substances 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 235000015203 fruit juice Nutrition 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 235000013376 functional food Nutrition 0.000 description 1
- 239000003349 gelling agent Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 238000007602 hot air drying Methods 0.000 description 1
- IKDUDTNKRLTJSI-UHFFFAOYSA-N hydrazine monohydrate Substances O.NN IKDUDTNKRLTJSI-UHFFFAOYSA-N 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229960004903 invert sugar Drugs 0.000 description 1
- 239000008274 jelly Substances 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000000865 liniment Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 208000030208 low-grade fever Diseases 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 208000018555 lymphatic system disease Diseases 0.000 description 1
- 238000005360 mashing Methods 0.000 description 1
- 235000020124 milk-based beverage Nutrition 0.000 description 1
- 239000012046 mixed solvent Substances 0.000 description 1
- 235000011929 mousse Nutrition 0.000 description 1
- 208000013465 muscle pain Diseases 0.000 description 1
- 208000010753 nasal discharge Diseases 0.000 description 1
- 229940100662 nasal drops Drugs 0.000 description 1
- 235000012149 noodles Nutrition 0.000 description 1
- 239000002417 nutraceutical Substances 0.000 description 1
- 235000021436 nutraceutical agent Nutrition 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 239000006259 organic additive Substances 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 235000019685 rice crackers Nutrition 0.000 description 1
- 229960003660 sertraline hydrochloride Drugs 0.000 description 1
- 208000019116 sleep disease Diseases 0.000 description 1
- 208000022925 sleep disturbance Diseases 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 235000014214 soft drink Nutrition 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 235000014347 soups Nutrition 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000001256 steam distillation Methods 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 238000002636 symptomatic treatment Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000013616 tea Nutrition 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 230000002618 waking effect Effects 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/10—Natural spices, flavouring agents or condiments; Extracts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/26—Cyanate or isocyanate esters; Thiocyanate or isothiocyanate esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nutrition Science (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Medical Informatics (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
本発明において、ω-メチルスルフィニルアルキルイソチオシアネートは化学的に合成された物質であってもよく、また、アブラナ科植物から得られた抽出物としての天然物であってもよい。
本発明において、ワサビの加工物そのものを慢性疲労症候群、特発性慢性疲労、線維筋痛症の予防・改善/治療剤として使用することができる。また、本発明のワサビの加工物を有効成分として含有する慢性疲労症候群、特発性慢性疲労、線維筋痛症の予防・改善/治療剤は、飲食品(機能性表示食品、特定保健食品)、医薬品、化粧料に配合することができる。また、本発明の一態様は、予防・改善/治療剤を有効成分及び/又は添加剤として含む、飲食品(機能性表示食品、特定保健食品)、医薬品、化粧料である。本発明の好ましい態様は、本発明の予防・改善/治療剤等を含む、内服用の医薬品(内服用の医薬部外品を含む)及び飲食品が挙げられる。
本発明は、ワサビの加工物、ω-メチルスルフィニルアルキルイソチオシアネート又はその生理学的に許容される塩を有効成分として含有する組成物にも関する。本発明の飲食品、医薬品、化粧料の説明は、本発明の飲食品、医薬品、又は化粧料組成物にも適用される。
本発明の慢性疲労症候群、特発性慢性疲労、線維筋痛症の予防・改善/治療剤;飲食品、医薬品、又は化粧料;及び飲食品、医薬品、又は化粧料組成物は、例えば、以下に示す用途に使用することができる。
本わさび1.0kgを凍結させ、凍結粉砕した。この粉砕された本わさびをガラス製の容器に入れ、40℃で1時間放置して酵素反応を起こさせた。反応終了後、容器内の空気を吸引することで揮発性成分であるアリルイソチオシアネートの多くを除去した。ここに、5リットルのアセトンを入れて1時間攪拌し、ろ過して抽出液を得た。この抽出液を濃縮して55gの濃縮液を得、100gのデキストリンに吸着させて乾燥させ、粉末化素材を得た。濃縮液をGC分析して(非特許文献4の条件を参照して分析した)、濃縮液は6-メチルスルフィニルヘキシルイソチオシアネートを主成分とすることを確認した。
・患者1
CDC(米国疾病対策センター)および平成25年厚生労働省による慢性疲労症候群の診断基準を満たす患者1には、頚部の疼痛に対して、抗生剤<シプロフロキサシン600mg/日1ヶ月に1、2週投与>が、近医耳鼻科より処方されていた。その後、わさびの癒し(登録商標、神戸ウェルネスサイエンス株式会社製)を1粒/日で投与することにより、抗生剤の使用頻度が半減した。
・患者2
CDC(米国疾病対策センター)および平成25年厚生労働省による慢性疲労症候群の診断基準を満たす患者2には、漢方(ヨクイニントウ7.5g)、向精神薬(ディロキセチン塩酸塩20mg)、消炎鎮痛薬(セレコキシブ100mg)による治療によっても改善しない微熱、熱感、労作性倦怠感が存在していたが、漢方薬を柴胡桂枝湯7.5g分散前に変更しわさびの癒し(登録商標、神戸ウェルネスサイエンス株式会社製)を1粒/日で投与することにより、微熱、熱感の症状が消失した。向精神薬(デュロキセチン塩酸塩)の中止が可能となった。
・患者3
CDC(米国疾病対策センター)および平成25年厚生労働省による慢性疲労症候群の診断基準を満たし、米国リウマチ学会2010年の線維筋痛症の診断基準を満たす患者3に、漢方薬(ホチュウエキキトウ7.5g)、向精神薬(塩酸セルトラリン75mg、ノリトリプチリン塩酸塩5mg)を投与するも残存していた背部痛、思考力の低下、起床困難などの症状が、わさびの癒し(登録商標、神戸ウェルネスサイエンス株式会社製)を1粒/日で投与することにより軽減した。
・患者4
CDC(米国疾病対策センター)および平成25年厚生労働省による慢性疲労症候群の診断基準を満たす患者4で、漢方(トウキシャクヤクサン7.5g)、ビタミンC1500mg、向精神薬(塩酸セルトラリン50mg、トラドゾン塩酸塩25mg)による治療をおこなっていたが持続する、倦怠感、頭重感、鼻汁などの感冒様症状に対し、わさびの癒し(登録商標、神戸ウェルネスサイエンス株式会社製)を1粒/日で投与することにより、症状の頻度が減少し、活動量が増加した。PSが6から5に改善した。
・患者5
CDC(米国疾病対策センター)および平成25年厚生労働省による慢性疲労症候群の診断基準を満たす患者5には、すでに漢方(ショウサイコトウ7.5g)、向精神薬(デュロキセチン塩酸塩40mg)による治療にて改善しなかった微熱、労作性倦怠感のために臥床傾向であったが、わさびの癒し(登録商標、神戸ウェルネスサイエンス株式会社製)を3粒/日で投与することにより改善し、外出が可能な時間が増えた。PSが7から6に改善した。
・患者6
うつ病に加え、CDC(米国疾病対策センター)および平成25年厚生労働省による慢性疲労症候群の診断基準を満たす患者6。抗うつ薬(デュロキセチン塩酸塩20mg)による治療により、うつ病は改善傾向であるが、労作性倦怠感のために仕事が十分におこなえず、頭痛が継続しロキソプロフェンナトリウム水和物60mgを頓服にてほぼ毎日常用していたが、わさびの癒し(登録商標、神戸ウェルネスサイエンス株式会社製)を1粒/日で投与することにより、頭痛が軽減し、鎮痛剤の使用が減少した。
CDC(米国疾病対策センター)および平成25年厚生労働省による慢性疲労症候群の診断基準を満たす患者17人に、わさびの癒し(登録商標、神戸ウェルネスサイエンス株式会社製)1粒:ワサビサプリを投与した。
・抗生物質、向精神薬、抗炎症薬の減薬
・PS値の改善(活動量)
・自覚症状の改善
・患者7
原因不明の慢性疲労で、CDC(米国疾病対策センター)および平成25年厚生労働省による特発性慢性疲労の診断基準を満たす患者7に対し、わさびの癒し(登録商標、神戸ウェルネスサイエンス株式会社製)を1粒/日で投与することにより、頭重感が減少し、「頭がすっきり」するようになった。
・患者8
反復性うつ病により休職と復職を繰り返している患者8、症状が不安定なため、残業制限等の措置がなされているが、わさびの癒し(登録商標、神戸ウェルネスサイエンス株式会社製)を1粒/日で服用するようになり、仕事の負荷が増えても悪化せずに経過している。
処方例1:カプセル剤
本わさびエキス/オリゴ糖 79重量%
ステアリン酸カルシウム 3重量%
HPMC/酸化チタン 18重量%
本わさびエキス/オリゴ糖 0.9重量%
還元麦芽糖水飴 55重量%
食用精製加工油脂 4.0重量%
ビタミンC 24重量%
セルロース 10重量%
香料 2.0重量%
ステアリン酸カルシウム 1.5重量%
シクロデキストリン 1.4重量%
クエン酸 1.0重量%
ビタミンB12 0.2重量%
Claims (3)
- ワサビの加工物を含有し、上記ワサビの加工物が、
粉砕されたわさびを容器に入れ、酵素反応を起こさせ、上記酵素反応終了後、容器内から揮発性成分を除去した後、エタノールで抽出を行って得られた抽出液を濃縮し、デキストリンに吸着させて乾燥させた粉末化素材であり、慢性疲労症候群、特発性慢性疲労又は線維筋痛症を治療するための抗生物質、向精神薬、抗炎症薬又は漢方による薬物治療後に、もしくは上記薬物治療と併用して用いられる、慢性疲労症候群、特発性慢性疲労、線維筋痛症の改善/治療剤。 - ワサビの加工物が、ワサビ属植物の加工物の総重量に対するωーメチルスルフィニルアルキルイソチオシアネートを0.00050~0.425重量%で含有する、請求項1に記載の改善/治療剤。
- ω-メチルスルフィニルアルキルイソチオシアネート又はその生理学的に許容される塩が、6-メチルスルフィニルヘキシルイソチオシアネートである、請求項2に記載の改善/治療剤。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2016254992 | 2016-12-28 | ||
JP2016254992 | 2016-12-28 | ||
JP2017094783 | 2017-05-11 | ||
JP2017094783 | 2017-05-11 | ||
PCT/JP2017/047152 WO2018124258A1 (ja) | 2016-12-28 | 2017-12-28 | 慢性疲労症候群の治療剤 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPWO2018124258A1 JPWO2018124258A1 (ja) | 2019-10-31 |
JP7274725B2 true JP7274725B2 (ja) | 2023-05-17 |
Family
ID=62709401
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2018559624A Active JP7274725B2 (ja) | 2016-12-28 | 2017-12-28 | 慢性疲労症候群の治療剤 |
Country Status (3)
Country | Link |
---|---|
US (1) | US10925304B2 (ja) |
JP (1) | JP7274725B2 (ja) |
WO (1) | WO2018124258A1 (ja) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN116723826A (zh) * | 2020-12-22 | 2023-09-08 | 金印株式会社 | 牙齿护理用组合物以及生物体组织的钙化促进方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009155333A (ja) | 2009-01-13 | 2009-07-16 | Tsujido Chemical Corp | 抗疲労剤 |
WO2010086972A1 (ja) | 2009-01-28 | 2010-08-05 | Sekiyama Atsuo | 抗ストレス剤 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3919489B2 (ja) | 2001-09-10 | 2007-05-23 | 金印株式会社 | アリルイソチオシアネートを含まないイソチオシアネート類含有食品素材の製造方法 |
JP2009155334A (ja) * | 2009-01-13 | 2009-07-16 | Tsujido Chemical Corp | 治療剤 |
JP2010280573A (ja) | 2009-06-02 | 2010-12-16 | Kinjirushi Kk | リラックス作用、集中力増強作用および抗ストレス作用を有する物質 |
WO2012142511A2 (en) * | 2011-04-15 | 2012-10-18 | Md Matrix Health Llc Dba Md Matrix Health Inc | Orthomolecular compositions and their use in stabilizing the extracellular matrix |
WO2014008353A2 (en) * | 2012-07-05 | 2014-01-09 | Nutramax Laboratories, Inc. | Compositions comprising sulforaphane or a sulforaphane precursor and a mushroom extract or powder |
EP3360548A4 (en) * | 2015-10-08 | 2019-06-19 | Productive Aging Laboratory, Co., Ltd. | INHIBITOR OF MUSCLE DENSION OR MUSCLE FATIGUE |
-
2017
- 2017-12-28 US US16/474,637 patent/US10925304B2/en active Active
- 2017-12-28 JP JP2018559624A patent/JP7274725B2/ja active Active
- 2017-12-28 WO PCT/JP2017/047152 patent/WO2018124258A1/ja active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009155333A (ja) | 2009-01-13 | 2009-07-16 | Tsujido Chemical Corp | 抗疲労剤 |
WO2010086972A1 (ja) | 2009-01-28 | 2010-08-05 | Sekiyama Atsuo | 抗ストレス剤 |
Non-Patent Citations (3)
Title |
---|
吉原一文,心身症と機能性身体症候群,日本心療内科学会誌,Vol.19,2015年,pp.158-162 |
松本美富士,慢性疲労症候群(線維筋痛症候群を含む)の臨床経過と予後(QOL)の解析,リウマチ,2002年,Vol.42 No.2,p.305 |
河合潔ほか,慢性疲労症候群-自験例と文献による検討-,日本医事新報,1992年,No.3563,pp.23-27 |
Also Published As
Publication number | Publication date |
---|---|
US20190343161A1 (en) | 2019-11-14 |
WO2018124258A1 (ja) | 2018-07-05 |
US10925304B2 (en) | 2021-02-23 |
JPWO2018124258A1 (ja) | 2019-10-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6564134B2 (ja) | モルシン、クワノンジ又は桑白皮を含有する筋肉疾患予防及び治療用又は筋機能改善用組成物 | |
WO2017138586A1 (ja) | インフラマソーム活性化抑制剤 | |
KR101933232B1 (ko) | 성장 호르몬 분비 촉진제 | |
KR20210014231A (ko) | 해조류 추출물을 함유하는 근육 질환 예방 또는 치료용 또는 근 기능 개선용 조성물 | |
JP3768795B2 (ja) | キサンチンオキシダーゼ阻害剤 | |
US20190070129A1 (en) | Composition comprising panduratin or fingerroot (boesenbergia pandurata) extract for treating, preventing, or ameliorating bone loss disease | |
JP6962564B2 (ja) | 筋肉損傷や筋肉疲労の抑制剤 | |
WO2005094860A1 (ja) | 末梢血流改善剤 | |
JP7176813B2 (ja) | 疲労改善用組成物 | |
JP7274725B2 (ja) | 慢性疲労症候群の治療剤 | |
KR101910013B1 (ko) | 한약재 추출물(socg)을 함유하는 통증의 개선, 예방 또는 치료용 조성물 | |
JP6787595B2 (ja) | 血流改善剤、ローヤルゼリー組成物及びローヤルゼリー組成物の製造方法 | |
KR20170122501A (ko) | 생강 추출물의 비극성 용매 분획물을 유효성분으로 포함하는 월경통 및 조기분만진통의 예방 및 치료용 약학적 조성물 | |
JP2010180141A (ja) | 抗アレルギー組成物 | |
KR20150113709A (ko) | 삼채 추출물을 유효성분으로 함유하는 피부 미백용 조성물 | |
JP7445689B2 (ja) | 脂肪分解促進剤 | |
KR20110051541A (ko) | 흑마늘 추출물을 유효성분으로 함유하는 통풍의 예방 또는 치료용 조성물 | |
KR102474229B1 (ko) | 식물성스테롤(Phytosterols)을 유효성분으로 함유하는 타액 분비 증강 또는 구강건조증 예방 또는 치료용 조성물 | |
JP2004292355A (ja) | 抗ストレス剤 | |
JP2021120358A (ja) | 経口皮膚バリア機能向上剤 | |
KR20240029006A (ko) | 피부 탄력 또는 보습 개선용 식품 조성물 | |
KR20240054619A (ko) | 참비녀골풀 추출물을 유효성분으로 함유하는 아토피 피부염의 예방, 개선 또는 치료용 조성물 | |
JP2021165237A (ja) | 皮膚における赤み改善剤 | |
JP2021013326A (ja) | 肉体的疲労及び疲労感を予防又は改善するオレアナン型トリテルペンを含有する組成物 | |
CN115040546A (zh) | 五倍子提取物和木糖醇的应用 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20190222 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20201127 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20211207 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20220201 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20220510 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20220707 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20220902 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20230110 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20230309 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20230328 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20230425 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 7274725 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |